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The map label for this gene is zraS [H]

Identifier: 220915998

GI number: 220915998

Start: 1002511

End: 1003875

Strand: Reverse

Name: zraS [H]

Synonym: A2cp1_0884

Alternate gene names: 220915998

Gene position: 1003875-1002511 (Counterclockwise)

Preceding gene: 220916003

Following gene: 220915997

Centisome position: 19.96

GC content: 76.41

Gene sequence:

>1365_bases
ATGGTGGTCGCGGCGAGCCGCCCCGCCCCCCGACGGATCGAGCAGATGCCACCGCCCGGCCACGACCAGATCCAGCGCGA
GGAGCTGTCCCGGCTGTTCGGGCAGCTCGTCGGCGCGCGCCTGCTGCTGGTGCCGCTGCTGGTCGGCACGGGCGCCTGGA
TCGCCTGGGAGGAGCCGGCGGGGTGGCGGCGCGCGCTGCTCGGCGGCCTGCTGGTGCCGGTCTCGGCGTTCTTCATCGTC
GAGTACGCCCGCTTCCGGCGGCGCGGCGGCCTCGCGCCCGGCCAGGTCCGGCTCAACCTCTCGGTGGCGGTGATCGCGCA
GATGCTGCTCACCGCGGCGACGGGCGGCCTCCAGAGCCCGTTCGTCTACGTGTCGGTGCTCCTGGCGGTGATCGTGAACG
TGTTCGTCCGCCCGCCGGTGTCCTCCTGGCTCACCGCGTTCCAGGTGGTGGCCGTCTGGGCGCTCGCCGGGGTCGGCGCC
GCCGGCGCGGCACCGCTCGAGATCGAGCTCCTCGGCGGGGCGGCGCGGCGGGCGGTGCCGGTGGGGCTGTGGCTGCACGC
GGCGCTCCTCACCGTCGTGCTGGTGGCGATCGCCTTCGCCGGACGGGCCGGCCGCAAGGTGTTCGAGGCCATCATCCGGC
GCGCGCTCGCCGCGCAGCAGGACTCGCTCCGCGCCTACGCCGAGCGCGCCGAAGAGCTGACCGCCCTCTCCGGCGAGATC
GCGCACGAGCTGAAGAACCCGCTCGCCAGCGTGAAGGGGCTGGCCGGCCTGCTCGCGCAGGGGGTCGGCCCGGGCAAGCC
CACCGAGCGGCTCGCGGTGCTCCGCCAGGAGGTGGACCGGATGCAGACCATCCTGGACGGCTTCCTCAACTTCTCCCGGC
CGCTCGTGCCGCTCGTGCTCGACGACTGCGACGTGGCCGCGCTGGCGCGCGAGGTCGCGGCGCTGCACGAGGGGCTGGCG
CGCGAGCGCGGCGTGGCGCTCGAGGCGCGCGGCGCCGGGGTCCGCGCGCGCTGCGATCCACGCAAGGTGAAGCAGATCCT
GGTGAACCTGGTGCAGAACGCGCTCGACGCGAGCCCGGCGGACGCCGCGGTGGAGCTGGTGGCGACGCCGGTGCGCGGCG
GCGGGGCGCGCATCCTCGTGCAGGACCGCGGCCCGGGGCTCGACCCCGCGGTGCGCGACGCCGCGTTCTCGCCCGGCTTC
ACCACCAAGGCGAGCGGCTCCGGGCTGGGCCTCACCATCGCCCGGTCGCTGGCGCGGCAGCACGGCGGCGACCTGGTCCT
CTCCCCGCGCACGGGCGGCGGGATGGTGGCCGAGCTCACCCTGCCCGCGACCCCCGCCGGCGCGGGGACGGGAGCGCTGG
CATGA

Upstream 100 bases:

>100_bases
TTCCATGGGTCGCGCGAATCTAGCGTGACCCGCGGGCGTCCGCTCGACTTCCTGCATGCGCGTCCGTGCGCCGCCCGTGC
GCAGGAACGCCGCCCGTCGT

Downstream 100 bases:

>100_bases
GCGAGCAGCCGGAGCGGCGCGGCGGGGCGCGGGTGCTGGTGGTGGACGACGATCCGGGCGTCCGCTACACGCTGCGCGAG
ATCCTCGCGTCGGAGGGGCT

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MVVAASRPAPRRIEQMPPPGHDQIQREELSRLFGQLVGARLLLVPLLVGTGAWIAWEEPAGWRRALLGGLLVPVSAFFIV
EYARFRRRGGLAPGQVRLNLSVAVIAQMLLTAATGGLQSPFVYVSVLLAVIVNVFVRPPVSSWLTAFQVVAVWALAGVGA
AGAAPLEIELLGGAARRAVPVGLWLHAALLTVVLVAIAFAGRAGRKVFEAIIRRALAAQQDSLRAYAERAEELTALSGEI
AHELKNPLASVKGLAGLLAQGVGPGKPTERLAVLRQEVDRMQTILDGFLNFSRPLVPLVLDDCDVAALAREVAALHEGLA
RERGVALEARGAGVRARCDPRKVKQILVNLVQNALDASPADAAVELVATPVRGGGARILVQDRGPGLDPAVRDAAFSPGF
TTKASGSGLGLTIARSLARQHGGDLVLSPRTGGGMVAELTLPATPAGAGTGALA

Sequences:

>Translated_454_residues
MVVAASRPAPRRIEQMPPPGHDQIQREELSRLFGQLVGARLLLVPLLVGTGAWIAWEEPAGWRRALLGGLLVPVSAFFIV
EYARFRRRGGLAPGQVRLNLSVAVIAQMLLTAATGGLQSPFVYVSVLLAVIVNVFVRPPVSSWLTAFQVVAVWALAGVGA
AGAAPLEIELLGGAARRAVPVGLWLHAALLTVVLVAIAFAGRAGRKVFEAIIRRALAAQQDSLRAYAERAEELTALSGEI
AHELKNPLASVKGLAGLLAQGVGPGKPTERLAVLRQEVDRMQTILDGFLNFSRPLVPLVLDDCDVAALAREVAALHEGLA
RERGVALEARGAGVRARCDPRKVKQILVNLVQNALDASPADAAVELVATPVRGGGARILVQDRGPGLDPAVRDAAFSPGF
TTKASGSGLGLTIARSLARQHGGDLVLSPRTGGGMVAELTLPATPAGAGTGALA
>Mature_454_residues
MVVAASRPAPRRIEQMPPPGHDQIQREELSRLFGQLVGARLLLVPLLVGTGAWIAWEEPAGWRRALLGGLLVPVSAFFIV
EYARFRRRGGLAPGQVRLNLSVAVIAQMLLTAATGGLQSPFVYVSVLLAVIVNVFVRPPVSSWLTAFQVVAVWALAGVGA
AGAAPLEIELLGGAARRAVPVGLWLHAALLTVVLVAIAFAGRAGRKVFEAIIRRALAAQQDSLRAYAERAEELTALSGEI
AHELKNPLASVKGLAGLLAQGVGPGKPTERLAVLRQEVDRMQTILDGFLNFSRPLVPLVLDDCDVAALAREVAALHEGLA
RERGVALEARGAGVRARCDPRKVKQILVNLVQNALDASPADAAVELVATPVRGGGARILVQDRGPGLDPAVRDAAFSPGF
TTKASGSGLGLTIARSLARQHGGDLVLSPRTGGGMVAELTLPATPAGAGTGALA

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=238, Percent_Identity=33.1932773109244, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1788549, Length=257, Percent_Identity=29.9610894941634, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1790300, Length=206, Percent_Identity=29.6116504854369, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790861, Length=234, Percent_Identity=29.0598290598291, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1789808, Length=227, Percent_Identity=26.8722466960352, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87082128, Length=217, Percent_Identity=26.7281105990783, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI87081816, Length=232, Percent_Identity=28.448275862069, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786912, Length=263, Percent_Identity=28.5171102661597, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47374; Mature: 47374

Theoretical pI: Translated: 10.98; Mature: 10.98

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVAASRPAPRRIEQMPPPGHDQIQREELSRLFGQLVGARLLLVPLLVGTGAWIAWEEPA
CEEECCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
GWRRALLGGLLVPVSAFFIVEYARFRRRGGLAPGQVRLNLSVAVIAQMLLTAATGGLQSP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCH
FVYVSVLLAVIVNVFVRPPVSSWLTAFQVVAVWALAGVGAAGAAPLEIELLGGAARRAVP
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHH
VGLWLHAALLTVVLVAIAFAGRAGRKVFEAIIRRALAAQQDSLRAYAERAEELTALSGEI
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHELKNPLASVKGLAGLLAQGVGPGKPTERLAVLRQEVDRMQTILDGFLNFSRPLVPLVL
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHC
DDCDVAALAREVAALHEGLARERGVALEARGAGVRARCDPRKVKQILVNLVQNALDASPA
CCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCH
DAAVELVATPVRGGGARILVQDRGPGLDPAVRDAAFSPGFTTKASGSGLGLTIARSLARQ
HHHHHHHEECCCCCCCEEEEECCCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
HGGDLVLSPRTGGGMVAELTLPATPAGAGTGALA
CCCCEEECCCCCCCEEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MVVAASRPAPRRIEQMPPPGHDQIQREELSRLFGQLVGARLLLVPLLVGTGAWIAWEEPA
CEEECCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
GWRRALLGGLLVPVSAFFIVEYARFRRRGGLAPGQVRLNLSVAVIAQMLLTAATGGLQSP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCH
FVYVSVLLAVIVNVFVRPPVSSWLTAFQVVAVWALAGVGAAGAAPLEIELLGGAARRAVP
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHH
VGLWLHAALLTVVLVAIAFAGRAGRKVFEAIIRRALAAQQDSLRAYAERAEELTALSGEI
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHELKNPLASVKGLAGLLAQGVGPGKPTERLAVLRQEVDRMQTILDGFLNFSRPLVPLVL
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHC
DDCDVAALAREVAALHEGLARERGVALEARGAGVRARCDPRKVKQILVNLVQNALDASPA
CCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCH
DAAVELVATPVRGGGARILVQDRGPGLDPAVRDAAFSPGFTTKASGSGLGLTIARSLARQ
HHHHHHHEECCCCCCCEEEEECCCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
HGGDLVLSPRTGGGMVAELTLPATPAGAGTGALA
CCCCEEECCCCCCCEEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 2666400; 11243806 [H]