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The map label for this gene is cobQ [H]

Identifier: 220905439

GI number: 220905439

Start: 2625855

End: 2627540

Strand: Reverse

Name: cobQ [H]

Synonym: Ddes_2177

Alternate gene names: 220905439

Gene position: 2627540-2625855 (Counterclockwise)

Preceding gene: 220905452

Following gene: 220905438

Centisome position: 91.44

GC content: 67.62

Gene sequence:

>1686_bases
ATGGCCGGGCCTGCGCCGTCCGGCACACCGCCAGCCGTGCGTTCCGTCGCGGGGCCGGATGATCTGCCCCCGGCCCTCAT
GCTGCAGGGAACCTGCTCCAACGCGGGTAAAAGCCTGCTCACGGCGGCTCTGTGCCGTCTTCTGGCCCGCCGTGGCCTCA
GGGTCGTGCCTTTCAAGGCGCAGAACATGGCCCTCAATTCTTTTGTCACCCACGACGGCAAGGAGATGGGGCGCGCCCAG
GCGCTCCAGGCCGCCGCCTGCGGCCTGCCCGCAGATGTGCGCATGAACCCGGTGCTGCTCAAGCCCACGTCCCACACCGG
GTCGCAGGTCATTGTGCTGGGCGAGCCTGTGGGGCAGATGCGTGTGGGGGCCTACCTGCGCTATAAACCGGAGGCCTGGA
AGGCCGTACGCCGTGCCTACCGCAGCCTTGCGTCCGGGGCTGATGTGGTGGTGCTCGAGGGCGCGGGCAGCCCGGCGGAG
ATAAATCTCAAGGCCCATGATATCGTCAACATGCGTATGGCCCGTTACGCGCGCGCACATGTGGCCCTTGTGGCGGATAT
TGACAGGGGCGGAGCTTTTGCGGCCCTGGCGGGAACCATGACCTTGCTGACCCGGGCGGAAAGGGCGCGGGTGGCGGGAT
TTATTCTCAACAAGTTTCGTGGTGACCCGGGCCTACTGGATCCGGCCCTGCACATGCTCACCCGGCGCACGGGCAAGCCC
TTCTGGGGCGTCGTGCCCATGCTGGAAAATCTGCGCCTGCCCGAAGAGGATTCCGTCAGCTTCAAGCTGGGGATCACTCC
CGGCCTGGATATGGCGGGTATGAAGGGCATGGACGGTGGGGCCGCCGCGGCTGGCGGCGTACTGGATGTGCTTGTGCCGG
ACCTGCCGCACATCAGTAACGCCACGGACCTTGACGCCCTGCGCCAGGAGCATGGCCTGCGGGTGCGCATCGTGCGCCGG
GCCGAAGACTGGGGGCAGCCCCATGCCGTAATCCTGCCGGGCAGTCGCAACACGGCAGCAGACCTGCGTTTTTTGCGGGC
AACGGGGCTGGCGGACGCCATAGTTCTTTTCGCCCGTACCGCCATGGAGCGGCAGCGCGGGGTTCTGGCCGGCATATGCG
GGGGACTGCAGATGCTCGGCCGGGTCATAGCCGACCCCCTTGGCCTTGAAGAGGGCGGTCAGGAGCCGGGTCTTGACCTG
CTGCCGCTGGCAACCCGGCTGGAAGCAGCAAAGCAGTTGCTCCGCGTCAGCGGACGGGCCTGCCGATGCCTGACCGCGGT
CCTGCCGAAGGGAGAAATACCCGGCGAAACCGGGGCGCTGCTTCCTGCCCAGGAAGTGGCCGGGTATGAGATACACCACG
GCCGTACCCTGCCCCTTGCCGGACAGGAGGCGGACGCTGGCGGCCCCGGCCTGCGTGTGGTTATGGCCGATACGGCGGGC
CGACCTCTGGGCTGGGGGCTGTGCGACGCTGCGGGGCGGGCGCGGGTGTGGGGCAGTTACATGCACGGGCTTTTTGATGC
GGATGCCTTCAGGCACGCATTTCTGGCGGCGCTCCGGCGGGACGCCGGTCTGGCCCCCCTTGCCGGAGCGTCCTATGGCC
TTGGGCCGGAACTGGACCGCCTGGCCGACACTGTGGAAGCGTCCCTGGACATGCAGGCCATTTACGGCCTGCTTGGCCTG
TGTTAG

Upstream 100 bases:

>100_bases
TGCAAGTTCGTTCCCGGCAGGGCTGTGCGGCCGTGCCGTATCTTGCCCGGATCGCCTCTTGGGCGTATGAAGGGGCATGT
CTTTTTTGCGCTCTCCACAT

Downstream 100 bases:

>100_bases
GGTTCATTCTCAAGTAATCGCCTGCTGCAAAAAGCCCTTTCCTTCCGACGCAGCACAAGCAATCAAGCCGGCCGCCCTGC
GTATATGGCCCGGCACAGAG

Product: cobyric acid synthase CobQ

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 561; Mature: 560

Protein sequence:

>561_residues
MAGPAPSGTPPAVRSVAGPDDLPPALMLQGTCSNAGKSLLTAALCRLLARRGLRVVPFKAQNMALNSFVTHDGKEMGRAQ
ALQAAACGLPADVRMNPVLLKPTSHTGSQVIVLGEPVGQMRVGAYLRYKPEAWKAVRRAYRSLASGADVVVLEGAGSPAE
INLKAHDIVNMRMARYARAHVALVADIDRGGAFAALAGTMTLLTRAERARVAGFILNKFRGDPGLLDPALHMLTRRTGKP
FWGVVPMLENLRLPEEDSVSFKLGITPGLDMAGMKGMDGGAAAAGGVLDVLVPDLPHISNATDLDALRQEHGLRVRIVRR
AEDWGQPHAVILPGSRNTAADLRFLRATGLADAIVLFARTAMERQRGVLAGICGGLQMLGRVIADPLGLEEGGQEPGLDL
LPLATRLEAAKQLLRVSGRACRCLTAVLPKGEIPGETGALLPAQEVAGYEIHHGRTLPLAGQEADAGGPGLRVVMADTAG
RPLGWGLCDAAGRARVWGSYMHGLFDADAFRHAFLAALRRDAGLAPLAGASYGLGPELDRLADTVEASLDMQAIYGLLGL
C

Sequences:

>Translated_561_residues
MAGPAPSGTPPAVRSVAGPDDLPPALMLQGTCSNAGKSLLTAALCRLLARRGLRVVPFKAQNMALNSFVTHDGKEMGRAQ
ALQAAACGLPADVRMNPVLLKPTSHTGSQVIVLGEPVGQMRVGAYLRYKPEAWKAVRRAYRSLASGADVVVLEGAGSPAE
INLKAHDIVNMRMARYARAHVALVADIDRGGAFAALAGTMTLLTRAERARVAGFILNKFRGDPGLLDPALHMLTRRTGKP
FWGVVPMLENLRLPEEDSVSFKLGITPGLDMAGMKGMDGGAAAAGGVLDVLVPDLPHISNATDLDALRQEHGLRVRIVRR
AEDWGQPHAVILPGSRNTAADLRFLRATGLADAIVLFARTAMERQRGVLAGICGGLQMLGRVIADPLGLEEGGQEPGLDL
LPLATRLEAAKQLLRVSGRACRCLTAVLPKGEIPGETGALLPAQEVAGYEIHHGRTLPLAGQEADAGGPGLRVVMADTAG
RPLGWGLCDAAGRARVWGSYMHGLFDADAFRHAFLAALRRDAGLAPLAGASYGLGPELDRLADTVEASLDMQAIYGLLGL
C
>Mature_560_residues
AGPAPSGTPPAVRSVAGPDDLPPALMLQGTCSNAGKSLLTAALCRLLARRGLRVVPFKAQNMALNSFVTHDGKEMGRAQA
LQAAACGLPADVRMNPVLLKPTSHTGSQVIVLGEPVGQMRVGAYLRYKPEAWKAVRRAYRSLASGADVVVLEGAGSPAEI
NLKAHDIVNMRMARYARAHVALVADIDRGGAFAALAGTMTLLTRAERARVAGFILNKFRGDPGLLDPALHMLTRRTGKPF
WGVVPMLENLRLPEEDSVSFKLGITPGLDMAGMKGMDGGAAAAGGVLDVLVPDLPHISNATDLDALRQEHGLRVRIVRRA
EDWGQPHAVILPGSRNTAADLRFLRATGLADAIVLFARTAMERQRGVLAGICGGLQMLGRVIADPLGLEEGGQEPGLDLL
PLATRLEAAKQLLRVSGRACRCLTAVLPKGEIPGETGALLPAQEVAGYEIHHGRTLPLAGQEADAGGPGLRVVMADTAGR
PLGWGLCDAAGRARVWGSYMHGLFDADAFRHAFLAALRRDAGLAPLAGASYGLGPELDRLADTVEASLDMQAIYGLLGLC

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation [H]

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698 [H]

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3 [H]

EC number: 6.3.5.10

Molecular weight: Translated: 58981; Mature: 58850

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGPAPSGTPPAVRSVAGPDDLPPALMLQGTCSNAGKSLLTAALCRLLARRGLRVVPFKA
CCCCCCCCCCHHHHHCCCCCCCCHHEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEECC
QNMALNSFVTHDGKEMGRAQALQAAACGLPADVRMNPVLLKPTSHTGSQVIVLGEPVGQM
CCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCEEEEEECCCCCH
RVGAYLRYKPEAWKAVRRAYRSLASGADVVVLEGAGSPAEINLKAHDIVNMRMARYARAH
HHCEEEEECCHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHE
VALVADIDRGGAFAALAGTMTLLTRAERARVAGFILNKFRGDPGLLDPALHMLTRRTGKP
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC
FWGVVPMLENLRLPEEDSVSFKLGITPGLDMAGMKGMDGGAAAAGGVLDVLVPDLPHISN
HHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHCCHHHHHCCCCCCCCC
ATDLDALRQEHGLRVRIVRRAEDWGQPHAVILPGSRNTAADLRFLRATGLADAIVLFART
CCHHHHHHHHCCCEEEEEEEHHHCCCCCEEEECCCCCCHHHHHHHHHHCHHHHHHHHHHH
AMERQRGVLAGICGGLQMLGRVIADPLGLEEGGQEPGLDLLPLATRLEAAKQLLRVSGRA
HHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHH
CRCLTAVLPKGEIPGETGALLPAQEVAGYEIHHGRTLPLAGQEADAGGPGLRVVMADTAG
HHHHHHHCCCCCCCCCCCCCCCHHHHCCEEEECCCCCCCCCCCCCCCCCCEEEEEECCCC
RPLGWGLCDAAGRARVWGSYMHGLFDADAFRHAFLAALRRDAGLAPLAGASYGLGPELDR
CCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHH
LADTVEASLDMQAIYGLLGLC
HHHHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure 
AGPAPSGTPPAVRSVAGPDDLPPALMLQGTCSNAGKSLLTAALCRLLARRGLRVVPFKA
CCCCCCCCCHHHHHCCCCCCCCHHEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEECC
QNMALNSFVTHDGKEMGRAQALQAAACGLPADVRMNPVLLKPTSHTGSQVIVLGEPVGQM
CCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCEEEEEECCCCCH
RVGAYLRYKPEAWKAVRRAYRSLASGADVVVLEGAGSPAEINLKAHDIVNMRMARYARAH
HHCEEEEECCHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHE
VALVADIDRGGAFAALAGTMTLLTRAERARVAGFILNKFRGDPGLLDPALHMLTRRTGKP
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC
FWGVVPMLENLRLPEEDSVSFKLGITPGLDMAGMKGMDGGAAAAGGVLDVLVPDLPHISN
HHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHCCHHHHHCCCCCCCCC
ATDLDALRQEHGLRVRIVRRAEDWGQPHAVILPGSRNTAADLRFLRATGLADAIVLFART
CCHHHHHHHHCCCEEEEEEEHHHCCCCCEEEECCCCCCHHHHHHHHHHCHHHHHHHHHHH
AMERQRGVLAGICGGLQMLGRVIADPLGLEEGGQEPGLDLLPLATRLEAAKQLLRVSGRA
HHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHH
CRCLTAVLPKGEIPGETGALLPAQEVAGYEIHHGRTLPLAGQEADAGGPGLRVVMADTAG
HHHHHHHCCCCCCCCCCCCCCCHHHHCCEEEECCCCCCCCCCCCCCCCCCEEEEEECCCC
RPLGWGLCDAAGRARVWGSYMHGLFDADAFRHAFLAALRRDAGLAPLAGASYGLGPELDR
CCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHH
LADTVEASLDMQAIYGLLGLC
HHHHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA