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The map label for this gene is folC [H]

Identifier: 220917797

GI number: 220917797

Start: 2979215

End: 2980441

Strand: Reverse

Name: folC [H]

Synonym: A2cp1_2698

Alternate gene names: 220917797

Gene position: 2980441-2979215 (Counterclockwise)

Preceding gene: 220917798

Following gene: 220917796

Centisome position: 59.26

GC content: 79.38

Gene sequence:

>1227_bases
GTGAAGCCCCTCGATCCCCACGCCTACCTCTCCTCGCTCCAGCCGCTCGCCATGCGCTTCGGCCTCGAGCGCATGGAGCG
CGCGCTCGACGCGCTCGGCCACCCCGAGCGCGGCTACCGCGTGCTGCACGTGGGCGGCACGAACGGCAAGGGCTCCACCT
GCGCGATGGCCGCCGCGGCGCTGCGCGAGGCGGGCCTCCGCACCGGCCTCTACACCTCGCCGCACCTGGTCCGGTTCAAC
GAGCGCATCCAGGTCGACGGGGTGGAGATCTCCGACGCCGTGCTCGCCGCGGCCCTGGAGGCGGTGCGGCGCGCCTGTCC
GTGGCACGAGGCGGGCGGGGAGGCCGACCGGCTCACCTACTTCGAGGTCGCCACGCTGGCCGGCCTGCTGCACCTCGCCG
ACGCGCGGGTGGACGCCGCGGTGATCGAGGTCGGCCTGGGCGGCCGCTTCGACGCGACGAACGCCATCCGCCCGGCGGTC
ACCGCCATCGCCCGCATCGGCCTCGACCACACCCAGCTCCTCGGCGACACCGTCGAGCGGGTGGCGTTCGAGAAGGCCGG
CATCTTCAAGCCGGGCGTGCCCGCGGTGGTGCACGCGGCCCAGCCGCCCGGCGCGCTGGGGGTGCTGCGCGCGGAGGCCG
CCCGCCGGGGCGCGCCCTTCGTGGTGGCCGGCGAGGCTTGGGACGGGCCGGTCGCGCTGCGCGGGCCGCACCAGCGCGCG
AACGCGGCGCTCGCGGCGGCCGCGCTGCGCGCGCTGGCGGGCGCGGGCGTGGCCGTGCCGGAGGACGCCATCGCGCGCGG
CATCGCCGGGGCGCGCTGGCCGGGGCGGCTGGAGGAGCTGGGCGGCGTGCTGCTCGACGGCGCGCACAACCCGCAGGGCG
CCGCGGCGCTCGCCGCCGCGCTGCCCGCGCTCCACCCGGGCCGGCCGGTGGAGCTCGTGTTCGGCGTGCTCGCCGACAAG
GACCACGCCGGCATGCTCGCGGCGCTGGCGCCGGCGGTGCGCCGCCTGCACCTCGTCACGCCGCCGAGCCCGCGGGCGCG
CCCGGCCCCCGAGCTGCGCGCGCTCGCCGAGGCGCACGGCGTCGCCGCCGACGTGCACGAGGGGCTCGCGGAGGCGATCG
CCTGCGCGCGGGCCGCGGCCGGCGAGGACGGGGTGGTGGGCGTGGCGGGCTCGCTCTACCTGGTCGGCGAGGCCCGCGCG
CTCCTCGGCGCTCCTGCGCCGGGGTAG

Upstream 100 bases:

>100_bases
TCGTGCCGCGCCTGGAGATGCGCGAGAAGCTCCGCCAGCTCCTGTCGCTGGTGGGCTGAGCGCCGCACGCCGGGGCGGCC
GCGCCGCCCGGAGCCCGCCG

Downstream 100 bases:

>100_bases
GTGGATATCGGACTGCAAATCCTGGGGAATTCTTCGGAGCCCTGGGACCGCGTGCTATCCTCGCGCCGACCTTTCCGCGG
AGCCCCCTCATGCGTCTTCG

Product: FolC bifunctional protein

Products: NA

Alternate protein names: Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolate synthase; Tetrahydrofolylpolyglutamate synthase [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MKPLDPHAYLSSLQPLAMRFGLERMERALDALGHPERGYRVLHVGGTNGKGSTCAMAAAALREAGLRTGLYTSPHLVRFN
ERIQVDGVEISDAVLAAALEAVRRACPWHEAGGEADRLTYFEVATLAGLLHLADARVDAAVIEVGLGGRFDATNAIRPAV
TAIARIGLDHTQLLGDTVERVAFEKAGIFKPGVPAVVHAAQPPGALGVLRAEAARRGAPFVVAGEAWDGPVALRGPHQRA
NAALAAAALRALAGAGVAVPEDAIARGIAGARWPGRLEELGGVLLDGAHNPQGAAALAAALPALHPGRPVELVFGVLADK
DHAGMLAALAPAVRRLHLVTPPSPRARPAPELRALAEAHGVAADVHEGLAEAIACARAAAGEDGVVGVAGSLYLVGEARA
LLGAPAPG

Sequences:

>Translated_408_residues
MKPLDPHAYLSSLQPLAMRFGLERMERALDALGHPERGYRVLHVGGTNGKGSTCAMAAAALREAGLRTGLYTSPHLVRFN
ERIQVDGVEISDAVLAAALEAVRRACPWHEAGGEADRLTYFEVATLAGLLHLADARVDAAVIEVGLGGRFDATNAIRPAV
TAIARIGLDHTQLLGDTVERVAFEKAGIFKPGVPAVVHAAQPPGALGVLRAEAARRGAPFVVAGEAWDGPVALRGPHQRA
NAALAAAALRALAGAGVAVPEDAIARGIAGARWPGRLEELGGVLLDGAHNPQGAAALAAALPALHPGRPVELVFGVLADK
DHAGMLAALAPAVRRLHLVTPPSPRARPAPELRALAEAHGVAADVHEGLAEAIACARAAAGEDGVVGVAGSLYLVGEARA
LLGAPAPG
>Mature_408_residues
MKPLDPHAYLSSLQPLAMRFGLERMERALDALGHPERGYRVLHVGGTNGKGSTCAMAAAALREAGLRTGLYTSPHLVRFN
ERIQVDGVEISDAVLAAALEAVRRACPWHEAGGEADRLTYFEVATLAGLLHLADARVDAAVIEVGLGGRFDATNAIRPAV
TAIARIGLDHTQLLGDTVERVAFEKAGIFKPGVPAVVHAAQPPGALGVLRAEAARRGAPFVVAGEAWDGPVALRGPHQRA
NAALAAAALRALAGAGVAVPEDAIARGIAGARWPGRLEELGGVLLDGAHNPQGAAALAAALPALHPGRPVELVFGVLADK
DHAGMLAALAPAVRRLHLVTPPSPRARPAPELRALAEAHGVAADVHEGLAEAIACARAAAGEDGVVGVAGSLYLVGEARA
LLGAPAPG

Specific function: Conversion of folates to polyglutamate derivatives. It preferes 5,10-methylenetetrahydrofolate, rather than 10- formyltetrahydrofolate as folate substrate [H]

COG id: COG0285

COG function: function code H; Folylpolyglutamate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the folylpolyglutamate synthase family [H]

Homologues:

Organism=Homo sapiens, GI66932984, Length=371, Percent_Identity=35.0404312668464, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI66932990, Length=371, Percent_Identity=35.0404312668464, Blast_Score=180, Evalue=3e-45,
Organism=Escherichia coli, GI1788654, Length=417, Percent_Identity=35.2517985611511, Blast_Score=179, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17553148, Length=421, Percent_Identity=30.166270783848, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI71984923, Length=421, Percent_Identity=30.166270783848, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17553150, Length=421, Percent_Identity=30.166270783848, Blast_Score=155, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6323760, Length=427, Percent_Identity=27.6346604215457, Blast_Score=168, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6324815, Length=295, Percent_Identity=31.864406779661, Blast_Score=140, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24641571, Length=314, Percent_Identity=32.1656050955414, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24581568, Length=162, Percent_Identity=31.4814814814815, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018109
- InterPro:   IPR001645
- InterPro:   IPR004101
- InterPro:   IPR013221 [H]

Pfam domain/function: PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.17 [H]

Molecular weight: Translated: 41733; Mature: 41733

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPLDPHAYLSSLQPLAMRFGLERMERALDALGHPERGYRVLHVGGTNGKGSTCAMAAAA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHH
LREAGLRTGLYTSPHLVRFNERIQVDGVEISDAVLAAALEAVRRACPWHEAGGEADRLTY
HHHHHHHCCCCCCCCEEEECCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
FEVATLAGLLHLADARVDAAVIEVGLGGRFDATNAIRPAVTAIARIGLDHTQLLGDTVER
HHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
VAFEKAGIFKPGVPAVVHAAQPPGALGVLRAEAARRGAPFVVAGEAWDGPVALRGPHQRA
HHHHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCEEECCCHHHH
NAALAAAALRALAGAGVAVPEDAIARGIAGARWPGRLEELGGVLLDGAHNPQGAAALAAA
HHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCHHHHHHCCEEECCCCCCCHHHHHHHH
LPALHPGRPVELVFGVLADKDHAGMLAALAPAVRRLHLVTPPSPRARPAPELRALAEAHG
HHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHC
VAADVHEGLAEAIACARAAAGEDGVVGVAGSLYLVGEARALLGAPAPG
CHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEEECHHHHHCCCCCC
>Mature Secondary Structure
MKPLDPHAYLSSLQPLAMRFGLERMERALDALGHPERGYRVLHVGGTNGKGSTCAMAAAA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHH
LREAGLRTGLYTSPHLVRFNERIQVDGVEISDAVLAAALEAVRRACPWHEAGGEADRLTY
HHHHHHHCCCCCCCCEEEECCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
FEVATLAGLLHLADARVDAAVIEVGLGGRFDATNAIRPAVTAIARIGLDHTQLLGDTVER
HHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHH
VAFEKAGIFKPGVPAVVHAAQPPGALGVLRAEAARRGAPFVVAGEAWDGPVALRGPHQRA
HHHHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCEEECCCHHHH
NAALAAAALRALAGAGVAVPEDAIARGIAGARWPGRLEELGGVLLDGAHNPQGAAALAAA
HHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCHHHHHHCCEEECCCCCCCHHHHHHHH
LPALHPGRPVELVFGVLADKDHAGMLAALAPAVRRLHLVTPPSPRARPAPELRALAEAHG
HHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHC
VAADVHEGLAEAIACARAAAGEDGVVGVAGSLYLVGEARALLGAPAPG
CHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEEECHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8419299; 9384377; 2553669 [H]