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The map label for this gene is phhA [H]

Identifier: 220918085

GI number: 220918085

Start: 3309064

End: 3310653

Strand: Reverse

Name: phhA [H]

Synonym: A2cp1_2986

Alternate gene names: 220918085

Gene position: 3310653-3309064 (Counterclockwise)

Preceding gene: 220918086

Following gene: 220918083

Centisome position: 65.83

GC content: 76.42

Gene sequence:

>1590_bases
TTGGGTCCCACCGAGCGCGCCATCGCCGAGCTGCCGCCGCACCTCCGCCGCTTCGTGGTCGCGCAGGACCACGCCGCGTA
CACGCCGCGCGACCACGCGGTCTGGCGCCACGTCCTCCGCCGGCTCACCGCGCACCTGGCCACGCGCGCGCACCCCCGCT
ACCTGGCCGGCCTGGCCGCCACCGGCATCGAGGTGGAGCGGATCCCGAGCCTCGACGAGATGAACCGGAAGCTGGCGCGG
GTGGGGTGGTCGGCGGTGGCGGTCCGCGGGTTCATCCCGCCCGCGGTGTTCACCGAGCTCCAGAGCCGGCGCGTGCTGGC
GATCGCCGCGGACATCCGCACCCACGAGCACATCGAGTACACGCCCGCGCCCGACATCATCCACGAGAGCGCCGGCCACG
CGCCGTTCATCGCCGACCCGACCTACGCCGAGTACCTGCAGCGCGCCGGCGAGGTGGGGTTCCGCGCCATCGCCTCGGCG
GAGGACCAGGCGGTGTTCGAGGCCATCCGCAACCTGTCCGTCGTGAAGGAGGACCCCGAGGCGAGCGACGAGGAGGTGGC
GCTGTCCGAGGCGCGGCTCCGGGCGGCGTCGGCCAGCGTCCGCTACGCGTCGGAGTCCACGCGCGCGAGCCGGCTCTACT
GGTGGACCGCCGAGTACGGCCTGGTGGGCACGCTCGACGACCCCAGGATCTACGGCGCGGGCCTGCTCTCCTCCATCGGC
GAGGCGGTGCACTGCCTCACCCCGGCCGTGCGCAAGCTGCCGCTCGATCCGGGCTGCGCCGACGTGGCCTACGACATCAC
CCGCATGCAGCCGCAGCTGTTCGTGGCCCGCGACTTCGACCAGCTCTTCGAGGTGCTGGACGCGTTCACCGCGGGGCTCT
CCTGGAGGCGCGGCGGCGACCACGGGCTGGAGGAGGCGCGCCGATCCCGGAGCGTGAACCACCTGGCGCTGTCCGGCGGG
CGGGAGCTGACCGGCAAGGTCGCGGAGCGGATCCCGGCGGCGGCCGAGCTCGCGCCCGGCCTGTCGACCGCGCTGGTGCG
CCTGGACGGGCCGGTGCTCGTCTCGCGGGAGGGGCGCGGCGAGGGGAAGCCGTGGCCGGGCGAGGTGGTGGTGGCGTTCG
GCGACGCGGAGGTCCCCGATCGCGGGCCCTTCGACCTGGCGCTGCCCGGCGGGCTCGCGCTGCGCGGGTTCGCGGTGGGC
GGTGGCGAGGTGGTGGACCTCCGCGCCTCGCGCGAGGGCCGGCCGCTCGACCTGCCCACCTGGGCGCTCCTGTTCGTCTC
GCGCGACCTGCGCTCGGTCGCGGGCGGGCCCGCCGACCCGGGCGCGTGGGATCGCTGGTTCGGCGAGCACGGCACGTTCA
CCGCAGGCGAGGGCGAGGCGCGGGCGCGCGCCCGGAAGGCGAAGGCGCTCCCGCCGGCGCTCGCCGCGCTGTACGACGAG
GTCCGGCGCCTGCGCGAGGCCGGGCGCGGCACGCGCGAGCGCCTGCTCGCGATCCGCGAGGCGGCGGCAGCGTTCCCGGG
GGACTGGCTGCTGCGCACCGAGGTGGACGAGCTGCTCGCGCCGGGCGCCGACGCCCCGGCGCACGCGTGA

Upstream 100 bases:

>100_bases
GCGCCGGGTGTCCGGGCCGGGGGGCCCGCGCCGGGCGGGCGTCGCCGGTCCGGAGCTTCCGGGCGCCGCGCGCCGTCGCA
GATTTCCCGTGGAGGCGAGA

Downstream 100 bases:

>100_bases
GCGGGGCTACCGGGCGTGGAGCGCCGCGACCGCCCGACGCAGCCGCGTGGCGTCGTCGTCGGTGAGCGCCGGGAGCAGCC
GGGTGGCGCGGCCGGAGATG

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 529; Mature: 528

Protein sequence:

>529_residues
MGPTERAIAELPPHLRRFVVAQDHAAYTPRDHAVWRHVLRRLTAHLATRAHPRYLAGLAATGIEVERIPSLDEMNRKLAR
VGWSAVAVRGFIPPAVFTELQSRRVLAIAADIRTHEHIEYTPAPDIIHESAGHAPFIADPTYAEYLQRAGEVGFRAIASA
EDQAVFEAIRNLSVVKEDPEASDEEVALSEARLRAASASVRYASESTRASRLYWWTAEYGLVGTLDDPRIYGAGLLSSIG
EAVHCLTPAVRKLPLDPGCADVAYDITRMQPQLFVARDFDQLFEVLDAFTAGLSWRRGGDHGLEEARRSRSVNHLALSGG
RELTGKVAERIPAAAELAPGLSTALVRLDGPVLVSREGRGEGKPWPGEVVVAFGDAEVPDRGPFDLALPGGLALRGFAVG
GGEVVDLRASREGRPLDLPTWALLFVSRDLRSVAGGPADPGAWDRWFGEHGTFTAGEGEARARARKAKALPPALAALYDE
VRRLREAGRGTRERLLAIREAAAAFPGDWLLRTEVDELLAPGADAPAHA

Sequences:

>Translated_529_residues
MGPTERAIAELPPHLRRFVVAQDHAAYTPRDHAVWRHVLRRLTAHLATRAHPRYLAGLAATGIEVERIPSLDEMNRKLAR
VGWSAVAVRGFIPPAVFTELQSRRVLAIAADIRTHEHIEYTPAPDIIHESAGHAPFIADPTYAEYLQRAGEVGFRAIASA
EDQAVFEAIRNLSVVKEDPEASDEEVALSEARLRAASASVRYASESTRASRLYWWTAEYGLVGTLDDPRIYGAGLLSSIG
EAVHCLTPAVRKLPLDPGCADVAYDITRMQPQLFVARDFDQLFEVLDAFTAGLSWRRGGDHGLEEARRSRSVNHLALSGG
RELTGKVAERIPAAAELAPGLSTALVRLDGPVLVSREGRGEGKPWPGEVVVAFGDAEVPDRGPFDLALPGGLALRGFAVG
GGEVVDLRASREGRPLDLPTWALLFVSRDLRSVAGGPADPGAWDRWFGEHGTFTAGEGEARARARKAKALPPALAALYDE
VRRLREAGRGTRERLLAIREAAAAFPGDWLLRTEVDELLAPGADAPAHA
>Mature_528_residues
GPTERAIAELPPHLRRFVVAQDHAAYTPRDHAVWRHVLRRLTAHLATRAHPRYLAGLAATGIEVERIPSLDEMNRKLARV
GWSAVAVRGFIPPAVFTELQSRRVLAIAADIRTHEHIEYTPAPDIIHESAGHAPFIADPTYAEYLQRAGEVGFRAIASAE
DQAVFEAIRNLSVVKEDPEASDEEVALSEARLRAASASVRYASESTRASRLYWWTAEYGLVGTLDDPRIYGAGLLSSIGE
AVHCLTPAVRKLPLDPGCADVAYDITRMQPQLFVARDFDQLFEVLDAFTAGLSWRRGGDHGLEEARRSRSVNHLALSGGR
ELTGKVAERIPAAAELAPGLSTALVRLDGPVLVSREGRGEGKPWPGEVVVAFGDAEVPDRGPFDLALPGGLALRGFAVGG
GEVVDLRASREGRPLDLPTWALLFVSRDLRSVAGGPADPGAWDRWFGEHGTFTAGEGEARARARKAKALPPALAALYDEV
RRLREAGRGTRERLLAIREAAAAFPGDWLLRTEVDELLAPGADAPAHA

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 57328; Mature: 57197

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGPTERAIAELPPHLRRFVVAQDHAAYTPRDHAVWRHVLRRLTAHLATRAHPRYLAGLAA
CCCHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
TGIEVERIPSLDEMNRKLARVGWSAVAVRGFIPPAVFTELQSRRVLAIAADIRTHEHIEY
CCCCHHHCCCHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHCCEEEEEEECCCCCCCEEE
TPAPDIIHESAGHAPFIADPTYAEYLQRAGEVGFRAIASAEDQAVFEAIRNLSVVKEDPE
CCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHCCCCCC
ASDEEVALSEARLRAASASVRYASESTRASRLYWWTAEYGLVGTLDDPRIYGAGLLSSIG
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCEEECCCCCCHHHHHHHHHHH
EAVHCLTPAVRKLPLDPGCADVAYDITRMQPQLFVARDFDQLFEVLDAFTAGLSWRRGGD
HHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHEEHHCHHHHHHHHHHHHHCCCCCCCCC
HGLEEARRSRSVNHLALSGGRELTGKVAERIPAAAELAPGLSTALVRLDGPVLVSREGRG
HHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCHHHHCCCHHHHHEEECCCEEEEECCCC
EGKPWPGEVVVAFGDAEVPDRGPFDLALPGGLALRGFAVGGGEVVDLRASREGRPLDLPT
CCCCCCCCEEEEECCCCCCCCCCCCEECCCCCEEEEEEECCCCEEEEECCCCCCCCCCHH
WALLFVSRDLRSVAGGPADPGAWDRWFGEHGTFTAGEGEARARARKAKALPPALAALYDE
HHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCEECCCCHHHHHHHHHHCCCHHHHHHHHH
VRRLREAGRGTRERLLAIREAAAAFPGDWLLRTEVDELLAPGADAPAHA
HHHHHHHCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
GPTERAIAELPPHLRRFVVAQDHAAYTPRDHAVWRHVLRRLTAHLATRAHPRYLAGLAA
CCHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
TGIEVERIPSLDEMNRKLARVGWSAVAVRGFIPPAVFTELQSRRVLAIAADIRTHEHIEY
CCCCHHHCCCHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHCCEEEEEEECCCCCCCEEE
TPAPDIIHESAGHAPFIADPTYAEYLQRAGEVGFRAIASAEDQAVFEAIRNLSVVKEDPE
CCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHCCCCCC
ASDEEVALSEARLRAASASVRYASESTRASRLYWWTAEYGLVGTLDDPRIYGAGLLSSIG
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCEEECCCCCCHHHHHHHHHHH
EAVHCLTPAVRKLPLDPGCADVAYDITRMQPQLFVARDFDQLFEVLDAFTAGLSWRRGGD
HHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHEEHHCHHHHHHHHHHHHHCCCCCCCCC
HGLEEARRSRSVNHLALSGGRELTGKVAERIPAAAELAPGLSTALVRLDGPVLVSREGRG
HHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCHHHHCCCHHHHHEEECCCEEEEECCCC
EGKPWPGEVVVAFGDAEVPDRGPFDLALPGGLALRGFAVGGGEVVDLRASREGRPLDLPT
CCCCCCCCEEEEECCCCCCCCCCCCEECCCCCEEEEEEECCCCEEEEECCCCCCCCCCHH
WALLFVSRDLRSVAGGPADPGAWDRWFGEHGTFTAGEGEARARARKAKALPPALAALYDE
HHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCEECCCCHHHHHHHHHHCCCHHHHHHHHH
VRRLREAGRGTRERLLAIREAAAAFPGDWLLRTEVDELLAPGADAPAHA
HHHHHHHCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8108417; 10984043 [H]