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The map label for this gene is atoS [H]

Identifier: 220917074

GI number: 220917074

Start: 2224150

End: 2225658

Strand: Direct

Name: atoS [H]

Synonym: A2cp1_1970

Alternate gene names: 220917074

Gene position: 2224150-2225658 (Clockwise)

Preceding gene: 220917073

Following gene: 220917076

Centisome position: 44.22

GC content: 73.09

Gene sequence:

>1509_bases
ATGAACCTGCTCGAGCGCAGCTACCGGAGCCTGGACTCCAGCATGCGCGCGCGCGTGCTGGTGCCGACGGCGCTGCTGTT
CGCGGTGACGCTCTCCGCGATGGTGGCCGCCGCCGTGCACTTCTACGGCGCCGACATCGAGAGCGGCCGGCAGGACCGGG
CCGAGCTGTTCGCGACCATGGTCTCCTCGGGCGTGTCGAACGTGATGCTCTCGGGGAAGCCGCGCGAGGTGAGCACGCTG
CTGGAGGCCCTGGTGGCCCACCGCAGCGACCTGCTCTCCGCCAGCCTGATCGCGCCGAACGGCTACATCTCGATCTCTAC
CAGCCCGGCGCTGCTGGGGCGGGTGCCGTGGTCCGAGGTGAACCGGGTCGAGGGCACCACCGTGGTGGTGGGGCCGGGCG
GCAACGACGCCGAGTACGCGGTGCTCCAGCCCATCGTCAACGCCGAGTCCTGCGCGCGCTGTCACGGCACCCAGAGCCAC
GTGAACGGCTGGCTCGACCTGCGCTTCACCCGCGAGCCGGTGCTGGAGGCGCAGGCGCAGCTCGCCAAGACGCTGTCGCT
GTCCGCCGGGGCCGCGCTGGTGTGCCTGCTCGGGATCCTGCTCTGGCTGCTGGGCCGCGAGGCGGTGACCCCGCTGCAGC
GGCTGGTGACGGTGATGCGCCGGGCCGAGGCGGGCGAGCTCTCGGTGCGGGCCGACGAGGGGCGCCCGGACGAGCTGGGC
GTGGCGGCGCGCGGCTTCGACGCCACGCTGGCGGCGCTGCGGCGCAGCCAGGCCGAGCTGGAGGCGTTCTACCGCGAGCG
CATGGTGCGGGCCGACCGGTTCGCCGCGGTGGGCGAGATCGCCACCGGCCTGGCGCACGAGATCAAGAACCCGCTGGCGG
GGCTGTCCGGCGCGCTGGAGCTGCTCGCCGAGGACTTCTCCGACGACGCGCGCCACTCCGACATCGTCACCGAGATGCAG
CACCAGGTGCGGCGGCTCACGCACACCATGGAGAGCCTGCTCAGCTTCGCCCGCCCGGCCAAGGCGAAGCTCCGCTCCAC
CGACGTGAACGCCACGCTCGAGAAGGTGCTGTTCCTCATCCGCCAGCAGTCGCGCGACGGCACGCTCGAGCTGGTCCCCG
AGCTCTCGCCCGGGCTCCCCGCGGTGCTGGCCGACCCGTCGCAGCTCGAGCAGGTGTTCCTCAACATCTGCCTGAACGCC
TGCCAGGCGATGATCGCGACCCGCCGCGGCGGGCGCCTCACCGTCCGCTCCCGCGCCGGCGACGGCACCGTGAGCGTCGA
GGTGGAGGACACCGGCCCGGGCATCCCGGCCGACCTCCGCGCCCAGATCTTCAAGCCGTTCTTCACGACCAAGCGCGAGG
GGAACGGGCTCGGGCTCGCCATCTCCGCGCGCATCGTGGCGGAGCACGGGGGCCACATCGGCTACCGCTGCCCGCCCGAG
GGCGGCACCACCTTCACCGTGACGCTGCAACAGGCGCGGCCCCAGCGCGCCCCGGAGCACGCCGCATGA

Upstream 100 bases:

>100_bases
GCCGGCCGCCCGGGGCGACGCCGCCTAGCGGGGAGGTCGGGCCTTCCCCAGGCCCGGAATTCCTGAGATATTGGCGCGCG
TTGTCTCACGGGCCGACCGC

Downstream 100 bases:

>100_bases
ACAGCACCCCGGCCCGCATCCTCGTCGTGGACGACGAGAAGCTCATCCGCTGGTCGGTGGCGGAGCGGCTGCAGCGCGGC
GGCTACGAGGTCCTCTCGGC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MNLLERSYRSLDSSMRARVLVPTALLFAVTLSAMVAAAVHFYGADIESGRQDRAELFATMVSSGVSNVMLSGKPREVSTL
LEALVAHRSDLLSASLIAPNGYISISTSPALLGRVPWSEVNRVEGTTVVVGPGGNDAEYAVLQPIVNAESCARCHGTQSH
VNGWLDLRFTREPVLEAQAQLAKTLSLSAGAALVCLLGILLWLLGREAVTPLQRLVTVMRRAEAGELSVRADEGRPDELG
VAARGFDATLAALRRSQAELEAFYRERMVRADRFAAVGEIATGLAHEIKNPLAGLSGALELLAEDFSDDARHSDIVTEMQ
HQVRRLTHTMESLLSFARPAKAKLRSTDVNATLEKVLFLIRQQSRDGTLELVPELSPGLPAVLADPSQLEQVFLNICLNA
CQAMIATRRGGRLTVRSRAGDGTVSVEVEDTGPGIPADLRAQIFKPFFTTKREGNGLGLAISARIVAEHGGHIGYRCPPE
GGTTFTVTLQQARPQRAPEHAA

Sequences:

>Translated_502_residues
MNLLERSYRSLDSSMRARVLVPTALLFAVTLSAMVAAAVHFYGADIESGRQDRAELFATMVSSGVSNVMLSGKPREVSTL
LEALVAHRSDLLSASLIAPNGYISISTSPALLGRVPWSEVNRVEGTTVVVGPGGNDAEYAVLQPIVNAESCARCHGTQSH
VNGWLDLRFTREPVLEAQAQLAKTLSLSAGAALVCLLGILLWLLGREAVTPLQRLVTVMRRAEAGELSVRADEGRPDELG
VAARGFDATLAALRRSQAELEAFYRERMVRADRFAAVGEIATGLAHEIKNPLAGLSGALELLAEDFSDDARHSDIVTEMQ
HQVRRLTHTMESLLSFARPAKAKLRSTDVNATLEKVLFLIRQQSRDGTLELVPELSPGLPAVLADPSQLEQVFLNICLNA
CQAMIATRRGGRLTVRSRAGDGTVSVEVEDTGPGIPADLRAQIFKPFFTTKREGNGLGLAISARIVAEHGGHIGYRCPPE
GGTTFTVTLQQARPQRAPEHAA
>Mature_502_residues
MNLLERSYRSLDSSMRARVLVPTALLFAVTLSAMVAAAVHFYGADIESGRQDRAELFATMVSSGVSNVMLSGKPREVSTL
LEALVAHRSDLLSASLIAPNGYISISTSPALLGRVPWSEVNRVEGTTVVVGPGGNDAEYAVLQPIVNAESCARCHGTQSH
VNGWLDLRFTREPVLEAQAQLAKTLSLSAGAALVCLLGILLWLLGREAVTPLQRLVTVMRRAEAGELSVRADEGRPDELG
VAARGFDATLAALRRSQAELEAFYRERMVRADRFAAVGEIATGLAHEIKNPLAGLSGALELLAEDFSDDARHSDIVTEMQ
HQVRRLTHTMESLLSFARPAKAKLRSTDVNATLEKVLFLIRQQSRDGTLELVPELSPGLPAVLADPSQLEQVFLNICLNA
CQAMIATRRGGRLTVRSRAGDGTVSVEVEDTGPGIPADLRAQIFKPFFTTKREGNGLGLAISARIVAEHGGHIGYRCPPE
GGTTFTVTLQQARPQRAPEHAA

Specific function: Member of the two-component regulatory system AtoS/AtoC; may activate AtoC by phosphorylation [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=226, Percent_Identity=34.9557522123894, Blast_Score=149, Evalue=6e-37,
Organism=Escherichia coli, GI1790436, Length=225, Percent_Identity=35.1111111111111, Blast_Score=140, Evalue=3e-34,
Organism=Escherichia coli, GI1790300, Length=235, Percent_Identity=34.0425531914894, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI1789149, Length=364, Percent_Identity=26.6483516483516, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI87081816, Length=337, Percent_Identity=28.1899109792285, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788393, Length=296, Percent_Identity=28.3783783783784, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI145693157, Length=223, Percent_Identity=29.1479820627803, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1786912, Length=225, Percent_Identity=32, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI48994928, Length=264, Percent_Identity=26.5151515151515, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1790861, Length=226, Percent_Identity=29.2035398230088, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1790346, Length=270, Percent_Identity=26.2962962962963, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1789808, Length=215, Percent_Identity=25.1162790697674, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54003; Mature: 54003

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLERSYRSLDSSMRARVLVPTALLFAVTLSAMVAAAVHFYGADIESGRQDRAELFATM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
VSSGVSNVMLSGKPREVSTLLEALVAHRSDLLSASLIAPNGYISISTSPALLGRVPWSEV
HHHCHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEECCCHHHCCCCHHHH
NRVEGTTVVVGPGGNDAEYAVLQPIVNAESCARCHGTQSHVNGWLDLRFTREPVLEAQAQ
HCCCCCEEEECCCCCCCCHHHHHHHHCHHHHHHHCCCHHHCCCEEEEEECCCHHHHHHHH
LAKTLSLSAGAALVCLLGILLWLLGREAVTPLQRLVTVMRRAEAGELSVRADEGRPDELG
HHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCC
VAARGFDATLAALRRSQAELEAFYRERMVRADRFAAVGEIATGLAHEIKNPLAGLSGALE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLAEDFSDDARHSDIVTEMQHQVRRLTHTMESLLSFARPAKAKLRSTDVNATLEKVLFLI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHH
RQQSRDGTLELVPELSPGLPAVLADPSQLEQVFLNICLNACQAMIATRRGGRLTVRSRAG
HHCCCCCCEEECCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
DGTVSVEVEDTGPGIPADLRAQIFKPFFTTKREGNGLGLAISARIVAEHGGHIGYRCPPE
CCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECCCCCCCCCCCCC
GGTTFTVTLQQARPQRAPEHAA
CCCEEEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MNLLERSYRSLDSSMRARVLVPTALLFAVTLSAMVAAAVHFYGADIESGRQDRAELFATM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
VSSGVSNVMLSGKPREVSTLLEALVAHRSDLLSASLIAPNGYISISTSPALLGRVPWSEV
HHHCHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEECCCHHHCCCCHHHH
NRVEGTTVVVGPGGNDAEYAVLQPIVNAESCARCHGTQSHVNGWLDLRFTREPVLEAQAQ
HCCCCCEEEECCCCCCCCHHHHHHHHCHHHHHHHCCCHHHCCCEEEEEECCCHHHHHHHH
LAKTLSLSAGAALVCLLGILLWLLGREAVTPLQRLVTVMRRAEAGELSVRADEGRPDELG
HHHHHHCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCC
VAARGFDATLAALRRSQAELEAFYRERMVRADRFAAVGEIATGLAHEIKNPLAGLSGALE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLAEDFSDDARHSDIVTEMQHQVRRLTHTMESLLSFARPAKAKLRSTDVNATLEKVLFLI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHH
RQQSRDGTLELVPELSPGLPAVLADPSQLEQVFLNICLNACQAMIATRRGGRLTVRSRAG
HHCCCCCCEEECCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
DGTVSVEVEDTGPGIPADLRAQIFKPFFTTKREGNGLGLAISARIVAEHGGHIGYRCPPE
CCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECCCCCCCCCCCCC
GGTTFTVTLQQARPQRAPEHAA
CCCEEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8346225; 9097040; 9278503 [H]