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The map label for this gene is moeA [H]

Identifier: 220916630

GI number: 220916630

Start: 1703250

End: 1704488

Strand: Reverse

Name: moeA [H]

Synonym: A2cp1_1524

Alternate gene names: 220916630

Gene position: 1704488-1703250 (Counterclockwise)

Preceding gene: 220916633

Following gene: 220916629

Centisome position: 33.89

GC content: 79.9

Gene sequence:

>1239_bases
GTGTATAAACGGTCCGTGCTCACCCCCGAGACCGCCCGGGCGCGCATCCTGGCCGCCCTCTCCCCGCTCGCGCCGCTGGC
CGGCGAGCGCGTGCCGCTCGCCGACGCGGTCGGCCGCGCGCTGGCGGAGGACCTCGTCCCCGACCGCGACCTGCCCGCGT
TCGACGCGTCCACCATGGACGGCTATGCGCTCCGCGCCGCCGACGCGCGCCGCGCCGGCGCGCGCCTGCCGGTCGCGTTC
GAGGTGTACGCCGGCCGCCCCGCCGCCGCGCCGCTGCCGCCGGGGAGCTGCTGCCGGATCTTCACCGGCGCGCCGTTGCC
GGCGGGCGCCGACGCGGTGGAGATGCAGGAGGAGGTGCGCCGCGCCGGGAAGGCGGCGGTCTTCCGCCGCCCCGTGGCCG
CGGGGCGCTTCGTGCGCGCGCGCGGCTCGGACCTCGCCGCCGGCGCGGTGGCGCTCGCCGCCGGGGCGGTGGTGGACCCG
GGCGCGGTCGGGCTCGCGGCCGGGATCGGTCGCGCCGAGCTGGTGGTGCGCCGGCGGCCGCGGGTCGCGATCCTGCCCAC
CGGCGACGAGCTCGTGCCGCCCGGCTCCGTCCCCGGCCCCGGCGAGCTGGTGGACTCGAACGGCCTCGCGCTCGCCGCGG
CGGTGCGCGAGGCGGGAGGCGAGCCCATCCTGCTCCGCCCCGCCCGCGACGAGGCCGCGAGCCTCTCGGCCGCGCTCGCG
GCCGTCCGCGGCGCCGACGCGCTCCTCACGTCCGGCGGCGTCTCGGTGGGCGAGCGCGACCTGGTGCGCGCGGCGCTGGA
GCACGCCGGGGCGCGGCTCGACTTCTGGCGGGTGGCGATGCGCCCCGGGAAGCCGTTCGCGTTCGGGCTGTGGGGCACCA
CCGCGGTGTTCGGCCTGCCGGGCAACCCGGCCAGCACGCTGGTCACGTTCGAGCTGTTCGTCCGCCCGGCGCTCCGCGCC
CTGGCGGGGCTCCCCGGCAGCGGGCGCGTGGTGTCGGTGGGCCGGCTCGCATCCGCGCAGGAGAAGCCCGCCGAGCTCAC
CGTCTACCTGCGCTGCCGCGTGCGGCACTCGGGGGACGAGCTGGTGCTCGAGCCGCTCCGGACGCAGGTCAGCGGCAACC
TCTCGTCCACCACCGGTCACGCCGCGCTGGCGGTGCTGCCGCCGGGGCGCGCGCGGCTCGCGCGCGGGGCCAGGGTCCGG
GCGATCCTGCTCGCCCCCGACGTGCGGCACGATGGGTGA

Upstream 100 bases:

>100_bases
CGCATGGCGCGAGTCTACACGCGATGCGGCGGGGCGAGGGGCGGAAGGCAGGGGAGCGCGGCACCGCCCCGCCCGCCCGC
GCGGGCGCCTCGCCGCCCGG

Downstream 100 bases:

>100_bases
ACGGTACCCCCCGTCCGTGCTATGAGGGGCGCGCAATGGCCCGCGCGCGATGGGAACGCCCGGAGGAGCATGACCATGTC
CTCCTCCTCGCCGACGACGA

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MYKRSVLTPETARARILAALSPLAPLAGERVPLADAVGRALAEDLVPDRDLPAFDASTMDGYALRAADARRAGARLPVAF
EVYAGRPAAAPLPPGSCCRIFTGAPLPAGADAVEMQEEVRRAGKAAVFRRPVAAGRFVRARGSDLAAGAVALAAGAVVDP
GAVGLAAGIGRAELVVRRRPRVAILPTGDELVPPGSVPGPGELVDSNGLALAAAVREAGGEPILLRPARDEAASLSAALA
AVRGADALLTSGGVSVGERDLVRAALEHAGARLDFWRVAMRPGKPFAFGLWGTTAVFGLPGNPASTLVTFELFVRPALRA
LAGLPGSGRVVSVGRLASAQEKPAELTVYLRCRVRHSGDELVLEPLRTQVSGNLSSTTGHAALAVLPPGRARLARGARVR
AILLAPDVRHDG

Sequences:

>Translated_412_residues
MYKRSVLTPETARARILAALSPLAPLAGERVPLADAVGRALAEDLVPDRDLPAFDASTMDGYALRAADARRAGARLPVAF
EVYAGRPAAAPLPPGSCCRIFTGAPLPAGADAVEMQEEVRRAGKAAVFRRPVAAGRFVRARGSDLAAGAVALAAGAVVDP
GAVGLAAGIGRAELVVRRRPRVAILPTGDELVPPGSVPGPGELVDSNGLALAAAVREAGGEPILLRPARDEAASLSAALA
AVRGADALLTSGGVSVGERDLVRAALEHAGARLDFWRVAMRPGKPFAFGLWGTTAVFGLPGNPASTLVTFELFVRPALRA
LAGLPGSGRVVSVGRLASAQEKPAELTVYLRCRVRHSGDELVLEPLRTQVSGNLSSTTGHAALAVLPPGRARLARGARVR
AILLAPDVRHDG
>Mature_412_residues
MYKRSVLTPETARARILAALSPLAPLAGERVPLADAVGRALAEDLVPDRDLPAFDASTMDGYALRAADARRAGARLPVAF
EVYAGRPAAAPLPPGSCCRIFTGAPLPAGADAVEMQEEVRRAGKAAVFRRPVAAGRFVRARGSDLAAGAVALAAGAVVDP
GAVGLAAGIGRAELVVRRRPRVAILPTGDELVPPGSVPGPGELVDSNGLALAAAVREAGGEPILLRPARDEAASLSAALA
AVRGADALLTSGGVSVGERDLVRAALEHAGARLDFWRVAMRPGKPFAFGLWGTTAVFGLPGNPASTLVTFELFVRPALRA
LAGLPGSGRVVSVGRLASAQEKPAELTVYLRCRVRHSGDELVLEPLRTQVSGNLSSTTGHAALAVLPPGRARLARGARVR
AILLAPDVRHDG

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=419, Percent_Identity=34.3675417661098, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI10880983, Length=419, Percent_Identity=34.3675417661098, Blast_Score=180, Evalue=3e-45,
Organism=Escherichia coli, GI1787049, Length=397, Percent_Identity=38.7909319899244, Blast_Score=237, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI25147659, Length=397, Percent_Identity=29.7229219143577, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17562606, Length=340, Percent_Identity=27.3529411764706, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17136978, Length=354, Percent_Identity=31.9209039548023, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24638841, Length=354, Percent_Identity=31.9209039548023, Blast_Score=136, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 42336; Mature: 42336

Theoretical pI: Translated: 11.09; Mature: 11.09

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKRSVLTPETARARILAALSPLAPLAGERVPLADAVGRALAEDLVPDRDLPAFDASTMD
CCCCCCCCCHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GYALRAADARRAGARLPVAFEVYAGRPAAAPLPPGSCCRIFTGAPLPAGADAVEMQEEVR
CEEEEECHHHHCCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHH
RAGKAAVFRRPVAAGRFVRARGSDLAAGAVALAAGAVVDPGAVGLAAGIGRAELVVRRRP
HHHHHHHHHCCHHCCCEEEECCCCCHHHHHHHHHCCEECCCCHHHHHCCCHHHEEEECCC
RVAILPTGDELVPPGSVPGPGELVDSNGLALAAAVREAGGEPILLRPARDEAASLSAALA
CEEEEECCCCCCCCCCCCCCCCEECCCCCEEEHHHHHCCCCEEEEECCCCHHHHHHHHHH
AVRGADALLTSGGVSVGERDLVRAALEHAGARLDFWRVAMRPGKPFAFGLWGTTAVFGLP
HHHCCHHHEECCCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCEEEEECC
GNPASTLVTFELFVRPALRALAGLPGSGRVVSVGRLASAQEKPAELTVYLRCRVRHSGDE
CCCHHHEEHHHHHHHHHHHHHHCCCCCCCEEEECCHHCCCCCCCEEEEEEEEEEECCCCH
LVLEPLRTQVSGNLSSTTGHAALAVLPPGRARLARGARVRAILLAPDVRHDG
HHHHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHCCCEEEEEEEECCCCCCC
>Mature Secondary Structure
MYKRSVLTPETARARILAALSPLAPLAGERVPLADAVGRALAEDLVPDRDLPAFDASTMD
CCCCCCCCCHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GYALRAADARRAGARLPVAFEVYAGRPAAAPLPPGSCCRIFTGAPLPAGADAVEMQEEVR
CEEEEECHHHHCCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHH
RAGKAAVFRRPVAAGRFVRARGSDLAAGAVALAAGAVVDPGAVGLAAGIGRAELVVRRRP
HHHHHHHHHCCHHCCCEEEECCCCCHHHHHHHHHCCEECCCCHHHHHCCCHHHEEEECCC
RVAILPTGDELVPPGSVPGPGELVDSNGLALAAAVREAGGEPILLRPARDEAASLSAALA
CEEEEECCCCCCCCCCCCCCCCEECCCCCEEEHHHHHCCCCEEEEECCCCHHHHHHHHHH
AVRGADALLTSGGVSVGERDLVRAALEHAGARLDFWRVAMRPGKPFAFGLWGTTAVFGLP
HHHCCHHHEECCCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCEEEEECC
GNPASTLVTFELFVRPALRALAGLPGSGRVVSVGRLASAQEKPAELTVYLRCRVRHSGDE
CCCHHHEEHHHHHHHHHHHHHHCCCCCCCEEEECCHHCCCCCCCEEEEEEEEEEECCCCH
LVLEPLRTQVSGNLSSTTGHAALAVLPPGRARLARGARVRAILLAPDVRHDG
HHHHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHCCCEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]