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The map label for this gene is thlA [H]

Identifier: 220916700

GI number: 220916700

Start: 1781839

End: 1783020

Strand: Direct

Name: thlA [H]

Synonym: A2cp1_1594

Alternate gene names: 220916700

Gene position: 1781839-1783020 (Clockwise)

Preceding gene: 220916698

Following gene: 220916701

Centisome position: 35.43

GC content: 74.03

Gene sequence:

>1182_bases
ATGACCGGACGCGAAGTGGTCATCGTCGGGGCGGCGCGCACGCCCATCGGCTCGTTCCTCGGCTCGCTCGCCTCCGTCAC
CGCGCCGCGCCTCGGCGCGGTCGCGATCCGCGCCGCGCTCGCGCGCGCCGGGGTGGAGCCCTCGACCGTGGACGAGGTGG
TGATGGGCAACGTCCTCCAGGCGGGCGAGGGGCAGGCGCCGGCCCGGCAGGCGGCGATCTACGCGGGCCTCCCGGAAAAG
ACCCCCGCCTGGACGCTCAACAAGGTGTGCGGCTCCGGCCTGAAGGCGGTGATCTCCGCCGCGCAGGCGATCGCCCTCGG
CGACGCCGACGTGGTGGTGGCGGGCGGCATGGAGTCGATGTCCAACGTGCCGTACTACGATCGGTCCGCGCGGACCGGCG
CGCGGATGGGCAACGTGGAGCTGGTGGACGGGATGATCCACGACGGCCTCTGGGACGTGTACGGGCAGCAGCACATGGGC
ATGTGCGCCGAGCACTGCGCCGCCACGCAGGGGATCTCGCGCGCCGCGCAGGACGAGTACGCGATCGAGTCCACCCGCCG
CGCGGTCGAGGCGTGGAAGGCGGGGGCGTTCAAGGCCGAGATCGTCCCGGTGGAGATCGAGGGCAAGAAGGGCGAGAAGA
CGGTCGTGGCCGAGGACGACGGCCCGAAGGGCGCGCGGCCGGAGAAGATCCCGACGCTCCGGCCGTCCTTCAAGAAGGAC
GGCACCGTCACCGCCGGCAGCTCCTCGTCCATCAACGACGGGGCGGCCGCGCTGGTGCTCGCGAGCGCCGAGCGCGCCGC
GCGCGACGGGCTGCCGGTGCTCGGGCGCCTGCGCGCCTGGGGCGGCGCCGCGCGCGCCCCGGTGGAGTTCACCATCGCCC
CGGCCGACGCGATCCGGACCACGCTGGCGAAGGCGCGGCTCCAGGTCTCGGACGTGGACCTCTGGGAGATCAACGAGGCG
TTCGCGGTGGTGTCGATCGCCAACAACGCGCTGCTCGGCCTCGACCCGCGCAAGGTGAACGTGCGCGGCGGCGCGGTGGT
GCTGGGCCACCCCATCGGCGCCTCCGGCGCGCGCATCCTGGTGACGCTGCTCCAGGCCATGAAGGACCTCGATCGCCGGC
GCGGCCTGGCGTCGCTCTGCATCGGCGGCGGCGAGGCCGTCGCGCTCGTGGTGGAGCGGTAG

Upstream 100 bases:

>100_bases
CGACGGGCTCCGACGATTGGTTGACGAGCGGGGAAACGCCTTCCTATCTTCGGGGCGCTGCCCGAGGTCCCTTGGGCGGG
TCCCTCACCCAGAGGTCACC

Downstream 100 bases:

>100_bases
GAGGGCGGATGAACAAGCTGGTCGAGTCGGCCGACGCCGCGGTCGCGGACGTGAAGGACGGGGCCACCATCATGGTGGGC
GGGTTCGGCCTGTGCGGGAA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTGREVVIVGAARTPIGSFLGSLASVTAPRLGAVAIRAALARAGVEPSTVDEVVMGNVLQAGEGQAPARQAAIYAGLPEK
TPAWTLNKVCGSGLKAVISAAQAIALGDADVVVAGGMESMSNVPYYDRSARTGARMGNVELVDGMIHDGLWDVYGQQHMG
MCAEHCAATQGISRAAQDEYAIESTRRAVEAWKAGAFKAEIVPVEIEGKKGEKTVVAEDDGPKGARPEKIPTLRPSFKKD
GTVTAGSSSSINDGAAALVLASAERAARDGLPVLGRLRAWGGAARAPVEFTIAPADAIRTTLAKARLQVSDVDLWEINEA
FAVVSIANNALLGLDPRKVNVRGGAVVLGHPIGASGARILVTLLQAMKDLDRRRGLASLCIGGGEAVALVVER

Sequences:

>Translated_393_residues
MTGREVVIVGAARTPIGSFLGSLASVTAPRLGAVAIRAALARAGVEPSTVDEVVMGNVLQAGEGQAPARQAAIYAGLPEK
TPAWTLNKVCGSGLKAVISAAQAIALGDADVVVAGGMESMSNVPYYDRSARTGARMGNVELVDGMIHDGLWDVYGQQHMG
MCAEHCAATQGISRAAQDEYAIESTRRAVEAWKAGAFKAEIVPVEIEGKKGEKTVVAEDDGPKGARPEKIPTLRPSFKKD
GTVTAGSSSSINDGAAALVLASAERAARDGLPVLGRLRAWGGAARAPVEFTIAPADAIRTTLAKARLQVSDVDLWEINEA
FAVVSIANNALLGLDPRKVNVRGGAVVLGHPIGASGARILVTLLQAMKDLDRRRGLASLCIGGGEAVALVVER
>Mature_392_residues
TGREVVIVGAARTPIGSFLGSLASVTAPRLGAVAIRAALARAGVEPSTVDEVVMGNVLQAGEGQAPARQAAIYAGLPEKT
PAWTLNKVCGSGLKAVISAAQAIALGDADVVVAGGMESMSNVPYYDRSARTGARMGNVELVDGMIHDGLWDVYGQQHMGM
CAEHCAATQGISRAAQDEYAIESTRRAVEAWKAGAFKAEIVPVEIEGKKGEKTVVAEDDGPKGARPEKIPTLRPSFKKDG
TVTAGSSSSINDGAAALVLASAERAARDGLPVLGRLRAWGGAARAPVEFTIAPADAIRTTLAKARLQVSDVDLWEINEAF
AVVSIANNALLGLDPRKVNVRGGAVVLGHPIGASGARILVTLLQAMKDLDRRRGLASLCIGGGEAVALVVER

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=50.1272264631043, Blast_Score=367, Evalue=1e-102,
Organism=Homo sapiens, GI148539872, Length=390, Percent_Identity=47.9487179487179, Blast_Score=339, Evalue=3e-93,
Organism=Homo sapiens, GI167614485, Length=394, Percent_Identity=39.5939086294416, Blast_Score=282, Evalue=5e-76,
Organism=Homo sapiens, GI4501853, Length=398, Percent_Identity=40.2010050251256, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI4504327, Length=424, Percent_Identity=31.6037735849057, Blast_Score=174, Evalue=9e-44,
Organism=Homo sapiens, GI194353979, Length=395, Percent_Identity=30.8860759493671, Blast_Score=132, Evalue=6e-31,
Organism=Escherichia coli, GI87082165, Length=391, Percent_Identity=50.6393861892583, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI1788554, Length=392, Percent_Identity=51.530612244898, Blast_Score=352, Evalue=3e-98,
Organism=Escherichia coli, GI1787663, Length=407, Percent_Identity=38.8206388206388, Blast_Score=237, Evalue=8e-64,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=38.75, Blast_Score=215, Evalue=3e-57,
Organism=Escherichia coli, GI1788683, Length=409, Percent_Identity=30.8068459657702, Blast_Score=156, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI25147385, Length=393, Percent_Identity=46.8193384223919, Blast_Score=353, Evalue=6e-98,
Organism=Caenorhabditis elegans, GI17535921, Length=395, Percent_Identity=43.7974683544304, Blast_Score=315, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI133906874, Length=394, Percent_Identity=40.8629441624365, Blast_Score=292, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI17535917, Length=396, Percent_Identity=37.8787878787879, Blast_Score=232, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17551802, Length=427, Percent_Identity=32.7868852459016, Blast_Score=184, Evalue=9e-47,
Organism=Saccharomyces cerevisiae, GI6325229, Length=395, Percent_Identity=48.8607594936709, Blast_Score=346, Evalue=3e-96,
Organism=Saccharomyces cerevisiae, GI6322031, Length=400, Percent_Identity=36.25, Blast_Score=208, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24640423, Length=390, Percent_Identity=51.5384615384615, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24655093, Length=389, Percent_Identity=50.8997429305913, Blast_Score=360, Evalue=1e-100,
Organism=Drosophila melanogaster, GI17648125, Length=396, Percent_Identity=37.6262626262626, Blast_Score=242, Evalue=4e-64,
Organism=Drosophila melanogaster, GI17137578, Length=427, Percent_Identity=31.1475409836066, Blast_Score=184, Evalue=9e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40611; Mature: 40480

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: PS00098 THIOLASE_1 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGREVVIVGAARTPIGSFLGSLASVTAPRLGAVAIRAALARAGVEPSTVDEVVMGNVLQ
CCCCEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
AGEGQAPARQAAIYAGLPEKTPAWTLNKVCGSGLKAVISAAQAIALGDADVVVAGGMESM
CCCCCCCHHHHEEEECCCCCCCCCHHHHHHCCHHHHHHHHHHHHEECCCCEEEECCHHHH
SNVPYYDRSARTGARMGNVELVDGMIHDGLWDVYGQQHMGMCAEHCAATQGISRAAQDEY
CCCCCCCCCCCCCCCCCCHHEEHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
AIESTRRAVEAWKAGAFKAEIVPVEIEGKKGEKTVVAEDDGPKGARPEKIPTLRPSFKKD
HHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCC
GTVTAGSSSSINDGAAALVLASAERAARDGLPVLGRLRAWGGAARAPVEFTIAPADAIRT
CCEECCCCCCCCCCCEEEEEECHHHHHHCCCCHHHHHHHCCCCCCCCEEEEECCHHHHHH
TLAKARLQVSDVDLWEINEAFAVVSIANNALLGLDPRKVNVRGGAVVLGHPIGASGARIL
HHHHHHEEECCCCCEECCCCEEEEEECCCEEEECCCCEEEECCCEEEEECCCCCCHHHHH
VTLLQAMKDLDRRRGLASLCIGGGEAVALVVER
HHHHHHHHHHHHHCCHHHEEECCCCEEEEEEEC
>Mature Secondary Structure 
TGREVVIVGAARTPIGSFLGSLASVTAPRLGAVAIRAALARAGVEPSTVDEVVMGNVLQ
CCCEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
AGEGQAPARQAAIYAGLPEKTPAWTLNKVCGSGLKAVISAAQAIALGDADVVVAGGMESM
CCCCCCCHHHHEEEECCCCCCCCCHHHHHHCCHHHHHHHHHHHHEECCCCEEEECCHHHH
SNVPYYDRSARTGARMGNVELVDGMIHDGLWDVYGQQHMGMCAEHCAATQGISRAAQDEY
CCCCCCCCCCCCCCCCCCHHEEHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
AIESTRRAVEAWKAGAFKAEIVPVEIEGKKGEKTVVAEDDGPKGARPEKIPTLRPSFKKD
HHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCC
GTVTAGSSSSINDGAAALVLASAERAARDGLPVLGRLRAWGGAARAPVEFTIAPADAIRT
CCEECCCCCCCCCCCEEEEEECHHHHHHCCCCHHHHHHHCCCCCCCCEEEEECCHHHHHH
TLAKARLQVSDVDLWEINEAFAVVSIANNALLGLDPRKVNVRGGAVVLGHPIGASGARIL
HHHHHHEEECCCCCEECCCCEEEEEECCCEEEECCCCEEEECCCEEEEECCCCCCHHHHH
VTLLQAMKDLDRRRGLASLCIGGGEAVALVVER
HHHHHHHHHHHHHCCHHHEEECCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]