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The map label for this gene is moaE1 [H]

Identifier: 220916354

GI number: 220916354

Start: 1398105

End: 1398758

Strand: Reverse

Name: moaE1 [H]

Synonym: A2cp1_1248

Alternate gene names: 220916354

Gene position: 1398758-1398105 (Counterclockwise)

Preceding gene: 220916355

Following gene: 220916353

Centisome position: 27.81

GC content: 76.91

Gene sequence:

>654_bases
ATGCCCGTCCACGTCCTCTACTTCGCCGGCGCCCGCGACGCGGCCGGCACCTCGCGCGAGACGCTCGCCGAGGTCCCCGC
CACCGTCGCCGACCTGCGGCGCGTCCTCGCCGCGGCGCACCCGGCGCTCGCGCGGATCCTGCCGCGCTGCCGCATCTCGG
TGGACCAGGCGTTCGCCGACGACGGCGACGCGGTCCGCGACGGCGCCGAGGTGGCGCTCATCCCGCCGGTGGCGGGCGGC
GCGCCGGTCTTCAAGGTGGTGGATCGCCCGCTGACGCTCACCGAGGTGGTAGACGCGGTGTCCGGGCCGGGGCTGGGCGG
GATCGTGACGTTCACCGGCACGGTGCGCGACGCGACGCGCGGCCGCCGCGTGCTGCGGCTCGAGTACGAGGCCTACCCGG
CCATGGCGGAGCGGACGCTCGCCGCCATCGGCGAGGCGGTCGGCCGCGAGCACGGGGTGCAGGTCGCCATCGTGCACCGG
GTGGGCGTGCTCGCGCCCGGCGAGGCGGCGGTGGTGATCGCCTGCGCCGCCCCGCACCGCACCCCGGCGTTCCGGGCCTG
CGAGGCGTGCATCGAGCGGCTGAAGCAGGACGTCCCCATCTGGAAGCGCGAGGTGTACGAGGACGGGTCGGAGTGGGTGG
GCCTGGGCCCGTGA

Upstream 100 bases:

>100_bases
GTGGCGCTCGTCGGGCTCCTCCTCGCGGTCACCGTCTTCGGCGACCTGGCCCGCCTGCGCGGGCGCTGAACCGGGCCTCC
CGGCGCGCTACGCTCCCTCC

Downstream 100 bases:

>100_bases
CGCGCGCGCCGGGCGCCCGCCCGCGCCCCGGCGGCGCCGGGGCGGCGTGCTATCCTCCGCGCTCCAGGTGCGGCGCGTGA
AGGTCCTCATCGCAGACGAC

Product: molybdopterin converting factor, subunit 1

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E 1; Molybdopterin-converting factor large subunit 1; Molybdopterin-converting factor subunit 2 [H]

Number of amino acids: Translated: 217; Mature: 216

Protein sequence:

>217_residues
MPVHVLYFAGARDAAGTSRETLAEVPATVADLRRVLAAAHPALARILPRCRISVDQAFADDGDAVRDGAEVALIPPVAGG
APVFKVVDRPLTLTEVVDAVSGPGLGGIVTFTGTVRDATRGRRVLRLEYEAYPAMAERTLAAIGEAVGREHGVQVAIVHR
VGVLAPGEAAVVIACAAPHRTPAFRACEACIERLKQDVPIWKREVYEDGSEWVGLGP

Sequences:

>Translated_217_residues
MPVHVLYFAGARDAAGTSRETLAEVPATVADLRRVLAAAHPALARILPRCRISVDQAFADDGDAVRDGAEVALIPPVAGG
APVFKVVDRPLTLTEVVDAVSGPGLGGIVTFTGTVRDATRGRRVLRLEYEAYPAMAERTLAAIGEAVGREHGVQVAIVHR
VGVLAPGEAAVVIACAAPHRTPAFRACEACIERLKQDVPIWKREVYEDGSEWVGLGP
>Mature_216_residues
PVHVLYFAGARDAAGTSRETLAEVPATVADLRRVLAAAHPALARILPRCRISVDQAFADDGDAVRDGAEVALIPPVAGGA
PVFKVVDRPLTLTEVVDAVSGPGLGGIVTFTGTVRDATRGRRVLRLEYEAYPAMAERTLAAIGEAVGREHGVQVAIVHRV
GVLAPGEAAVVIACAAPHRTPAFRACEACIERLKQDVPIWKREVYEDGSEWVGLGP

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD [H]

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family [H]

Homologues:

Organism=Homo sapiens, GI4758732, Length=133, Percent_Identity=37.593984962406, Blast_Score=100, Evalue=7e-22,
Organism=Escherichia coli, GI1787003, Length=109, Percent_Identity=41.2844036697248, Blast_Score=85, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17509279, Length=134, Percent_Identity=38.0597014925373, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21356259, Length=135, Percent_Identity=36.2962962962963, Blast_Score=95, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003448 [H]

Pfam domain/function: PF02391 MoaE [H]

EC number: NA

Molecular weight: Translated: 22899; Mature: 22767

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVHVLYFAGARDAAGTSRETLAEVPATVADLRRVLAAAHPALARILPRCRISVDQAFAD
CCEEEEEEECCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCC
DGDAVRDGAEVALIPPVAGGAPVFKVVDRPLTLTEVVDAVSGPGLGGIVTFTGTVRDATR
CCCHHHCCCCEEEECCCCCCCHHHHHHCCCCHHHHHHHHHCCCCCCEEEEEECCHHHHHC
GRRVLRLEYEAYPAMAERTLAAIGEAVGREHGVQVAIVHRVGVLAPGEAAVVIACAAPHR
CCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEEECCCCC
TPAFRACEACIERLKQDVPIWKREVYEDGSEWVGLGP
CHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCEECCCC
>Mature Secondary Structure 
PVHVLYFAGARDAAGTSRETLAEVPATVADLRRVLAAAHPALARILPRCRISVDQAFAD
CEEEEEEECCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCC
DGDAVRDGAEVALIPPVAGGAPVFKVVDRPLTLTEVVDAVSGPGLGGIVTFTGTVRDATR
CCCHHHCCCCEEEECCCCCCCHHHHHHCCCCHHHHHHHHHCCCCCCEEEEEECCHHHHHC
GRRVLRLEYEAYPAMAERTLAAIGEAVGREHGVQVAIVHRVGVLAPGEAAVVIACAAPHR
CCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEEECCCCC
TPAFRACEACIERLKQDVPIWKREVYEDGSEWVGLGP
CHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]