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The map label for this gene is glcD [H]

Identifier: 220905256

GI number: 220905256

Start: 2401144

End: 2402529

Strand: Reverse

Name: glcD [H]

Synonym: Ddes_1994

Alternate gene names: 220905256

Gene position: 2402529-2401144 (Counterclockwise)

Preceding gene: 220905260

Following gene: 220905255

Centisome position: 83.61

GC content: 60.53

Gene sequence:

>1386_bases
ATGGCAAGCCAGGCGTTGATCAGGGATTTTGAAGATCTCATCGGCAAGGAAAACGTGTTCAGCTCCGAAGCTGACCGGCA
GAGCTATTCGTATGACTCGGCAGTGCTGACCCCCGTGGTGCCTGCGCTTGTGCTGCGTCCGACCACTGCCGAGCAGCTGG
GAGCATGTGTCAAAAAGCTGTATGACAACGGTCTGCCCATGACTGTACGCGGCGCGGGAACCAACCTCTCCGGCGGCACC
ATCCCCGACAATTCCGACTCTGTGGTTATTCTGACCACCGGACTCAACCGCATTCTTGAGATCAACTCCGACGACCTTTA
TGCCGTGGTGGAGCCGGGCGTGATCACTGCCCAGTTCGCCGCCGAAGTGGCCAAGAAAAATCTGTTCTATCCCCCGGACC
CGGGTTCTCAGGCCGTATCGACCATTGGCGGCAATATTGCTGAAAACGCCGGCGGCCTACGCGGCCTCAAGTACGGCGTC
ACCAAAGACTATCTCATGGGCATCGAATTTTTTGACGCCACCGGCGAGATGGTCAAGTCCGGTTCGCGCACGGTCAAGTG
CGTTACGGGCTACAACCTGGCCGGCATGATGGTGCAGTCTGAAGGTACGCTGGGCATTATTTCCCAGGCCATTCTCAAGC
TTGTGCCCCCGCCGAAGGCCTCCAAGGCCCTGATGGCCGTGTTTGAAAATGTGCAGGACGCCGCCGAAGCCGTGGCTGGC
ATTATTGCCGCCCACGTTGTGCCCTGTACGCTTGAGTTCCTTGACAACAATACCATTGTGCGCGTGGACGACTTCACCAA
GGCCGGTCTGCCGCGCGAAGCCGGAGCCATCCTGCTCATCGAGGTGGACGGCCACCCCGCCCAGGTCGCGGACGACGCCG
AAGCTGTGGAGCGTGTGCTCAAGGCCAACCGCGCCACCGCCGTGCATGTGCCCAAGGACGCCGACGAAAAATTCAAACTG
TGGGAAGCCCGCCGCATGGCTCTGCCCGTGCTGGCCCGCTGCCGTCCCACTACCGTGCTTGAAGACGCCACCGTGCCGCG
TTCGCAGATTCCTGCCATGATGAAGGCCGTTAACGAAATCGCCGCCAAGTACAAGGTTGAAGTGGGCACGTTCGGCCATG
CCGGCGACGGCAACCTGCACCCCACCTTCCTGTGCGACAAGCGCGACAAGGACGAGTTCCACCGGGTGGAAGAGGCCATT
GACGAAATGTTCGATGTGGCCCTCAAGCTGCACGGCACGCTTTCGGGTGAGCACGGCATCGGCACGGCCAAGGCCAAGTG
GATGGAAAAAGAAACCTCGCGCGGCACCATTCTGTTCTCTCAGCGGCTGCGTCGCGCCCTTGACCCCAAGGGCCTGTTCA
ACGCCACCAAGCTGGTGGGAATCTAG

Upstream 100 bases:

>100_bases
GGCCGGTCAACCGGCCGCACATGTGCCCGGCATGTCCGGGCTGGCGCGTGGGGCGCGCGGGCTGCGCCCTCCACCATTAC
AGATGTTCTAAGGAGGCCAC

Downstream 100 bases:

>100_bases
GAGCCTTACATGAGTAATCTGCACGAACTGGCCCAGCGCCTTATGGCGCTGGACGACAAAGTCACGGCCTGCATGAAATG
CGGCATGTGCCAGGCCGTGT

Product: FAD linked oxidase domain-containing protein

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MASQALIRDFEDLIGKENVFSSEADRQSYSYDSAVLTPVVPALVLRPTTAEQLGACVKKLYDNGLPMTVRGAGTNLSGGT
IPDNSDSVVILTTGLNRILEINSDDLYAVVEPGVITAQFAAEVAKKNLFYPPDPGSQAVSTIGGNIAENAGGLRGLKYGV
TKDYLMGIEFFDATGEMVKSGSRTVKCVTGYNLAGMMVQSEGTLGIISQAILKLVPPPKASKALMAVFENVQDAAEAVAG
IIAAHVVPCTLEFLDNNTIVRVDDFTKAGLPREAGAILLIEVDGHPAQVADDAEAVERVLKANRATAVHVPKDADEKFKL
WEARRMALPVLARCRPTTVLEDATVPRSQIPAMMKAVNEIAAKYKVEVGTFGHAGDGNLHPTFLCDKRDKDEFHRVEEAI
DEMFDVALKLHGTLSGEHGIGTAKAKWMEKETSRGTILFSQRLRRALDPKGLFNATKLVGI

Sequences:

>Translated_461_residues
MASQALIRDFEDLIGKENVFSSEADRQSYSYDSAVLTPVVPALVLRPTTAEQLGACVKKLYDNGLPMTVRGAGTNLSGGT
IPDNSDSVVILTTGLNRILEINSDDLYAVVEPGVITAQFAAEVAKKNLFYPPDPGSQAVSTIGGNIAENAGGLRGLKYGV
TKDYLMGIEFFDATGEMVKSGSRTVKCVTGYNLAGMMVQSEGTLGIISQAILKLVPPPKASKALMAVFENVQDAAEAVAG
IIAAHVVPCTLEFLDNNTIVRVDDFTKAGLPREAGAILLIEVDGHPAQVADDAEAVERVLKANRATAVHVPKDADEKFKL
WEARRMALPVLARCRPTTVLEDATVPRSQIPAMMKAVNEIAAKYKVEVGTFGHAGDGNLHPTFLCDKRDKDEFHRVEEAI
DEMFDVALKLHGTLSGEHGIGTAKAKWMEKETSRGTILFSQRLRRALDPKGLFNATKLVGI
>Mature_460_residues
ASQALIRDFEDLIGKENVFSSEADRQSYSYDSAVLTPVVPALVLRPTTAEQLGACVKKLYDNGLPMTVRGAGTNLSGGTI
PDNSDSVVILTTGLNRILEINSDDLYAVVEPGVITAQFAAEVAKKNLFYPPDPGSQAVSTIGGNIAENAGGLRGLKYGVT
KDYLMGIEFFDATGEMVKSGSRTVKCVTGYNLAGMMVQSEGTLGIISQAILKLVPPPKASKALMAVFENVQDAAEAVAGI
IAAHVVPCTLEFLDNNTIVRVDDFTKAGLPREAGAILLIEVDGHPAQVADDAEAVERVLKANRATAVHVPKDADEKFKLW
EARRMALPVLARCRPTTVLEDATVPRSQIPAMMKAVNEIAAKYKVEVGTFGHAGDGNLHPTFLCDKRDKDEFHRVEEAID
EMFDVALKLHGTLSGEHGIGTAKAKWMEKETSRGTILFSQRLRRALDPKGLFNATKLVGI

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=463, Percent_Identity=31.1015118790497, Blast_Score=223, Evalue=4e-58,
Organism=Homo sapiens, GI37595754, Length=486, Percent_Identity=29.8353909465021, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI119964728, Length=423, Percent_Identity=26.4775413711584, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI4501993, Length=262, Percent_Identity=24.8091603053435, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI1789351, Length=439, Percent_Identity=35.9908883826879, Blast_Score=285, Evalue=4e-78,
Organism=Escherichia coli, GI1787977, Length=517, Percent_Identity=21.2765957446809, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI48994914, Length=151, Percent_Identity=29.1390728476821, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71992373, Length=457, Percent_Identity=28.2275711159737, Blast_Score=195, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI71992381, Length=457, Percent_Identity=27.1334792122538, Blast_Score=181, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI71992392, Length=365, Percent_Identity=28.4931506849315, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17534361, Length=470, Percent_Identity=25.3191489361702, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17556096, Length=226, Percent_Identity=21.2389380530973, Blast_Score=82, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6320027, Length=469, Percent_Identity=27.0788912579957, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6320023, Length=475, Percent_Identity=26.7368421052632, Blast_Score=150, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6320764, Length=476, Percent_Identity=22.4789915966387, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI18921117, Length=469, Percent_Identity=25.5863539445629, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24639277, Length=469, Percent_Identity=25.5863539445629, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24639275, Length=469, Percent_Identity=25.5863539445629, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24653753, Length=225, Percent_Identity=24.4444444444444, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 49522; Mature: 49391

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASQALIRDFEDLIGKENVFSSEADRQSYSYDSAVLTPVVPALVLRPTTAEQLGACVKKL
CCCHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
YDNGLPMTVRGAGTNLSGGTIPDNSDSVVILTTGLNRILEINSDDLYAVVEPGVITAQFA
HCCCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCCEEEEECCCEEHHHHH
AEVAKKNLFYPPDPGSQAVSTIGGNIAENAGGLRGLKYGVTKDYLMGIEFFDATGEMVKS
HHHHHCCCCCCCCCCHHHHHHHCCCHHHCCCCCCCEECCCCHHHHHCCCEECCCHHHHHC
GSRTVKCVTGYNLAGMMVQSEGTLGIISQAILKLVPPPKASKALMAVFENVQDAAEAVAG
CCCEEEEEECCCEEEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
IIAAHVVPCTLEFLDNNTIVRVDDFTKAGLPREAGAILLIEVDGHPAQVADDAEAVERVL
HHHHHHHHHHHEEECCCCEEEECCCHHCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHH
KANRATAVHVPKDADEKFKLWEARRMALPVLARCRPTTVLEDATVPRSQIPAMMKAVNEI
HCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHH
AAKYKVEVGTFGHAGDGNLHPTFLCDKRDKDEFHRVEEAIDEMFDVALKLHGTLSGEHGI
HHHEEEEECCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GTAKAKWMEKETSRGTILFSQRLRRALDPKGLFNATKLVGI
CHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCCCCCHHHCCC
>Mature Secondary Structure 
ASQALIRDFEDLIGKENVFSSEADRQSYSYDSAVLTPVVPALVLRPTTAEQLGACVKKL
CCHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
YDNGLPMTVRGAGTNLSGGTIPDNSDSVVILTTGLNRILEINSDDLYAVVEPGVITAQFA
HCCCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCCEEEEECCCEEHHHHH
AEVAKKNLFYPPDPGSQAVSTIGGNIAENAGGLRGLKYGVTKDYLMGIEFFDATGEMVKS
HHHHHCCCCCCCCCCHHHHHHHCCCHHHCCCCCCCEECCCCHHHHHCCCEECCCHHHHHC
GSRTVKCVTGYNLAGMMVQSEGTLGIISQAILKLVPPPKASKALMAVFENVQDAAEAVAG
CCCEEEEEECCCEEEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
IIAAHVVPCTLEFLDNNTIVRVDDFTKAGLPREAGAILLIEVDGHPAQVADDAEAVERVL
HHHHHHHHHHHEEECCCCEEEECCCHHCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHH
KANRATAVHVPKDADEKFKLWEARRMALPVLARCRPTTVLEDATVPRSQIPAMMKAVNEI
HCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHH
AAKYKVEVGTFGHAGDGNLHPTFLCDKRDKDEFHRVEEAIDEMFDVALKLHGTLSGEHGI
HHHEEEEECCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GTAKAKWMEKETSRGTILFSQRLRRALDPKGLFNATKLVGI
CHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]