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The map label for this gene is hpt [H]

Identifier: 220904708

GI number: 220904708

Start: 1725513

End: 1726064

Strand: Reverse

Name: hpt [H]

Synonym: Ddes_1440

Alternate gene names: 220904708

Gene position: 1726064-1725513 (Counterclockwise)

Preceding gene: 220904709

Following gene: 220904707

Centisome position: 60.07

GC content: 51.81

Gene sequence:

>552_bases
ATGTCTAAGGTGGGGCATGAGCTCAAGGTCAAAGAACTGAAGACTGTTTTCAGCCAGGAACAGATTGCCGAACGGGTGCA
GGAACTGGCGGCTGAAATTGACGCCTGTTACGGCCAGGAACCCTTGGTAGCCATATGTGTGCTCAAGGGCGGCTTTGTGT
TTTTCAGCGATCTGGTACGGGCTTTGCAAAATAAAAATCTGGAGCTGGACTTCGTGCGCCTGTCCAGCTACGGCAAGGGA
GCAAGCAGCTCCAAGCATGTTATTTTCAGCAAGGATGTTGAGATTGACATCTGTGACAAGCATGTGCTGATTGTTGAAGA
TATTGTGGACAGCGGCCACAGCATGCGTTTTCTGCTCGGGCAGTTTGCCGCGCGCAAGGCCCGCAGCCTGCGCCTGGCCG
CATTGGTAGACAAGAATGAAAGGCGCGAAATTGACGTTCACGTCGACTTTGCCGGCTTCAAGCTGACTCAGGGCTTTATT
GTGGGGTATGGTCTCGATTACGCCGAACACTATCGTAATCTGCCCGCTGTTTTTGAGATCATTCCCGAATAA

Upstream 100 bases:

>100_bases
CCTACCGCATTGATCAATGCGGATATGTTCGCCATGGAGCCGGAAAATCTTGCGGCCCCTGAAGATGGGGCCGCCCGCGC
GGCCCGTGCTGGAGGATCAG

Downstream 100 bases:

>100_bases
ATGTTCTGCTGTTCCGGCTGCCGGATACGGTTTTGGAGAGTAACGGCATGGAAGTAAGATGTCCCAATTGTTCAAGCCGC
TTTAACCTGCCGGATCAACT

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 183; Mature: 182

Protein sequence:

>183_residues
MSKVGHELKVKELKTVFSQEQIAERVQELAAEIDACYGQEPLVAICVLKGGFVFFSDLVRALQNKNLELDFVRLSSYGKG
ASSSKHVIFSKDVEIDICDKHVLIVEDIVDSGHSMRFLLGQFAARKARSLRLAALVDKNERREIDVHVDFAGFKLTQGFI
VGYGLDYAEHYRNLPAVFEIIPE

Sequences:

>Translated_183_residues
MSKVGHELKVKELKTVFSQEQIAERVQELAAEIDACYGQEPLVAICVLKGGFVFFSDLVRALQNKNLELDFVRLSSYGKG
ASSSKHVIFSKDVEIDICDKHVLIVEDIVDSGHSMRFLLGQFAARKARSLRLAALVDKNERREIDVHVDFAGFKLTQGFI
VGYGLDYAEHYRNLPAVFEIIPE
>Mature_182_residues
SKVGHELKVKELKTVFSQEQIAERVQELAAEIDACYGQEPLVAICVLKGGFVFFSDLVRALQNKNLELDFVRLSSYGKGA
SSSKHVIFSKDVEIDICDKHVLIVEDIVDSGHSMRFLLGQFAARKARSLRLAALVDKNERREIDVHVDFAGFKLTQGFIV
GYGLDYAEHYRNLPAVFEIIPE

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=173, Percent_Identity=35.2601156069364, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI9910262, Length=161, Percent_Identity=36.0248447204969, Blast_Score=104, Evalue=5e-23,
Organism=Escherichia coli, GI87081689, Length=171, Percent_Identity=39.1812865497076, Blast_Score=129, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17510817, Length=165, Percent_Identity=34.5454545454545, Blast_Score=100, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20575; Mature: 20444

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVGHELKVKELKTVFSQEQIAERVQELAAEIDACYGQEPLVAICVLKGGFVFFSDLVR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCHHHHHHHHH
ALQNKNLELDFVRLSSYGKGASSSKHVIFSKDVEIDICDKHVLIVEDIVDSGHSMRFLLG
HHHCCCCEEEEEEECCCCCCCCCCCEEEEECCCEEEECCCEEEEEEHHHCCCCHHHHHHH
QFAARKARSLRLAALVDKNERREIDVHVDFAGFKLTQGFIVGYGLDYAEHYRNLPAVFEI
HHHHHHHHHEEEEEEECCCCCEEEEEEEEECCEEEECCEEEEECCCHHHHHCCCCHHHEE
IPE
CCC
>Mature Secondary Structure 
SKVGHELKVKELKTVFSQEQIAERVQELAAEIDACYGQEPLVAICVLKGGFVFFSDLVR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCHHHHHHHHH
ALQNKNLELDFVRLSSYGKGASSSKHVIFSKDVEIDICDKHVLIVEDIVDSGHSMRFLLG
HHHCCCCEEEEEEECCCCCCCCCCCEEEEECCCEEEECCCEEEEEEHHHCCCCHHHHHHH
QFAARKARSLRLAALVDKNERREIDVHVDFAGFKLTQGFIVGYGLDYAEHYRNLPAVFEI
HHHHHHHHHEEEEEEECCCCCEEEEEEEEECCEEEECCEEEEECCCHHHHHCCCCHHHEE
IPE
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663927 [H]