Click here to switch to the map view.

The map label for this gene is pan [H]

Identifier: 220917770

GI number: 220917770

Start: 2947457

End: 2948956

Strand: Reverse

Name: pan [H]

Synonym: A2cp1_2671

Alternate gene names: 220917770

Gene position: 2948956-2947457 (Counterclockwise)

Preceding gene: 220917771

Following gene: 220917769

Centisome position: 58.64

GC content: 79.07

Gene sequence:

>1500_bases
ATGAGCGTCTCCTCCGAGATCGCCGAGCTGTGGTCGGCGGGCACCCCGGTCCTCTACCTGGTCACGCCGGAGGAGGACCG
CGCCGTGGCCGCGTGCCAGGCCGCGGCCGCCGCGTTCGACGCGCGCTGCGCGGTATGGTCCTCGCACCGGGGCCTCGACC
CGGCGGCGCCGGGCGCCAAGGAGCCCGCGGCGCTGCTCGACGCGCTCCTCCGCGCCCCGGCGCCGTTCCTGGCGGTGGCG
CTCGACTTCCATCACGCGCTCGCCTCGCCCGCGGTGGCGCGCCAGCTCCGCGACGCGTTGCCCCGCATGGCGGCCGAGGG
GCGGTGCCTGGCGGTGGTGGCCCCGCGCCTGGCGCTGCCGGACGGGCTCGGCACCGACGCCGCGGTGATCCGCGTGCCGC
TCCCGGACGACGCCGAGCTGGGCGCGCTGCTCGAGGTGGTCCAGGCCGGCCTGGCGCACCCGGCCGCGCCGCCGCCGCTC
CCGGCGGACGTGCGCCACCGCGCGCTGGTGGCGGCGCGCGGGCTGTCGGAGGCCCAGGCGCGCCGCGCGTTCACGCGGGC
GCTGCGCCGCGACGCGGCGCTCGGGCCGGAGGGCATCGGCGCGGTGGCGGCCGAGAAGAAGCGGCTGCTGGCGCGGGACC
TCGGCCTCGAGCTGGTCGAGGCGGCAGAGCGCCCGGAGGACCTGGGTGGGCTGGGCGCGTTCAAGGCCTGGATGGACGAG
CGCGCGCTCGCGTTCGACCCGGACGCCTCGCGCTGGGGGCTCCCGCCGCCGCGCGGCGTGCTGCTCGTGGGCGTGCAGGG
CTGCGGGAAGTCGCTCGCGGCCAAGGCGGCGGCCGCGCGCCTGGGCGTGCCGGTGCTGCGGCTGGACCTGCCGCGCGTGC
TGGGCGCGCAGACCGGCGCCGAGGAGGGGCTGGCGCGCGCGCTGGAGGCGGCGGAGGCGCTCGCGCCGGTGGCGCTCTGG
GTGGACGAGATCGAGAAGGGCTTCGCGGGCAGCGCGCCCGGCGACGGCGGCGAGCCGCGCGCCGCGCGCCTGCTGGGCGC
GTTCTCCACCTGGCTGCAGGAGCGCAAGGGGCCGGTGTTCGTGGTGGCGACCGCGAACGACGTCTCGCGGCTGCCGCCGG
AGCTGCTGCGCCGCGGGCGCTTCGACGAGCTGTTCTTCGTCGACCTGCCGGACCCGGAGGCGCGCCGCGAGATCCTGGCG
CTGCACCTGCGGCGCCGCGGCCGCGAGCCCGGGGCGGTGGACGTGGCCGCCATCGCCGAGCTGTGCGCCGACTACTCCGG
GGCGGAGCTGGAGCAGGTGGTGATCGGGGCGCTGCACCGCGCCTACGCGCTCGGGCGCGAGCTCGAGACCGCCGACCTCC
GCCGCGTGGCGCAGGACCTGGTCCCGCTGTTCCGGACCTACGAGGAGCAGATCAAGGCGCTGCGCGAGTGGGCGCGCGGG
CGGGCGCGGGTGGCCGGCCGGGCCGGCGCGGTGGTGGACCTGTTCCGGCGGGTGCAATGA

Upstream 100 bases:

>100_bases
GGCGTCACCTCCTTCGAGGAGGCGATGCGCGCCACCGCCGACGCCGAGGCGGCGCCGTGAGCCGGGCGGCCCGGATCCCC
GAACCCACGGTGAGCGAGCC

Downstream 100 bases:

>100_bases
CCGGCGGCCGCCTCGAGATCCACCCGGCCTCGCCGGAGCGCTGGGCCGACCTGGAGCGGCTGTTCGGCCCGAACGGCGCC
TGCGCCGGCTGCTGGTGCAT

Product: AAA ATPase central domain-containing protein

Products: NA

Alternate protein names: PAN; Proteasomal ATPase; Proteasome regulatory ATPase; Proteasome regulatory particle [H]

Number of amino acids: Translated: 499; Mature: 498

Protein sequence:

>499_residues
MSVSSEIAELWSAGTPVLYLVTPEEDRAVAACQAAAAAFDARCAVWSSHRGLDPAAPGAKEPAALLDALLRAPAPFLAVA
LDFHHALASPAVARQLRDALPRMAAEGRCLAVVAPRLALPDGLGTDAAVIRVPLPDDAELGALLEVVQAGLAHPAAPPPL
PADVRHRALVAARGLSEAQARRAFTRALRRDAALGPEGIGAVAAEKKRLLARDLGLELVEAAERPEDLGGLGAFKAWMDE
RALAFDPDASRWGLPPPRGVLLVGVQGCGKSLAAKAAAARLGVPVLRLDLPRVLGAQTGAEEGLARALEAAEALAPVALW
VDEIEKGFAGSAPGDGGEPRAARLLGAFSTWLQERKGPVFVVATANDVSRLPPELLRRGRFDELFFVDLPDPEARREILA
LHLRRRGREPGAVDVAAIAELCADYSGAELEQVVIGALHRAYALGRELETADLRRVAQDLVPLFRTYEEQIKALREWARG
RARVAGRAGAVVDLFRRVQ

Sequences:

>Translated_499_residues
MSVSSEIAELWSAGTPVLYLVTPEEDRAVAACQAAAAAFDARCAVWSSHRGLDPAAPGAKEPAALLDALLRAPAPFLAVA
LDFHHALASPAVARQLRDALPRMAAEGRCLAVVAPRLALPDGLGTDAAVIRVPLPDDAELGALLEVVQAGLAHPAAPPPL
PADVRHRALVAARGLSEAQARRAFTRALRRDAALGPEGIGAVAAEKKRLLARDLGLELVEAAERPEDLGGLGAFKAWMDE
RALAFDPDASRWGLPPPRGVLLVGVQGCGKSLAAKAAAARLGVPVLRLDLPRVLGAQTGAEEGLARALEAAEALAPVALW
VDEIEKGFAGSAPGDGGEPRAARLLGAFSTWLQERKGPVFVVATANDVSRLPPELLRRGRFDELFFVDLPDPEARREILA
LHLRRRGREPGAVDVAAIAELCADYSGAELEQVVIGALHRAYALGRELETADLRRVAQDLVPLFRTYEEQIKALREWARG
RARVAGRAGAVVDLFRRVQ
>Mature_498_residues
SVSSEIAELWSAGTPVLYLVTPEEDRAVAACQAAAAAFDARCAVWSSHRGLDPAAPGAKEPAALLDALLRAPAPFLAVAL
DFHHALASPAVARQLRDALPRMAAEGRCLAVVAPRLALPDGLGTDAAVIRVPLPDDAELGALLEVVQAGLAHPAAPPPLP
ADVRHRALVAARGLSEAQARRAFTRALRRDAALGPEGIGAVAAEKKRLLARDLGLELVEAAERPEDLGGLGAFKAWMDER
ALAFDPDASRWGLPPPRGVLLVGVQGCGKSLAAKAAAARLGVPVLRLDLPRVLGAQTGAEEGLARALEAAEALAPVALWV
DEIEKGFAGSAPGDGGEPRAARLLGAFSTWLQERKGPVFVVATANDVSRLPPELLRRGRFDELFFVDLPDPEARREILAL
HLRRRGREPGAVDVAAIAELCADYSGAELEQVVIGALHRAYALGRELETADLRRVAQDLVPLFRTYEEQIKALREWARGR
ARVAGRAGAVVDLFRRVQ

Specific function: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereb

COG id: COG0464

COG function: function code O; ATPases of the AAA+ class

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AAA ATPase family [H]

Homologues:

Organism=Homo sapiens, GI6005942, Length=217, Percent_Identity=31.3364055299539, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI157671927, Length=210, Percent_Identity=30.952380952381, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI45643123, Length=287, Percent_Identity=28.2229965156794, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI45643125, Length=287, Percent_Identity=28.2229965156794, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI24497618, Length=239, Percent_Identity=29.7071129707113, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI21361144, Length=232, Percent_Identity=30.6034482758621, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI195539395, Length=197, Percent_Identity=29.4416243654822, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI24430151, Length=186, Percent_Identity=30.6451612903226, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI4507173, Length=202, Percent_Identity=31.1881188118812, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI153792536, Length=239, Percent_Identity=28.4518828451883, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI4506209, Length=191, Percent_Identity=30.8900523560209, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI24497435, Length=185, Percent_Identity=31.3513513513514, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1789568, Length=182, Percent_Identity=34.6153846153846, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17532375, Length=216, Percent_Identity=30.5555555555556, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17531535, Length=181, Percent_Identity=32.5966850828729, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17508053, Length=216, Percent_Identity=30.5555555555556, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193209502, Length=279, Percent_Identity=25.089605734767, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17508701, Length=193, Percent_Identity=29.5336787564767, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71987364, Length=192, Percent_Identity=29.6875, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71987372, Length=192, Percent_Identity=29.6875, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25153574, Length=279, Percent_Identity=25.089605734767, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17563250, Length=158, Percent_Identity=32.2784810126582, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17537217, Length=186, Percent_Identity=30.6451612903226, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17554786, Length=189, Percent_Identity=31.2169312169312, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17563248, Length=191, Percent_Identity=30.3664921465969, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI133931034, Length=228, Percent_Identity=32.4561403508772, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI193206114, Length=228, Percent_Identity=32.4561403508772, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17554264, Length=195, Percent_Identity=31.2820512820513, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI193206116, Length=228, Percent_Identity=32.4561403508772, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17505546, Length=157, Percent_Identity=30.5732484076433, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17541226, Length=258, Percent_Identity=25.968992248062, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17541224, Length=215, Percent_Identity=27.4418604651163, Blast_Score=66, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI25146157, Length=214, Percent_Identity=25.7009345794392, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6320077, Length=218, Percent_Identity=33.9449541284404, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322994, Length=194, Percent_Identity=34.020618556701, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323429, Length=213, Percent_Identity=34.2723004694836, Blast_Score=88, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320197, Length=217, Percent_Identity=27.6497695852535, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322704, Length=189, Percent_Identity=32.2751322751323, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322651, Length=228, Percent_Identity=28.9473684210526, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324691, Length=192, Percent_Identity=30.2083333333333, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320854, Length=231, Percent_Identity=30.7359307359307, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324000, Length=245, Percent_Identity=26.530612244898, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321709, Length=225, Percent_Identity=28.4444444444444, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321465, Length=183, Percent_Identity=26.775956284153, Blast_Score=68, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6325281, Length=247, Percent_Identity=27.5303643724696, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI45552965, Length=232, Percent_Identity=31.0344827586207, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281365776, Length=232, Percent_Identity=31.0344827586207, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24660075, Length=232, Percent_Identity=31.0344827586207, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI161076488, Length=251, Percent_Identity=31.0756972111554, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI161076486, Length=251, Percent_Identity=31.4741035856574, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI17137560, Length=251, Percent_Identity=31.0756972111554, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24652279, Length=243, Percent_Identity=30.8641975308642, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19921202, Length=271, Percent_Identity=29.8892988929889, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24656825, Length=247, Percent_Identity=31.1740890688259, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24656820, Length=247, Percent_Identity=31.1740890688259, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24640100, Length=193, Percent_Identity=30.5699481865285, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17738151, Length=235, Percent_Identity=29.7872340425532, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24639391, Length=225, Percent_Identity=31.1111111111111, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24649446, Length=218, Percent_Identity=29.3577981651376, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24658770, Length=215, Percent_Identity=30.6976744186047, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17137738, Length=191, Percent_Identity=30.3664921465969, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19920408, Length=189, Percent_Identity=31.7460317460317, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI20129529, Length=226, Percent_Identity=29.2035398230088, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281363136, Length=231, Percent_Identity=29.8701298701299, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI78707192, Length=231, Percent_Identity=29.8701298701299, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24663015, Length=203, Percent_Identity=29.5566502463054, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005937
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR003960 [H]

Pfam domain/function: PF00004 AAA [H]

EC number: 3.4.24.- [C]

Molecular weight: Translated: 52867; Mature: 52736

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSSEIAELWSAGTPVLYLVTPEEDRAVAACQAAAAAFDARCAVWSSHRGLDPAAPGAK
CCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
EPAALLDALLRAPAPFLAVALDFHHALASPAVARQLRDALPRMAAEGRCLAVVAPRLALP
CHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEECCHHHCC
DGLGTDAAVIRVPLPDDAELGALLEVVQAGLAHPAAPPPLPADVRHRALVAARGLSEAQA
CCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHH
RRAFTRALRRDAALGPEGIGAVAAEKKRLLARDLGLELVEAAERPEDLGGLGAFKAWMDE
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHC
RALAFDPDASRWGLPPPRGVLLVGVQGCGKSLAAKAAAARLGVPVLRLDLPRVLGAQTGA
CCEEECCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCH
EEGLARALEAAEALAPVALWVDEIEKGFAGSAPGDGGEPRAARLLGAFSTWLQERKGPVF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEE
VVATANDVSRLPPELLRRGRFDELFFVDLPDPEARREILALHLRRRGREPGAVDVAAIAE
EEEECCHHHHCCHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
LCADYSGAELEQVVIGALHRAYALGRELETADLRRVAQDLVPLFRTYEEQIKALREWARG
HHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RARVAGRAGAVVDLFRRVQ
HHHHHCCCHHHHHHHHHCC
>Mature Secondary Structure 
SVSSEIAELWSAGTPVLYLVTPEEDRAVAACQAAAAAFDARCAVWSSHRGLDPAAPGAK
CCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
EPAALLDALLRAPAPFLAVALDFHHALASPAVARQLRDALPRMAAEGRCLAVVAPRLALP
CHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEECCHHHCC
DGLGTDAAVIRVPLPDDAELGALLEVVQAGLAHPAAPPPLPADVRHRALVAARGLSEAQA
CCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHH
RRAFTRALRRDAALGPEGIGAVAAEKKRLLARDLGLELVEAAERPEDLGGLGAFKAWMDE
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHC
RALAFDPDASRWGLPPPRGVLLVGVQGCGKSLAAKAAAARLGVPVLRLDLPRVLGAQTGA
CCEEECCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCH
EEGLARALEAAEALAPVALWVDEIEKGFAGSAPGDGGEPRAARLLGAFSTWLQERKGPVF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEE
VVATANDVSRLPPELLRRGRFDELFFVDLPDPEARREILALHLRRRGREPGAVDVAAIAE
EEEECCHHHHCCHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
LCADYSGAELEQVVIGALHRAYALGRELETADLRRVAQDLVPLFRTYEEQIKALREWARG
HHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RARVAGRAGAVVDLFRRVQ
HHHHHCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Metalloendopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]