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The map label for this gene is hisN [H]

Identifier: 220917768

GI number: 220917768

Start: 2946107

End: 2946898

Strand: Direct

Name: hisN [H]

Synonym: A2cp1_2669

Alternate gene names: 220917768

Gene position: 2946107-2946898 (Clockwise)

Preceding gene: 220917767

Following gene: 220917779

Centisome position: 58.58

GC content: 77.65

Gene sequence:

>792_bases
ATGCCCGAGCTCGATCTGCAGCGCGCGATGGAGACCGCCCGCGCGGCGGTGGAGGCCGCCTCCGCGGCCAGCCTCGCCCA
CTTCCGCCGCGGCGTGCGCGTGGAGCGCAAGCCGGACCGCAGCCCGGTCACCGCGGCGGATCGGGAGTCGGAGGCAGCGG
TGCTGGCGGTCGTGCGCGCCGCGTTCCCGGACCACGGCTTCCTGGGCGAGGAGACCGGCGAGCACGCCGGCAGCGCCGAG
ACCCGCTGGATCGTGGACCCGCTCGACGGCACCAAGGGCTTCACCCGCGGGCGCGGGTTCTGGGGCCCGCTGGTCGCGTG
CGAGCACCGCGGCGAGATCGTGGCGGGCGCGATGGCGCTGCCCGCGCTCGGCGAGGCGTACTGGGCGGCGCGCGGCCAGG
GCACCTGGCTCCGCGCCGGCGACGCCGCCCCGGCGCGGCTGCGCGTCTCCGGCCTCGCCGCCTGGGAGGACGCGACGCTG
TCGCTGGGCGAGCCGCACGTCCTGTTCCGGCCGCCCATGCTGGAGCGCGTCGCGGCGCTGGCGATCTCGGCGCAGGCGGC
GCGCTGCTACGGCGACCTGGCGGGCTGCGCGCTGGTGCTGAAGGGCGAGGCCGAGGCCTGGGTGGAGGCGGGGGTCAACC
TGTGGGACCTCGCCCCGCTGAAGATCCTGGCGGAGGAGGCGGGCGGCCGCTTCACCGACCTCGACGGGAGGCCGACGGTC
GCGTCGGGGAGCTGCGTGGCGTCGAACGGGCTCCTGCACGACCACGTGCTGCGGGCGCTCTCGGGGCGGTGA

Upstream 100 bases:

>100_bases
GCCTCCGAGAGACCGTCGCAGCCGCGGCGGCCGTCCTCCCGGGCGGCCGCCGTTCCATTTTCCGGCGGCGCCTCGCCGCC
GCCGCGCTAGGCTCCCGGCC

Downstream 100 bases:

>100_bases
GCAGCTTGCGGACGATGGGCCGGGTCGGGCTGCGCCGCAGCACCTCCTCGAAGCCGGCGGCGCGGAACGTGGAGGCGAGG
CCGGTGTAGAGGAACGCGGA

Product: inositol monophosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MPELDLQRAMETARAAVEAASAASLAHFRRGVRVERKPDRSPVTAADRESEAAVLAVVRAAFPDHGFLGEETGEHAGSAE
TRWIVDPLDGTKGFTRGRGFWGPLVACEHRGEIVAGAMALPALGEAYWAARGQGTWLRAGDAAPARLRVSGLAAWEDATL
SLGEPHVLFRPPMLERVAALAISAQAARCYGDLAGCALVLKGEAEAWVEAGVNLWDLAPLKILAEEAGGRFTDLDGRPTV
ASGSCVASNGLLHDHVLRALSGR

Sequences:

>Translated_263_residues
MPELDLQRAMETARAAVEAASAASLAHFRRGVRVERKPDRSPVTAADRESEAAVLAVVRAAFPDHGFLGEETGEHAGSAE
TRWIVDPLDGTKGFTRGRGFWGPLVACEHRGEIVAGAMALPALGEAYWAARGQGTWLRAGDAAPARLRVSGLAAWEDATL
SLGEPHVLFRPPMLERVAALAISAQAARCYGDLAGCALVLKGEAEAWVEAGVNLWDLAPLKILAEEAGGRFTDLDGRPTV
ASGSCVASNGLLHDHVLRALSGR
>Mature_262_residues
PELDLQRAMETARAAVEAASAASLAHFRRGVRVERKPDRSPVTAADRESEAAVLAVVRAAFPDHGFLGEETGEHAGSAET
RWIVDPLDGTKGFTRGRGFWGPLVACEHRGEIVAGAMALPALGEAYWAARGQGTWLRAGDAAPARLRVSGLAAWEDATLS
LGEPHVLFRPPMLERVAALAISAQAARCYGDLAGCALVLKGEAEAWVEAGVNLWDLAPLKILAEEAGGRFTDLDGRPTVA
SGSCVASNGLLHDHVLRALSGR

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine (Probable) [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI5031789, Length=208, Percent_Identity=29.8076923076923, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI221625487, Length=208, Percent_Identity=29.8076923076923, Blast_Score=78, Evalue=7e-15,
Organism=Escherichia coli, GI1788882, Length=223, Percent_Identity=28.6995515695067, Blast_Score=87, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21357329, Length=241, Percent_Identity=26.9709543568465, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24664918, Length=209, Percent_Identity=27.7511961722488, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24664926, Length=216, Percent_Identity=26.8518518518519, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21357303, Length=229, Percent_Identity=26.2008733624454, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 27745; Mature: 27613

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00629 IMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELDLQRAMETARAAVEAASAASLAHFRRGVRVERKPDRSPVTAADRESEAAVLAVVRA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
AFPDHGFLGEETGEHAGSAETRWIVDPLDGTKGFTRGRGFWGPLVACEHRGEIVAGAMAL
HCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEECCCCCEEEHHHHH
PALGEAYWAARGQGTWLRAGDAAPARLRVSGLAAWEDATLSLGEPHVLFRPPMLERVAAL
HHHHHHHHHCCCCCCEEECCCCCCCEEEEEEEEECCCCEEECCCCEEEECCCHHHHHHHH
AISAQAARCYGDLAGCALVLKGEAEAWVEAGVNLWDLAPLKILAEEAGGRFTDLDGRPTV
HHHHHHHHHHHHHCCEEEEEECCHHHHHHCCCCEECCCHHHHHHHHCCCCEECCCCCCCC
ASGSCVASNGLLHDHVLRALSGR
CCCCEEECCCCHHHHHHHHHCCC
>Mature Secondary Structure 
PELDLQRAMETARAAVEAASAASLAHFRRGVRVERKPDRSPVTAADRESEAAVLAVVRA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
AFPDHGFLGEETGEHAGSAETRWIVDPLDGTKGFTRGRGFWGPLVACEHRGEIVAGAMAL
HCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEECCCCCEEEHHHHH
PALGEAYWAARGQGTWLRAGDAAPARLRVSGLAAWEDATLSLGEPHVLFRPPMLERVAAL
HHHHHHHHHCCCCCCEEECCCCCCCEEEEEEEEECCCCEEECCCCEEEECCCHHHHHHHH
AISAQAARCYGDLAGCALVLKGEAEAWVEAGVNLWDLAPLKILAEEAGGRFTDLDGRPTV
HHHHHHHHHHHHHCCEEEEEECCHHHHHHCCCCEECCCHHHHHHHHCCCCEECCCCCCCC
ASGSCVASNGLLHDHVLRALSGR
CCCCEEECCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]