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The map label for this gene is selB [H]

Identifier: 220915567

GI number: 220915567

Start: 512305

End: 514254

Strand: Reverse

Name: selB [H]

Synonym: A2cp1_0448

Alternate gene names: 220915567

Gene position: 514254-512305 (Counterclockwise)

Preceding gene: 220915568

Following gene: 220915566

Centisome position: 10.23

GC content: 77.03

Gene sequence:

>1950_bases
ATGAAGCGCGTCGTCATCGGCACGGCCGGCCACATCGATCACGGGAAGACCTCGCTCGTCCGGGCGCTCACCGGCATCGA
CACCGACCGGCTGCGCGACGAGAAGCGGCGCGGCATCACCATCGAGCTGGGCTTCGCGCACCTGGCGCTGCCCGACGGCT
CGGTGGCCGGCGTGGTGGACGTGCCCGGCCACGAGCGCTTCGTCCGCTCCATGGCGGCCGGCGCGGGCGGCATCGACCTG
GTGGTGCTCGTGATCGCGGCGGACGAGGGGGTGATGCCCCAGACCCGCGAGCACCTCGACATCTGCCGGCTGCTGGGCGT
GCCGCGGGGGCTGGTCGCCGTCACCAAGGCCGACCTGCTGCCGGAGCTGGGCGCGGACTGGCTGCCGCTGCTCGAGCAGG
ACGTACGCGAGGTGACGCGCGGCACGTTCCTGGAGGGCGCGCCCATCGTCCCCGTCTCCTCCGCGACGGGGGAGGGGCTG
GACGCGCTGCGCGCCGCGCTGGCCGCGCTCGCCGCCGAGGTGCCGGAGCGGCCCACCGACGGCCCGCTGTTCCTGCCCAT
CGACCGCGCGTTCTCGATGAAGGGCTTCGGGACCGTGGTCACCGGCACGCTGCTCTCCGGGCAGATCGCCGAGGGCGACG
CCGCCGCGCTCCTGCCCGCCTCGCCCGGCGGCGACGGGCTGCGGGTCCGCTCGGTCCAGGTGCACGGCAAGCCCACCCCG
CGCGCGCTCGCCGGCCAGCGCACGGCGGTGAACCTGCCCGGCATCGAGCCCGCCGCCATCCGCCGCGGTCAGGTGCTGGT
CCACCCCGGGGTCGTGCCGCCGTCGTCCATCGTCGACGCGGAGCTGACGCTGCTCGCGGCCGCCCCGAAGCCGCTCCGCC
ACCGCGCCAAGCTGCTCCTGCACGTGGGCACGGCGCAGGTCCCGGCGGTCATCTCGCTCCTCGATCGCGCCGAGCTCGCG
CCCGGCGCCACCGCTCACGCGCAGCTCCGGCTGGCGGAGCCGGCCGCGGCGCTGCCGGGGCAGCGCTTCATCCTGCGCGG
GTTCGCGGTGCTGGAGGGGCGCGGCAAGACGGTCGGCGGCGGGCGGGTGCTCGCGGTGGCCGCGCCGAAGCGCCGCCGCG
GGCGGCCGGACTCGCTCGCGCAGCTCACGGTCCTCGCCGGCGCCGACCCGGAGGCGCGCCTCGCCACGGTGCTCGCCATG
GCCGGACCGGCCGGCCTCGACCTGCCCGCGCTGGTGGGGCGCACCGCGCTCTCCCCGAAGGCCGCGCAGGCGACGCTGGA
CCGGCTGGGCGCGCGCGGCGGCGCGGTGCTGTTCGACCGCGAGCGGCGCGCCTACGTGGCCGGGACGGTCGCGCAGGAGC
TGACCCGCCGGATGGCCGCGGCGGTGGCCGCGTTCCACCGCGACCACCCGCTCGCGGCCGGCATGGGGCGCGAGGCGCTG
CGCGGGAAGCTGCCGCCGGTGACCGATCCGCGGCTGTTCCAGCGGCTGCTGGCGCACGCCGCCGAGCGGGGCGAGCTGGT
GGTGGAGGGCGACGCGGTCCGCGAGAAGGGCCACGCGGCCGCGAGCGGCGAGAGCGCCGGCGGCGCGCTCAAGGAGAAGG
TCGCCGCCGCGCTGGCCAAGGGCGGGCTCACCCCGCCGTGGCTGGCCGAGCTGCCAGGCGCGGTGGGCGCGAGCGCCCCG
GACGTGCAGGCCGTCCTGAAGCTGCTCGCCGCGGAGGGGCGCGCGCTGCGCGTCTCGTCGGAGCTGTACTTCGACGCGGC
GGCGGTGAAGACGCTCGAGACGAAGCTGGTGGCCTGGCTGCGGGAACGCCGCCAGATCACCACCCAGGAGTTCAAGGACC
TGGTGGGCGCGACCCGCAAGCACGTCATCCCGCTGGCCGAGTTCTTCGACCGCGAGAAGGTCACGCTGCGGGTGGGCGAG
AAGCGGGTGCTGCGCGGCGAGGGACGCTGA

Upstream 100 bases:

>100_bases
ACGAGCTCATCCTGTTCGCCTGGGACTACCAGCTCGACCAGCTGGGCGCGGCCGTGGATCCGGGCGAGGTCGGGGTCTAG
CCGGTCGCGGCCGGAGAGCC

Downstream 100 bases:

>100_bases
TGGCGGAGCGGTTCCAGGCCGGCTCGCTGGTGCTGCGCGATCGGAAGATCGTGCACGCGAGCGAGGGCGCGGCGGCCCTC
GCCGGCCGCACCGTGCCGGA

Product: selenocysteine-specific translation elongation factor

Products: NA

Alternate protein names: SelB translation factor [H]

Number of amino acids: Translated: 649; Mature: 649

Protein sequence:

>649_residues
MKRVVIGTAGHIDHGKTSLVRALTGIDTDRLRDEKRRGITIELGFAHLALPDGSVAGVVDVPGHERFVRSMAAGAGGIDL
VVLVIAADEGVMPQTREHLDICRLLGVPRGLVAVTKADLLPELGADWLPLLEQDVREVTRGTFLEGAPIVPVSSATGEGL
DALRAALAALAAEVPERPTDGPLFLPIDRAFSMKGFGTVVTGTLLSGQIAEGDAAALLPASPGGDGLRVRSVQVHGKPTP
RALAGQRTAVNLPGIEPAAIRRGQVLVHPGVVPPSSIVDAELTLLAAAPKPLRHRAKLLLHVGTAQVPAVISLLDRAELA
PGATAHAQLRLAEPAAALPGQRFILRGFAVLEGRGKTVGGGRVLAVAAPKRRRGRPDSLAQLTVLAGADPEARLATVLAM
AGPAGLDLPALVGRTALSPKAAQATLDRLGARGGAVLFDRERRAYVAGTVAQELTRRMAAAVAAFHRDHPLAAGMGREAL
RGKLPPVTDPRLFQRLLAHAAERGELVVEGDAVREKGHAAASGESAGGALKEKVAAALAKGGLTPPWLAELPGAVGASAP
DVQAVLKLLAAEGRALRVSSELYFDAAAVKTLETKLVAWLRERRQITTQEFKDLVGATRKHVIPLAEFFDREKVTLRVGE
KRVLRGEGR

Sequences:

>Translated_649_residues
MKRVVIGTAGHIDHGKTSLVRALTGIDTDRLRDEKRRGITIELGFAHLALPDGSVAGVVDVPGHERFVRSMAAGAGGIDL
VVLVIAADEGVMPQTREHLDICRLLGVPRGLVAVTKADLLPELGADWLPLLEQDVREVTRGTFLEGAPIVPVSSATGEGL
DALRAALAALAAEVPERPTDGPLFLPIDRAFSMKGFGTVVTGTLLSGQIAEGDAAALLPASPGGDGLRVRSVQVHGKPTP
RALAGQRTAVNLPGIEPAAIRRGQVLVHPGVVPPSSIVDAELTLLAAAPKPLRHRAKLLLHVGTAQVPAVISLLDRAELA
PGATAHAQLRLAEPAAALPGQRFILRGFAVLEGRGKTVGGGRVLAVAAPKRRRGRPDSLAQLTVLAGADPEARLATVLAM
AGPAGLDLPALVGRTALSPKAAQATLDRLGARGGAVLFDRERRAYVAGTVAQELTRRMAAAVAAFHRDHPLAAGMGREAL
RGKLPPVTDPRLFQRLLAHAAERGELVVEGDAVREKGHAAASGESAGGALKEKVAAALAKGGLTPPWLAELPGAVGASAP
DVQAVLKLLAAEGRALRVSSELYFDAAAVKTLETKLVAWLRERRQITTQEFKDLVGATRKHVIPLAEFFDREKVTLRVGE
KRVLRGEGR
>Mature_649_residues
MKRVVIGTAGHIDHGKTSLVRALTGIDTDRLRDEKRRGITIELGFAHLALPDGSVAGVVDVPGHERFVRSMAAGAGGIDL
VVLVIAADEGVMPQTREHLDICRLLGVPRGLVAVTKADLLPELGADWLPLLEQDVREVTRGTFLEGAPIVPVSSATGEGL
DALRAALAALAAEVPERPTDGPLFLPIDRAFSMKGFGTVVTGTLLSGQIAEGDAAALLPASPGGDGLRVRSVQVHGKPTP
RALAGQRTAVNLPGIEPAAIRRGQVLVHPGVVPPSSIVDAELTLLAAAPKPLRHRAKLLLHVGTAQVPAVISLLDRAELA
PGATAHAQLRLAEPAAALPGQRFILRGFAVLEGRGKTVGGGRVLAVAAPKRRRGRPDSLAQLTVLAGADPEARLATVLAM
AGPAGLDLPALVGRTALSPKAAQATLDRLGARGGAVLFDRERRAYVAGTVAQELTRRMAAAVAAFHRDHPLAAGMGREAL
RGKLPPVTDPRLFQRLLAHAAERGELVVEGDAVREKGHAAASGESAGGALKEKVAAALAKGGLTPPWLAELPGAVGASAP
DVQAVLKLLAAEGRALRVSSELYFDAAAVKTLETKLVAWLRERRQITTQEFKDLVGATRKHVIPLAEFFDREKVTLRVGE
KRVLRGEGR

Specific function: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP [H]

COG id: COG3276

COG function: function code J; Selenocysteine-specific translation elongation factor

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. SelB subfamily [H]

Homologues:

Organism=Homo sapiens, GI34147630, Length=374, Percent_Identity=33.1550802139037, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI54607086, Length=349, Percent_Identity=30.6590257879656, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI82546879, Length=375, Percent_Identity=29.3333333333333, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI223555963, Length=396, Percent_Identity=27.020202020202, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI5729864, Length=396, Percent_Identity=27.020202020202, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI4503475, Length=334, Percent_Identity=26.6467065868263, Blast_Score=94, Evalue=5e-19,
Organism=Homo sapiens, GI45593140, Length=433, Percent_Identity=26.7898383371824, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI4503507, Length=261, Percent_Identity=27.9693486590038, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI53729339, Length=218, Percent_Identity=36.2385321100917, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI53729337, Length=218, Percent_Identity=36.2385321100917, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI2367247, Length=646, Percent_Identity=32.8173374613003, Blast_Score=275, Evalue=6e-75,
Organism=Escherichia coli, GI1790412, Length=391, Percent_Identity=33.5038363171356, Blast_Score=145, Evalue=1e-35,
Organism=Escherichia coli, GI1789737, Length=391, Percent_Identity=33.5038363171356, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1789108, Length=284, Percent_Identity=27.4647887323944, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1789559, Length=93, Percent_Identity=44.0860215053763, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25141371, Length=311, Percent_Identity=32.475884244373, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17556456, Length=401, Percent_Identity=30.4239401496259, Blast_Score=132, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI17565438, Length=341, Percent_Identity=28.1524926686217, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17552884, Length=330, Percent_Identity=26.969696969697, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17569207, Length=330, Percent_Identity=26.969696969697, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17506081, Length=359, Percent_Identity=26.1838440111421, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI115532067, Length=335, Percent_Identity=26.5671641791045, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17563834, Length=349, Percent_Identity=28.3667621776504, Blast_Score=86, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI32566303, Length=303, Percent_Identity=24.7524752475248, Blast_Score=86, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI115532065, Length=335, Percent_Identity=26.5671641791045, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71994658, Length=280, Percent_Identity=29.6428571428571, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324761, Length=395, Percent_Identity=30.8860759493671, Blast_Score=146, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6325337, Length=334, Percent_Identity=26.9461077844311, Blast_Score=107, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6319594, Length=334, Percent_Identity=26.9461077844311, Blast_Score=107, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6320863, Length=268, Percent_Identity=28.7313432835821, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324550, Length=228, Percent_Identity=27.6315789473684, Blast_Score=80, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6322937, Length=416, Percent_Identity=22.1153846153846, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19921738, Length=387, Percent_Identity=31.7829457364341, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI281363316, Length=382, Percent_Identity=29.8429319371728, Blast_Score=145, Evalue=8e-35,
Organism=Drosophila melanogaster, GI17864358, Length=382, Percent_Identity=29.8429319371728, Blast_Score=145, Evalue=8e-35,
Organism=Drosophila melanogaster, GI19922690, Length=338, Percent_Identity=32.5443786982249, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI19922512, Length=343, Percent_Identity=28.2798833819242, Blast_Score=112, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24654852, Length=343, Percent_Identity=28.2798833819242, Blast_Score=112, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24647046, Length=264, Percent_Identity=28.7878787878788, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24647048, Length=264, Percent_Identity=28.7878787878788, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI28572034, Length=172, Percent_Identity=34.8837209302326, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17137380, Length=442, Percent_Identity=25.5656108597285, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI45550900, Length=331, Percent_Identity=26.2839879154079, Blast_Score=76, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015190
- InterPro:   IPR015191
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR009001
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR004535
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF09106 SelB-wing_2; PF09107 SelB-wing_3 [H]

EC number: NA

Molecular weight: Translated: 67819; Mature: 67819

Theoretical pI: Translated: 10.72; Mature: 10.72

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVVIGTAGHIDHGKTSLVRALTGIDTDRLRDEKRRGITIELGFAHLALPDGSVAGVVD
CCEEEEECCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCEEEEECCEEEECCCCCEEEEEE
VPGHERFVRSMAAGAGGIDLVVLVIAADEGVMPQTREHLDICRLLGVPRGLVAVTKADLL
CCCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHH
PELGADWLPLLEQDVREVTRGTFLEGAPIVPVSSATGEGLDALRAALAALAAEVPERPTD
HHCCCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCCCC
GPLFLPIDRAFSMKGFGTVVTGTLLSGQIAEGDAAALLPASPGGDGLRVRSVQVHGKPTP
CCEEEECCCHHCCCCCCHHHHHHHHCCCCCCCCCEEEEECCCCCCCEEEEEEEECCCCCC
RALAGQRTAVNLPGIEPAAIRRGQVLVHPGVVPPSSIVDAELTLLAAAPKPLRHRAKLLL
HHHCCCCEEEECCCCCHHHHCCCEEEEECCCCCCCHHCCHHEEEEECCCHHHHHHHHEEE
HVGTAQVPAVISLLDRAELAPGATAHAQLRLAEPAAALPGQRFILRGFAVLEGRGKTVGG
EECCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHCCCCHHHHHHHHEEECCCCCCCC
GRVLAVAAPKRRRGRPDSLAQLTVLAGADPEARLATVLAMAGPAGLDLPALVGRTALSPK
CEEEEEECCHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHCCCCCCCH
AAQATLDRLGARGGAVLFDRERRAYVAGTVAQELTRRMAAAVAAFHRDHPLAAGMGREAL
HHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCHHHH
RGKLPPVTDPRLFQRLLAHAAERGELVVEGDAVREKGHAAASGESAGGALKEKVAAALAK
CCCCCCCCCHHHHHHHHHHHHHCCCEEEECHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
GGLTPPWLAELPGAVGASAPDVQAVLKLLAAEGRALRVSSELYFDAAAVKTLETKLVAWL
CCCCCCHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
RERRQITTQEFKDLVGATRKHVIPLAEFFDREKVTLRVGEKRVLRGEGR
HHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCEEEEECCHHHHCCCCC
>Mature Secondary Structure
MKRVVIGTAGHIDHGKTSLVRALTGIDTDRLRDEKRRGITIELGFAHLALPDGSVAGVVD
CCEEEEECCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCEEEEECCEEEECCCCCEEEEEE
VPGHERFVRSMAAGAGGIDLVVLVIAADEGVMPQTREHLDICRLLGVPRGLVAVTKADLL
CCCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHH
PELGADWLPLLEQDVREVTRGTFLEGAPIVPVSSATGEGLDALRAALAALAAEVPERPTD
HHCCCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCCCC
GPLFLPIDRAFSMKGFGTVVTGTLLSGQIAEGDAAALLPASPGGDGLRVRSVQVHGKPTP
CCEEEECCCHHCCCCCCHHHHHHHHCCCCCCCCCEEEEECCCCCCCEEEEEEEECCCCCC
RALAGQRTAVNLPGIEPAAIRRGQVLVHPGVVPPSSIVDAELTLLAAAPKPLRHRAKLLL
HHHCCCCEEEECCCCCHHHHCCCEEEEECCCCCCCHHCCHHEEEEECCCHHHHHHHHEEE
HVGTAQVPAVISLLDRAELAPGATAHAQLRLAEPAAALPGQRFILRGFAVLEGRGKTVGG
EECCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHCCCCHHHHHHHHEEECCCCCCCC
GRVLAVAAPKRRRGRPDSLAQLTVLAGADPEARLATVLAMAGPAGLDLPALVGRTALSPK
CEEEEEECCHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHCCCCCCCH
AAQATLDRLGARGGAVLFDRERRAYVAGTVAQELTRRMAAAVAAFHRDHPLAAGMGREAL
HHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCHHHH
RGKLPPVTDPRLFQRLLAHAAERGELVVEGDAVREKGHAAASGESAGGALKEKVAAALAK
CCCCCCCCCHHHHHHHHHHHHHCCCEEEECHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
GGLTPPWLAELPGAVGASAPDVQAVLKLLAAEGRALRVSSELYFDAAAVKTLETKLVAWL
CCCCCCHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
RERRQITTQEFKDLVGATRKHVIPLAEFFDREKVTLRVGEKRVLRGEGR
HHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCEEEEECCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8893853 [H]