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The map label for this gene is frzE [H]

Identifier: 220917872

GI number: 220917872

Start: 3058707

End: 3060824

Strand: Direct

Name: frzE [H]

Synonym: A2cp1_2773

Alternate gene names: 220917872

Gene position: 3058707-3060824 (Clockwise)

Preceding gene: 220917871

Following gene: 220917873

Centisome position: 60.82

GC content: 80.64

Gene sequence:

>2118_bases
ATGGACGCCGATCGCCTCCAGGCGCTGCTGCGGGCCACGTTCCTCGGCGAGCTCGAGGACCACGTGCGCAGCCTGACCGC
CGACCTGCTCGCGCTCGAGCGGGCGCCCGGGCCGGACCGCGCCGAGCTGCTCCAGCGCATCTTCCGCACCGTCCACAGCG
TGAAGGGGTCGTCGCGCGCGGCCAGCGTGGAGGCGGTGGAGGCGCAGGCGGCGCGCATGGAGCGGACGCTGGCGGCGGCG
CGCGACCGGCCGCCGGAGGAGGCGCGGCCCCTGGTGGACGAGCTCCTCGACGCGGTGGACGCCATCGAGGAGGCCGGCCG
CCGGCTGCGTGGCCCCGGCGAGCGCGAGGGCGCGCCCCTCTCGGCGGTGGTGCGGCCCGCCGAGCCGCCCGGCGCCGGCG
CCGGCTCGGTGCGGCTGGACGCGGCCCGCCTCGACCGGCTGCAGGCGCTCGAGGCAGAGCTGCGGGCGGCCCGCCACGCG
GGCGAGGGCGCGCGCGCGCCGCTGGAGGCGTTGCAGGCGGAGGTCCGCCGCTGGCGGGCGGAGTGGGCCGAGGACGAGCG
GGTGCTCCGCGACGCGCTCGGCCGCGCCTCGGCGCCGCCCGCCGCCCAGGCCGCCCCGGGCCGGCAGGCGGCGCGCCTGG
CGCGGCTGGAGTCGGAGCTGGAGCGCCTCGCCGCGGCGGGCGCCTCGGCCCGGCGCCGCGTGGCGCAGGCCGTCGAGCCG
CTCGCCGAGGAGCTCCGCGCGCTGCGCATGGTGCCGTTCGCCGAGGCCTGCGCCGGGCTGGAGCGGGCCGCGCGGGACGT
GGCCCGCGGCGCCGGCAAGGAGGTGGACGTCTCGATCGCCGGCGGTGAGGTCTCGCTCGACCGGGCGGTCGCGGACGCGC
TCCGGGCGCCGCTCCTGCACCTGGTGCGGAACGCGGTGGACCACGGGCTGGAGTCCCCCTCGGCGCGCGCCGCCGCCGGG
AAGCCCGCGCGCGGACGGATCGGCGTGACGGCGGTGCTGCGCGGGGGCGAGGTGGAGATCGCGGTCGAGGACGACGGCGC
CGGCCTCGATCTCGACGCCATCCGGCGCCGGGCCGAGCGCGGCGGGCTGCCCGAGGCGGCGGACGCGCGGGCGCTGGCGC
GCCGCGTCTTCCTGCCCGGGTTCACCACCGCGCCGCGTGTCACCGAGGTGTCGGGCCAGGGGGTCGGCCTGGACGCGGTC
CGCGCCGCGGTCGAGGCGCTGCAGGGCGCGGTGGACGTGGAGACGCGGCCCGGGCACGGGACCCGCTTCGTGCTGGTGGT
GCCGCTCACGCTGCTGGCGCTGCGCGCGCTGGTCGTCTCCTGCGGCGGCGAGTCGGTGGCCATCCCGGCGAGCCAGCTCC
GGCGGCTGCTGCAGGTCCACCCGGACGGCCTGCGGCCGCTGGGCGGGCGGGACACCGTGACCGTGGACTGCGAGCCGGTG
CCGGCCGTCGCGCTCGCCGAGGTGCTGGGCCTGCCGGCCGCGGCGCCGGCGGGCGGACGCGCGCCGCTGCAGCTCGCCGT
GGTCGCCGCGGGCGGACGCGCGGTGGCCCTGGCGGTGGACGCGCTCGTCGCCGAGCAGGAGCTCCGCGTGCGCGGGCTCG
GCGCCCGCGTCCGCGCCCTGCCCCACCTCGCCGGCGCGGCGCTGCTCCCCGACGGCGGCGTGGCGCTCGTGCTGAACGTG
CCGGCGGTGGTGGCCTCGGCGCTGGGCCGGCCCACCGCCTCGCTCGCGCCCGCCGCGGCCGCGCCGCGGCGAAGGCCGCG
CATCCTGCTGGTGGACGACTCGCCCACCACCCGCGCGCTGGAGCGCTCGATCCTCGAGACCGCGGGCTACCGGGTCGCGA
CCGCCGCCGACGGGGCGGAGGCCTGGGCCATCCTGGAGCGCGAGGGCGCGGACGCGCTGGTGGCCGACGTGGAGATGCCG
CGGCTCGACGGCTTCGCGCTCACCGAGGCGGTGCGCGCCTCGAGGGCCCTGGCCGCCCTGCCGGTGGTGCTGGTGACCGC
GCGCGAGGCCGAGGCGGACCGCGCGCGCGGCCTCGCCGCCGGCGCCAGCGCGTACCTGGTGAAGAGCGCGTTCGACCAGC
GGAGCCTGCTCGACACGCTGGAACACCTGCTGGGGTGA

Upstream 100 bases:

>100_bases
CGCCAGACCGAGCAGGCGGTCCAGGACCTCTCCACGCTCGCGGTGCGGCTCACGCAGCTGCTCTCCGAGCCGGACCGGGC
CGCCTAGCGCCGCGCCCGCC

Downstream 100 bases:

>100_bases
CCATGATCCGCGTGCTCGTGGTCGAGGACATGCCCACCGCCCGCCAGCTGCTGGTGGGCATCCTCTCGGCCGATCCGGAG
CTCGAGGTGGTGGGCCAGGC

Product: chemotaxis protein CheA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 705; Mature: 705

Protein sequence:

>705_residues
MDADRLQALLRATFLGELEDHVRSLTADLLALERAPGPDRAELLQRIFRTVHSVKGSSRAASVEAVEAQAARMERTLAAA
RDRPPEEARPLVDELLDAVDAIEEAGRRLRGPGEREGAPLSAVVRPAEPPGAGAGSVRLDAARLDRLQALEAELRAARHA
GEGARAPLEALQAEVRRWRAEWAEDERVLRDALGRASAPPAAQAAPGRQAARLARLESELERLAAAGASARRRVAQAVEP
LAEELRALRMVPFAEACAGLERAARDVARGAGKEVDVSIAGGEVSLDRAVADALRAPLLHLVRNAVDHGLESPSARAAAG
KPARGRIGVTAVLRGGEVEIAVEDDGAGLDLDAIRRRAERGGLPEAADARALARRVFLPGFTTAPRVTEVSGQGVGLDAV
RAAVEALQGAVDVETRPGHGTRFVLVVPLTLLALRALVVSCGGESVAIPASQLRRLLQVHPDGLRPLGGRDTVTVDCEPV
PAVALAEVLGLPAAAPAGGRAPLQLAVVAAGGRAVALAVDALVAEQELRVRGLGARVRALPHLAGAALLPDGGVALVLNV
PAVVASALGRPTASLAPAAAAPRRRPRILLVDDSPTTRALERSILETAGYRVATAADGAEAWAILEREGADALVADVEMP
RLDGFALTEAVRASRALAALPVVLVTAREAEADRARGLAAGASAYLVKSAFDQRSLLDTLEHLLG

Sequences:

>Translated_705_residues
MDADRLQALLRATFLGELEDHVRSLTADLLALERAPGPDRAELLQRIFRTVHSVKGSSRAASVEAVEAQAARMERTLAAA
RDRPPEEARPLVDELLDAVDAIEEAGRRLRGPGEREGAPLSAVVRPAEPPGAGAGSVRLDAARLDRLQALEAELRAARHA
GEGARAPLEALQAEVRRWRAEWAEDERVLRDALGRASAPPAAQAAPGRQAARLARLESELERLAAAGASARRRVAQAVEP
LAEELRALRMVPFAEACAGLERAARDVARGAGKEVDVSIAGGEVSLDRAVADALRAPLLHLVRNAVDHGLESPSARAAAG
KPARGRIGVTAVLRGGEVEIAVEDDGAGLDLDAIRRRAERGGLPEAADARALARRVFLPGFTTAPRVTEVSGQGVGLDAV
RAAVEALQGAVDVETRPGHGTRFVLVVPLTLLALRALVVSCGGESVAIPASQLRRLLQVHPDGLRPLGGRDTVTVDCEPV
PAVALAEVLGLPAAAPAGGRAPLQLAVVAAGGRAVALAVDALVAEQELRVRGLGARVRALPHLAGAALLPDGGVALVLNV
PAVVASALGRPTASLAPAAAAPRRRPRILLVDDSPTTRALERSILETAGYRVATAADGAEAWAILEREGADALVADVEMP
RLDGFALTEAVRASRALAALPVVLVTAREAEADRARGLAAGASAYLVKSAFDQRSLLDTLEHLLG
>Mature_705_residues
MDADRLQALLRATFLGELEDHVRSLTADLLALERAPGPDRAELLQRIFRTVHSVKGSSRAASVEAVEAQAARMERTLAAA
RDRPPEEARPLVDELLDAVDAIEEAGRRLRGPGEREGAPLSAVVRPAEPPGAGAGSVRLDAARLDRLQALEAELRAARHA
GEGARAPLEALQAEVRRWRAEWAEDERVLRDALGRASAPPAAQAAPGRQAARLARLESELERLAAAGASARRRVAQAVEP
LAEELRALRMVPFAEACAGLERAARDVARGAGKEVDVSIAGGEVSLDRAVADALRAPLLHLVRNAVDHGLESPSARAAAG
KPARGRIGVTAVLRGGEVEIAVEDDGAGLDLDAIRRRAERGGLPEAADARALARRVFLPGFTTAPRVTEVSGQGVGLDAV
RAAVEALQGAVDVETRPGHGTRFVLVVPLTLLALRALVVSCGGESVAIPASQLRRLLQVHPDGLRPLGGRDTVTVDCEPV
PAVALAEVLGLPAAAPAGGRAPLQLAVVAAGGRAVALAVDALVAEQELRVRGLGARVRALPHLAGAALLPDGGVALVLNV
PAVVASALGRPTASLAPAAAAPRRRPRILLVDDSPTTRALERSILETAGYRVATAADGAEAWAILEREGADALVADVEMP
RLDGFALTEAVRASRALAALPVVLVTAREAEADRARGLAAGASAYLVKSAFDQRSLLDTLEHLLG

Specific function: FrzE is involved in a sensory transduction pathway that controls the frequency at which cells reverse their gliding direction. FrzE seems to be capable of autophosphorylating itself on an histidine residue and then to transfer that group to an aspartate r

COG id: COG0643

COG function: function code NT; Chemotaxis protein histidine kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788197, Length=328, Percent_Identity=35.0609756097561, Blast_Score=198, Evalue=1e-51,
Organism=Escherichia coli, GI1788713, Length=142, Percent_Identity=31.6901408450704, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI145693157, Length=101, Percent_Identity=37.6237623762376, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1790863, Length=111, Percent_Identity=36.036036036036, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1788191, Length=103, Percent_Identity=37.8640776699029, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1787229, Length=102, Percent_Identity=34.3137254901961, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI87082012, Length=102, Percent_Identity=31.3725490196078, Blast_Score=63, Evalue=5e-11,
Organism=Escherichia coli, GI1789809, Length=111, Percent_Identity=34.2342342342342, Blast_Score=63, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002545
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR005467
- InterPro:   IPR001789 [H]

Pfam domain/function: PF01584 CheW; PF02518 HATPase_c; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 73353; Mature: 73353

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS50851 CHEW ; PS50894 HPT ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDADRLQALLRATFLGELEDHVRSLTADLLALERAPGPDRAELLQRIFRTVHSVKGSSRA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHH
ASVEAVEAQAARMERTLAAARDRPPEEARPLVDELLDAVDAIEEAGRRLRGPGEREGAPL
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
SAVVRPAEPPGAGAGSVRLDAARLDRLQALEAELRAARHAGEGARAPLEALQAEVRRWRA
HHEECCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
EWAEDERVLRDALGRASAPPAAQAAPGRQAARLARLESELERLAAAGASARRRVAQAVEP
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
LAEELRALRMVPFAEACAGLERAARDVARGAGKEVDVSIAGGEVSLDRAVADALRAPLLH
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHH
LVRNAVDHGLESPSARAAAGKPARGRIGVTAVLRGGEVEIAVEDDGAGLDLDAIRRRAER
HHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCEEEEEEECCCCCCCHHHHHHHHHH
GGLPEAADARALARRVFLPGFTTAPRVTEVSGQGVGLDAVRAAVEALQGAVDVETRPGHG
CCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
TRFVLVVPLTLLALRALVVSCGGESVAIPASQLRRLLQVHPDGLRPLGGRDTVTVDCEPV
CEEEHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCC
PAVALAEVLGLPAAAPAGGRAPLQLAVVAAGGRAVALAVDALVAEQELRVRGLGARVRAL
CHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCEEHHHHHHHHHHHHHHHHCCCHHHHHH
PHLAGAALLPDGGVALVLNVPAVVASALGRPTASLAPAAAAPRRRPRILLVDDSPTTRAL
HHHHCCCCCCCCCEEEEEECHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHH
ERSILETAGYRVATAADGAEAWAILEREGADALVADVEMPRLDGFALTEAVRASRALAAL
HHHHHHHCCCEEEECCCCHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHH
PVVLVTAREAEADRARGLAAGASAYLVKSAFDQRSLLDTLEHLLG
HHHHEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MDADRLQALLRATFLGELEDHVRSLTADLLALERAPGPDRAELLQRIFRTVHSVKGSSRA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHH
ASVEAVEAQAARMERTLAAARDRPPEEARPLVDELLDAVDAIEEAGRRLRGPGEREGAPL
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
SAVVRPAEPPGAGAGSVRLDAARLDRLQALEAELRAARHAGEGARAPLEALQAEVRRWRA
HHEECCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
EWAEDERVLRDALGRASAPPAAQAAPGRQAARLARLESELERLAAAGASARRRVAQAVEP
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
LAEELRALRMVPFAEACAGLERAARDVARGAGKEVDVSIAGGEVSLDRAVADALRAPLLH
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHH
LVRNAVDHGLESPSARAAAGKPARGRIGVTAVLRGGEVEIAVEDDGAGLDLDAIRRRAER
HHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCEEEEEEECCCCCCCHHHHHHHHHH
GGLPEAADARALARRVFLPGFTTAPRVTEVSGQGVGLDAVRAAVEALQGAVDVETRPGHG
CCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
TRFVLVVPLTLLALRALVVSCGGESVAIPASQLRRLLQVHPDGLRPLGGRDTVTVDCEPV
CEEEHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCC
PAVALAEVLGLPAAAPAGGRAPLQLAVVAAGGRAVALAVDALVAEQELRVRGLGARVRAL
CHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCEEHHHHHHHHHHHHHHHHCCCHHHHHH
PHLAGAALLPDGGVALVLNVPAVVASALGRPTASLAPAAAAPRRRPRILLVDDSPTTRAL
HHHHCCCCCCCCCEEEEEECHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHH
ERSILETAGYRVATAADGAEAWAILEREGADALVADVEMPRLDGFALTEAVRASRALAAL
HHHHHHHCCCEEEECCCCHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHH
PVVLVTAREAEADRARGLAAGASAYLVKSAFDQRSLLDTLEHLLG
HHHHEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2165608; 2123853 [H]