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The map label for this gene is nadC [H]

Identifier: 220916676

GI number: 220916676

Start: 1758088

End: 1758924

Strand: Direct

Name: nadC [H]

Synonym: A2cp1_1570

Alternate gene names: 220916676

Gene position: 1758088-1758924 (Clockwise)

Preceding gene: 220916675

Following gene: 220916677

Centisome position: 34.96

GC content: 76.94

Gene sequence:

>837_bases
ATGCCCCGGCTCTCCGCCCACGCCGAGCGCCTCCTCGATCTGGCGCTCGAGGAGGACCTCCTCCTCGGCGACGCGACGAG
CGAGGCGACCATCGACGCCTCGGCGACCGGGGAGGGCCGGTTCCTCGCGAAGGAGGACCTGGTCCTCGCCGGTACCGCGG
TGGCGGTGCGGGTGTTCGAGCGGCTCGGGGCATCCTGCACGTTCGACCGCGCCGACGGCGCGCGCGCCGCGCGCGGCGAG
GTCGTCGGCACCGCGCGCGGCACCGTGCGCGCGCTGCTCGCCGCCGAGCGCACCGCGCTGAACTTCCTCCAGCGCCTCTC
CGGCGTGGCGACCGCCACCCGGCGCTGCGCCGACGCGCTGGCCGCGGGCGGCGGGCGCACCCGCCTGCTCGACACGCGCA
AGACCACGCCCGGCTGGCGCATGCTGGAGAAGGCGGCGGTGCGCGCCGGCGGCGGCAAGAACCACCGCTTCAGCCTGGGC
GACGGCGTCCTCATCAAGGACAACCACGTCGCGGCGTGCGGCGGCGTCGCCGAGGCGGTCCGGCGCGCCCGCGCGTCGGC
GGGCGCGATGCTGCGCGTCGAGGTCGAGGTCGAGGATCTACCGGGGCTGGAGGAGGCCATCGCCGCCGGCGCCGACCTGG
TGCTGCTCGACAACATGGACGACGCCGCCATGGCCGAGGCGGTCCGCCGCGCGGCCGGGCGCGCGCTGCTCGAGGCCAGC
GGCAACATGACGCTGGAGCGGCTCCCGCGCGTGGCCGCGACCGGGGTGGACTTCGTGTCCATGGGCGCGGTCACGCACAG
CGCGCGGGCCGTGGACCTCGCGTTCGACCTCGCCTGA

Upstream 100 bases:

>100_bases
AGGCGCCCGCGAAGAAGGTCGCGCGGAAGCCGGCCGCGAAGAAGACCGCGAAGAAGCCGGCCCGGAAGGCCGCGAAGCGG
AAGTAGGCGGCGGCGCGCGG

Downstream 100 bases:

>100_bases
GCCGCGCCCTGCCCGGGCGCGCCATTTGACAGGCCGCCGCCGGCCCCGGAAGATCCCGGGACCATGGCGACCGAGCCGTC
CGACTCCGCCGAGCTGGTGC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 278; Mature: 277

Protein sequence:

>278_residues
MPRLSAHAERLLDLALEEDLLLGDATSEATIDASATGEGRFLAKEDLVLAGTAVAVRVFERLGASCTFDRADGARAARGE
VVGTARGTVRALLAAERTALNFLQRLSGVATATRRCADALAAGGGRTRLLDTRKTTPGWRMLEKAAVRAGGGKNHRFSLG
DGVLIKDNHVAACGGVAEAVRRARASAGAMLRVEVEVEDLPGLEEAIAAGADLVLLDNMDDAAMAEAVRRAAGRALLEAS
GNMTLERLPRVAATGVDFVSMGAVTHSARAVDLAFDLA

Sequences:

>Translated_278_residues
MPRLSAHAERLLDLALEEDLLLGDATSEATIDASATGEGRFLAKEDLVLAGTAVAVRVFERLGASCTFDRADGARAARGE
VVGTARGTVRALLAAERTALNFLQRLSGVATATRRCADALAAGGGRTRLLDTRKTTPGWRMLEKAAVRAGGGKNHRFSLG
DGVLIKDNHVAACGGVAEAVRRARASAGAMLRVEVEVEDLPGLEEAIAAGADLVLLDNMDDAAMAEAVRRAAGRALLEAS
GNMTLERLPRVAATGVDFVSMGAVTHSARAVDLAFDLA
>Mature_277_residues
PRLSAHAERLLDLALEEDLLLGDATSEATIDASATGEGRFLAKEDLVLAGTAVAVRVFERLGASCTFDRADGARAARGEV
VGTARGTVRALLAAERTALNFLQRLSGVATATRRCADALAAGGGRTRLLDTRKTTPGWRMLEKAAVRAGGGKNHRFSLGD
GVLIKDNHVAACGGVAEAVRRARASAGAMLRVEVEVEDLPGLEEAIAAGADLVLLDNMDDAAMAEAVRRAAGRALLEASG
NMTLERLPRVAATGVDFVSMGAVTHSARAVDLAFDLA

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=270, Percent_Identity=37.037037037037, Blast_Score=152, Evalue=3e-37,
Organism=Escherichia coli, GI1786299, Length=237, Percent_Identity=44.7257383966245, Blast_Score=157, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6321162, Length=253, Percent_Identity=33.9920948616601, Blast_Score=137, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 28883; Mature: 28752

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRLSAHAERLLDLALEEDLLLGDATSEATIDASATGEGRFLAKEDLVLAGTAVAVRVFE
CCCHHHHHHHHHHHHHHCCCEEECCCCCCEEECCCCCCCCEEECCCEEEEHHHHHHHHHH
RLGASCTFDRADGARAARGEVVGTARGTVRALLAAERTALNFLQRLSGVATATRRCADAL
HHCCCEEECCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAGGGRTRLLDTRKTTPGWRMLEKAAVRAGGGKNHRFSLGDGVLIKDNHVAACGGVAEAV
HCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEECCCCEEEECCCEEEHHHHHHHH
RRARASAGAMLRVEVEVEDLPGLEEAIAAGADLVLLDNMDDAAMAEAVRRAAGRALLEAS
HHHHHCCCCEEEEEEEECCCCCHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHEECCC
GNMTLERLPRVAATGVDFVSMGAVTHSARAVDLAFDLA
CCCCHHHCCHHHHCCCCHHHHCCHHCCCEEEEEEEECC
>Mature Secondary Structure 
PRLSAHAERLLDLALEEDLLLGDATSEATIDASATGEGRFLAKEDLVLAGTAVAVRVFE
CCHHHHHHHHHHHHHHCCCEEECCCCCCEEECCCCCCCCEEECCCEEEEHHHHHHHHHH
RLGASCTFDRADGARAARGEVVGTARGTVRALLAAERTALNFLQRLSGVATATRRCADAL
HHCCCEEECCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAGGGRTRLLDTRKTTPGWRMLEKAAVRAGGGKNHRFSLGDGVLIKDNHVAACGGVAEAV
HCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEECCCCEEEECCCEEEHHHHHHHH
RRARASAGAMLRVEVEVEDLPGLEEAIAAGADLVLLDNMDDAAMAEAVRRAAGRALLEAS
HHHHHCCCCEEEEEEEECCCCCHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHEECCC
GNMTLERLPRVAATGVDFVSMGAVTHSARAVDLAFDLA
CCCCHHHCCHHHHCCCCHHHHCCHHCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]