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The map label for this gene is serA [H]

Identifier: 220917793

GI number: 220917793

Start: 2972699

End: 2974285

Strand: Reverse

Name: serA [H]

Synonym: A2cp1_2694

Alternate gene names: 220917793

Gene position: 2974285-2972699 (Counterclockwise)

Preceding gene: 220917794

Following gene: 220917792

Centisome position: 59.14

GC content: 73.53

Gene sequence:

>1587_bases
ATGGCAGCCCGTGTCCTCGTGTCCGATGACCTTTCCCCGGAGGCCGTGGCCGTGTTGAAGCAGGCCGGCCTCGAGGTGGA
CGTGAAGGTCGGCCTCAAGCCCGACGCGCTCGAGGCCATCATCGGCGACTACGACGCGCTCGCGGTGCGCAGCGCCACCA
AGGTGACCGCGAAGCTGCTGGAGAAGGCCTCGCGGCTCCGCGTGATCGGCCGCGCCGGGGTCGGCGTGGACAACGTCGAC
CTCGATGCCGCGACCCGCCGCGGCGTGGTGGTGATGAACACGCCGGGCGGCTCGTCGGTCACGGTCGCCGAGCTCGCGCT
CGCGATGATCCTGGCGCTCTCCCGCCACGTGCCGGCCGCCACCGCCAGCGTGAAGGCGGGCAAGTGGGAGAAGAAGCGCT
TCCAGGGGCACGAGCTCGCCGGCAAGACGCTGGGCGTGGTCGGCATCGGCAACATCGGGTCGGTGCTGGTGGACCGCGCG
CTCGCCATGAAGATGCGCGTGGTCGCCTACGACCCGTTCATCTCCGCCGAGGCCGCGGCCAAGCTGGGGGTCGAGCGCGT
CGAGCTGGACGCGCTCTGGGCCCAGGCCGACGTCGTCTCGCTGCACGTCCCGCTCACCGAGCAGACCCGCAACCTGGTGG
ACGCGAAGGTGCTCGCCCGCATGAAGAAGGGCGCGCTCCTGGTGAACTGCGCCCGCGGGGGGATCGTGGACGAGCGGGCG
CTCGCGGACGCGCTCGCGTCCGGGCACCTGGGCGGCGCCGCGCTGGACGTGTTCGAGCAGGAGCCGCCCCCGGCCGATCA
CCCGCTGCTCGGGCTGGACGGGTTCGTCGCCACGCCGCACATCGGCGCCTCCACCGAGGAGGCGCAGTCGGCGGTGGCGG
TCGCGGTGGCGGAGCAGCTCGCCGCGTACCTGAACCACGGCGTGGTGAAGAACGCGGTGAACGTGCCGGGGCTGCCGCGG
GAGATCATGGACCAGATCGCGCCGTTCCTGCCGCTCTGCGAGAAGCTCGGGTCGCTCGCGGCGCAGCTCGCGCCGCAGGG
GCCGAGCGAGGTCACCGTCGAGGTGGCCGGAGAGCTGGCCGCCGCGCCGATCCGCCCGCTCGCCGCGCGCACGCTGGCGG
CCTTTCTGCGCCACCACCTCGAGACGCCGGTGAACGACGTGAGCGCCCCGGCGGTCGCGAAGGAGCGCGGGATCGCGGTG
CGCGAGGTCCGCTCCGCCGAGCCGCACGACTACGCCAGCCTGGTCACGGTGACCGTGCGCGGGCAGGGCGGGGAGGCGCA
CGTCGCGGGCACCGTGTACGGCAAGCGCGAGGCCCGCCTCGTGCGCGTGGACGGGTTCCGCCTGGAGGCGGTGCCGGAGG
GCCACGTCATCCTGTGCGAGAACGACGACGCGCCCGGCGTGGTCGGCAACCTCGGCACGGCGCTCGGCGCGGCCGGCGTG
AACATCGCGCGCATCTCGCTGTCGCGGCTCGACGACCACTCTCGCGCGTTCGCCTTCCTGAACGTGGACTCGGCGCCCGC
GCCCGGGGTCCTCGAGCAGGTGCGCAGGCTTCCGCACGTCCGGACGGTCCGCTCCATCCACCTGTGA

Upstream 100 bases:

>100_bases
TGACGCGCACGTGGCCGGACACTAGGTCCCTCCTCCCTCGCAGCTCGACCGACAACGTGAACGCCCGCGTGCACACCCCA
GCCCGGGCGGGAGGAGATCG

Downstream 100 bases:

>100_bases
GCGGCGCCCTCGCCGTCGCGGCCGCCCTTCCGCCCGCCCGTCCCGGTCCCCATCTTCGGACCGGGGCGGGGTCTTCCCCG
CCGGGAGGGATGACATGGCT

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MAARVLVSDDLSPEAVAVLKQAGLEVDVKVGLKPDALEAIIGDYDALAVRSATKVTAKLLEKASRLRVIGRAGVGVDNVD
LDAATRRGVVVMNTPGGSSVTVAELALAMILALSRHVPAATASVKAGKWEKKRFQGHELAGKTLGVVGIGNIGSVLVDRA
LAMKMRVVAYDPFISAEAAAKLGVERVELDALWAQADVVSLHVPLTEQTRNLVDAKVLARMKKGALLVNCARGGIVDERA
LADALASGHLGGAALDVFEQEPPPADHPLLGLDGFVATPHIGASTEEAQSAVAVAVAEQLAAYLNHGVVKNAVNVPGLPR
EIMDQIAPFLPLCEKLGSLAAQLAPQGPSEVTVEVAGELAAAPIRPLAARTLAAFLRHHLETPVNDVSAPAVAKERGIAV
REVRSAEPHDYASLVTVTVRGQGGEAHVAGTVYGKREARLVRVDGFRLEAVPEGHVILCENDDAPGVVGNLGTALGAAGV
NIARISLSRLDDHSRAFAFLNVDSAPAPGVLEQVRRLPHVRTVRSIHL

Sequences:

>Translated_528_residues
MAARVLVSDDLSPEAVAVLKQAGLEVDVKVGLKPDALEAIIGDYDALAVRSATKVTAKLLEKASRLRVIGRAGVGVDNVD
LDAATRRGVVVMNTPGGSSVTVAELALAMILALSRHVPAATASVKAGKWEKKRFQGHELAGKTLGVVGIGNIGSVLVDRA
LAMKMRVVAYDPFISAEAAAKLGVERVELDALWAQADVVSLHVPLTEQTRNLVDAKVLARMKKGALLVNCARGGIVDERA
LADALASGHLGGAALDVFEQEPPPADHPLLGLDGFVATPHIGASTEEAQSAVAVAVAEQLAAYLNHGVVKNAVNVPGLPR
EIMDQIAPFLPLCEKLGSLAAQLAPQGPSEVTVEVAGELAAAPIRPLAARTLAAFLRHHLETPVNDVSAPAVAKERGIAV
REVRSAEPHDYASLVTVTVRGQGGEAHVAGTVYGKREARLVRVDGFRLEAVPEGHVILCENDDAPGVVGNLGTALGAAGV
NIARISLSRLDDHSRAFAFLNVDSAPAPGVLEQVRRLPHVRTVRSIHL
>Mature_527_residues
AARVLVSDDLSPEAVAVLKQAGLEVDVKVGLKPDALEAIIGDYDALAVRSATKVTAKLLEKASRLRVIGRAGVGVDNVDL
DAATRRGVVVMNTPGGSSVTVAELALAMILALSRHVPAATASVKAGKWEKKRFQGHELAGKTLGVVGIGNIGSVLVDRAL
AMKMRVVAYDPFISAEAAAKLGVERVELDALWAQADVVSLHVPLTEQTRNLVDAKVLARMKKGALLVNCARGGIVDERAL
ADALASGHLGGAALDVFEQEPPPADHPLLGLDGFVATPHIGASTEEAQSAVAVAVAEQLAAYLNHGVVKNAVNVPGLPRE
IMDQIAPFLPLCEKLGSLAAQLAPQGPSEVTVEVAGELAAAPIRPLAARTLAAFLRHHLETPVNDVSAPAVAKERGIAVR
EVRSAEPHDYASLVTVTVRGQGGEAHVAGTVYGKREARLVRVDGFRLEAVPEGHVILCENDDAPGVVGNLGTALGAAGVN
IARISLSRLDDHSRAFAFLNVDSAPAPGVLEQVRRLPHVRTVRSIHL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=403, Percent_Identity=41.9354838709677, Blast_Score=308, Evalue=7e-84,
Organism=Homo sapiens, GI145580578, Length=289, Percent_Identity=36.6782006920415, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI4557499, Length=289, Percent_Identity=36.6782006920415, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI145580575, Length=289, Percent_Identity=36.6782006920415, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI61743967, Length=272, Percent_Identity=35.6617647058824, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI4557497, Length=272, Percent_Identity=35.6617647058824, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI6912396, Length=260, Percent_Identity=33.8461538461538, Blast_Score=141, Evalue=2e-33,
Organism=Escherichia coli, GI1789279, Length=321, Percent_Identity=39.2523364485981, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI87082289, Length=301, Percent_Identity=37.5415282392027, Blast_Score=181, Evalue=9e-47,
Organism=Escherichia coli, GI1787645, Length=200, Percent_Identity=36, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1788660, Length=274, Percent_Identity=30.6569343065693, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI87081824, Length=199, Percent_Identity=26.6331658291457, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=326, Percent_Identity=46.6257668711656, Blast_Score=293, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI25147481, Length=349, Percent_Identity=28.9398280802292, Blast_Score=147, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6320925, Length=328, Percent_Identity=36.5853658536585, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6322116, Length=336, Percent_Identity=35.7142857142857, Blast_Score=196, Evalue=9e-51,
Organism=Saccharomyces cerevisiae, GI6324964, Length=275, Percent_Identity=33.0909090909091, Blast_Score=136, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6324055, Length=237, Percent_Identity=29.535864978903, Blast_Score=123, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6324980, Length=196, Percent_Identity=33.6734693877551, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6321253, Length=282, Percent_Identity=27.3049645390071, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6325144, Length=92, Percent_Identity=40.2173913043478, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19921140, Length=302, Percent_Identity=45.6953642384106, Blast_Score=259, Evalue=3e-69,
Organism=Drosophila melanogaster, GI24646446, Length=280, Percent_Identity=36.4285714285714, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24646448, Length=280, Percent_Identity=36.4285714285714, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24646452, Length=280, Percent_Identity=36.4285714285714, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24646450, Length=280, Percent_Identity=36.4285714285714, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI62472511, Length=273, Percent_Identity=37.3626373626374, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI28574286, Length=296, Percent_Identity=29.7297297297297, Blast_Score=138, Evalue=9e-33,
Organism=Drosophila melanogaster, GI24585516, Length=291, Percent_Identity=29.553264604811, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24585514, Length=241, Percent_Identity=30.2904564315353, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI28574282, Length=241, Percent_Identity=30.2904564315353, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI45552429, Length=241, Percent_Identity=30.2904564315353, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI45551003, Length=241, Percent_Identity=30.2904564315353, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI28574284, Length=241, Percent_Identity=30.2904564315353, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI28571528, Length=270, Percent_Identity=31.4814814814815, Blast_Score=123, Evalue=4e-28,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 55088; Mature: 54957

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAARVLVSDDLSPEAVAVLKQAGLEVDVKVGLKPDALEAIIGDYDALAVRSATKVTAKLL
CCEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHH
EKASRLRVIGRAGVGVDNVDLDAATRRGVVVMNTPGGSSVTVAELALAMILALSRHVPAA
HHHHHEEEEECCCCCCCCCCCCHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCC
TASVKAGKWEKKRFQGHELAGKTLGVVGIGNIGSVLVDRALAMKMRVVAYDPFISAEAAA
CCCCCCCCCHHHHCCCCHHCCCEEEEEEECCHHHHHHHHHHHHHEEEEEECCCCCHHHHH
KLGVERVELDALWAQADVVSLHVPLTEQTRNLVDAKVLARMKKGALLVNCARGGIVDERA
HHCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHH
LADALASGHLGGAALDVFEQEPPPADHPLLGLDGFVATPHIGASTEEAQSAVAVAVAEQL
HHHHHHCCCCCCHHHHHHCCCCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHH
AAYLNHGVVKNAVNVPGLPREIMDQIAPFLPLCEKLGSLAAQLAPQGPSEVTVEVAGELA
HHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHH
AAPIRPLAARTLAAFLRHHLETPVNDVSAPAVAKERGIAVREVRSAEPHDYASLVTVTVR
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCHHHHHCCCCCCCEEEEEEEEE
GQGGEAHVAGTVYGKREARLVRVDGFRLEAVPEGHVILCENDDAPGVVGNLGTALGAAGV
CCCCCEEEEEEEECCCCCEEEEECCEEEEECCCCCEEEECCCCCCCCHHHHHHHHHHCCC
NIARISLSRLDDHSRAFAFLNVDSAPAPGVLEQVRRLPHVRTVRSIHL
EEEEEEHHHCCCCCCEEEEEECCCCCCCHHHHHHHHCCHHHHHHHCCC
>Mature Secondary Structure 
AARVLVSDDLSPEAVAVLKQAGLEVDVKVGLKPDALEAIIGDYDALAVRSATKVTAKLL
CEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHH
EKASRLRVIGRAGVGVDNVDLDAATRRGVVVMNTPGGSSVTVAELALAMILALSRHVPAA
HHHHHEEEEECCCCCCCCCCCCHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCC
TASVKAGKWEKKRFQGHELAGKTLGVVGIGNIGSVLVDRALAMKMRVVAYDPFISAEAAA
CCCCCCCCCHHHHCCCCHHCCCEEEEEEECCHHHHHHHHHHHHHEEEEEECCCCCHHHHH
KLGVERVELDALWAQADVVSLHVPLTEQTRNLVDAKVLARMKKGALLVNCARGGIVDERA
HHCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHH
LADALASGHLGGAALDVFEQEPPPADHPLLGLDGFVATPHIGASTEEAQSAVAVAVAEQL
HHHHHHCCCCCCHHHHHHCCCCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHH
AAYLNHGVVKNAVNVPGLPREIMDQIAPFLPLCEKLGSLAAQLAPQGPSEVTVEVAGELA
HHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHH
AAPIRPLAARTLAAFLRHHLETPVNDVSAPAVAKERGIAVREVRSAEPHDYASLVTVTVR
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCHHHHHCCCCCCCEEEEEEEEE
GQGGEAHVAGTVYGKREARLVRVDGFRLEAVPEGHVILCENDDAPGVVGNLGTALGAAGV
CCCCCEEEEEEEECCCCCEEEEECCEEEEECCCCCEEEECCCCCCCCHHHHHHHHHHCCC
NIARISLSRLDDHSRAFAFLNVDSAPAPGVLEQVRRLPHVRTVRSIHL
EEEEEEHHHCCCCCCEEEEEECCCCCCCHHHHHHHHCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]