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The map label for this gene is adh1 [H]

Identifier: 220904637

GI number: 220904637

Start: 1641739

End: 1642845

Strand: Direct

Name: adh1 [H]

Synonym: Ddes_1369

Alternate gene names: 220904637

Gene position: 1641739-1642845 (Clockwise)

Preceding gene: 220904636

Following gene: 220904638

Centisome position: 57.14

GC content: 58.36

Gene sequence:

>1107_bases
GTGACCCAGTTCTACGGAAAGACGAAAATCTGCTACGGCCCTTACGCGCTGGAAACCCTTGAAAGTTTCCCCGCCAGTCA
CGCCTTTGTGGTAACTGACCCCTTTATGGTCAAAAGCGGCTTTGCCGACCAGGCTGTAAGCCACTTGAAACGTAAAGGGA
TAGGCTTCAGCATTTTTTCAGGTGTGGAGCCGGACCCCACACTGCAGGCCGTGGTAGAAGCCACGGGACATTTTCTGCGC
AGCAAGGCAGACATGATTCTTGCTCTCGGCGGCGGCTCGGCCATTGACATGGCCAAAGCCATCTCCTACTTCGGGCACAA
AGCCGCCCGCGACCGCAAGGCCATGCTGGTGGCCATTCCCACTACCAGTGGCACCGGGTCAGAAGTAACCTCCATCGCCG
TCATCACCGACAAGGTCAATGCGGTCAAGATTCCTCTTAATGACGAGTTGCTCATTCCGGACGCGGCCATCCTTGACGCC
CGCTTCACACGCACCGTACCGCCGCATGTGACCGCCTCCACCGGAATGGACGTGCTTACTCACGCTGTGGAGGCCTACAC
CTCGCGCCACAGCAACGTTTTTACGGCCATATATGCCGAACGGGCCATACGCAACGTCTTTACCTACCTGCACCGCGCCT
ACGAGCAGGGTGACGACATGGTAGCCAGAGACAACATGCTCATAGGTTCCTGCATGGCCGGTCTGGCCTTCACCAACAGC
GGGCTTGGCATTACGCACAGCATGGCCCACAGCCTTGGCGGCCAGTTCCACATTCCTCACGGCCTGGCTAACGCGGTGCT
GCTGCCCATTGTCATTGACTTCAACAGCTTTGATGCGGGCGTGAAATATCGCGAAATCGCCGAAATGGCAGGCTTGCCCG
CCGCCACCGTGGAAGAAGGAACCCGCAATCTGGTGGCAGCCGTGCGCGACCTCAACGCTTCGCTGGGCATTCCCGCTCGC
GTGAGGGAACTCAAGGTTGATGAAGGCGAGTACCGCCGCAATCTTGACGCCATGGCCACCAATGCCCTTGAGGACATCTG
CACGCAAAGCAATCCGCGCATGCCCTCGCACGATGATATTGTGAGCCTGTTCGAGCGCGTCTGGTAA

Upstream 100 bases:

>100_bases
GCCCAAATGCAAGTAAGGCCGGGCAAGGCTTTACTGACCAGACCACACGACGGTAACGCGGGGGCTTTCTTCCGCCCCCG
CGTACGCCTCGGAGGATAAC

Downstream 100 bases:

>100_bases
ATACAGGCCGAAAACCCACAGGATAAAAGCCATCGCCTGCGCGCGCCAGACGCATGCGCAGAAACGGCCCGGATTTCAGA
CCGGAGAAACCTGTTTCTCC

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: BDH [H]

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MTQFYGKTKICYGPYALETLESFPASHAFVVTDPFMVKSGFADQAVSHLKRKGIGFSIFSGVEPDPTLQAVVEATGHFLR
SKADMILALGGGSAIDMAKAISYFGHKAARDRKAMLVAIPTTSGTGSEVTSIAVITDKVNAVKIPLNDELLIPDAAILDA
RFTRTVPPHVTASTGMDVLTHAVEAYTSRHSNVFTAIYAERAIRNVFTYLHRAYEQGDDMVARDNMLIGSCMAGLAFTNS
GLGITHSMAHSLGGQFHIPHGLANAVLLPIVIDFNSFDAGVKYREIAEMAGLPAATVEEGTRNLVAAVRDLNASLGIPAR
VRELKVDEGEYRRNLDAMATNALEDICTQSNPRMPSHDDIVSLFERVW

Sequences:

>Translated_368_residues
MTQFYGKTKICYGPYALETLESFPASHAFVVTDPFMVKSGFADQAVSHLKRKGIGFSIFSGVEPDPTLQAVVEATGHFLR
SKADMILALGGGSAIDMAKAISYFGHKAARDRKAMLVAIPTTSGTGSEVTSIAVITDKVNAVKIPLNDELLIPDAAILDA
RFTRTVPPHVTASTGMDVLTHAVEAYTSRHSNVFTAIYAERAIRNVFTYLHRAYEQGDDMVARDNMLIGSCMAGLAFTNS
GLGITHSMAHSLGGQFHIPHGLANAVLLPIVIDFNSFDAGVKYREIAEMAGLPAATVEEGTRNLVAAVRDLNASLGIPAR
VRELKVDEGEYRRNLDAMATNALEDICTQSNPRMPSHDDIVSLFERVW
>Mature_367_residues
TQFYGKTKICYGPYALETLESFPASHAFVVTDPFMVKSGFADQAVSHLKRKGIGFSIFSGVEPDPTLQAVVEATGHFLRS
KADMILALGGGSAIDMAKAISYFGHKAARDRKAMLVAIPTTSGTGSEVTSIAVITDKVNAVKIPLNDELLIPDAAILDAR
FTRTVPPHVTASTGMDVLTHAVEAYTSRHSNVFTAIYAERAIRNVFTYLHRAYEQGDDMVARDNMLIGSCMAGLAFTNSG
LGITHSMAHSLGGQFHIPHGLANAVLLPIVIDFNSFDAGVKYREIAEMAGLPAATVEEGTRNLVAAVRDLNASLGIPARV
RELKVDEGEYRRNLDAMATNALEDICTQSNPRMPSHDDIVSLFERVW

Specific function: This enzyme has activity using butanol and ethanol as substrates [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Integral Membrane Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=402, Percent_Identity=27.363184079602, Blast_Score=112, Evalue=6e-25,
Organism=Escherichia coli, GI87082107, Length=349, Percent_Identity=39.541547277937, Blast_Score=238, Evalue=6e-64,
Organism=Escherichia coli, GI1787493, Length=382, Percent_Identity=38.7434554973822, Blast_Score=234, Evalue=5e-63,
Organism=Escherichia coli, GI1789163, Length=358, Percent_Identity=36.8715083798883, Blast_Score=217, Evalue=9e-58,
Organism=Escherichia coli, GI48994951, Length=362, Percent_Identity=34.2541436464088, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1789386, Length=342, Percent_Identity=25.1461988304094, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17537053, Length=396, Percent_Identity=24.2424242424242, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321181, Length=383, Percent_Identity=31.0704960835509, Blast_Score=187, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24657991, Length=400, Percent_Identity=27.5, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: NA

Molecular weight: Translated: 39775; Mature: 39644

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQFYGKTKICYGPYALETLESFPASHAFVVTDPFMVKSGFADQAVSHLKRKGIGFSIFS
CCCCCCCCEEEECCHHHHHHHHCCCCCEEEEECCHHHHCCCHHHHHHHHHHCCCCEEEEC
GVEPDPTLQAVVEATGHFLRSKADMILALGGGSAIDMAKAISYFGHKAARDRKAMLVAIP
CCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEEEE
TTSGTGSEVTSIAVITDKVNAVKIPLNDELLIPDAAILDARFTRTVPPHVTASTGMDVLT
CCCCCCCCCEEEEEEEECCCEEEECCCCCEECCCHHHHHHHHHCCCCCCCCCCCCHHHHH
HAVEAYTSRHSNVFTAIYAERAIRNVFTYLHRAYEQGDDMVARDNMLIGSCMAGLAFTNS
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCCC
GLGITHSMAHSLGGQFHIPHGLANAVLLPIVIDFNSFDAGVKYREIAEMAGLPAATVEEG
CCCHHHHHHHHCCCCEECCHHHHHHEEEEEEEECCCCCCCCHHHHHHHHHCCCCHHHHHH
TRNLVAAVRDLNASLGIPARVRELKVDEGEYRRNLDAMATNALEDICTQSNPRMPSHDDI
HHHHHHHHHHCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
VSLFERVW
HHHHHHHC
>Mature Secondary Structure 
TQFYGKTKICYGPYALETLESFPASHAFVVTDPFMVKSGFADQAVSHLKRKGIGFSIFS
CCCCCCCEEEECCHHHHHHHHCCCCCEEEEECCHHHHCCCHHHHHHHHHHCCCCEEEEC
GVEPDPTLQAVVEATGHFLRSKADMILALGGGSAIDMAKAISYFGHKAARDRKAMLVAIP
CCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEEEE
TTSGTGSEVTSIAVITDKVNAVKIPLNDELLIPDAAILDARFTRTVPPHVTASTGMDVLT
CCCCCCCCCEEEEEEEECCCEEEECCCCCEECCCHHHHHHHHHCCCCCCCCCCCCHHHHH
HAVEAYTSRHSNVFTAIYAERAIRNVFTYLHRAYEQGDDMVARDNMLIGSCMAGLAFTNS
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCCC
GLGITHSMAHSLGGQFHIPHGLANAVLLPIVIDFNSFDAGVKYREIAEMAGLPAATVEEG
CCCHHHHHHHHCCCCEECCHHHHHHEEEEEEEECCCCCCCCHHHHHHHHHCCCCHHHHHH
TRNLVAAVRDLNASLGIPARVRELKVDEGEYRRNLDAMATNALEDICTQSNPRMPSHDDI
HHHHHHHHHHCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
VSLFERVW
HHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2673928 [H]