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The map label for this gene is zraS [H]

Identifier: 220917056

GI number: 220917056

Start: 2206067

End: 2207749

Strand: Direct

Name: zraS [H]

Synonym: A2cp1_1952

Alternate gene names: 220917056

Gene position: 2206067-2207749 (Clockwise)

Preceding gene: 220917051

Following gene: 220917057

Centisome position: 43.86

GC content: 72.13

Gene sequence:

>1683_bases
GTGCGTACCCCGGAGCCGGACCGCACACCGGAGGAGGACCGCGCGCTGCAGCGCCTCGCCAGGGCCATCGCGCCCGCGTC
GCTCGGCGCGCTCGGCCTGGAGATCCCCTGGCAGCAGCGGCTCTCCACCAAGCTGTTCGCCATGATCGGCGCGGTGGCGC
TCGGCACCGTGGGCCTGTTCTTCCTGGCGGAGATCGCGGTGCAGCGCCACCTGCTCGGCCAGGTGGTGCAGGAGTCCGAC
CTCCTCAGCCAGACCGTCCGCAACGCGCTCCACCGCGCCATGCTCCAGGACCGCCGCGGCGACGCCTACCTCATCATGCA
GGACGTGGCGCGGCAGGGAGGCATCGAGCGCGTCCGCATGATGGACGCGAGCGGGCGCGTCACCTTCTCCACCGTGCCGG
AGGAGGTGGGCCGGATGGTGGACCGCGACGCGGAGGCCTGCTCCGGCTGCCACGCGGCCGGCCAGCCGCTGCGCAAGCTC
GAGCTGGAGGAGCGGAGCCGCGTCTTCCGCGCGGGCGACCACCGCGTGCTGGGGATCATGACCCCGGTCTACAACGAGGC
GTCCTGCTCGACCGGCGCCTGCCACGCGCACCCGGCCACGAAGGAGGTCCTGGGCGTCATCGACCTGGACGTCTCGCTGG
CGCGCCTCGACGCGCAGACCCACACGTTCCGCTGGCGCACGCTGGCGGCCGCCGCGCTCGCCTCGGGCCTGCTCGGGCTG
TTCGCCTGGCTGTTCACGCGCCACCACCTGATGCGGCCGGTGGCCGCGCTGGTGCAGGCCACCCGGCGCGTGGCGCGCGA
GCAGCTGGAGCTCGAGGTGCCGGTCACCTGGAACGGCGAGCTGGGCCTGCTGGCCGCCTCCTTCAACGACATGACGCGCT
CGCTGCGCTCGGCGCGCCGGGACCTCGACGCGCTCATGTCGAGCCTCGAGCAGCAGGTGCAGGAGCGGACCGCCGCGCTC
CGGGCCGCGCAGGACCAGCTGGTCCGGTCGGAGAAGCTCTCCTCGCTGGGCAAGCTGTCCGCGTCCATCGCGCACGAGAT
CAACAACCCGCTCGCGGGGATCCTCACCTTCGCGAAGCTCATCGTCCGCACGCTGGACCAGGGCGTGCCCGACGACGCGA
CGCGCAAGACGCTCGTGAAGCACCTGCTCCTCGTCCAGCGCGAGACCGAGCGGTGCAGCGCCATCGTGCGCAACCTGCTC
GACTTCGCGCGCGAGCGGCCGCTCACGCTCAAGGACGTGGACCTGGACGCGGTGGTCGAGGAGGGCCTCCAGCTCCTCTC
CAACCAGATCAACATCCAGAACGTGACGCTGGAGAAGCGGCTCGTGCCGCTGCCGCCGGTGGAGGGCGACTTCGGGCAGC
TCCGGCAGGCGTGCGTGAACGTGATCATGAACGCCTGCGAGGCGATGGCGCGCGGCGGGAAGCTGACGGTCGAGTCGTCG
GCGTCGGCGGGCGGCGGCTGGGTGGAGATCGCGTTCACCGACACCGGCCCGGGCATCCCGCCCGACCACCTGTCCAAGAT
CTTCGACCCGTTCTTCACCACCAAGGAGCGCGGCACCGGGCTCGGGCTGTCGGTGGTGTACGGCATCGTCGAGCGGCACC
ACGGGAAGATCGAGATCCAGAGCGAGGTGGGGAAGGGGACGCGCATCGCCATCCGGCTGCCGCCCCGGAGGGCGGCGGAG
TGA

Upstream 100 bases:

>100_bases
GCGGTACGGGTGAGCGGCCGAGCACGCCGTGAGCGCATCGCCAGGAACCTCGCCCGGGATCTCCCCGGCCCCCGAGCCGC
CCCCGCCGGCGGAGCCCGCG

Downstream 100 bases:

>100_bases
TGCGCGGCGGCGGGCGGACCAGGGCGGGTTCCGGGGGCGCGCGTCGGCGGCGCGCCCAGGGCATCGAATGAATGGACCCG
ATCTTCATCTGGTGGATCGG

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 560; Mature: 560

Protein sequence:

>560_residues
MRTPEPDRTPEEDRALQRLARAIAPASLGALGLEIPWQQRLSTKLFAMIGAVALGTVGLFFLAEIAVQRHLLGQVVQESD
LLSQTVRNALHRAMLQDRRGDAYLIMQDVARQGGIERVRMMDASGRVTFSTVPEEVGRMVDRDAEACSGCHAAGQPLRKL
ELEERSRVFRAGDHRVLGIMTPVYNEASCSTGACHAHPATKEVLGVIDLDVSLARLDAQTHTFRWRTLAAAALASGLLGL
FAWLFTRHHLMRPVAALVQATRRVAREQLELEVPVTWNGELGLLAASFNDMTRSLRSARRDLDALMSSLEQQVQERTAAL
RAAQDQLVRSEKLSSLGKLSASIAHEINNPLAGILTFAKLIVRTLDQGVPDDATRKTLVKHLLLVQRETERCSAIVRNLL
DFARERPLTLKDVDLDAVVEEGLQLLSNQINIQNVTLEKRLVPLPPVEGDFGQLRQACVNVIMNACEAMARGGKLTVESS
ASAGGGWVEIAFTDTGPGIPPDHLSKIFDPFFTTKERGTGLGLSVVYGIVERHHGKIEIQSEVGKGTRIAIRLPPRRAAE

Sequences:

>Translated_560_residues
MRTPEPDRTPEEDRALQRLARAIAPASLGALGLEIPWQQRLSTKLFAMIGAVALGTVGLFFLAEIAVQRHLLGQVVQESD
LLSQTVRNALHRAMLQDRRGDAYLIMQDVARQGGIERVRMMDASGRVTFSTVPEEVGRMVDRDAEACSGCHAAGQPLRKL
ELEERSRVFRAGDHRVLGIMTPVYNEASCSTGACHAHPATKEVLGVIDLDVSLARLDAQTHTFRWRTLAAAALASGLLGL
FAWLFTRHHLMRPVAALVQATRRVAREQLELEVPVTWNGELGLLAASFNDMTRSLRSARRDLDALMSSLEQQVQERTAAL
RAAQDQLVRSEKLSSLGKLSASIAHEINNPLAGILTFAKLIVRTLDQGVPDDATRKTLVKHLLLVQRETERCSAIVRNLL
DFARERPLTLKDVDLDAVVEEGLQLLSNQINIQNVTLEKRLVPLPPVEGDFGQLRQACVNVIMNACEAMARGGKLTVESS
ASAGGGWVEIAFTDTGPGIPPDHLSKIFDPFFTTKERGTGLGLSVVYGIVERHHGKIEIQSEVGKGTRIAIRLPPRRAAE
>Mature_560_residues
MRTPEPDRTPEEDRALQRLARAIAPASLGALGLEIPWQQRLSTKLFAMIGAVALGTVGLFFLAEIAVQRHLLGQVVQESD
LLSQTVRNALHRAMLQDRRGDAYLIMQDVARQGGIERVRMMDASGRVTFSTVPEEVGRMVDRDAEACSGCHAAGQPLRKL
ELEERSRVFRAGDHRVLGIMTPVYNEASCSTGACHAHPATKEVLGVIDLDVSLARLDAQTHTFRWRTLAAAALASGLLGL
FAWLFTRHHLMRPVAALVQATRRVAREQLELEVPVTWNGELGLLAASFNDMTRSLRSARRDLDALMSSLEQQVQERTAAL
RAAQDQLVRSEKLSSLGKLSASIAHEINNPLAGILTFAKLIVRTLDQGVPDDATRKTLVKHLLLVQRETERCSAIVRNLL
DFARERPLTLKDVDLDAVVEEGLQLLSNQINIQNVTLEKRLVPLPPVEGDFGQLRQACVNVIMNACEAMARGGKLTVESS
ASAGGGWVEIAFTDTGPGIPPDHLSKIFDPFFTTKERGTGLGLSVVYGIVERHHGKIEIQSEVGKGTRIAIRLPPRRAAE

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=234, Percent_Identity=38.034188034188, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1788549, Length=243, Percent_Identity=32.0987654320988, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1789149, Length=407, Percent_Identity=25.7985257985258, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1790300, Length=249, Percent_Identity=30.1204819277108, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1786600, Length=233, Percent_Identity=27.8969957081545, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI87081816, Length=335, Percent_Identity=25.3731343283582, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788393, Length=318, Percent_Identity=26.7295597484277, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI145693157, Length=227, Percent_Identity=27.7533039647577, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1789808, Length=345, Percent_Identity=24.6376811594203, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1790346, Length=232, Percent_Identity=25, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786912, Length=254, Percent_Identity=27.5590551181102, Blast_Score=66, Evalue=7e-12,
Organism=Escherichia coli, GI48994928, Length=234, Percent_Identity=27.7777777777778, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 61424; Mature: 61424

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTPEPDRTPEEDRALQRLARAIAPASLGALGLEIPWQQRLSTKLFAMIGAVALGTVGLF
CCCCCCCCCCHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FLAEIAVQRHLLGQVVQESDLLSQTVRNALHRAMLQDRRGDAYLIMQDVARQGGIERVRM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHCCCHHHHHE
MDASGRVTFSTVPEEVGRMVDRDAEACSGCHAAGQPLRKLELEERSRVFRAGDHRVLGIM
ECCCCCEEEECCHHHHHHHHCCCHHHHCCCHHCCCHHHHHHHHHHHHHHHCCCCEEEEEE
TPVYNEASCSTGACHAHPATKEVLGVIDLDVSLARLDAQTHTFRWRTLAAAALASGLLGL
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
FAWLFTRHHLMRPVAALVQATRRVAREQLELEVPVTWNGELGLLAASFNDMTRSLRSARR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCEEECCCCEEEEHHHHHHHHHHHHHHH
DLDALMSSLEQQVQERTAALRAAQDQLVRSEKLSSLGKLSASIAHEINNPLAGILTFAKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
IVRTLDQGVPDDATRKTLVKHLLLVQRETERCSAIVRNLLDFARERPLTLKDVDLDAVVE
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHH
EGLQLLSNQINIQNVTLEKRLVPLPPVEGDFGQLRQACVNVIMNACEAMARGGKLTVESS
HHHHHHHCCCCCEEEEHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
ASAGGGWVEIAFTDTGPGIPPDHLSKIFDPFFTTKERGTGLGLSVVYGIVERHHGKIEIQ
CCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEE
SEVGKGTRIAIRLPPRRAAE
ECCCCCCEEEEECCCCCCCC
>Mature Secondary Structure
MRTPEPDRTPEEDRALQRLARAIAPASLGALGLEIPWQQRLSTKLFAMIGAVALGTVGLF
CCCCCCCCCCHHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FLAEIAVQRHLLGQVVQESDLLSQTVRNALHRAMLQDRRGDAYLIMQDVARQGGIERVRM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHCCCHHHHHE
MDASGRVTFSTVPEEVGRMVDRDAEACSGCHAAGQPLRKLELEERSRVFRAGDHRVLGIM
ECCCCCEEEECCHHHHHHHHCCCHHHHCCCHHCCCHHHHHHHHHHHHHHHCCCCEEEEEE
TPVYNEASCSTGACHAHPATKEVLGVIDLDVSLARLDAQTHTFRWRTLAAAALASGLLGL
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
FAWLFTRHHLMRPVAALVQATRRVAREQLELEVPVTWNGELGLLAASFNDMTRSLRSARR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCEEECCCCEEEEHHHHHHHHHHHHHHH
DLDALMSSLEQQVQERTAALRAAQDQLVRSEKLSSLGKLSASIAHEINNPLAGILTFAKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
IVRTLDQGVPDDATRKTLVKHLLLVQRETERCSAIVRNLLDFARERPLTLKDVDLDAVVE
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHH
EGLQLLSNQINIQNVTLEKRLVPLPPVEGDFGQLRQACVNVIMNACEAMARGGKLTVESS
HHHHHHHCCCCCEEEEHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
ASAGGGWVEIAFTDTGPGIPPDHLSKIFDPFFTTKERGTGLGLSVVYGIVERHHGKIEIQ
CCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEE
SEVGKGTRIAIRLPPRRAAE
ECCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]