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The map label for this gene is atpB

Identifier: 220917861

GI number: 220917861

Start: 3047158

End: 3048591

Strand: Reverse

Name: atpB

Synonym: A2cp1_2762

Alternate gene names: 220917861

Gene position: 3048591-3047158 (Counterclockwise)

Preceding gene: 220917862

Following gene: 220917860

Centisome position: 60.62

GC content: 76.08

Gene sequence:

>1434_bases
ATGGACCTCGTCACCCGCCGGATCCGCGGGGCGCTCGGCATCGCCGGCCCGCTGCTGTTCCTGGAGGGCGTGCCGCGCGC
GCGCCTGGGCGAGGTGGTGCGCATCCGGGGCGAGCCCGAGGCGAACGGGCGCGCCGCGGAGGAGCGGAGCGGGCAGGTGA
TCGCGCTCTCGCGCGACCGGATCGCGGTGCAGGTGCTGGAGGAGACGCGCGGCCTCGCGCCCGCGCGCGCCGAGGTCACG
CTCACCGGGCAGGTGGCGCGCCTGGGCGTCTCGCGCGGCATGCTGGGGCGGGTGCTGGACGGGCTCGGCCGGCCCGCCGA
CGGCCTGCCGCCGCCGGTGCCGGAGGCGCGCCCCGCCATCCACGGGGCGGCCCTCAACGTCACGCGGCGCGAGAAGCCCT
CCGACTTCATCGAGACCGGCGTCTCCGCCATCGACGGGATGAACACGCTGGTGCGCGGCCAGAAGCTGCCGGTGTTCTCC
TGCGCCGGGCTGCCGGCCTCGCGCCTCGCGGCGCAGATCGTGTGCCAGGCGCGGGTGCGCGGGGGCGAGGCGTTCGCGGT
GGTGTTCGCGGCCATGGGCTCGCCGTTCCGCGAGTACCACGCGTTCCTGGAGGCGTTCCGCGCCGCGGGCGTGCTGGCTC
GCACGGTGGTGTTCCTGAACCGCGCCGAGGACCCGCCCATCGAGCGGCTCATGACGCCGCGGTGCGCGCTCACCTGCGCC
GAGCACCTGGCGTTCGTGCACGGGCTCCACGTGCTGGTGGTGCTCACCGACGTGACCAGCTACTGCGAGGCGCTGCGCGA
GGTGGCGCTGGCGCGCGAGGAGGTGCCGGGGCGGCGCGGTTACCCCGGCTACATGTACACCGACCTCGCCACGATCTTCG
AGCGCGCGGGGCGCGTGCGGGGGCGGCCGGGCTCGCTCACCCAGCTCCCGGTGCTCACCATGCCGGACGACGACCTCACC
CACCCCATCCCCGACCTGACCGGCTACATCACCGAGGGGCAGATCGTCCTCTCGCGCGACCTGGACCGCCGCGGCGTGTA
CCCGCCCATCGACGTGCTGCCCTCGCTGTCGCGGCTCATGGGCCTGGGCGCGGGGCCGGGCAAGACCCGGGACGACCACC
GCCCCGTGGCGGACCAGCTGTACGCGTTCTACGCGCGCGGCCGCGACGTGCGGCGCATGGCGGCCATCGTGGGCGCGGCC
AGCCTGGGCGAGGAGGAGAAGCGGCTGCTCGCGTTCGCGGACGCGTTCGAGGACGAGCTGGTGGGACAGGGCGGCACCTT
CCGCACCATCGAGGACACGCTCGAGGCCGGCTGGCGGCTGCTGTCCGGCTTCCCGCCCGCGGCGCTCACCCGCATCCCGG
AGCGGCTGCTGCGCGCCCGTTCGGCCCGACCCGCGGCCGGGGCGGCGGCGGTGTCCGGCGGAGCCGTCGCATGA

Upstream 100 bases:

>100_bases
TCCGGCTGGCGCAGCTCCCGGCCGCCGAGGTGCCCGGGGCGGCGGCCGCGCTGCGCGCGGATCTCTCGGAGGCGCTGGCG
CGCCTGGAGGCGGAGTGATC

Downstream 100 bases:

>100_bases
GCCGCGCCGCCACCACGCGGATGGGGCTGCTCGAGGTCCGTGCCCGCCGCGCCGTGGCCGGCAAGGGGGCGCGGCTCCTG
CGCGCCAAGCGCGAGGTGCT

Product: V-type ATP synthase subunit B

Products: ATP; H+; H2O [C]

Alternate protein names: V-ATPase subunit B

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MDLVTRRIRGALGIAGPLLFLEGVPRARLGEVVRIRGEPEANGRAAEERSGQVIALSRDRIAVQVLEETRGLAPARAEVT
LTGQVARLGVSRGMLGRVLDGLGRPADGLPPPVPEARPAIHGAALNVTRREKPSDFIETGVSAIDGMNTLVRGQKLPVFS
CAGLPASRLAAQIVCQARVRGGEAFAVVFAAMGSPFREYHAFLEAFRAAGVLARTVVFLNRAEDPPIERLMTPRCALTCA
EHLAFVHGLHVLVVLTDVTSYCEALREVALAREEVPGRRGYPGYMYTDLATIFERAGRVRGRPGSLTQLPVLTMPDDDLT
HPIPDLTGYITEGQIVLSRDLDRRGVYPPIDVLPSLSRLMGLGAGPGKTRDDHRPVADQLYAFYARGRDVRRMAAIVGAA
SLGEEEKRLLAFADAFEDELVGQGGTFRTIEDTLEAGWRLLSGFPPAALTRIPERLLRARSARPAAGAAAVSGGAVA

Sequences:

>Translated_477_residues
MDLVTRRIRGALGIAGPLLFLEGVPRARLGEVVRIRGEPEANGRAAEERSGQVIALSRDRIAVQVLEETRGLAPARAEVT
LTGQVARLGVSRGMLGRVLDGLGRPADGLPPPVPEARPAIHGAALNVTRREKPSDFIETGVSAIDGMNTLVRGQKLPVFS
CAGLPASRLAAQIVCQARVRGGEAFAVVFAAMGSPFREYHAFLEAFRAAGVLARTVVFLNRAEDPPIERLMTPRCALTCA
EHLAFVHGLHVLVVLTDVTSYCEALREVALAREEVPGRRGYPGYMYTDLATIFERAGRVRGRPGSLTQLPVLTMPDDDLT
HPIPDLTGYITEGQIVLSRDLDRRGVYPPIDVLPSLSRLMGLGAGPGKTRDDHRPVADQLYAFYARGRDVRRMAAIVGAA
SLGEEEKRLLAFADAFEDELVGQGGTFRTIEDTLEAGWRLLSGFPPAALTRIPERLLRARSARPAAGAAAVSGGAVA
>Mature_477_residues
MDLVTRRIRGALGIAGPLLFLEGVPRARLGEVVRIRGEPEANGRAAEERSGQVIALSRDRIAVQVLEETRGLAPARAEVT
LTGQVARLGVSRGMLGRVLDGLGRPADGLPPPVPEARPAIHGAALNVTRREKPSDFIETGVSAIDGMNTLVRGQKLPVFS
CAGLPASRLAAQIVCQARVRGGEAFAVVFAAMGSPFREYHAFLEAFRAAGVLARTVVFLNRAEDPPIERLMTPRCALTCA
EHLAFVHGLHVLVVLTDVTSYCEALREVALAREEVPGRRGYPGYMYTDLATIFERAGRVRGRPGSLTQLPVLTMPDDDLT
HPIPDLTGYITEGQIVLSRDLDRRGVYPPIDVLPSLSRLMGLGAGPGKTRDDHRPVADQLYAFYARGRDVRRMAAIVGAA
SLGEEEKRLLAFADAFEDELVGQGGTFRTIEDTLEAGWRLLSGFPPAALTRIPERLLRARSARPAAGAAAVSGGAVA

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit

COG id: COG1156

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit B

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI19913428, Length=464, Percent_Identity=50, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI19913426, Length=468, Percent_Identity=48.5042735042735, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI32189394, Length=395, Percent_Identity=25.3164556962025, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI50345984, Length=288, Percent_Identity=27.0833333333333, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4757810, Length=288, Percent_Identity=27.0833333333333, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI19913424, Length=332, Percent_Identity=23.7951807228916, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1788251, Length=327, Percent_Identity=33.6391437308869, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI1790170, Length=376, Percent_Identity=26.063829787234, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1790172, Length=321, Percent_Identity=26.791277258567, Blast_Score=110, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17510931, Length=463, Percent_Identity=49.8920086393089, Blast_Score=441, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17570191, Length=462, Percent_Identity=49.7835497835498, Blast_Score=438, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI25144756, Length=390, Percent_Identity=25.8974358974359, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71988080, Length=317, Percent_Identity=27.7602523659306, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71988063, Length=317, Percent_Identity=27.7602523659306, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71988074, Length=265, Percent_Identity=27.5471698113208, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17565854, Length=268, Percent_Identity=25.7462686567164, Blast_Score=86, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6319603, Length=455, Percent_Identity=50.7692307692308, Blast_Score=436, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6322581, Length=417, Percent_Identity=25.4196642685851, Blast_Score=116, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6319370, Length=323, Percent_Identity=27.2445820433437, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320016, Length=266, Percent_Identity=23.3082706766917, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI281361666, Length=456, Percent_Identity=50.219298245614, Blast_Score=434, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24646341, Length=456, Percent_Identity=50.219298245614, Blast_Score=434, Evalue=1e-122,
Organism=Drosophila melanogaster, GI17136796, Length=456, Percent_Identity=50.219298245614, Blast_Score=434, Evalue=1e-122,
Organism=Drosophila melanogaster, GI28574560, Length=379, Percent_Identity=27.4406332453826, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24638766, Length=443, Percent_Identity=25.0564334085779, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24658560, Length=318, Percent_Identity=26.1006289308176, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24583992, Length=332, Percent_Identity=25.3012048192771, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24583988, Length=333, Percent_Identity=24.024024024024, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24583986, Length=333, Percent_Identity=24.024024024024, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24583984, Length=333, Percent_Identity=24.024024024024, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI20129479, Length=275, Percent_Identity=23.6363636363636, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: 10-20 (rich media) [C]

Swissprot (AC and ID): VATB_ANAD2 (B8JE34)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002493165.1
- ProteinModelPortal:   B8JE34
- SMR:   B8JE34
- GeneID:   7298830
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_2762
- HOGENOM:   HBG565875
- ProtClustDB:   PRK04196
- HAMAP:   MF_00310
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR000793
- InterPro:   IPR004100
- InterPro:   IPR022879

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N

EC number: 3.6.3.14 [C]

Molecular weight: Translated: 51186; Mature: 51186

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLVTRRIRGALGIAGPLLFLEGVPRARLGEVVRIRGEPEANGRAAEERSGQVIALSRDR
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCEEEECCCCCCCCCCHHHCCCCEEEEECCH
IAVQVLEETRGLAPARAEVTLTGQVARLGVSRGMLGRVLDGLGRPADGLPPPVPEARPAI
HHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
HGAALNVTRREKPSDFIETGVSAIDGMNTLVRGQKLPVFSCAGLPASRLAAQIVCQARVR
CHHEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHC
GGEAFAVVFAAMGSPFREYHAFLEAFRAAGVLARTVVFLNRAEDPPIERLMTPRCALTCA
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHH
EHLAFVHGLHVLVVLTDVTSYCEALREVALAREEVPGRRGYPGYMYTDLATIFERAGRVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCC
GRPGSLTQLPVLTMPDDDLTHPIPDLTGYITEGQIVLSRDLDRRGVYPPIDVLPSLSRLM
CCCCCCCCCEEEECCCCCCCCCCCCHHCEECCCEEEEECCCCCCCCCCCHHHHHHHHHHH
GLGAGPGKTRDDHRPVADQLYAFYARGRDVRRMAAIVGAASLGEEEKRLLAFADAFEDEL
CCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
VGQGGTFRTIEDTLEAGWRLLSGFPPAALTRIPERLLRARSARPAAGAAAVSGGAVA
CCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCC
>Mature Secondary Structure
MDLVTRRIRGALGIAGPLLFLEGVPRARLGEVVRIRGEPEANGRAAEERSGQVIALSRDR
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCEEEECCCCCCCCCCHHHCCCCEEEEECCH
IAVQVLEETRGLAPARAEVTLTGQVARLGVSRGMLGRVLDGLGRPADGLPPPVPEARPAI
HHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
HGAALNVTRREKPSDFIETGVSAIDGMNTLVRGQKLPVFSCAGLPASRLAAQIVCQARVR
CHHEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHC
GGEAFAVVFAAMGSPFREYHAFLEAFRAAGVLARTVVFLNRAEDPPIERLMTPRCALTCA
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHH
EHLAFVHGLHVLVVLTDVTSYCEALREVALAREEVPGRRGYPGYMYTDLATIFERAGRVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCC
GRPGSLTQLPVLTMPDDDLTHPIPDLTGYITEGQIVLSRDLDRRGVYPPIDVLPSLSRLM
CCCCCCCCCEEEECCCCCCCCCCCCHHCEECCCEEEEECCCCCCCCCCCHHHHHHHHHHH
GLGAGPGKTRDDHRPVADQLYAFYARGRDVRRMAAIVGAASLGEEEKRLLAFADAFEDEL
CCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
VGQGGTFRTIEDTLEAGWRLLSGFPPAALTRIPERLLRARSARPAAGAAAVSGGAVA
CCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Borate; Diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ADP; H+; Phosphate [C]

Specific reaction: ADP + (4) H+ + Phosphate <==> ATP + (3) H+ + H2O [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines various reactions catalyzed by ATPase, analogs; Oligomycin; Quercetin; Trialkyl tinderivatives; Venturicidin [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA