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The map label for this gene is nuoI2 [H]

Identifier: 220916479

GI number: 220916479

Start: 1538927

End: 1539730

Strand: Reverse

Name: nuoI2 [H]

Synonym: A2cp1_1373

Alternate gene names: 220916479

Gene position: 1539730-1538927 (Counterclockwise)

Preceding gene: 220916480

Following gene: 220916478

Centisome position: 30.62

GC content: 75.12

Gene sequence:

>804_bases
ATGCCTCAGACCGTCCGCGAGTACACCGGCGCCATCCGGGACACGGTGAAGTCCTTCTGGCACGGCCTCTCGATCACGCT
CTCGTACCTCGCCCGCCGCCCGACGACGGTCCAGTACCCGGACCGCACGCCCATGCCGGTGCGCGACATGCTCCCGCCGC
GCTACCGCGGGTTCCTCGAGGTCGACACCGGCATCTGCACCGGGTGCCAGGCCTGCGAGCGCGCCTGCCCGATCGGCTGC
ATCCAGATCTCCCTGGAGAAGGACGCGGCGAACCCGAAGCAGCGCGTCGTCACGCAGTTCGACATCGACGAGGCGAAGTG
CATGTTCTGCGGCCTGTGCGTCGAGCCCTGCCCCACCGGCTCGATCCAGCACACCCGCGAGTTCGAGGGCACGCACCGGC
ACATCCGCAACCTGGTGTTCCGGTGGGCCGACCCGATGAGCCCGTTCCCGGTCTACAAGGTGGACAAGAACGCGGAGTAC
TACCCGCGCGTCCCGCTGGGCTCGCTGGTGCGCAAGCGCCTCGAGACCAACGCCTGGGATCGGGCGGCCCCGCAGTTCCT
GCCGCCCGAGCCGCCCAAGCCCGCCGAGGCGAAGCCCGCCGCGAAGGCGGCCCCGGCCGCGAAGCCCGCGCCGGCCGCGA
AGGCGGATGGCGCCGCCGCGGCCCCCGCCGCGCCCGCGCCGGCCAAGGCGGCCGCCCCGGCTCCCGCCCCTGCTGCGGCC
GCCCCCGCGCCCGCGCCCGCCGCGCCGGCCGCCGAGGCGCCGGCCGCGCCCGCGGCCCCCGCCGCCAACCCCGAGTCCAA
GTGA

Upstream 100 bases:

>100_bases
GCGGTGGTGGCGGGCTTCTTCTTCCTCCGCCTGACGCGGCGGAACATCTCCGCGGTCGGCGACCGCGTCGACTTCACCAA
CTGGTAAGGGGACCGGAACG

Downstream 100 bases:

>100_bases
GGCCGCCGATGGAATCCAAGGGAGGAAAGCTCACCGCCTGGGCCATCGCCACCGTCGTGGTGGTCGCCTTCGTCGCCTAC
ATGACCACGCAGGTGATCCG

Product: 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein

Products: NA

Alternate protein names: NADH dehydrogenase I subunit I 2; NDH-1 subunit I 2 [H]

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MPQTVREYTGAIRDTVKSFWHGLSITLSYLARRPTTVQYPDRTPMPVRDMLPPRYRGFLEVDTGICTGCQACERACPIGC
IQISLEKDAANPKQRVVTQFDIDEAKCMFCGLCVEPCPTGSIQHTREFEGTHRHIRNLVFRWADPMSPFPVYKVDKNAEY
YPRVPLGSLVRKRLETNAWDRAAPQFLPPEPPKPAEAKPAAKAAPAAKPAPAAKADGAAAAPAAPAPAKAAAPAPAPAAA
APAPAPAAPAAEAPAAPAAPAANPESK

Sequences:

>Translated_267_residues
MPQTVREYTGAIRDTVKSFWHGLSITLSYLARRPTTVQYPDRTPMPVRDMLPPRYRGFLEVDTGICTGCQACERACPIGC
IQISLEKDAANPKQRVVTQFDIDEAKCMFCGLCVEPCPTGSIQHTREFEGTHRHIRNLVFRWADPMSPFPVYKVDKNAEY
YPRVPLGSLVRKRLETNAWDRAAPQFLPPEPPKPAEAKPAAKAAPAAKPAPAAKADGAAAAPAAPAPAKAAAPAPAPAAA
APAPAPAAPAAEAPAAPAAPAANPESK
>Mature_266_residues
PQTVREYTGAIRDTVKSFWHGLSITLSYLARRPTTVQYPDRTPMPVRDMLPPRYRGFLEVDTGICTGCQACERACPIGCI
QISLEKDAANPKQRVVTQFDIDEAKCMFCGLCVEPCPTGSIQHTREFEGTHRHIRNLVFRWADPMSPFPVYKVDKNAEYY
PRVPLGSLVRKRLETNAWDRAAPQFLPPEPPKPAEAKPAAKAAPAAKPAPAAKADGAAAAPAAPAPAKAAAPAPAPAAAA
PAPAPAAPAAEAPAAPAAPAANPESK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI4505371, Length=128, Percent_Identity=35.15625, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI1788617, Length=153, Percent_Identity=35.2941176470588, Blast_Score=75, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17864306, Length=125, Percent_Identity=32, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR010226 [H]

Pfam domain/function: PF00037 Fer4 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 28432; Mature: 28301

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQTVREYTGAIRDTVKSFWHGLSITLSYLARRPTTVQYPDRTPMPVRDMLPPRYRGFLE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHCCCHHHCCEEE
VDTGICTGCQACERACPIGCIQISLEKDAANPKQRVVTQFDIDEAKCMFCGLCVEPCPTG
ECCCHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCC
SIQHTREFEGTHRHIRNLVFRWADPMSPFPVYKVDKNAEYYPRVPLGSLVRKRLETNAWD
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCHH
RAAPQFLPPEPPKPAEAKPAAKAAPAAKPAPAAKADGAAAAPAAPAPAKAAAPAPAPAAA
HCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
APAPAPAAPAAEAPAAPAAPAANPESK
CCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PQTVREYTGAIRDTVKSFWHGLSITLSYLARRPTTVQYPDRTPMPVRDMLPPRYRGFLE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHCCCHHHCCEEE
VDTGICTGCQACERACPIGCIQISLEKDAANPKQRVVTQFDIDEAKCMFCGLCVEPCPTG
ECCCHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCC
SIQHTREFEGTHRHIRNLVFRWADPMSPFPVYKVDKNAEYYPRVPLGSLVRKRLETNAWD
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCHH
RAAPQFLPPEPPKPAEAKPAAKAAPAAKPAPAAKADGAAAAPAAPAPAKAAAPAPAPAAA
HCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
APAPAPAAPAAEAPAAPAAPAANPESK
CCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA