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The map label for this gene is map [C]

Identifier: 220917585

GI number: 220917585

Start: 2746556

End: 2747305

Strand: Reverse

Name: map [C]

Synonym: A2cp1_2485

Alternate gene names: 220917585

Gene position: 2747305-2746556 (Counterclockwise)

Preceding gene: 220917587

Following gene: 220917584

Centisome position: 54.63

GC content: 74.0

Gene sequence:

>750_bases
ATGGGCATTCCGCTCCTGGGTGGGCCGGCGGTCGAACGGATGAGGCAGGCGGGGAAGGCCGCGGCGGCGACGCTCGCGCA
CGTCGGCGAGCGGCTCGCCGCGGGGATCAGCACCGCGGACATCGATCGCTGGGTGCGCGAGGACACGGCGCGCCGCGGCG
GCACGCCGAGCCAGCTCGGCTTCCACGGCTTCCCCGCGGCGGTCTGCACGAGCCGGAACGAGGTCGTGTGCCACGGCATC
CCGCGCGCCGCGGAGCGGCTGCGTCCCGGCGACATCGTCAACGTGGACGTCACCACGCGCCTGGATGGCTTCCACGGCGA
CACCTCGGCCACGTTCTGCATCGGAGACGTCTCCGCCGACGCGCGGCACGTGGTGGACGTCGCCCGCCGCTGCCGGGATG
CCGGCATCGCGGTGGTGCGGCACGGCGTCCGGCTCGGGGACGTCGGGGCAGCCATCGAGGAGGTCGCGCGCGCGGAAGGC
TGCAGCGTGGTGCGCGACTACGGCGGGCACGGCATCGGGAAGGCGATGCACGGCCCGCCGACCGTGATGCACGTCGGTCC
GAGGGGGCAGGGCGTGAGGCTGACGGCGGGGATGGCCATCACCATCGAGCCGATGGTGAACCTGGGCCGGCCGGAGGTGA
GGCTGCTGGCCGACGGGTGGACCGTGGTCACCGCGGACGGAAGCCTCTCGGCGCAGTTCGAGCACACGGTGGTCGTGACG
CGCGACGGCTGCGAGGTGATGACGGGGTGA

Upstream 100 bases:

>100_bases
CAGGTCCCAGCGGCGGCCTGGCCTCGGAGGCCCGCGAGCGGCCTCCCGGATACCGAGACGGTATTGGATCGCCGCTGCGC
CGCGCTGGCAGGCTGCAGGC

Downstream 100 bases:

>100_bases
GCCTGCGCCAGCGCGCGGGATCCCCTCTCGCGGGGAGGCGTCCCCACTCCAAGCGGTGAGACCGGGGGGCCGATCGTCGC
CCTGGCGGCGCGCCGGCGCC

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MGIPLLGGPAVERMRQAGKAAAATLAHVGERLAAGISTADIDRWVREDTARRGGTPSQLGFHGFPAAVCTSRNEVVCHGI
PRAAERLRPGDIVNVDVTTRLDGFHGDTSATFCIGDVSADARHVVDVARRCRDAGIAVVRHGVRLGDVGAAIEEVARAEG
CSVVRDYGGHGIGKAMHGPPTVMHVGPRGQGVRLTAGMAITIEPMVNLGRPEVRLLADGWTVVTADGSLSAQFEHTVVVT
RDGCEVMTG

Sequences:

>Translated_249_residues
MGIPLLGGPAVERMRQAGKAAAATLAHVGERLAAGISTADIDRWVREDTARRGGTPSQLGFHGFPAAVCTSRNEVVCHGI
PRAAERLRPGDIVNVDVTTRLDGFHGDTSATFCIGDVSADARHVVDVARRCRDAGIAVVRHGVRLGDVGAAIEEVARAEG
CSVVRDYGGHGIGKAMHGPPTVMHVGPRGQGVRLTAGMAITIEPMVNLGRPEVRLLADGWTVVTADGSLSAQFEHTVVVT
RDGCEVMTG
>Mature_248_residues
GIPLLGGPAVERMRQAGKAAAATLAHVGERLAAGISTADIDRWVREDTARRGGTPSQLGFHGFPAAVCTSRNEVVCHGIP
RAAERLRPGDIVNVDVTTRLDGFHGDTSATFCIGDVSADARHVVDVARRCRDAGIAVVRHGVRLGDVGAAIEEVARAEGC
SVVRDYGGHGIGKAMHGPPTVMHVGPRGQGVRLTAGMAITIEPMVNLGRPEVRLLADGWTVVTADGSLSAQFEHTVVVTR
DGCEVMTG

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI40385867, Length=238, Percent_Identity=41.5966386554622, Blast_Score=199, Evalue=2e-51,
Organism=Homo sapiens, GI164420681, Length=246, Percent_Identity=41.869918699187, Blast_Score=186, Evalue=1e-47,
Organism=Escherichia coli, GI1786364, Length=249, Percent_Identity=45.7831325301205, Blast_Score=229, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI71996291, Length=247, Percent_Identity=41.7004048582996, Blast_Score=189, Evalue=9e-49,
Organism=Saccharomyces cerevisiae, GI6323273, Length=250, Percent_Identity=38, Blast_Score=191, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24583427, Length=249, Percent_Identity=37.7510040160643, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI21355531, Length=246, Percent_Identity=39.8373983739837, Blast_Score=186, Evalue=1e-47,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 26021; Mature: 25890

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIPLLGGPAVERMRQAGKAAAATLAHVGERLAAGISTADIDRWVREDTARRGGTPSQLG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCC
FHGFPAAVCTSRNEVVCHGIPRAAERLRPGDIVNVDVTTRLDGFHGDTSATFCIGDVSAD
CCCCCHHHHCCCCCEEEECCCHHHHHCCCCCEEEEEEEEEECCCCCCCCCEEEEECCCCC
ARHVVDVARRCRDAGIAVVRHGVRLGDVGAAIEEVARAEGCSVVRDYGGHGIGKAMHGPP
HHHHHHHHHHHHHCCCHHHHCCCEECHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCC
TVMHVGPRGQGVRLTAGMAITIEPMVNLGRPEVRLLADGWTVVTADGSLSAQFEHTVVVT
CEEEECCCCCCEEEECCEEEEEEHHHCCCCCCEEEEECCEEEEEECCCCEEEEEEEEEEE
RDGCEVMTG
ECCCEECCC
>Mature Secondary Structure 
GIPLLGGPAVERMRQAGKAAAATLAHVGERLAAGISTADIDRWVREDTARRGGTPSQLG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCC
FHGFPAAVCTSRNEVVCHGIPRAAERLRPGDIVNVDVTTRLDGFHGDTSATFCIGDVSAD
CCCCCHHHHCCCCCEEEECCCHHHHHCCCCCEEEEEEEEEECCCCCCCCCEEEEECCCCC
ARHVVDVARRCRDAGIAVVRHGVRLGDVGAAIEEVARAEGCSVVRDYGGHGIGKAMHGPP
HHHHHHHHHHHHHCCCHHHHCCCEECHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCC
TVMHVGPRGQGVRLTAGMAITIEPMVNLGRPEVRLLADGWTVVTADGSLSAQFEHTVVVT
CEEEECCCCCCEEEECCEEEEEEHHHCCCCCCEEEEECCEEEEEECCCCEEEEEEEEEEE
RDGCEVMTG
ECCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]