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The map label for this gene is yqeC [H]

Identifier: 220917609

GI number: 220917609

Start: 2771368

End: 2772354

Strand: Reverse

Name: yqeC [H]

Synonym: A2cp1_2509

Alternate gene names: 220917609

Gene position: 2772354-2771368 (Counterclockwise)

Preceding gene: 220917613

Following gene: 220917608

Centisome position: 55.12

GC content: 77.51

Gene sequence:

>987_bases
ATGGACATCGGGATGGTGGGGCTGGGGCGGATGGGCGGCCGGATGGCCCGCAGGCTGCTCCGCGGAGGCCACCGGGTGGT
CGGCTTCGATCCGGATGCGCGCGCGGTCGAGGACCTGGCCGCCGACGGCGGCGCCGGGGCGGCCTCGCTGGACGCCCTGG
TGGCGGCGCTCGCCCCCCCGCGGGCGGTCTGGCTGATGGTGCCGGCCGGCGGGCCCACCGAGCAGGCGATCGCGTCGCTG
GCGGAGCGGCTCGGGCCGGGCGACGTGGTGGTGGACGGGGGAAACTCCTGGTTCAAGGACGACGTGCGCCGGGCCGAGCT
GCTCCGGGCCCGCGGCGTGCGGTTCCTCGACGCCGGGACGAGCGGCGGGGTGGCCGGGCTGGAGCGCGGCTACTGCCTGA
TGGTGGGGGGCGATCGCGACGCGTTCGACCGGCTCGAGCCGGTGCTCCGGACGCTGGCGCCCGGCAGCGCCGCGGCGCCG
CCGACGCCGGGGCGGACCGCCGGCGGGACCGCCGAGGAGGGCTACCTGTACTGCGGCCCGGCCGGCGCCGGCCACTTCGT
GAAGATGATCCACAACGGCGTGGAGTACGGGCTGATGCAGGCGTACGCGGAGGGCTTCGACCTGCTGCGCGGCGCCGCCG
GCGAGGGCATGCCCGAGGCGATCCGCTACCGGATCGACCTCGCCGAGGTCGCCGAGCTGTGGCGGCGCGGGAGCGTGGTG
ACCTCCTGGCTGCTGGACCTGTCCGCCGCGGCCCTGGCGCGCGACCCCGGGCTGGAGGCGTTCGAGGGCGCGGTGGCCGA
CTCGGGCGAGGGGCGCTGGACGATCCAGGCCGCGGTGGAGGAGGGCGTGGCCGCCCCGGCGCTCTCCGCGGCGCTGTTCG
CGCGCTTCCGCTCGCGCCGGGCGCACACGTTCGGCGAGAAGCTGCTGAGCGCGATGCGCCGCGGGTTCGGCGGGCACCAC
GAGGCGGTGAAGGGGGGCTCCCGATGA

Upstream 100 bases:

>100_bases
CGTCGCGCCCCTCCGCGCGACCCCACGGGTGCCGGAATCCGTCCGGGCGGGCGGCGTTCCGTCCGCTTAACCTTGCCCCA
CGTCAACCACGGGAGGCGCG

Downstream 100 bases:

>100_bases
CCGCGCTCCCCGACCGCCCCGGCGACCCCTGCGCGTTCGTGATCTTCGGCGCGATGGGCGATCTCGCCCGGCGCAAGCTC
CTCCCGTCGCTCTACAACCT

Product: 6-phosphogluconate dehydrogenase-like protein

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MDIGMVGLGRMGGRMARRLLRGGHRVVGFDPDARAVEDLAADGGAGAASLDALVAALAPPRAVWLMVPAGGPTEQAIASL
AERLGPGDVVVDGGNSWFKDDVRRAELLRARGVRFLDAGTSGGVAGLERGYCLMVGGDRDAFDRLEPVLRTLAPGSAAAP
PTPGRTAGGTAEEGYLYCGPAGAGHFVKMIHNGVEYGLMQAYAEGFDLLRGAAGEGMPEAIRYRIDLAEVAELWRRGSVV
TSWLLDLSAAALARDPGLEAFEGAVADSGEGRWTIQAAVEEGVAAPALSAALFARFRSRRAHTFGEKLLSAMRRGFGGHH
EAVKGGSR

Sequences:

>Translated_328_residues
MDIGMVGLGRMGGRMARRLLRGGHRVVGFDPDARAVEDLAADGGAGAASLDALVAALAPPRAVWLMVPAGGPTEQAIASL
AERLGPGDVVVDGGNSWFKDDVRRAELLRARGVRFLDAGTSGGVAGLERGYCLMVGGDRDAFDRLEPVLRTLAPGSAAAP
PTPGRTAGGTAEEGYLYCGPAGAGHFVKMIHNGVEYGLMQAYAEGFDLLRGAAGEGMPEAIRYRIDLAEVAELWRRGSVV
TSWLLDLSAAALARDPGLEAFEGAVADSGEGRWTIQAAVEEGVAAPALSAALFARFRSRRAHTFGEKLLSAMRRGFGGHH
EAVKGGSR
>Mature_328_residues
MDIGMVGLGRMGGRMARRLLRGGHRVVGFDPDARAVEDLAADGGAGAASLDALVAALAPPRAVWLMVPAGGPTEQAIASL
AERLGPGDVVVDGGNSWFKDDVRRAELLRARGVRFLDAGTSGGVAGLERGYCLMVGGDRDAFDRLEPVLRTLAPGSAAAP
PTPGRTAGGTAEEGYLYCGPAGAGHFVKMIHNGVEYGLMQAYAEGFDLLRGAAGEGMPEAIRYRIDLAEVAELWRRGSVV
TSWLLDLSAAALARDPGLEAFEGAVADSGEGRWTIQAAVEEGVAAPALSAALFARFRSRRAHTFGEKLLSAMRRGFGGHH
EAVKGGSR

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=307, Percent_Identity=33.8762214983713, Blast_Score=145, Evalue=5e-35,
Organism=Escherichia coli, GI1788341, Length=305, Percent_Identity=31.8032786885246, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI145693186, Length=158, Percent_Identity=29.1139240506329, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17542558, Length=307, Percent_Identity=33.5504885993485, Blast_Score=159, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6321695, Length=307, Percent_Identity=32.2475570032573, Blast_Score=156, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6321977, Length=307, Percent_Identity=30.9446254071661, Blast_Score=141, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24639279, Length=308, Percent_Identity=30.1948051948052, Blast_Score=123, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 34176; Mature: 34176

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIGMVGLGRMGGRMARRLLRGGHRVVGFDPDARAVEDLAADGGAGAASLDALVAALAPP
CCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHCCC
RAVWLMVPAGGPTEQAIASLAERLGPGDVVVDGGNSWFKDDVRRAELLRARGVRFLDAGT
CEEEEEECCCCCHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCEEEECCC
SGGVAGLERGYCLMVGGDRDAFDRLEPVLRTLAPGSAAAPPTPGRTAGGTAEEGYLYCGP
CCCCCHHCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEECC
AGAGHFVKMIHNGVEYGLMQAYAEGFDLLRGAAGEGMPEAIRYRIDLAEVAELWRRGSVV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHCCHHH
TSWLLDLSAAALARDPGLEAFEGAVADSGEGRWTIQAAVEEGVAAPALSAALFARFRSRR
HHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCEEEHHHHHCCCCHHHHHHHHHHHHHHHH
AHTFGEKLLSAMRRGFGGHHEAVKGGSR
HHHHHHHHHHHHHHCCCCCHHHHCCCCC
>Mature Secondary Structure
MDIGMVGLGRMGGRMARRLLRGGHRVVGFDPDARAVEDLAADGGAGAASLDALVAALAPP
CCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHCCC
RAVWLMVPAGGPTEQAIASLAERLGPGDVVVDGGNSWFKDDVRRAELLRARGVRFLDAGT
CEEEEEECCCCCHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCEEEECCC
SGGVAGLERGYCLMVGGDRDAFDRLEPVLRTLAPGSAAAPPTPGRTAGGTAEEGYLYCGP
CCCCCHHCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEECC
AGAGHFVKMIHNGVEYGLMQAYAEGFDLLRGAAGEGMPEAIRYRIDLAEVAELWRRGSVV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHCCHHH
TSWLLDLSAAALARDPGLEAFEGAVADSGEGRWTIQAAVEEGVAAPALSAALFARFRSRR
HHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCEEEHHHHHCCCCHHHHHHHHHHHHHHHH
AHTFGEKLLSAMRRGFGGHHEAVKGGSR
HHHHHHHHHHHHHHCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]