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The map label for this gene is map [H]

Identifier: 220917647

GI number: 220917647

Start: 2823986

End: 2824975

Strand: Reverse

Name: map [H]

Synonym: A2cp1_2548

Alternate gene names: 220917647

Gene position: 2824975-2823986 (Counterclockwise)

Preceding gene: 220917648

Following gene: 220917645

Centisome position: 56.17

GC content: 73.03

Gene sequence:

>990_bases
GTGAGCGGATCGGAGCTGGCGGCGCACGCGAGGCCGGGGCGGAACGACCCCTGCTGGTGCGGCAGCGGGCAGAAGTACAA
GAAGTGCCACCTCGACGCGGACTCGCGCGGCGCGCTGCAGGGCGCGCCGGCAAGGAACGGCCGGCGTCCGCTCGCGCCGG
GCGTGGTCTCGCCCCGCCGCGCCGTCCCCGCGACCATCGCCCGCCCGGACTACGCCGTGAGCGGCCGCCCGCGCGCCCAG
GGCAAGGACGTGAAGACGCCGGACGAGCTGGCGCGCCTGCGCCGCGCCTGCCGGGCGGCGGCGCGGGTGCTGCGGGTGGC
CGGCGAGGCGGTGCGGCCGGGCATCACCACCGACGCGATCGACGAGATCGCCCACGCGGAGACCCTCCGCCTCGGCGCCT
ACCCGAGCCCGCTCAACTACCGCGGCTTCCCCAAGGCCATCTGCACCTCGGTGAACGAGGTCATCTGCCACGGCATCCCG
GACAGCCGGCCGCTCGAGGACGGCGACATCGTCAACCTCGACATCACGGTCTTCCGCGAGGGCATGCACGCCGACTGCTC
CGCCACCTTCCTGGTGGGCAGCGTGGATCCCGAGGGGCGTCGCCTGGTGCAGGTGGCGCAGGAGTGCCTGGCGAAGGGCA
TCGGCGTGGTGAGGCCGGGCCGGCCCATCTCCGACATCGGCAAGGCCATCGAGGCGCACGCGTCGCGCCACGGCTACGGC
GTGGTCCGCTCCTACTGCGGCCACGGCATCGGCGAGAGCTTCCACACCTCGCTCCAGATCGCGCACCACTACGATCCGTC
GCTGAAGCGCGTCATGGAGCCCGGGCTCACCTTCACCATCGAGCCCATGATCACCGAGGGCACCTGGGAGGATCTCCTCT
GGGACGACGGCTGGACCGCCGTGACCGCCGACGGGAAGCGCTCGGCGCAGTTCGAGCACACCGTGGCGGTGACCGAGGAC
GGCGTCGAGGTGCTCACCGTCGAGGAGTGA

Upstream 100 bases:

>100_bases
CCGCCCGTCGAGGACGCGCTGTTGCCCGGGACGGGTGATTCCCTTACAAACACCCGACGACCTGGGCCGTTCGAGCCCTG
GGCCGGACGGAGGTCGTGCG

Downstream 100 bases:

>100_bases
GCCGGCCCTGCGGACCGCTCACACCCGCAGCCCCACCGCGCGCATGAGCGCGAGGGCGTTGGAGTGGCCGACCACGCCCG
GCCGCAGCCGGTAGTCGAAC

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MSGSELAAHARPGRNDPCWCGSGQKYKKCHLDADSRGALQGAPARNGRRPLAPGVVSPRRAVPATIARPDYAVSGRPRAQ
GKDVKTPDELARLRRACRAAARVLRVAGEAVRPGITTDAIDEIAHAETLRLGAYPSPLNYRGFPKAICTSVNEVICHGIP
DSRPLEDGDIVNLDITVFREGMHADCSATFLVGSVDPEGRRLVQVAQECLAKGIGVVRPGRPISDIGKAIEAHASRHGYG
VVRSYCGHGIGESFHTSLQIAHHYDPSLKRVMEPGLTFTIEPMITEGTWEDLLWDDGWTAVTADGKRSAQFEHTVAVTED
GVEVLTVEE

Sequences:

>Translated_329_residues
MSGSELAAHARPGRNDPCWCGSGQKYKKCHLDADSRGALQGAPARNGRRPLAPGVVSPRRAVPATIARPDYAVSGRPRAQ
GKDVKTPDELARLRRACRAAARVLRVAGEAVRPGITTDAIDEIAHAETLRLGAYPSPLNYRGFPKAICTSVNEVICHGIP
DSRPLEDGDIVNLDITVFREGMHADCSATFLVGSVDPEGRRLVQVAQECLAKGIGVVRPGRPISDIGKAIEAHASRHGYG
VVRSYCGHGIGESFHTSLQIAHHYDPSLKRVMEPGLTFTIEPMITEGTWEDLLWDDGWTAVTADGKRSAQFEHTVAVTED
GVEVLTVEE
>Mature_328_residues
SGSELAAHARPGRNDPCWCGSGQKYKKCHLDADSRGALQGAPARNGRRPLAPGVVSPRRAVPATIARPDYAVSGRPRAQG
KDVKTPDELARLRRACRAAARVLRVAGEAVRPGITTDAIDEIAHAETLRLGAYPSPLNYRGFPKAICTSVNEVICHGIPD
SRPLEDGDIVNLDITVFREGMHADCSATFLVGSVDPEGRRLVQVAQECLAKGIGVVRPGRPISDIGKAIEAHASRHGYGV
VRSYCGHGIGESFHTSLQIAHHYDPSLKRVMEPGLTFTIEPMITEGTWEDLLWDDGWTAVTADGKRSAQFEHTVAVTEDG
VEVLTVEE

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=287, Percent_Identity=49.4773519163763, Blast_Score=286, Evalue=1e-77,
Organism=Homo sapiens, GI40385867, Length=278, Percent_Identity=47.4820143884892, Blast_Score=263, Evalue=1e-70,
Organism=Escherichia coli, GI1786364, Length=246, Percent_Identity=43.9024390243902, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI1789275, Length=246, Percent_Identity=25.2032520325203, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71996291, Length=304, Percent_Identity=47.0394736842105, Blast_Score=273, Evalue=7e-74,
Organism=Saccharomyces cerevisiae, GI6323273, Length=279, Percent_Identity=49.4623655913978, Blast_Score=302, Evalue=4e-83,
Organism=Drosophila melanogaster, GI21355531, Length=327, Percent_Identity=45.565749235474, Blast_Score=276, Evalue=2e-74,
Organism=Drosophila melanogaster, GI24583427, Length=282, Percent_Identity=45.3900709219858, Blast_Score=261, Evalue=4e-70,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 35463; Mature: 35332

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGSELAAHARPGRNDPCWCGSGQKYKKCHLDADSRGALQGAPARNGRRPLAPGVVSPRR
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AVPATIARPDYAVSGRPRAQGKDVKTPDELARLRRACRAAARVLRVAGEAVRPGITTDAI
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
DEIAHAETLRLGAYPSPLNYRGFPKAICTSVNEVICHGIPDSRPLEDGDIVNLDITVFRE
HHHHHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEEC
GMHADCSATFLVGSVDPEGRRLVQVAQECLAKGIGVVRPGRPISDIGKAIEAHASRHGYG
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCHH
VVRSYCGHGIGESFHTSLQIAHHYDPSLKRVMEPGLTFTIEPMITEGTWEDLLWDDGWTA
HHHHHHCCCCCCHHHHHEEEEECCCHHHHHHHCCCCEEEEECEEECCCHHHHHCCCCCEE
VTADGKRSAQFEHTVAVTEDGVEVLTVEE
EECCCCCCCCEEEEEEEECCCEEEEEECC
>Mature Secondary Structure 
SGSELAAHARPGRNDPCWCGSGQKYKKCHLDADSRGALQGAPARNGRRPLAPGVVSPRR
CCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AVPATIARPDYAVSGRPRAQGKDVKTPDELARLRRACRAAARVLRVAGEAVRPGITTDAI
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
DEIAHAETLRLGAYPSPLNYRGFPKAICTSVNEVICHGIPDSRPLEDGDIVNLDITVFRE
HHHHHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEEC
GMHADCSATFLVGSVDPEGRRLVQVAQECLAKGIGVVRPGRPISDIGKAIEAHASRHGYG
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCHH
VVRSYCGHGIGESFHTSLQIAHHYDPSLKRVMEPGLTFTIEPMITEGTWEDLLWDDGWTA
HHHHHHCCCCCCHHHHHEEEEECCCHHHHHHHCCCCEEEEECEEECCCHHHHHCCCCCEE
VTADGKRSAQFEHTVAVTEDGVEVLTVEE
EECCCCCCCCEEEEEEEECCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]