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The map label for this gene is sppA [C]

Identifier: 220917534

GI number: 220917534

Start: 2691796

End: 2692944

Strand: Reverse

Name: sppA [C]

Synonym: A2cp1_2434

Alternate gene names: 220917534

Gene position: 2692944-2691796 (Counterclockwise)

Preceding gene: 220917535

Following gene: 220917533

Centisome position: 53.54

GC content: 74.5

Gene sequence:

>1149_bases
ATGAACCCCAGCGATCCCAACGAGCCCCTCCCCACCACGCCGGTCGGCCCGCAGGAGCCGCAGCCCGGGGCGACCGGGCC
GGGATCGCCCGCGCGGCCGGAGCCGCCGCGCTGGGGCGCGCCGCCCCCGCCGCCGCCGAGCTGGGGCCCGCCGCCCGGCC
CGCCGCCGCCGCCCGCGAGCTGGGGCGCGCCCCCGCCCGGCATGCCGCCGCAGCCGCCGCCGCGCCGCGATCGCCTGGCG
CTCGGCATCGTCGCCTTCATCTTCGGCGGCCTGTTCCTGGTGTTCTTCGGGTTCCTGCTGCTGGCGTTCGGCGCGGTGCG
GGGCGAGTCCCCGCGCCTCGGCTCCGGTCCGCGCGTCGGCGTCATCGACGTGAAGGGCACCATCGGCGGCGGCGAGCGCG
ACGAGACCGAGGACATCCTGAAGCGCATCCGCCGGTTCGCCGAGGACGGCGATCTCAAGGCGGTGGTGATCCGGGTGGAC
TCTCCCGGCGGCTCGGTGGGCGCCAGCCAGGAGATCCACGACGAGGTGAAGCGCCTCGCGCAGAAGAAGGTCGTGGTCTG
CTCGATGGGCAACCTGGCCGCCTCGGGCGGCCTGTACGTGTCGGTGGCCTGCCCGAAGATCGTCGCGAACCCCGGCACGC
TCACCGGCTCGATCGGCGTCATCAGCCAGTTCCCGAACGTGAAGGATCTCGCCGAGAAGCTGGGGGTGAAGGTCGAGACG
GTGAAGACCGGCAAGCTGAAGGACGCCGGCAACCCGTTCCGCGACATGACGCCGGAGGACCGCGCCTACTGGCAGGGGCT
GGTCGAGAACACGCTGGGCCAGTTCGTGAAGGCGGTGGCCGAGGGGCGCAAGCTCGACGAGGCGAAGGTGCGCGCCATCG
CCGACGGCCGCGTGCTCACCGGCGCGCAGGCGAAGGAGGCCGGGCTGGTGGACCAGCTCGGCAACTTCTACGACGCGGTC
GAGCTGGCGAAGCAGGAGGCGAAGCTGAGCGGCGAGGCGGTGCTGGTCTACCCGCCCGACGAGCACGGCCGGTTCCTCGA
GCAGCTCATGGGCGGCGCGGCCGGCGCGGTGGCCGACGCGGTCGCCACCCGGGTGGCGCAGGGCGCGGCCGACGCGCGGC
AGCCCGGCGTCTACTTCCTCGCGCGGTAG

Upstream 100 bases:

>100_bases
CGGCGGTCCGGAGCACCGGCGGGCGGCCTGCGCGAGCGGGCCGCCCGCTTCATTTTTGCCGGTTGCGACCCCCCCGGCCG
CGTGCTTACCTGACCCGACC

Downstream 100 bases:

>100_bases
CGGCGCGCGCCGCAAGGAGACTCCCGTGCAGCAGCCGCTCTGGGCCCCGTGGCGCATGGAGTTCATCCGGTCCGAGAAGC
CGGCCGGGTGCATCTTCTGC

Product: signal peptide peptidase SppA, 36K type

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MNPSDPNEPLPTTPVGPQEPQPGATGPGSPARPEPPRWGAPPPPPPSWGPPPGPPPPPASWGAPPPGMPPQPPPRRDRLA
LGIVAFIFGGLFLVFFGFLLLAFGAVRGESPRLGSGPRVGVIDVKGTIGGGERDETEDILKRIRRFAEDGDLKAVVIRVD
SPGGSVGASQEIHDEVKRLAQKKVVVCSMGNLAASGGLYVSVACPKIVANPGTLTGSIGVISQFPNVKDLAEKLGVKVET
VKTGKLKDAGNPFRDMTPEDRAYWQGLVENTLGQFVKAVAEGRKLDEAKVRAIADGRVLTGAQAKEAGLVDQLGNFYDAV
ELAKQEAKLSGEAVLVYPPDEHGRFLEQLMGGAAGAVADAVATRVAQGAADARQPGVYFLAR

Sequences:

>Translated_382_residues
MNPSDPNEPLPTTPVGPQEPQPGATGPGSPARPEPPRWGAPPPPPPSWGPPPGPPPPPASWGAPPPGMPPQPPPRRDRLA
LGIVAFIFGGLFLVFFGFLLLAFGAVRGESPRLGSGPRVGVIDVKGTIGGGERDETEDILKRIRRFAEDGDLKAVVIRVD
SPGGSVGASQEIHDEVKRLAQKKVVVCSMGNLAASGGLYVSVACPKIVANPGTLTGSIGVISQFPNVKDLAEKLGVKVET
VKTGKLKDAGNPFRDMTPEDRAYWQGLVENTLGQFVKAVAEGRKLDEAKVRAIADGRVLTGAQAKEAGLVDQLGNFYDAV
ELAKQEAKLSGEAVLVYPPDEHGRFLEQLMGGAAGAVADAVATRVAQGAADARQPGVYFLAR
>Mature_382_residues
MNPSDPNEPLPTTPVGPQEPQPGATGPGSPARPEPPRWGAPPPPPPSWGPPPGPPPPPASWGAPPPGMPPQPPPRRDRLA
LGIVAFIFGGLFLVFFGFLLLAFGAVRGESPRLGSGPRVGVIDVKGTIGGGERDETEDILKRIRRFAEDGDLKAVVIRVD
SPGGSVGASQEIHDEVKRLAQKKVVVCSMGNLAASGGLYVSVACPKIVANPGTLTGSIGVISQFPNVKDLAEKLGVKVET
VKTGKLKDAGNPFRDMTPEDRAYWQGLVENTLGQFVKAVAEGRKLDEAKVRAIADGRVLTGAQAKEAGLVDQLGNFYDAV
ELAKQEAKLSGEAVLVYPPDEHGRFLEQLMGGAAGAVADAVATRVAQGAADARQPGVYFLAR

Specific function: Digestion Of The Cleaved Signal Peptides. This Activity Is Necessary To Maintain Proper Secretion Of Mature Proteins Across The Membrane. [C]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=248, Percent_Identity=38.3064516129032, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1787527, Length=257, Percent_Identity=30.3501945525292, Blast_Score=82, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 39914; Mature: 39914

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPSDPNEPLPTTPVGPQEPQPGATGPGSPARPEPPRWGAPPPPPPSWGPPPGPPPPPAS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
WGAPPPGMPPQPPPRRDRLALGIVAFIFGGLFLVFFGFLLLAFGAVRGESPRLGSGPRVG
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEE
VIDVKGTIGGGERDETEDILKRIRRFAEDGDLKAVVIRVDSPGGSVGASQEIHDEVKRLA
EEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHH
QKKVVVCSMGNLAASGGLYVSVACPKIVANPGTLTGSIGVISQFPNVKDLAEKLGVKVET
HHCEEEEECCCEECCCCEEEEEECCHHHCCCCCCCCCCHHHHHCCCHHHHHHHHCCEEEE
VKTGKLKDAGNPFRDMTPEDRAYWQGLVENTLGQFVKAVAEGRKLDEAKVRAIADGRVLT
EECCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEE
GAQAKEAGLVDQLGNFYDAVELAKQEAKLSGEAVLVYPPDEHGRFLEQLMGGAAGAVADA
CCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCHHHHHHHH
VATRVAQGAADARQPGVYFLAR
HHHHHHHCCCCCCCCCEEEEEC
>Mature Secondary Structure
MNPSDPNEPLPTTPVGPQEPQPGATGPGSPARPEPPRWGAPPPPPPSWGPPPGPPPPPAS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
WGAPPPGMPPQPPPRRDRLALGIVAFIFGGLFLVFFGFLLLAFGAVRGESPRLGSGPRVG
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEE
VIDVKGTIGGGERDETEDILKRIRRFAEDGDLKAVVIRVDSPGGSVGASQEIHDEVKRLA
EEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHH
QKKVVVCSMGNLAASGGLYVSVACPKIVANPGTLTGSIGVISQFPNVKDLAEKLGVKVET
HHCEEEEECCCEECCCCEEEEEECCHHHCCCCCCCCCCHHHHHCCCHHHHHHHHCCEEEE
VKTGKLKDAGNPFRDMTPEDRAYWQGLVENTLGQFVKAVAEGRKLDEAKVRAIADGRVLT
EECCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEE
GAQAKEAGLVDQLGNFYDAVELAKQEAKLSGEAVLVYPPDEHGRFLEQLMGGAAGAVADA
CCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCHHHHHHHH
VATRVAQGAADARQPGVYFLAR
HHHHHHHCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]