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The map label for this gene is coaBC [H]

Identifier: 220916693

GI number: 220916693

Start: 1774483

End: 1775700

Strand: Direct

Name: coaBC [H]

Synonym: A2cp1_1587

Alternate gene names: 220916693

Gene position: 1774483-1775700 (Clockwise)

Preceding gene: 220916689

Following gene: 220916695

Centisome position: 35.28

GC content: 75.37

Gene sequence:

>1218_bases
ATGGACTTCCGCAACCGGACGGTGGTGGTGTGCGTGGGCGGCGGCATCGCCGCGTACAAGGCCTGCGACCTCACGCGACT
CATCGTGAAGGGGAACGGCAAGGTGCGCGTCGCCATGACCCCGGCCGCGACCCGCTTCGTCGCCCCGCTCACGTTCCAGG
CGCTGTCCGGCGCGCCCGTGCTCACCGACCTGTTCGAGCCGGCGGCGGACCTCACCTACGGCCACCTCGAGATGGCGCGC
GTCGCCGACCTGGTGGTGGTCGCGCCCGCCACCGCCGACCTGATCGCGCGGATCCGCGCCGGCATGGCGGACGACGCCGT
CACCACCGCGGTGCTCGCCGCCACCTGCCCGGTGCTGCTCGCCCCCGCCATGAACACGCGGATGTGGCGCAACGTCGCGA
CGCAGGAGAACCTGGCCGCGCTGCGGGCGCGCGGGATGCACGTGGTCGGCCCGGCCGCGGGGCTGCTCGCCGACGGGGAC
GTGGGCGAGGGCCGGCTCGCCGAGCCGCAGGAGATCGCGCTCGCCGCCGCGCGGCTGCTGGGACGCCAGGACCTGGCCGG
GCGCAAGGTGCTGGTGACCGCCGGCCCGACCCGCGAGCCCATCGACCCGGTCCGCTTCGTCTCCAACCCGTCGTCGGGGA
AGATGGGCTATGCGGTGGCGCGGGTGGCGGCCCGCCGTGGCGCGCAGGTGACGCTCGTGTCGGGGCCCACCGCGCTGGAG
GACCCCTCCGGCGTCGAGGTGGTGCGCGTCGAGACCGCCGAGGAGATGGCGCGCGCGGTCGAGTCGGCCCAGGCGGAGAT
GGATCTGTTCGTGGGCGCGGCCGCCGTGTCGGATTACCGGCCCGCCGCGCCGGCCGCGCACAAGCTCAAGAAGAAGCCGG
GCGAGGAGACGCTGGTGCTCGCGCGCACGCCGGACATCCTGGCCGGGCTGGGCGCGCGCCACGCCGGCAGGCCCGGCGCG
CCGGTGCTGGTGGGGTTCGCGGCGGAGACCGAGGAGGTCATCGCGCGCGCCCGCGAGAAGCTGAAGGGCAAGCGCTGCGA
CCTGGTGGTGGCGAACAAGGTCGGCGCCCCGGGCGCCGGCTTCGGCGGCGACACCAACCGCGTGGCGCTCGTCTCGGCCG
CCGAGCTGGCCGAGATCGAGGGGACGAAGGACAAGGTCGCCGAGGCGATCCTGGACTGGATCCTGCCCGTGCTCGACGCG
CGCCGCCCGCGAGGCTGA

Upstream 100 bases:

>100_bases
GCGACGGGCCGGGACGGGAGGGATCCACTCGGGCGGATGATAGCCGCGCCGGGCGCCGCGCGCGCCCTCGTCTGCGCCGG
AACGCGGGTAAGATGCGCGC

Downstream 100 bases:

>100_bases
GCCTACGCCGCCAGCTTCGCGATCGACGGCGGCAGGATCAGCTTGCCGTTGATGCCGCGCCGGAAGCTGAGGCGCGTCTC
CTCGGCGATGTCGGCCGCGT

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MDFRNRTVVVCVGGGIAAYKACDLTRLIVKGNGKVRVAMTPAATRFVAPLTFQALSGAPVLTDLFEPAADLTYGHLEMAR
VADLVVVAPATADLIARIRAGMADDAVTTAVLAATCPVLLAPAMNTRMWRNVATQENLAALRARGMHVVGPAAGLLADGD
VGEGRLAEPQEIALAAARLLGRQDLAGRKVLVTAGPTREPIDPVRFVSNPSSGKMGYAVARVAARRGAQVTLVSGPTALE
DPSGVEVVRVETAEEMARAVESAQAEMDLFVGAAAVSDYRPAAPAAHKLKKKPGEETLVLARTPDILAGLGARHAGRPGA
PVLVGFAAETEEVIARAREKLKGKRCDLVVANKVGAPGAGFGGDTNRVALVSAAELAEIEGTKDKVAEAILDWILPVLDA
RRPRG

Sequences:

>Translated_405_residues
MDFRNRTVVVCVGGGIAAYKACDLTRLIVKGNGKVRVAMTPAATRFVAPLTFQALSGAPVLTDLFEPAADLTYGHLEMAR
VADLVVVAPATADLIARIRAGMADDAVTTAVLAATCPVLLAPAMNTRMWRNVATQENLAALRARGMHVVGPAAGLLADGD
VGEGRLAEPQEIALAAARLLGRQDLAGRKVLVTAGPTREPIDPVRFVSNPSSGKMGYAVARVAARRGAQVTLVSGPTALE
DPSGVEVVRVETAEEMARAVESAQAEMDLFVGAAAVSDYRPAAPAAHKLKKKPGEETLVLARTPDILAGLGARHAGRPGA
PVLVGFAAETEEVIARAREKLKGKRCDLVVANKVGAPGAGFGGDTNRVALVSAAELAEIEGTKDKVAEAILDWILPVLDA
RRPRG
>Mature_405_residues
MDFRNRTVVVCVGGGIAAYKACDLTRLIVKGNGKVRVAMTPAATRFVAPLTFQALSGAPVLTDLFEPAADLTYGHLEMAR
VADLVVVAPATADLIARIRAGMADDAVTTAVLAATCPVLLAPAMNTRMWRNVATQENLAALRARGMHVVGPAAGLLADGD
VGEGRLAEPQEIALAAARLLGRQDLAGRKVLVTAGPTREPIDPVRFVSNPSSGKMGYAVARVAARRGAQVTLVSGPTALE
DPSGVEVVRVETAEEMARAVESAQAEMDLFVGAAAVSDYRPAAPAAHKLKKKPGEETLVLARTPDILAGLGARHAGRPGA
PVLVGFAAETEEVIARAREKLKGKRCDLVVANKVGAPGAGFGGDTNRVALVSAAELAEIEGTKDKVAEAILDWILPVLDA
RRPRG

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Escherichia coli, GI87082301, Length=410, Percent_Identity=46.3414634146341, Blast_Score=311, Evalue=5e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 42095; Mature: 42095

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFRNRTVVVCVGGGIAAYKACDLTRLIVKGNGKVRVAMTPAATRFVAPLTFQALSGAPV
CCCCCCEEEEEECCCCHHHHHHCEEEEEEECCCEEEEEECCCHHHHCCHHHHHHHCCCCH
LTDLFEPAADLTYGHLEMARVADLVVVAPATADLIARIRAGMADDAVTTAVLAATCPVLL
HHHHHCHHHHCCHHHHHHHHHHCEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
APAMNTRMWRNVATQENLAALRARGMHVVGPAAGLLADGDVGEGRLAEPQEIALAAARLL
HCCHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEECCCCCCCCCCCHHHHHHHHHHHH
GRQDLAGRKVLVTAGPTREPIDPVRFVSNPSSGKMGYAVARVAARRGAQVTLVSGPTALE
CCCCCCCCEEEEECCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCC
DPSGVEVVRVETAEEMARAVESAQAEMDLFVGAAAVSDYRPAAPAAHKLKKKPGEETLVL
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCEEEE
ARTPDILAGLGARHAGRPGAPVLVGFAAETEEVIARAREKLKGKRCDLVVANKVGAPGAG
EECCHHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCC
FGGDTNRVALVSAAELAEIEGTKDKVAEAILDWILPVLDARRPRG
CCCCCCCEEEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MDFRNRTVVVCVGGGIAAYKACDLTRLIVKGNGKVRVAMTPAATRFVAPLTFQALSGAPV
CCCCCCEEEEEECCCCHHHHHHCEEEEEEECCCEEEEEECCCHHHHCCHHHHHHHCCCCH
LTDLFEPAADLTYGHLEMARVADLVVVAPATADLIARIRAGMADDAVTTAVLAATCPVLL
HHHHHCHHHHCCHHHHHHHHHHCEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
APAMNTRMWRNVATQENLAALRARGMHVVGPAAGLLADGDVGEGRLAEPQEIALAAARLL
HCCHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEECCCCCCCCCCCHHHHHHHHHHHH
GRQDLAGRKVLVTAGPTREPIDPVRFVSNPSSGKMGYAVARVAARRGAQVTLVSGPTALE
CCCCCCCCEEEEECCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCC
DPSGVEVVRVETAEEMARAVESAQAEMDLFVGAAAVSDYRPAAPAAHKLKKKPGEETLVL
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCEEEE
ARTPDILAGLGARHAGRPGAPVLVGFAAETEEVIARAREKLKGKRCDLVVANKVGAPGAG
EECCHHHHHCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCC
FGGDTNRVALVSAAELAEIEGTKDKVAEAILDWILPVLDARRPRG
CCCCCCCEEEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]