Click here to switch to the map view.

The map label for this gene is sasA [H]

Identifier: 220917874

GI number: 220917874

Start: 3061921

End: 3063216

Strand: Direct

Name: sasA [H]

Synonym: A2cp1_2775

Alternate gene names: 220917874

Gene position: 3061921-3063216 (Clockwise)

Preceding gene: 220917873

Following gene: 220917875

Centisome position: 60.88

GC content: 76.39

Gene sequence:

>1296_bases
ATGGACGCCACCCAGCCCCTTTCGGGTGCGCCCGACGCCGCAGCCCAGGCCGCGGCCGACCTGGACGCGCGCGCGCAGCT
CGAGGAGACGCAGCGCCGCATCGCGTTCCTGTACGAGGTCACCGGCGCGCTGTTCGAGGACGCGCGCGGGCACCGCGCCA
CGCTGGGCAAGCTCGCGCGGCTGGTGGTGCCGCACCTCGCCGACTGGTGCCTGGTCCACCTGGTCCGCGACGATCAGGCC
GAGCGCGTCGCCGCCGAGCACTGGAACCCGGATCTCGCGCCGCTCTCGAGCACCCTGCCCCGCACCGTCCCGCTCGCCGG
CCCGGCGGCGCAGGGGCTCGCCGCGGTGGTGGCGAGCGGGCGCGCCGAGCTGGTGCCCGATCCCCCGCCGACCCATCCCG
CCGAGCCGGCCGACCTGGCCGCGCTGCGCCGGCTCCGCGCACGGTCCTGGATGATCGTCCCGCTGCGGGTGCGCGGCCGG
ACGCGCGCGGTGATGACGCTCGCGTTCGCCGAGTCCACCCGGCGCTACACCGGCCACGACCTGGCGCTGGCCGAGGACCT
CGCGGCGCGGGCCGCCATGGCGCTCGAGAACGCGCTGCTGTTCGAGGAGGTCGAGCGCGCGGTGCGGGCGCGGGAGGACA
CGCTCTCGATCGTCTCGCACGACCTCAAGAACCCGATGTCCGCGCTGCTGCTGGGCATCCAGCGGCTGGCGCGCCTGGTG
GACGAGCCGCGCCGCCCGCAGGGCGACGCGCTCCTGGCGAAGCTGGAGCGCACCGTCCGCGGCATGAACCGGCTCATCGA
GGGGCTGCTGGACCTCGCCCGCATCGAGGCCGGGCGGCTGCAGCTCGATCGCCGGCCCGAGCCGCCCGCGGCGGTGGTGG
CCCGGGCCACCGAGCCGCTCGAGGCGCTGGCCGCGGAGCGCCGCCAGCGCATCGCGGTGCGCCTCGCGCCGGACCTGCCG
GTGCCGGCCTGGGATCCGGACCGCATGGCGCAGGTGATCGCGAACCTGGTCGGGAACGCGCTGAAGTTCGGACCGGACGG
CGAGGAGGTCGTGATCACCGCCGAGCGCCACGGCGGCGGCGTGCGCTTCGGGGTGGTGGACCGCGGCCCCGGCATCGCGC
CGGAGATCCGCGAGCACCTGTTCGACCGCTACTGGCAGCCGGCGGCCGACCAGAAGCGCGGCCACGGCCTGGGGCTGTTC
ATCGTGCGCGGCATCGTCGAGGCGCACGGCGGGCAGGCGTGGGTCGAGAGCGAGCCGGGCCGCGGCGCCGCGTTCTACTT
CGTGATCCCCACCTAG

Upstream 100 bases:

>100_bases
TTGCCGATCGGCTGGCGCTCTGGATCCGCCGCTGAGGGGCGCCCGCTGGCCTCCCGGGCAGGTTGTGTTCGTCCCACATG
CGGCCTAGAGTCGCCTCCGA

Downstream 100 bases:

>100_bases
CCTCTCACTGGCGCGGCGTCGCTCCGCCGCACCCACCCACCCCGCTTGATCCGGCGCCGGCGGCGCGCTAGAAGAGCGCG
ATGCGGAAGTAACTAACCGG

Product: GAF sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MDATQPLSGAPDAAAQAAADLDARAQLEETQRRIAFLYEVTGALFEDARGHRATLGKLARLVVPHLADWCLVHLVRDDQA
ERVAAEHWNPDLAPLSSTLPRTVPLAGPAAQGLAAVVASGRAELVPDPPPTHPAEPADLAALRRLRARSWMIVPLRVRGR
TRAVMTLAFAESTRRYTGHDLALAEDLAARAAMALENALLFEEVERAVRAREDTLSIVSHDLKNPMSALLLGIQRLARLV
DEPRRPQGDALLAKLERTVRGMNRLIEGLLDLARIEAGRLQLDRRPEPPAAVVARATEPLEALAAERRQRIAVRLAPDLP
VPAWDPDRMAQVIANLVGNALKFGPDGEEVVITAERHGGGVRFGVVDRGPGIAPEIREHLFDRYWQPAADQKRGHGLGLF
IVRGIVEAHGGQAWVESEPGRGAAFYFVIPT

Sequences:

>Translated_431_residues
MDATQPLSGAPDAAAQAAADLDARAQLEETQRRIAFLYEVTGALFEDARGHRATLGKLARLVVPHLADWCLVHLVRDDQA
ERVAAEHWNPDLAPLSSTLPRTVPLAGPAAQGLAAVVASGRAELVPDPPPTHPAEPADLAALRRLRARSWMIVPLRVRGR
TRAVMTLAFAESTRRYTGHDLALAEDLAARAAMALENALLFEEVERAVRAREDTLSIVSHDLKNPMSALLLGIQRLARLV
DEPRRPQGDALLAKLERTVRGMNRLIEGLLDLARIEAGRLQLDRRPEPPAAVVARATEPLEALAAERRQRIAVRLAPDLP
VPAWDPDRMAQVIANLVGNALKFGPDGEEVVITAERHGGGVRFGVVDRGPGIAPEIREHLFDRYWQPAADQKRGHGLGLF
IVRGIVEAHGGQAWVESEPGRGAAFYFVIPT
>Mature_431_residues
MDATQPLSGAPDAAAQAAADLDARAQLEETQRRIAFLYEVTGALFEDARGHRATLGKLARLVVPHLADWCLVHLVRDDQA
ERVAAEHWNPDLAPLSSTLPRTVPLAGPAAQGLAAVVASGRAELVPDPPPTHPAEPADLAALRRLRARSWMIVPLRVRGR
TRAVMTLAFAESTRRYTGHDLALAEDLAARAAMALENALLFEEVERAVRAREDTLSIVSHDLKNPMSALLLGIQRLARLV
DEPRRPQGDALLAKLERTVRGMNRLIEGLLDLARIEAGRLQLDRRPEPPAAVVARATEPLEALAAERRQRIAVRLAPDLP
VPAWDPDRMAQVIANLVGNALKFGPDGEEVVITAERHGGGVRFGVVDRGPGIAPEIREHLFDRYWQPAADQKRGHGLGLF
IVRGIVEAHGGQAWVESEPGRGAAFYFVIPT

Specific function: May be involved in signal transduction. Participates in the kaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with kaiC. Required for robustness of the circadian rhythm of gene expression an

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=271, Percent_Identity=28.7822878228782, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1789149, Length=233, Percent_Identity=30.0429184549356, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1788713, Length=247, Percent_Identity=29.1497975708502, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI48994928, Length=235, Percent_Identity=28.5106382978723, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1786600, Length=231, Percent_Identity=32.034632034632, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1786783, Length=234, Percent_Identity=28.2051282051282, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1790436, Length=217, Percent_Identity=29.9539170506912, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1786912, Length=289, Percent_Identity=28.0276816608997, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082128, Length=225, Percent_Identity=26.2222222222222, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87081816, Length=271, Percent_Identity=28.7822878228782, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1788393, Length=264, Percent_Identity=27.2727272727273, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790300, Length=241, Percent_Identity=29.045643153527, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1790346, Length=233, Percent_Identity=27.0386266094421, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787894, Length=233, Percent_Identity=27.0386266094421, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1788549, Length=214, Percent_Identity=24.2990654205607, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789808, Length=195, Percent_Identity=30.7692307692308, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787374, Length=248, Percent_Identity=28.2258064516129, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1790861, Length=207, Percent_Identity=27.536231884058, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011649
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF07689 KaiB [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 46893; Mature: 46893

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDATQPLSGAPDAAAQAAADLDARAQLEETQRRIAFLYEVTGALFEDARGHRATLGKLAR
CCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LVVPHLADWCLVHLVRDDQAERVAAEHWNPDLAPLSSTLPRTVPLAGPAAQGLAAVVASG
HHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHCC
RAELVPDPPPTHPAEPADLAALRRLRARSWMIVPLRVRGRTRAVMTLAFAESTRRYTGHD
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCCC
LALAEDLAARAAMALENALLFEEVERAVRAREDTLSIVSHDLKNPMSALLLGIQRLARLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
DEPRRPQGDALLAKLERTVRGMNRLIEGLLDLARIEAGRLQLDRRPEPPAAVVARATEPL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHCCCHH
EALAAERRQRIAVRLAPDLPVPAWDPDRMAQVIANLVGNALKFGPDGEEVVITAERHGGG
HHHHHHHHHHEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCC
VRFGVVDRGPGIAPEIREHLFDRYWQPAADQKRGHGLGLFIVRGIVEAHGGQAWVESEPG
EEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCC
RGAAFYFVIPT
CCEEEEEEECC
>Mature Secondary Structure
MDATQPLSGAPDAAAQAAADLDARAQLEETQRRIAFLYEVTGALFEDARGHRATLGKLAR
CCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LVVPHLADWCLVHLVRDDQAERVAAEHWNPDLAPLSSTLPRTVPLAGPAAQGLAAVVASG
HHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHCC
RAELVPDPPPTHPAEPADLAALRRLRARSWMIVPLRVRGRTRAVMTLAFAESTRRYTGHD
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCCC
LALAEDLAARAAMALENALLFEEVERAVRAREDTLSIVSHDLKNPMSALLLGIQRLARLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
DEPRRPQGDALLAKLERTVRGMNRLIEGLLDLARIEAGRLQLDRRPEPPAAVVARATEPL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHCCCHH
EALAAERRQRIAVRLAPDLPVPAWDPDRMAQVIANLVGNALKFGPDGEEVVITAERHGGG
HHHHHHHHHHEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCC
VRFGVVDRGPGIAPEIREHLFDRYWQPAADQKRGHGLGLFIVRGIVEAHGGQAWVESEPG
EEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCC
RGAAFYFVIPT
CCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]