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The map label for this gene is aspC [H]

Identifier: 220905506

GI number: 220905506

Start: 2704779

End: 2705972

Strand: Reverse

Name: aspC [H]

Synonym: Ddes_2245

Alternate gene names: 220905506

Gene position: 2705972-2704779 (Counterclockwise)

Preceding gene: 220905508

Following gene: 220905504

Centisome position: 94.17

GC content: 60.47

Gene sequence:

>1194_bases
ATGCAGATTTCAGATCGTTTGAGCAGCATCAAACCCTCTCTGACCCTCAGTGTCAACAGTCGCGCCCTGGAACTCAAGGC
CCAGGGCGTTGCCGTAACCAGTCTGGCCGTGGGCGAACCGGACTTTCCCACGCCGCCCCACGTCTGTGAGGCCGCCAAGG
CCGCCATTGACGCAAATTTTTGCCGCTATACCGCCGTGCCCGGCATTCCGGATCTGCGCAAGGCCGCCGGAGCGTATTTT
GACCGCGCCTATGGCGTACCCGTGCCGCAGGAATCCATTGTTATCGGGGCCGGGGGCAAGCATTGCCTCTACAATTTTTT
GCAGGCCACTGTTAATCCGGGCGATGAGGTGCTTATTCCCGCGCCATACTGGCTGAGCTACCCTGATATGGTCATGCTGG
CGGGGGGGGTGCCGGTTACCGTGCACGCCGGGCCGGAGCAGGGCTTCAAGGTAACGCCCGGCATGCTGGATGCCGCGGCT
ACGGACAAAACACGTCTTCTTATCCTCAACTCGCCCAGCAACCCCACAGGGGCGGTGTACACCGAGGCGGAGTTTACGGC
CATTATGGACTGGGCCTTGGCACGCGGCATTTTTGTGCTGTCTGACGAAATTTATGACCAGCTTGTTTTTGCTCCGGCCA
AAATGACCAGCGCTATCGGCTGGTTTGCGCGCTATCCCGAGCAGGTGGCCGTGCTCAACGGGCTTTCAAAAAGCTACGCC
ATGACAGGCTGGCGGGTGGGTTTTCTTGCCGCGCACCCCACGCTGATAAAAAAAATATCGTCCATGCAGGGACACAGCAC
CTCCAGCATCTGTTCCATTGCGCAAAAGGCGGCTCTGGCGGCCCTGACCGGCCCCACGGACTGCATCGACACCATGCGCG
AGGCCTTTATGCGCCGTCGCGATCTGGGAATGAAGATCATAGGCTCCTGGCCCTGGGCCGTGTGCCCCAAGCCTGACGGG
GCCTTTTATCTTTTTGTGGACGTGCGCAAGTGCTATGGCGGCACGGTGAACAACTCCACCGAGCTGTGCACCCACCTGCT
GGACAAGGCGCATGTGGCCCTTGTGCCCGGCGCGGCCTTTGGCGACGACAATTGCATCCGCCTTTCCTATGCTGTGGCCG
ATGACGTTCTGGCACACGCGCTGAAAAACGCCGGAGCAGAGATGGCCCGGCTGGCCGAAGAGGTGGGCAGATAG

Upstream 100 bases:

>100_bases
TTTGGTACGCATTTACACCCCGTGGCGAAGCTGATAAAATTAACGGCTGTAATCTCGCCGCATGCGCCGCATTGCGTCCC
CCTTCGTGAAGGAGCCTCTC

Downstream 100 bases:

>100_bases
GACAGGTTTGCTGTTCCGTCAGGGCTTTCTGTGGATACTGGGGCTGGCCGGAAGGGTGCAGGTTCCCGAAGGCGTACAAA
GCGGACTTGTATGACGCCCG

Product: class I and II aminotransferase

Products: NA

Alternate protein names: AspAT; Transaminase A [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MQISDRLSSIKPSLTLSVNSRALELKAQGVAVTSLAVGEPDFPTPPHVCEAAKAAIDANFCRYTAVPGIPDLRKAAGAYF
DRAYGVPVPQESIVIGAGGKHCLYNFLQATVNPGDEVLIPAPYWLSYPDMVMLAGGVPVTVHAGPEQGFKVTPGMLDAAA
TDKTRLLILNSPSNPTGAVYTEAEFTAIMDWALARGIFVLSDEIYDQLVFAPAKMTSAIGWFARYPEQVAVLNGLSKSYA
MTGWRVGFLAAHPTLIKKISSMQGHSTSSICSIAQKAALAALTGPTDCIDTMREAFMRRRDLGMKIIGSWPWAVCPKPDG
AFYLFVDVRKCYGGTVNNSTELCTHLLDKAHVALVPGAAFGDDNCIRLSYAVADDVLAHALKNAGAEMARLAEEVGR

Sequences:

>Translated_397_residues
MQISDRLSSIKPSLTLSVNSRALELKAQGVAVTSLAVGEPDFPTPPHVCEAAKAAIDANFCRYTAVPGIPDLRKAAGAYF
DRAYGVPVPQESIVIGAGGKHCLYNFLQATVNPGDEVLIPAPYWLSYPDMVMLAGGVPVTVHAGPEQGFKVTPGMLDAAA
TDKTRLLILNSPSNPTGAVYTEAEFTAIMDWALARGIFVLSDEIYDQLVFAPAKMTSAIGWFARYPEQVAVLNGLSKSYA
MTGWRVGFLAAHPTLIKKISSMQGHSTSSICSIAQKAALAALTGPTDCIDTMREAFMRRRDLGMKIIGSWPWAVCPKPDG
AFYLFVDVRKCYGGTVNNSTELCTHLLDKAHVALVPGAAFGDDNCIRLSYAVADDVLAHALKNAGAEMARLAEEVGR
>Mature_397_residues
MQISDRLSSIKPSLTLSVNSRALELKAQGVAVTSLAVGEPDFPTPPHVCEAAKAAIDANFCRYTAVPGIPDLRKAAGAYF
DRAYGVPVPQESIVIGAGGKHCLYNFLQATVNPGDEVLIPAPYWLSYPDMVMLAGGVPVTVHAGPEQGFKVTPGMLDAAA
TDKTRLLILNSPSNPTGAVYTEAEFTAIMDWALARGIFVLSDEIYDQLVFAPAKMTSAIGWFARYPEQVAVLNGLSKSYA
MTGWRVGFLAAHPTLIKKISSMQGHSTSSICSIAQKAALAALTGPTDCIDTMREAFMRRRDLGMKIIGSWPWAVCPKPDG
AFYLFVDVRKCYGGTVNNSTELCTHLLDKAHVALVPGAAFGDDNCIRLSYAVADDVLAHALKNAGAEMARLAEEVGR

Specific function: Unknown

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=321, Percent_Identity=27.1028037383178, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI169881279, Length=321, Percent_Identity=27.1028037383178, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI56713254, Length=321, Percent_Identity=28.3489096573209, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI56713256, Length=321, Percent_Identity=28.3489096573209, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI4507369, Length=368, Percent_Identity=24.7282608695652, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI169881281, Length=233, Percent_Identity=24.4635193133047, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI215599424, Length=340, Percent_Identity=21.1764705882353, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI19263340, Length=340, Percent_Identity=21.1764705882353, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786816, Length=371, Percent_Identity=27.2237196765499, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI1788722, Length=391, Percent_Identity=27.8772378516624, Blast_Score=138, Evalue=8e-34,
Organism=Escherichia coli, GI1788627, Length=378, Percent_Identity=26.984126984127, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71994472, Length=429, Percent_Identity=24.9417249417249, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI71994476, Length=429, Percent_Identity=24.9417249417249, Blast_Score=101, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17567369, Length=263, Percent_Identity=28.5171102661597, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17567663, Length=279, Percent_Identity=25.8064516129032, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322401, Length=327, Percent_Identity=24.1590214067278, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323118, Length=346, Percent_Identity=23.9884393063584, Blast_Score=69, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6320317, Length=336, Percent_Identity=25, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI28573069, Length=366, Percent_Identity=25.1366120218579, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24646114, Length=366, Percent_Identity=25.1366120218579, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI28573067, Length=366, Percent_Identity=25.1366120218579, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI28573065, Length=366, Percent_Identity=25.1366120218579, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI18859735, Length=390, Percent_Identity=22.8205128205128, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR004839
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.1 [H]

Molecular weight: Translated: 42442; Mature: 42442

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQISDRLSSIKPSLTLSVNSRALELKAQGVAVTSLAVGEPDFPTPPHVCEAAKAAIDANF
CCCHHHHHHCCCCEEEEECCEEEEEEECCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCH
CRYTAVPGIPDLRKAAGAYFDRAYGVPVPQESIVIGAGGKHCLYNFLQATVNPGDEVLIP
HEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCEEEC
APYWLSYPDMVMLAGGVPVTVHAGPEQGFKVTPGMLDAAATDKTRLLILNSPSNPTGAVY
CCHHCCCCCEEEEECCCEEEEECCCCCCCEECCCCHHHCCCCCEEEEEEECCCCCCCEEE
TEAEFTAIMDWALARGIFVLSDEIYDQLVFAPAKMTSAIGWFARYPEQVAVLNGLSKSYA
ECCHHHHHHHHHHHCCEEEECHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHCCCHHHH
MTGWRVGFLAAHPTLIKKISSMQGHSTSSICSIAQKAALAALTGPTDCIDTMREAFMRRR
CCCEEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
DLGMKIIGSWPWAVCPKPDGAFYLFVDVRKCYGGTVNNSTELCTHLLDKAHVALVPGAAF
HCCCEEEECCCEEECCCCCCCEEEEEEEHHHCCCCCCCHHHHHHHHHCCCCEEEECCCCC
GDDNCIRLSYAVADDVLAHALKNAGAEMARLAEEVGR
CCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure
MQISDRLSSIKPSLTLSVNSRALELKAQGVAVTSLAVGEPDFPTPPHVCEAAKAAIDANF
CCCHHHHHHCCCCEEEEECCEEEEEEECCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCH
CRYTAVPGIPDLRKAAGAYFDRAYGVPVPQESIVIGAGGKHCLYNFLQATVNPGDEVLIP
HEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCEEEC
APYWLSYPDMVMLAGGVPVTVHAGPEQGFKVTPGMLDAAATDKTRLLILNSPSNPTGAVY
CCHHCCCCCEEEEECCCEEEEECCCCCCCEECCCCHHHCCCCCEEEEEEECCCCCCCEEE
TEAEFTAIMDWALARGIFVLSDEIYDQLVFAPAKMTSAIGWFARYPEQVAVLNGLSKSYA
ECCHHHHHHHHHHHCCEEEECHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHCCCHHHH
MTGWRVGFLAAHPTLIKKISSMQGHSTSSICSIAQKAALAALTGPTDCIDTMREAFMRRR
CCCEEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
DLGMKIIGSWPWAVCPKPDGAFYLFVDVRKCYGGTVNNSTELCTHLLDKAHVALVPGAAF
HCCCEEEECCCEEECCCCCCCEEEEEEEHHHCCCCCCCHHHHHHHHHCCCCEEEECCCCC
GDDNCIRLSYAVADDVLAHALKNAGAEMARLAEEVGR
CCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]