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The map label for this gene is atoC [H]

Identifier: 220915997

GI number: 220915997

Start: 1001114

End: 1002514

Strand: Reverse

Name: atoC [H]

Synonym: A2cp1_0883

Alternate gene names: 220915997

Gene position: 1002514-1001114 (Counterclockwise)

Preceding gene: 220915998

Following gene: 220915996

Centisome position: 19.93

GC content: 75.66

Gene sequence:

>1401_bases
ATGAGCGAGCAGCCGGAGCGGCGCGGCGGGGCGCGGGTGCTGGTGGTGGACGACGATCCGGGCGTCCGCTACACGCTGCG
CGAGATCCTCGCGTCGGAGGGGCTGGAGGTGGAGGAGGCGACCGACGGCGAGGCGGCGCTGGAGAAGCTCGGCGCGCAGC
CGTGCCCGCTCGTGCTCACCGACCTGCGCATGCCGCGCCTGGACGGCATGGCGCTGCTCCGCAAGATCACCGCCGGCCAC
CCGGCCACGCGCGTGGTGGTGATCACCGCGCACGGCTCGGAGCGGCAGGCGGTCGAGGCGGTGAAGGCCGGCGCCTACGA
CTACTTCAAGAAGCCGTTCGAGACCGAGGAGCTGCTGGCCGTGGTGCGCCGCGCGGTCGAGGCGCTGCGGCTCGCCGACG
AGAACGAGCGGCTGGCCGGCGAGCTGGCCCTGTCGCGGTCGATGGTGTTCTCCTCGGAGGCCATGCGCCGGCTGGCGGTG
CTGGTGGGCCGGGTGGCGCCGCGCGACGTCACCGTGCTCATCACCGGCGAGAGCGGCACCGGCAAGGAGCGCGTCGCCGA
GGCCATCGTGCGCGCGTCGCGCCGGGCCGGCGGGCCGTTCGTCCGGTTCAACTGCGCCGCGCTCTCGCCGGAGCTGGCCG
AGGCCGAGCTGTTCGGCCACGTGAAGGGCGCGTTCACCGGGGCGGTGCGGTCGCGGCCCGGCCTGTTCGGCGAGGCCGAT
GGCGGGACCATCCTGCTCGACGAGGTGGGCGAGCTGGCGGCGCCGGCGCAGGGGAAGCTCCTGCGCGTGCTGCAGGAGGG
CGAGGTCCGGCCGGTGGGCGACGAGAAGGCGCGCACCGTGGACGTGCGGGTCATCGCCGCCACGCACCGCGACCTGCAGG
AGCTGGTGCGCGCCGGCCGTTTCCGCGAGGACCTCTACTACCGGCTCGACGTGGTCCACCTCTCCATCCCGCCGCTCCGC
GACCGCCCCGAGGACATCCCGGTGCTGGCGCGCCACTTCCTGGAGCGCTTCGCCGATCGCTTCGGCGCGTCGCCGCTGCA
CGTGCCGCCGGCGCTGTTCGACCGCCTGGCGGCGCACCGCTGGCCGGGCAACGTGCGCGAGCTGGAGAACGCCATCGAGG
GGCTGGTGGCGCTCTCGCCGCCGGACGGCCTCGACCTGTCGCTCCTGCCGGGCGAGCCCGCCGCCGGCTCGCCCGAGGCG
CCGGCGGAGGAGAGCACGCCGCTCCCGCTCAAGCAGCGCGTCGAGGCGTACGAGCGCGGGCTCATCGTGGACGCGCTGCG
CGCCGCGCGCGGGAACCGGAGCGAGGCGGCGCGCCGGCTGGGCATGTCGCGCGTCACGCTGCACGACAAGCTCCGCAAGT
ACGGGCTCGCCGGGGGCGACGAGGAGGCGGGCGAGCGCTAG

Upstream 100 bases:

>100_bases
ACGGCGGCGACCTGGTCCTCTCCCCGCGCACGGGCGGCGGGATGGTGGCCGAGCTCACCCTGCCCGCGACCCCCGCCGGC
GCGGGGACGGGAGCGCTGGC

Downstream 100 bases:

>100_bases
CGCTGGTGGCGCCCACCTCGCGGGCGCGCGCGCGTGCCCCAACTTCCCTCCCCGCCGGAGGCGCCGCCGGGCGCGCGCGC
GCCGCATCGTGCCGGTGATG

Product: two component sigma-54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MSEQPERRGGARVLVVDDDPGVRYTLREILASEGLEVEEATDGEAALEKLGAQPCPLVLTDLRMPRLDGMALLRKITAGH
PATRVVVITAHGSERQAVEAVKAGAYDYFKKPFETEELLAVVRRAVEALRLADENERLAGELALSRSMVFSSEAMRRLAV
LVGRVAPRDVTVLITGESGTGKERVAEAIVRASRRAGGPFVRFNCAALSPELAEAELFGHVKGAFTGAVRSRPGLFGEAD
GGTILLDEVGELAAPAQGKLLRVLQEGEVRPVGDEKARTVDVRVIAATHRDLQELVRAGRFREDLYYRLDVVHLSIPPLR
DRPEDIPVLARHFLERFADRFGASPLHVPPALFDRLAAHRWPGNVRELENAIEGLVALSPPDGLDLSLLPGEPAAGSPEA
PAEESTPLPLKQRVEAYERGLIVDALRAARGNRSEAARRLGMSRVTLHDKLRKYGLAGGDEEAGER

Sequences:

>Translated_466_residues
MSEQPERRGGARVLVVDDDPGVRYTLREILASEGLEVEEATDGEAALEKLGAQPCPLVLTDLRMPRLDGMALLRKITAGH
PATRVVVITAHGSERQAVEAVKAGAYDYFKKPFETEELLAVVRRAVEALRLADENERLAGELALSRSMVFSSEAMRRLAV
LVGRVAPRDVTVLITGESGTGKERVAEAIVRASRRAGGPFVRFNCAALSPELAEAELFGHVKGAFTGAVRSRPGLFGEAD
GGTILLDEVGELAAPAQGKLLRVLQEGEVRPVGDEKARTVDVRVIAATHRDLQELVRAGRFREDLYYRLDVVHLSIPPLR
DRPEDIPVLARHFLERFADRFGASPLHVPPALFDRLAAHRWPGNVRELENAIEGLVALSPPDGLDLSLLPGEPAAGSPEA
PAEESTPLPLKQRVEAYERGLIVDALRAARGNRSEAARRLGMSRVTLHDKLRKYGLAGGDEEAGER
>Mature_465_residues
SEQPERRGGARVLVVDDDPGVRYTLREILASEGLEVEEATDGEAALEKLGAQPCPLVLTDLRMPRLDGMALLRKITAGHP
ATRVVVITAHGSERQAVEAVKAGAYDYFKKPFETEELLAVVRRAVEALRLADENERLAGELALSRSMVFSSEAMRRLAVL
VGRVAPRDVTVLITGESGTGKERVAEAIVRASRRAGGPFVRFNCAALSPELAEAELFGHVKGAFTGAVRSRPGLFGEADG
GTILLDEVGELAAPAQGKLLRVLQEGEVRPVGDEKARTVDVRVIAATHRDLQELVRAGRFREDLYYRLDVVHLSIPPLRD
RPEDIPVLARHFLERFADRFGASPLHVPPALFDRLAAHRWPGNVRELENAIEGLVALSPPDGLDLSLLPGEPAAGSPEAP
AEESTPLPLKQRVEAYERGLIVDALRAARGNRSEAARRLGMSRVTLHDKLRKYGLAGGDEEAGER

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=457, Percent_Identity=42.4507658643326, Blast_Score=349, Evalue=2e-97,
Organism=Escherichia coli, GI1790437, Length=449, Percent_Identity=46.5478841870824, Blast_Score=343, Evalue=2e-95,
Organism=Escherichia coli, GI1790299, Length=469, Percent_Identity=41.1513859275053, Blast_Score=326, Evalue=2e-90,
Organism=Escherichia coli, GI1788905, Length=464, Percent_Identity=42.2413793103448, Blast_Score=308, Evalue=7e-85,
Organism=Escherichia coli, GI87082117, Length=340, Percent_Identity=44.4117647058823, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI87082152, Length=317, Percent_Identity=45.4258675078864, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI1789233, Length=319, Percent_Identity=39.4984326018809, Blast_Score=228, Evalue=5e-61,
Organism=Escherichia coli, GI1789087, Length=334, Percent_Identity=43.4131736526946, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1787583, Length=325, Percent_Identity=41.8461538461538, Blast_Score=214, Evalue=9e-57,
Organism=Escherichia coli, GI87081872, Length=318, Percent_Identity=38.0503144654088, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1786524, Length=321, Percent_Identity=41.1214953271028, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1789828, Length=306, Percent_Identity=33.9869281045752, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI87081858, Length=306, Percent_Identity=34.640522875817, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1787375, Length=109, Percent_Identity=34.8623853211009, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1789809, Length=114, Percent_Identity=31.5789473684211, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=37.1900826446281, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1790860, Length=111, Percent_Identity=35.1351351351351, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50638; Mature: 50507

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQPERRGGARVLVVDDDPGVRYTLREILASEGLEVEEATDGEAALEKLGAQPCPLVLT
CCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCHHH
DLRMPRLDGMALLRKITAGHPATRVVVITAHGSERQAVEAVKAGAYDYFKKPFETEELLA
CCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHCCHHHHCCCCCHHHHHH
VVRRAVEALRLADENERLAGELALSRSMVFSSEAMRRLAVLVGRVAPRDVTVLITGESGT
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCC
GKERVAEAIVRASRRAGGPFVRFNCAALSPELAEAELFGHVKGAFTGAVRSRPGLFGEAD
CHHHHHHHHHHHHHHCCCCEEEEEEHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GGTILLDEVGELAAPAQGKLLRVLQEGEVRPVGDEKARTVDVRVIAATHRDLQELVRAGR
CCEEEHCCHHHHCCCCCHHHHHHHHCCCCCCCCCCCCEEEEEEEEEHHHHHHHHHHHHCC
FREDLYYRLDVVHLSIPPLRDRPEDIPVLARHFLERFADRFGASPLHVPPALFDRLAAHR
HHHHHHEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHC
WPGNVRELENAIEGLVALSPPDGLDLSLLPGEPAAGSPEAPAEESTPLPLKQRVEAYERG
CCCCHHHHHHHHHCEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCC
LIVDALRAARGNRSEAARRLGMSRVTLHDKLRKYGLAGGDEEAGER
HHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHCCCC
>Mature Secondary Structure 
SEQPERRGGARVLVVDDDPGVRYTLREILASEGLEVEEATDGEAALEKLGAQPCPLVLT
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCHHH
DLRMPRLDGMALLRKITAGHPATRVVVITAHGSERQAVEAVKAGAYDYFKKPFETEELLA
CCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHCCHHHHCCCCCHHHHHH
VVRRAVEALRLADENERLAGELALSRSMVFSSEAMRRLAVLVGRVAPRDVTVLITGESGT
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCC
GKERVAEAIVRASRRAGGPFVRFNCAALSPELAEAELFGHVKGAFTGAVRSRPGLFGEAD
CHHHHHHHHHHHHHHCCCCEEEEEEHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GGTILLDEVGELAAPAQGKLLRVLQEGEVRPVGDEKARTVDVRVIAATHRDLQELVRAGR
CCEEEHCCHHHHCCCCCHHHHHHHHCCCCCCCCCCCCEEEEEEEEEHHHHHHHHHHHHCC
FREDLYYRLDVVHLSIPPLRDRPEDIPVLARHFLERFADRFGASPLHVPPALFDRLAAHR
HHHHHHEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHC
WPGNVRELENAIEGLVALSPPDGLDLSLLPGEPAAGSPEAPAEESTPLPLKQRVEAYERG
CCCCHHHHHHHHHCEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCC
LIVDALRAARGNRSEAARRLGMSRVTLHDKLRKYGLAGGDEEAGER
HHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]