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The map label for this gene is apt

Identifier: 220915916

GI number: 220915916

Start: 902897

End: 903415

Strand: Reverse

Name: apt

Synonym: A2cp1_0802

Alternate gene names: 220915916

Gene position: 903415-902897 (Counterclockwise)

Preceding gene: 220915917

Following gene: 220915915

Centisome position: 17.96

GC content: 70.33

Gene sequence:

>519_bases
ATGATGGACGCCGTCCGCGCCAGGATCCGCGACGTTCCCGACTTCCCGAAGAAGGGGATCGTCTTCAAGGACATCACCCC
GGTCCTCTCGGATCCGCACACCTTCCGCGAGGTGATCGACGCGTTCGTCGAGCGCTGGAAGGGCGAGCGCGTCGACAAGG
TGATCGGGATCGAGTCGCGCGGCTTCATCTTCGCGGCGCCCATCGCCTACGCGCTCGGCGCCGGCTTCACCATCGTGCGC
AAGCCGGGGAAGCTGCCCTGGGAGACCATCCGCGAGGTCTACGCGCTGGAGTACGGCGAGGGCGCGCTGGAGCTGCACAT
CGACGCCATCGGGCCCGGCGACCGGGTGCTGGTGGTGGACGACGTGCTCGCCACCGGCGGCACCGCCGGCGCGGCGGGCC
GGCTGGTGGTCCGGCAGGGCGCGGAGCTGCTCGGCTACGCGTTCCTGGCCGAGCTCTCCTTCCTGAACGGCGCGCGCCAG
CTCGGGCACGCCAAGGTCCACTCCCTCCTGACGTTCTGA

Upstream 100 bases:

>100_bases
CCGCACCTGCACTTCGAGGTGCGCGAAGGCACGCGGCCGCGCAACCCGCTGCTCTTCCTCCCCTGAGGTCGGCGCGGATC
CCGTGGTAAGGTGCGCCCCC

Downstream 100 bases:

>100_bases
TCGCGACGCGGGCGGCGCGTGCCCGCCCGCGGCCGCGCGCTTATGATCGCGGCGTGATCCCGCCCGCGCACCGCACGCTC
AAGTTCCTCGGCACCGCCGG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 172; Mature: 172

Protein sequence:

>172_residues
MMDAVRARIRDVPDFPKKGIVFKDITPVLSDPHTFREVIDAFVERWKGERVDKVIGIESRGFIFAAPIAYALGAGFTIVR
KPGKLPWETIREVYALEYGEGALELHIDAIGPGDRVLVVDDVLATGGTAGAAGRLVVRQGAELLGYAFLAELSFLNGARQ
LGHAKVHSLLTF

Sequences:

>Translated_172_residues
MMDAVRARIRDVPDFPKKGIVFKDITPVLSDPHTFREVIDAFVERWKGERVDKVIGIESRGFIFAAPIAYALGAGFTIVR
KPGKLPWETIREVYALEYGEGALELHIDAIGPGDRVLVVDDVLATGGTAGAAGRLVVRQGAELLGYAFLAELSFLNGARQ
LGHAKVHSLLTF
>Mature_172_residues
MMDAVRARIRDVPDFPKKGIVFKDITPVLSDPHTFREVIDAFVERWKGERVDKVIGIESRGFIFAAPIAYALGAGFTIVR
KPGKLPWETIREVYALEYGEGALELHIDAIGPGDRVLVVDDVLATGGTAGAAGRLVVRQGAELLGYAFLAELSFLNGARQ
LGHAKVHSLLTF

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=174, Percent_Identity=46.551724137931, Blast_Score=151, Evalue=3e-37,
Organism=Homo sapiens, GI71773201, Length=128, Percent_Identity=49.21875, Blast_Score=125, Evalue=1e-29,
Organism=Escherichia coli, GI1786675, Length=174, Percent_Identity=48.8505747126437, Blast_Score=168, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17509087, Length=171, Percent_Identity=43.2748538011696, Blast_Score=126, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6323619, Length=171, Percent_Identity=43.2748538011696, Blast_Score=125, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6320649, Length=170, Percent_Identity=38.2352941176471, Blast_Score=100, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17136334, Length=173, Percent_Identity=40.4624277456647, Blast_Score=120, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_ANAD2 (B8JDQ9)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002491220.1
- ProteinModelPortal:   B8JDQ9
- SMR:   B8JDQ9
- GeneID:   7299188
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_0802
- HOGENOM:   HBG703830
- ProtClustDB:   PRK02304
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18744; Mature: 18744

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDAVRARIRDVPDFPKKGIVFKDITPVLSDPHTFREVIDAFVERWKGERVDKVIGIESR
CCHHHHHHHHCCCCCCCCCEECCCCCHHHCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCC
GFIFAAPIAYALGAGFTIVRKPGKLPWETIREVYALEYGEGALELHIDAIGPGDRVLVVD
CCEEEHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEEEECCCCEEEEEE
DVLATGGTAGAAGRLVVRQGAELLGYAFLAELSFLNGARQLGHAKVHSLLTF
CHHHCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMDAVRARIRDVPDFPKKGIVFKDITPVLSDPHTFREVIDAFVERWKGERVDKVIGIESR
CCHHHHHHHHCCCCCCCCCEECCCCCHHHCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCC
GFIFAAPIAYALGAGFTIVRKPGKLPWETIREVYALEYGEGALELHIDAIGPGDRVLVVD
CCEEEHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEEEECCCCEEEEEE
DVLATGGTAGAAGRLVVRQGAELLGYAFLAELSFLNGARQLGHAKVHSLLTF
CHHHCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA