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The map label for this gene is lpxB

Identifier: 220917905

GI number: 220917905

Start: 3103383

End: 3104534

Strand: Reverse

Name: lpxB

Synonym: A2cp1_2806

Alternate gene names: 220917905

Gene position: 3104534-3103383 (Counterclockwise)

Preceding gene: 220917907

Following gene: 220917904

Centisome position: 61.73

GC content: 74.57

Gene sequence:

>1152_bases
GTGCTATATAGCCCGCGCTTGACGGACCAGATCCTGATCGTGGCGGGCGAGGCCAGCGCGGACCTTCACGCGGCCCGGAC
CCTCCACGAGCTGCAGCGGCTCCGCCCCGGGATCACCGCCTTCGGCGTGGGCGGGCCGCGGCTGCGCGAGGCGGGGCTCG
AGGCGCTCGCGCCGGCCGAGGACATCTCGGTGATGGGCCTCGCCGAGGTCCTCCCCCGCATCCCGCGGATCCTCGGGATC
CTGCGGATGCTCGGCCGCGCCGCCGCCGAGCGCCGCCCCAGGGCCGCGCTCCTGGTGGACCTGCCGGACTTCAACCTCCG
GCTCGCGGCGCGCCTCAAGAAGCTCGGGATCCCGGTGGTCTACTACGTGTCGCCGACCATCTGGGCCTGGCGCCAGGGCC
GCGCGAAGAAGATCGCGCGGGTGGTGGACCGGATGCTGTGCATCCTCCCCTTCGAGGAGCGCTTCTACGAAGGCACCGGG
GTGTCGGCCCGCTTCGTCGGCCACCCGTTCGCCGAGCGCCCGCCGCCCGGGCCGGCCGAGGCCTACCGATCGGCGCTGGG
CCTCCCCGCCTCCCGGACCACCATCGCCATGGTCCCGGGCAGCCGCCCGTCCGAGCTGAAGCGCCTGCTCCCGCCGATGC
TCCAGGCCGCCGAGCGGCTGCGCGCGGCCCACCCGGATGCGCAGTTCGTGGTCCCGGTGGCGCCCACGCTGGACCGCGCC
GCGCTCGAGCCGTACCTCGCGGCCCACCGCACGCTGGAGGTGCGACTGGTGGACGGCCGCACCGAGGAGGTGGTCGGCGC
GAGCGACGCGGCGCTGGTGAAGAGCGGGACCTCCACCCTGGAGGCGGGGCTCATGCTCCGGCCCATGGTGGTGGTCTACA
AGCTGTCGTGGCTCTCCTACGCGGTCGCGCGGATGCTGGTGAAGATTGCGCACGTGGCGCTGGTGAACATCCTGGCAGGG
AGGGGGATCGTTCCCGAGCTGCTCCAGGGGGACGCGAGCCCCGAGCGGATGGCGGCGGAGGTGGAGCGCCTGCTCGGCGA
TCGCGCCGCGCGGGAGGCGCAGATCGCGGCGCTGCGGGAGGTGCGGGCGTCGCTGGGCGAGCCGGGCGCGCCGCTCCGGG
TCGCGGAAGAGGTGCTGGGGGTGATGCGATGA

Upstream 100 bases:

>100_bases
AGCCATCCCACCTCGCGCGCCCGCGCGCCCGCGGTTCCCCCATCCATGTGCGACAGCACATCACGGATCGGCCTCCGGAG
CCAGACCGCCCGGGGGCGGC

Downstream 100 bases:

>100_bases
CGCCTGGGCGCGCGCTGGTGTGCCTGCCGACGTACGAGGAGCGGGACAACCTCGAGCCGATCCTCCGCGCGATCCTGGAG
GCCGCACCGTCCGTCGAGGT

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MLYSPRLTDQILIVAGEASADLHAARTLHELQRLRPGITAFGVGGPRLREAGLEALAPAEDISVMGLAEVLPRIPRILGI
LRMLGRAAAERRPRAALLVDLPDFNLRLAARLKKLGIPVVYYVSPTIWAWRQGRAKKIARVVDRMLCILPFEERFYEGTG
VSARFVGHPFAERPPPGPAEAYRSALGLPASRTTIAMVPGSRPSELKRLLPPMLQAAERLRAAHPDAQFVVPVAPTLDRA
ALEPYLAAHRTLEVRLVDGRTEEVVGASDAALVKSGTSTLEAGLMLRPMVVVYKLSWLSYAVARMLVKIAHVALVNILAG
RGIVPELLQGDASPERMAAEVERLLGDRAAREAQIAALREVRASLGEPGAPLRVAEEVLGVMR

Sequences:

>Translated_383_residues
MLYSPRLTDQILIVAGEASADLHAARTLHELQRLRPGITAFGVGGPRLREAGLEALAPAEDISVMGLAEVLPRIPRILGI
LRMLGRAAAERRPRAALLVDLPDFNLRLAARLKKLGIPVVYYVSPTIWAWRQGRAKKIARVVDRMLCILPFEERFYEGTG
VSARFVGHPFAERPPPGPAEAYRSALGLPASRTTIAMVPGSRPSELKRLLPPMLQAAERLRAAHPDAQFVVPVAPTLDRA
ALEPYLAAHRTLEVRLVDGRTEEVVGASDAALVKSGTSTLEAGLMLRPMVVVYKLSWLSYAVARMLVKIAHVALVNILAG
RGIVPELLQGDASPERMAAEVERLLGDRAAREAQIAALREVRASLGEPGAPLRVAEEVLGVMR
>Mature_383_residues
MLYSPRLTDQILIVAGEASADLHAARTLHELQRLRPGITAFGVGGPRLREAGLEALAPAEDISVMGLAEVLPRIPRILGI
LRMLGRAAAERRPRAALLVDLPDFNLRLAARLKKLGIPVVYYVSPTIWAWRQGRAKKIARVVDRMLCILPFEERFYEGTG
VSARFVGHPFAERPPPGPAEAYRSALGLPASRTTIAMVPGSRPSELKRLLPPMLQAAERLRAAHPDAQFVVPVAPTLDRA
ALEPYLAAHRTLEVRLVDGRTEEVVGASDAALVKSGTSTLEAGLMLRPMVVVYKLSWLSYAVARMLVKIAHVALVNILAG
RGIVPELLQGDASPERMAAEVERLLGDRAAREAQIAALREVRASLGEPGAPLRVAEEVLGVMR

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=357, Percent_Identity=40.0560224089636, Blast_Score=239, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_ANAD2 (B8JE78)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002493209.1
- ProteinModelPortal:   B8JE78
- GeneID:   7298879
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_2806
- HOGENOM:   HBG584837
- ProtClustDB:   CLSK946302
- HAMAP:   MF_00392
- InterPro:   IPR003835
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 41563; Mature: 41563

Theoretical pI: Translated: 10.52; Mature: 10.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYSPRLTDQILIVAGEASADLHAARTLHELQRLRPGITAFGVGGPRLREAGLEALAPAE
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHCCHH
DISVMGLAEVLPRIPRILGILRMLGRAAAERRPRAALLVDLPDFNLRLAARLKKLGIPVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCCEE
YYVSPTIWAWRQGRAKKIARVVDRMLCILPFEERFYEGTGVSARFVGHPFAERPPPGPAE
EEECCCHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEECCCCCCCCCCCCHHH
AYRSALGLPASRTTIAMVPGSRPSELKRLLPPMLQAAERLRAAHPDAQFVVPVAPTLDRA
HHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHH
ALEPYLAAHRTLEVRLVDGRTEEVVGASDAALVKSGTSTLEAGLMLRPMVVVYKLSWLSY
HHHHHHHHCCEEEEEEECCCCHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
AVARMLVKIAHVALVNILAGRGIVPELLQGDASPERMAAEVERLLGDRAAREAQIAALRE
HHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRASLGEPGAPLRVAEEVLGVMR
HHHHHCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MLYSPRLTDQILIVAGEASADLHAARTLHELQRLRPGITAFGVGGPRLREAGLEALAPAE
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHCCHH
DISVMGLAEVLPRIPRILGILRMLGRAAAERRPRAALLVDLPDFNLRLAARLKKLGIPVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCCEE
YYVSPTIWAWRQGRAKKIARVVDRMLCILPFEERFYEGTGVSARFVGHPFAERPPPGPAE
EEECCCHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEECCCCCCCCCCCCHHH
AYRSALGLPASRTTIAMVPGSRPSELKRLLPPMLQAAERLRAAHPDAQFVVPVAPTLDRA
HHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHH
ALEPYLAAHRTLEVRLVDGRTEEVVGASDAALVKSGTSTLEAGLMLRPMVVVYKLSWLSY
HHHHHHHHCCEEEEEEECCCCHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
AVARMLVKIAHVALVNILAGRGIVPELLQGDASPERMAAEVERLLGDRAAREAQIAALRE
HHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRASLGEPGAPLRVAEEVLGVMR
HHHHHCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA