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The map label for this gene is folP [H]

Identifier: 220917559

GI number: 220917559

Start: 2716177

End: 2717028

Strand: Reverse

Name: folP [H]

Synonym: A2cp1_2459

Alternate gene names: 220917559

Gene position: 2717028-2716177 (Counterclockwise)

Preceding gene: 220917560

Following gene: 220917558

Centisome position: 54.02

GC content: 77.58

Gene sequence:

>852_bases
ATGCGGATGCGGATCGGGGCCAGGCTCTTCGACGGGCCTGGCCCCTTCGTCATGGGGGTCGTGAACGCGACCCCGGACTC
GTTCTCGGACGGCGGCCGGTTCCTCGAGCGCGACGCGGCGGTGGCGCACGCGCTGCGGCTCGCGGACGAGGGCGCCGATC
TGGTGGACCTGGGCGGCGAGTCCACCCGGCCCGGCGCGCCGCCGGTGACGGCCGACGAGGAGCTCCGGCGGGTGGTGCCG
GTCGTCGCCGCGCTGCGCGCGCGCGGGTTCACGCTCCCGATCTCGGTGGACACGTGGAAGGCGCGGGTGGCGCGGGAGGC
GCTCGCGGCCGGGGCGGACCTGGTGAACGACGTGACCGGCCTCGCCGACCCGGACATGGGCGGCGTGGTCGCCGGGGCCG
GCGTGCCGATCGTGCTCCAGCACATGCGCGGCACGTTCGCCGACATGGCCACGCGCGCGGTGTATGCGGACGTGGTCGAG
GAGGTCGCCGCCGAGCTGGACGAGGCGCTGGCCCGGGCCGGGGCGGCCGGCATCCCGCGCGATCGCGTGGTGCTCGACCC
CGGCATCGGCTTCGCGAAGGACGCCCGGCAGAGCCTGGAGCTGCTGGCGCGGGTCGGGGAGCTGCGGCGCCTCGGGTGCC
CGCTGCTGGTGGGCCCGTCGCGCAAGAGCTTCATCGGGAAGGTCACCGGCGCGCCCGCGGCGGAGCGCCTGCCCGGCACG
CTCGCGGCGGTGACCGCGTGCGTGCTGGCCGGCGTGGAGCTGGTGCGCGTCCACGACGTCGCGGCCGCCCGGCAGGCAGC
CGACGTCGCGGCCGCGATCCGGGGAGCGGCGCGCGCTCCCGGTCCGCTGTAG

Upstream 100 bases:

>100_bases
CGGCGGGCTGCTCGACGCGGTGGGCGGCGTCCCGGCGGCGGGCAAGGCCTGATCGGCCGCGGCGCCCGTTCCGCGGGCAC
CGGCCGGAGATCACGTCGCG

Downstream 100 bases:

>100_bases
ACTGCCGCGCCGGAGAAGCCCGTTGCAGCGGATCCTCGTCTACCTCATCGGCCCCGACGTCTCGCTGGGCGACCTCGCGC
TCGCGCTGGTCGACATCGGC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MRMRIGARLFDGPGPFVMGVVNATPDSFSDGGRFLERDAAVAHALRLADEGADLVDLGGESTRPGAPPVTADEELRRVVP
VVAALRARGFTLPISVDTWKARVAREALAAGADLVNDVTGLADPDMGGVVAGAGVPIVLQHMRGTFADMATRAVYADVVE
EVAAELDEALARAGAAGIPRDRVVLDPGIGFAKDARQSLELLARVGELRRLGCPLLVGPSRKSFIGKVTGAPAAERLPGT
LAAVTACVLAGVELVRVHDVAAARQAADVAAAIRGAARAPGPL

Sequences:

>Translated_283_residues
MRMRIGARLFDGPGPFVMGVVNATPDSFSDGGRFLERDAAVAHALRLADEGADLVDLGGESTRPGAPPVTADEELRRVVP
VVAALRARGFTLPISVDTWKARVAREALAAGADLVNDVTGLADPDMGGVVAGAGVPIVLQHMRGTFADMATRAVYADVVE
EVAAELDEALARAGAAGIPRDRVVLDPGIGFAKDARQSLELLARVGELRRLGCPLLVGPSRKSFIGKVTGAPAAERLPGT
LAAVTACVLAGVELVRVHDVAAARQAADVAAAIRGAARAPGPL
>Mature_283_residues
MRMRIGARLFDGPGPFVMGVVNATPDSFSDGGRFLERDAAVAHALRLADEGADLVDLGGESTRPGAPPVTADEELRRVVP
VVAALRARGFTLPISVDTWKARVAREALAAGADLVNDVTGLADPDMGGVVAGAGVPIVLQHMRGTFADMATRAVYADVVE
EVAAELDEALARAGAAGIPRDRVVLDPGIGFAKDARQSLELLARVGELRRLGCPLLVGPSRKSFIGKVTGAPAAERLPGT
LAAVTACVLAGVELVRVHDVAAARQAADVAAAIRGAARAPGPL

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=276, Percent_Identity=42.3913043478261, Blast_Score=216, Evalue=9e-58,
Organism=Saccharomyces cerevisiae, GI6324073, Length=316, Percent_Identity=30.6962025316456, Blast_Score=150, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 29081; Mature: 29081

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMRIGARLFDGPGPFVMGVVNATPDSFSDGGRFLERDAAVAHALRLADEGADLVDLGGE
CCCCCCCEEECCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCC
STRPGAPPVTADEELRRVVPVVAALRARGFTLPISVDTWKARVAREALAAGADLVNDVTG
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHC
LADPDMGGVVAGAGVPIVLQHMRGTFADMATRAVYADVVEEVAAELDEALARAGAAGIPR
CCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DRVVLDPGIGFAKDARQSLELLARVGELRRLGCPLLVGPSRKSFIGKVTGAPAAERLPGT
CCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHCCCCCHHHHCCHH
LAAVTACVLAGVELVRVHDVAAARQAADVAAAIRGAARAPGPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRMRIGARLFDGPGPFVMGVVNATPDSFSDGGRFLERDAAVAHALRLADEGADLVDLGGE
CCCCCCCEEECCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCC
STRPGAPPVTADEELRRVVPVVAALRARGFTLPISVDTWKARVAREALAAGADLVNDVTG
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHC
LADPDMGGVVAGAGVPIVLQHMRGTFADMATRAVYADVVEEVAAELDEALARAGAAGIPR
CCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DRVVLDPGIGFAKDARQSLELLARVGELRRLGCPLLVGPSRKSFIGKVTGAPAAERLPGT
CCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHCCCCCHHHHCCHH
LAAVTACVLAGVELVRVHDVAAARQAADVAAAIRGAARAPGPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]