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The map label for this gene is pth

Identifier: 220915258

GI number: 220915258

Start: 155090

End: 155668

Strand: Reverse

Name: pth

Synonym: A2cp1_0137

Alternate gene names: 220915258

Gene position: 155668-155090 (Counterclockwise)

Preceding gene: 220915259

Following gene: 220915257

Centisome position: 3.1

GC content: 72.37

Gene sequence:

>579_bases
TTGAAGCTCGTGGTCGGCCTCGGCAACCCCGGCGAGGAATACGCCCGCACCCGCCACAACGTCGGCTTCGTGGTGGCGGA
TCGGCTGGCGCAGCTCGCGGGGGCGAGCTTCTCCGCGAAGAAGTTCGCGGCGGAGCTCGCCGAGGCCCGCCTCGGGCCGG
AGCGGGTCTGGATCATGAAGCCCCAGACCTACATGAACCACTCCGGCGAGGCGGTCGGCGCGGCCCTGCGGTTCTGGAAG
CTGGGGCTCGACGACCTCGTGGTGGTGCACGACGACCTGGAGCTGGATCCGTATCGCGTCCAGCTCAAGGTCGGCGGCGG
CCACGGCGGGCACAACGGCGTGAAGAGCGTGAACGCCCACGTGGGCAGCCCCGAGTACGCGCGCGTGCGCGTGGGCGTGG
GCCGCCCGCCGCCGCGGATGGACCCGGCCGACTACGTGCTGGGGAAGTTCGCGAAGGGCGAGGATGCCGAGCTCGACCTG
TGCGTCGAGCAGGCGGTCGAGGCGACGCGGCTCGCGGTCGAGCTGGGCGCCGCCAGGGCGATGAACCAGGTGAACCGCCG
CTCCCGCGCGGCGGACTGA

Upstream 100 bases:

>100_bases
TGCGGCTCCGGCCGGCGGCGCGGCCCCGGCCGCGGGCGCTGCCCCTGCCAAGGGCGGCGAGGCCAAGGGCGGCGACAAGG
CCAAGAAGTAAGGGCGTCGC

Downstream 100 bases:

>100_bases
AGCACGGCAGCACCGGACGCGCCGGCATGGGGCCGGCGGGCCGGGATTGGCGGGAACGACTCCTCGCGGCGGGCGAACCG
CCGCTACCGAACCCGAGGGG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MKLVVGLGNPGEEYARTRHNVGFVVADRLAQLAGASFSAKKFAAELAEARLGPERVWIMKPQTYMNHSGEAVGAALRFWK
LGLDDLVVVHDDLELDPYRVQLKVGGGHGGHNGVKSVNAHVGSPEYARVRVGVGRPPPRMDPADYVLGKFAKGEDAELDL
CVEQAVEATRLAVELGAARAMNQVNRRSRAAD

Sequences:

>Translated_192_residues
MKLVVGLGNPGEEYARTRHNVGFVVADRLAQLAGASFSAKKFAAELAEARLGPERVWIMKPQTYMNHSGEAVGAALRFWK
LGLDDLVVVHDDLELDPYRVQLKVGGGHGGHNGVKSVNAHVGSPEYARVRVGVGRPPPRMDPADYVLGKFAKGEDAELDL
CVEQAVEATRLAVELGAARAMNQVNRRSRAAD
>Mature_192_residues
MKLVVGLGNPGEEYARTRHNVGFVVADRLAQLAGASFSAKKFAAELAEARLGPERVWIMKPQTYMNHSGEAVGAALRFWK
LGLDDLVVVHDDLELDPYRVQLKVGGGHGGHNGVKSVNAHVGSPEYARVRVGVGRPPPRMDPADYVLGKFAKGEDAELDL
CVEQAVEATRLAVELGAARAMNQVNRRSRAAD

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=168, Percent_Identity=36.9047619047619, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI1787455, Length=187, Percent_Identity=38.5026737967914, Blast_Score=109, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_ANAD2 (B8J804)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002490562.1
- ProteinModelPortal:   B8J804
- SMR:   B8J804
- GeneID:   7299779
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_0137
- HOGENOM:   HBG610927
- ProtClustDB:   PRK05426
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 20737; Mature: 20737

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVVGLGNPGEEYARTRHNVGFVVADRLAQLAGASFSAKKFAAELAEARLGPERVWIMK
CEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEC
PQTYMNHSGEAVGAALRFWKLGLDDLVVVHDDLELDPYRVQLKVGGGHGGHNGVKSVNAH
CHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCHHHHCCC
VGSPEYARVRVGVGRPPPRMDPADYVLGKFAKGEDAELDLCVEQAVEATRLAVELGAARA
CCCCCEEEEEEECCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
MNQVNRRSRAAD
HHHHHHHHCCCC
>Mature Secondary Structure
MKLVVGLGNPGEEYARTRHNVGFVVADRLAQLAGASFSAKKFAAELAEARLGPERVWIMK
CEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEC
PQTYMNHSGEAVGAALRFWKLGLDDLVVVHDDLELDPYRVQLKVGGGHGGHNGVKSVNAH
CHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCHHHHCCC
VGSPEYARVRVGVGRPPPRMDPADYVLGKFAKGEDAELDLCVEQAVEATRLAVELGAARA
CCCCCEEEEEEECCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
MNQVNRRSRAAD
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA