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The map label for this gene is kbl [C]

Identifier: 220905321

GI number: 220905321

Start: 2475913

End: 2477235

Strand: Reverse

Name: kbl [C]

Synonym: Ddes_2059

Alternate gene names: 220905321

Gene position: 2477235-2475913 (Counterclockwise)

Preceding gene: 220905322

Following gene: 220905320

Centisome position: 86.21

GC content: 58.81

Gene sequence:

>1323_bases
ATGAAGAAAGACCATTCCTGTCAGGCCGGAAAAGAGGCGGCATCAACAACCGCTGCCGCTACTGAAAGCTCCGCCGGCGG
TTTCAGCCGCATGCGTTCCAAGCTCGCCTTTGACCGGCTTGTGGAGATGGGAGCCAAGATGGGGATGGAGAATCCTCTTT
TTCTTTGCCACGAGCGCGCGGCCAAGGCCACAACGCTCATTGAAGGCAAGGAATATCTGAACTTTTCCACCTACGATTAT
CTGGATATCAACGCCCATCCGGAAATAACCGAGGTCGTCACCGAGGCCGCCGCCGTGTACGGCACTTCTGCCGGAGCCAG
CCGTCTTGTGGGTGGCGAGCGCCCGCCCCACCGTGCGCTGGAGCGCGCCTTCGCTGACCTGTACGGCGTGGAAGACAGTA
TCGTATACGTGAGCGGCCACGCCACCAACGTATCCACTCTGGGTTTTCTGCTTGGCCACCGCGACGCCATCTTTCACGAC
GGTCTGGCCCACAATTCGCTGATTCAGGGCGCACGCCTGTCCCATGCGGCGCGCTACTCGTATAATCACAACGACTGCGA
TGCCCTTGAGGAGATTCTCAAGGCCAAGCGCGCAGAGCATAAACGGGCCATTATCGTTACCGAAGGCCTGTTCAGCATGG
ACGGCAACATTCCCGACCTGCCCCGCATCATTCAGCTGAAAAAGCAGTACGACTGCATGCTGCTGGTGGACGAGGCGCAC
TCGCTGGGCGTGCTAGGCGCAACCGGGCGCGGCGCTCACGAGCACTTCGGCATTGACGCCAACGAAGTGGACATGTGGAT
GAGCACGCTCTCCAAGTCCATGTGCGGGTGCGGCGGTTTTATCGCCGGCCGGCATGAGCTGGTGGAATTTCTCAAGTATG
GTTCGCCGGGCTTTGTGTTCAGCGTGGGTATGCCCCCGGTTATTGCCGTGGCCTGCCACAAGGCTCTGGACATCATGCTG
CGCGAACCGGAACGGGTACACAAGCTGCAGCGGATTTCCAAGTTTTTTGTGGAGTATGCTTCGAGCATCGGCCTTGATAC
GGGCGCGGCCCAGGGCTACGCCATTGTACCTGTCATGGTGGGTGACCCCATGGTGGCGGGTTTTCTGTCCAACGCCCTGT
TCAAGCGCGGCATCTACGTCATGCCCATCACCTTCCCCGCCGTCAAGGAAGGCACAGACCGGCTGCGTTTCTTCCTTTCG
GCCGCCCATACGGAAGAGCATATCCGCAAGGCGCTCGATGCTGTGAAAGAAGAGATTCCCAAGGCGCAGGCCATTGTTGA
AAAATACAAAAACGACCACGCCGAAGAATCCCTGGGCGAATAA

Upstream 100 bases:

>100_bases
TTTGGCTATACTAAATCCTTACAAAGTTGCGCTCTGTGCCCGGCGGCTCGCCGCAGGGTGCGGATAGGCGCGTTTTTTGG
ACAAATTAAGAGGACAAGGC

Downstream 100 bases:

>100_bases
AAAATAACACTCCGGCCGGGCCTTATGGCCCGGCTCTCGTTTGCTGCGGAGACCGACATGTCTTTTACCAGTGGCGATGC
CACAGAAGCGGGAGCGGAAC

Product: glycine C-acetyltransferase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MKKDHSCQAGKEAASTTAAATESSAGGFSRMRSKLAFDRLVEMGAKMGMENPLFLCHERAAKATTLIEGKEYLNFSTYDY
LDINAHPEITEVVTEAAAVYGTSAGASRLVGGERPPHRALERAFADLYGVEDSIVYVSGHATNVSTLGFLLGHRDAIFHD
GLAHNSLIQGARLSHAARYSYNHNDCDALEEILKAKRAEHKRAIIVTEGLFSMDGNIPDLPRIIQLKKQYDCMLLVDEAH
SLGVLGATGRGAHEHFGIDANEVDMWMSTLSKSMCGCGGFIAGRHELVEFLKYGSPGFVFSVGMPPVIAVACHKALDIML
REPERVHKLQRISKFFVEYASSIGLDTGAAQGYAIVPVMVGDPMVAGFLSNALFKRGIYVMPITFPAVKEGTDRLRFFLS
AAHTEEHIRKALDAVKEEIPKAQAIVEKYKNDHAEESLGE

Sequences:

>Translated_440_residues
MKKDHSCQAGKEAASTTAAATESSAGGFSRMRSKLAFDRLVEMGAKMGMENPLFLCHERAAKATTLIEGKEYLNFSTYDY
LDINAHPEITEVVTEAAAVYGTSAGASRLVGGERPPHRALERAFADLYGVEDSIVYVSGHATNVSTLGFLLGHRDAIFHD
GLAHNSLIQGARLSHAARYSYNHNDCDALEEILKAKRAEHKRAIIVTEGLFSMDGNIPDLPRIIQLKKQYDCMLLVDEAH
SLGVLGATGRGAHEHFGIDANEVDMWMSTLSKSMCGCGGFIAGRHELVEFLKYGSPGFVFSVGMPPVIAVACHKALDIML
REPERVHKLQRISKFFVEYASSIGLDTGAAQGYAIVPVMVGDPMVAGFLSNALFKRGIYVMPITFPAVKEGTDRLRFFLS
AAHTEEHIRKALDAVKEEIPKAQAIVEKYKNDHAEESLGE
>Mature_440_residues
MKKDHSCQAGKEAASTTAAATESSAGGFSRMRSKLAFDRLVEMGAKMGMENPLFLCHERAAKATTLIEGKEYLNFSTYDY
LDINAHPEITEVVTEAAAVYGTSAGASRLVGGERPPHRALERAFADLYGVEDSIVYVSGHATNVSTLGFLLGHRDAIFHD
GLAHNSLIQGARLSHAARYSYNHNDCDALEEILKAKRAEHKRAIIVTEGLFSMDGNIPDLPRIIQLKKQYDCMLLVDEAH
SLGVLGATGRGAHEHFGIDANEVDMWMSTLSKSMCGCGGFIAGRHELVEFLKYGSPGFVFSVGMPPVIAVACHKALDIML
REPERVHKLQRISKFFVEYASSIGLDTGAAQGYAIVPVMVGDPMVAGFLSNALFKRGIYVMPITFPAVKEGTDRLRFFLS
AAHTEEHIRKALDAVKEEIPKAQAIVEKYKNDHAEESLGE

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI119220554, Length=387, Percent_Identity=33.5917312661499, Blast_Score=211, Evalue=2e-54,
Organism=Homo sapiens, GI7657118, Length=346, Percent_Identity=33.5260115606936, Blast_Score=201, Evalue=8e-52,
Organism=Homo sapiens, GI284448556, Length=346, Percent_Identity=33.5260115606936, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI4758668, Length=366, Percent_Identity=35.2459016393443, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI83977442, Length=346, Percent_Identity=29.4797687861272, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI83977444, Length=347, Percent_Identity=29.3948126801153, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI83977440, Length=347, Percent_Identity=29.6829971181556, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI4502025, Length=355, Percent_Identity=28.7323943661972, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI40316939, Length=355, Percent_Identity=28.7323943661972, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI5454084, Length=268, Percent_Identity=30.2238805970149, Blast_Score=135, Evalue=8e-32,
Organism=Escherichia coli, GI1790046, Length=352, Percent_Identity=36.9318181818182, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1786993, Length=351, Percent_Identity=30.4843304843305, Blast_Score=155, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI71994529, Length=348, Percent_Identity=34.4827586206897, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17560912, Length=310, Percent_Identity=35.4838709677419, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17560914, Length=311, Percent_Identity=35.3697749196142, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI32566772, Length=365, Percent_Identity=31.5068493150685, Blast_Score=185, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI71982617, Length=276, Percent_Identity=30.7971014492754, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71982625, Length=276, Percent_Identity=30.7971014492754, Blast_Score=150, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6320267, Length=360, Percent_Identity=30.5555555555556, Blast_Score=179, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6320438, Length=379, Percent_Identity=28.7598944591029, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6323954, Length=271, Percent_Identity=30.6273062730627, Blast_Score=138, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24662918, Length=349, Percent_Identity=37.8223495702006, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI17136286, Length=361, Percent_Identity=33.5180055401662, Blast_Score=191, Evalue=9e-49,
Organism=Drosophila melanogaster, GI17137420, Length=381, Percent_Identity=29.1338582677165, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24653280, Length=293, Percent_Identity=31.0580204778157, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24653276, Length=293, Percent_Identity=31.0580204778157, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24653278, Length=293, Percent_Identity=31.0580204778157, Blast_Score=146, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 48049; Mature: 48049

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKDHSCQAGKEAASTTAAATESSAGGFSRMRSKLAFDRLVEMGAKMGMENPLFLCHERA
CCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
AKATTLIEGKEYLNFSTYDYLDINAHPEITEVVTEAAAVYGTSAGASRLVGGERPPHRAL
HHHHHEECCHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCHHCCCCCCCHHHHH
ERAFADLYGVEDSIVYVSGHATNVSTLGFLLGHRDAIFHDGLAHNSLIQGARLSHAARYS
HHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCHHHHHCCCHHHHHHHCHHHHHHHHCC
YNHNDCDALEEILKAKRAEHKRAIIVTEGLFSMDGNIPDLPRIIQLKKQYDCMLLVDEAH
CCCCCHHHHHHHHHHHHHCCCEEEEEECCHHHCCCCCCCCHHHHHHHHCCCEEEEEECCC
SLGVLGATGRGAHEHFGIDANEVDMWMSTLSKSMCGCGGFIAGRHELVEFLKYGSPGFVF
CCCEEECCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHCCCCCEEE
SVGMPPVIAVACHKALDIMLREPERVHKLQRISKFFVEYASSIGLDTGAAQGYAIVPVMV
ECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEE
GDPMVAGFLSNALFKRGIYVMPITFPAVKEGTDRLRFFLSAAHTEEHIRKALDAVKEEIP
CCHHHHHHHHHHHHHCCCEEEEEECHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KAQAIVEKYKNDHAEESLGE
HHHHHHHHHHCCCHHHHCCC
>Mature Secondary Structure
MKKDHSCQAGKEAASTTAAATESSAGGFSRMRSKLAFDRLVEMGAKMGMENPLFLCHERA
CCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
AKATTLIEGKEYLNFSTYDYLDINAHPEITEVVTEAAAVYGTSAGASRLVGGERPPHRAL
HHHHHEECCHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCHHCCCCCCCHHHHH
ERAFADLYGVEDSIVYVSGHATNVSTLGFLLGHRDAIFHDGLAHNSLIQGARLSHAARYS
HHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCHHHHHCCCHHHHHHHCHHHHHHHHCC
YNHNDCDALEEILKAKRAEHKRAIIVTEGLFSMDGNIPDLPRIIQLKKQYDCMLLVDEAH
CCCCCHHHHHHHHHHHHHCCCEEEEEECCHHHCCCCCCCCHHHHHHHHCCCEEEEEECCC
SLGVLGATGRGAHEHFGIDANEVDMWMSTLSKSMCGCGGFIAGRHELVEFLKYGSPGFVF
CCCEEECCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHCCCCCEEE
SVGMPPVIAVACHKALDIMLREPERVHKLQRISKFFVEYASSIGLDTGAAQGYAIVPVMV
ECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEE
GDPMVAGFLSNALFKRGIYVMPITFPAVKEGTDRLRFFLSAAHTEEHIRKALDAVKEEIP
CCHHHHHHHHHHHHHCCCEEEEEECHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KAQAIVEKYKNDHAEESLGE
HHHHHHHHHHCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA