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The map label for this gene is hemN [H]

Identifier: 220915384

GI number: 220915384

Start: 290935

End: 292074

Strand: Reverse

Name: hemN [H]

Synonym: A2cp1_0263

Alternate gene names: 220915384

Gene position: 292074-290935 (Counterclockwise)

Preceding gene: 220915385

Following gene: 220915383

Centisome position: 5.81

GC content: 77.81

Gene sequence:

>1140_bases
ATGGCGCGCCCGTTCGGCGTGTACGTGCACTATCCGTACTGCACGCACCGCTGCCCCTACTGCGACTTCGCGGTCACCAC
CGAGCGCCCGCCCGGCGCCGGCCGGTACGCGCGCGCGGTGCGGGCCGAGCTCGGGCTGCGCGCGCCCGCGTTCGAGGGCC
TCTCGCTCCGGAGCGTCTACCTGGGCGGCGGCACGCCCTCGCTCTGGGACGCCGACGAGCTCCGCGACGTCCTCGCCGCC
GTCCGCGACCGGTTCGGCCTCCCCGGCGGCGCCGAGGTCACGCTGGAGGTGAACCCCGAGTCCAGCGACCCGGCGCGGCT
CGAGGCCTGGCGGGCCGCCGGGGTGAACCGGATCTCGGTCGGCGCGCAGTCGTTCGACCCGGGCGTGCTCGCGAAGCTCG
GCCGCCGCCACGGGCCGGAGCGCGCCGAGCAGGCCATCCGCGAGGCCGCCGCCGCCATCGGCAACGTGAGCGTGGACCTC
ATCTACGGCGCGCGCCGGTCGAGCGTGGAGACCGCGCGGCGCGACGCCGAGCGGGCGGTGGAGGCCGGCGCGGTGCACGT
GTCCGCCTACGCGCTCACGCTCGATCCCGACGTGATGGCCGAGGAGGTGCCGCTCGCGCGCATGCGGCGCGAGGGCCGGC
TGCCGCTCCCCTCCGACGAGGACGCGCTGGCGCAGGCGGCGGCGCTGCGCGCGGCGCTCCGGCGCCTCGGGCTCCGCCGC
TACGAGATCTCCAACTTCGCCCGGCCCGGCCGCGAGTCGGTCCACAACGGCCTCTACTGGCGGCACGAGAGCTACCTCGG
CCTCGGCGCCGGCGCGTACGGCTGCCGGCGCGGGGACGCGGGCTCGGTGCGCTACGGCAACCTGCGCGACGCCGGCGCCT
GGCTGGCGACGGTGGAGGCGGGACGGCTGCCCACCGCCGAGGAGGACCGGATCGACGCGCGCGCCGACCGGAACGAGCGG
CTCATGCTGGCGCTGCGGACCCGCGACGGCGCGCCGCTCGCCGCGCTCGGCCCGGCGCAGACGCGCGAGGCCGCCGACCT
GGTGCGGCACCGGCTGGCGGTGCGGCGGGATGGCGCGCTGGTCCTCACCAGCCGGGGCCTCGACCTGCACAGCGCGATCT
CGGAGCGGCTGTTCGAGTGA

Upstream 100 bases:

>100_bases
CCTCTCCGCGGAGGAGCGCGGGCCGTTCCAGGTGGCCCGGCGCGACCGGCGCTGACCGGCGGCGCGGCGCCGCCCGCGCG
GCCGCGCTATCCTCCCCGGG

Downstream 100 bases:

>100_bases
GGTACGCTCGGCGGCACCGGGAGGCGCGCCGACATGCCCATCTCACCTTCGTTCGTGGACCACGCCGTCGACCTCGTCTC
CGCGCTCGGTCCCGTCCAGG

Product: oxygen-independent coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MARPFGVYVHYPYCTHRCPYCDFAVTTERPPGAGRYARAVRAELGLRAPAFEGLSLRSVYLGGGTPSLWDADELRDVLAA
VRDRFGLPGGAEVTLEVNPESSDPARLEAWRAAGVNRISVGAQSFDPGVLAKLGRRHGPERAEQAIREAAAAIGNVSVDL
IYGARRSSVETARRDAERAVEAGAVHVSAYALTLDPDVMAEEVPLARMRREGRLPLPSDEDALAQAAALRAALRRLGLRR
YEISNFARPGRESVHNGLYWRHESYLGLGAGAYGCRRGDAGSVRYGNLRDAGAWLATVEAGRLPTAEEDRIDARADRNER
LMLALRTRDGAPLAALGPAQTREAADLVRHRLAVRRDGALVLTSRGLDLHSAISERLFE

Sequences:

>Translated_379_residues
MARPFGVYVHYPYCTHRCPYCDFAVTTERPPGAGRYARAVRAELGLRAPAFEGLSLRSVYLGGGTPSLWDADELRDVLAA
VRDRFGLPGGAEVTLEVNPESSDPARLEAWRAAGVNRISVGAQSFDPGVLAKLGRRHGPERAEQAIREAAAAIGNVSVDL
IYGARRSSVETARRDAERAVEAGAVHVSAYALTLDPDVMAEEVPLARMRREGRLPLPSDEDALAQAAALRAALRRLGLRR
YEISNFARPGRESVHNGLYWRHESYLGLGAGAYGCRRGDAGSVRYGNLRDAGAWLATVEAGRLPTAEEDRIDARADRNER
LMLALRTRDGAPLAALGPAQTREAADLVRHRLAVRRDGALVLTSRGLDLHSAISERLFE
>Mature_378_residues
ARPFGVYVHYPYCTHRCPYCDFAVTTERPPGAGRYARAVRAELGLRAPAFEGLSLRSVYLGGGTPSLWDADELRDVLAAV
RDRFGLPGGAEVTLEVNPESSDPARLEAWRAAGVNRISVGAQSFDPGVLAKLGRRHGPERAEQAIREAAAAIGNVSVDLI
YGARRSSVETARRDAERAVEAGAVHVSAYALTLDPDVMAEEVPLARMRREGRLPLPSDEDALAQAAALRAALRRLGLRRY
EISNFARPGRESVHNGLYWRHESYLGLGAGAYGCRRGDAGSVRYGNLRDAGAWLATVEAGRLPTAEEDRIDARADRNERL
MLALRTRDGAPLAALGPAQTREAADLVRHRLAVRRDGALVLTSRGLDLHSAISERLFE

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=271, Percent_Identity=39.1143911439114, Blast_Score=151, Evalue=8e-37,
Organism=Escherichia coli, GI1789325, Length=276, Percent_Identity=35.1449275362319, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI87082341, Length=253, Percent_Identity=29.2490118577075, Blast_Score=113, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 41207; Mature: 41076

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARPFGVYVHYPYCTHRCPYCDFAVTTERPPGAGRYARAVRAELGLRAPAFEGLSLRSVY
CCCCEEEEEECCHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEE
LGGGTPSLWDADELRDVLAAVRDRFGLPGGAEVTLEVNPESSDPARLEAWRAAGVNRISV
ECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEC
GAQSFDPGVLAKLGRRHGPERAEQAIREAAAAIGNVSVDLIYGARRSSVETARRDAERAV
CCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHH
EAGAVHVSAYALTLDPDVMAEEVPLARMRREGRLPLPSDEDALAQAAALRAALRRLGLRR
HHCEEEEEEEEEEECHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHH
YEISNFARPGRESVHNGLYWRHESYLGLGAGAYGCRRGDAGSVRYGNLRDAGAWLATVEA
HHHHHHCCCCHHHHHCCEEEEECCCEECCCCCCCCCCCCCCCEEECCCCCCCCEEEEEEC
GRLPTAEEDRIDARADRNERLMLALRTRDGAPLAALGPAQTREAADLVRHRLAVRRDGAL
CCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCEE
VLTSRGLDLHSAISERLFE
EEEECCCCHHHHHHHHHCC
>Mature Secondary Structure 
ARPFGVYVHYPYCTHRCPYCDFAVTTERPPGAGRYARAVRAELGLRAPAFEGLSLRSVY
CCCEEEEEECCHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEE
LGGGTPSLWDADELRDVLAAVRDRFGLPGGAEVTLEVNPESSDPARLEAWRAAGVNRISV
ECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEC
GAQSFDPGVLAKLGRRHGPERAEQAIREAAAAIGNVSVDLIYGARRSSVETARRDAERAV
CCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHH
EAGAVHVSAYALTLDPDVMAEEVPLARMRREGRLPLPSDEDALAQAAALRAALRRLGLRR
HHCEEEEEEEEEEECHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHH
YEISNFARPGRESVHNGLYWRHESYLGLGAGAYGCRRGDAGSVRYGNLRDAGAWLATVEA
HHHHHHCCCCHHHHHCCEEEEECCCEECCCCCCCCCCCCCCCEEECCCCCCCCEEEEEEC
GRLPTAEEDRIDARADRNERLMLALRTRDGAPLAALGPAQTREAADLVRHRLAVRRDGAL
CCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHCCCCEE
VLTSRGLDLHSAISERLFE
EEEECCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]