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The map label for this gene is fhs

Identifier: 220904565

GI number: 220904565

Start: 1533445

End: 1535220

Strand: Reverse

Name: fhs

Synonym: Ddes_1296

Alternate gene names: 220904565

Gene position: 1535220-1533445 (Counterclockwise)

Preceding gene: 220904568

Following gene: 220904564

Centisome position: 53.43

GC content: 57.32

Gene sequence:

>1776_bases
ATGACTTTGGATCCTACCAAGCACCCTGACTGGAAAATCGCTCTTGATGCGGAATCCCGCATGAAAACCGTTGAAACCCT
TGCTGCAGAACTGGGCCTTGAAAAGGCTGAACTGCTGCCGTATGGGCATTATATGGGCAAGGTTGAGCAGCAGGCCGTGA
TGCAGCGGCTAAAAGACCGCCCCAACGGAAAGTATATTGATGTTACTGCTATCACCCCCACGCCTTTGGGGGAGGGCAAG
TCTACAACCACCATCGGCCTTGTGCAGGGTCTTGCACGACGCGGGCGGCGTTCTTCAGCGGCTATCCGTCAACCTTCCGG
CGGACCCACCATGGGTATGAAAGGCTCCGCCGCAGGCGGCGGGCTTTCGCAATGCATTCCGCTGACCCCCTATTCTCTCA
ATTTTACCGGCGACCTCCATGCCGTGGGCGCGGCCCACAACCTGGGCATGACGGCTTTGACATCGCGCATGCAGCATGAG
CGCAATTATGACGATGCCACGCTGGAAAAACTTTCGGGTATGGCGCGTCTGAATATCGACCCCACCAGAATCAATACCGG
CTGGGTCATGGATTTTTGTGTTCAGGCCCTGCGCAACATCATTATCGGCATCGAGGGTGATGGGCGACGTAATGATGGTT
TCATGATGCGTTCGCACTTTGACATTACCGTTGCCTCTGAAGTTATGTGCATCCTTTCCATTGCCCGCGACCTGCGCGAC
CTGCGCGAGCGGATGGGACGGATGGTGCTGGCACATGACCGCAACGGCAAACCTGTGACCACCAGCGACCTGGGCGTTGC
CGGGGCCATGACTGCCTGGCTGGTAGAGGCCGCCAAACCCAACCTTATCCAGACCATTGAAGGGCAGCCCGTTTTTGTGC
ATACCGGGCCTTTTGCCAATATTGCCCTTGGGCAAAGTTCGGTCATTGCCGACAGGGTGGCGCTCAAACTCAGCGACTAT
CATGTGACGGAATCCGGCTTTGCTGCAGAAATGGGCTACGAAAAATTCTGGAACCTCAAATGCCATTATAGCGGCCTTGT
GCCTGACGCAGCTGTTGTTGTGGCTACAGTGCGGGCGCTCAAAAATCACGGTGGTGCTCCCCAGCCCAAACCCGGTCAGG
CACTGCCAGAGCCCTATACCCGTGAAGACGTGGGCCTTGTGGAAGCCGGATGCGCCAACCTGCTGCATCATCTGGGCATT
GTACGGCGTTCGGGCGTACCCGCAGTGGTCTGCATCAATAAGTTCCATACCGATACCAAGGCAGAGGTCGACGCCATCCG
TCGCATTTGCGAGCAGGCCGGAGCAAGGGTAGCCCTGTCGGAGCACTGGGAAAAAGGCGGAGAGGGCGCTCTGGAACTTG
CTGACGCCGTTACGGACGCCTGCAATGAAAAGAACGAATTCCGGCCGCTCTACAATTGGAATTCGCCTCTTACCGAGCGC
ATCACGACCATTGCTCAGGAGGTTTACGGGGCTGACGGAGTGGAGTTTGAGCCGCTTGCAGCCCAGCGCCTCAAAGATTT
GCAGGAAAGACCCGATGCTGATGAACTGGGCGTCTGCATGGTGAAGACCCAATATTCCCTGTCTGACAAGCCTGCGCTCA
AGGGCGTTCCCAAGGGCTGGAGGCTGCATGTGCGCGATGTGCTTTTCTTTGGCGGCGCGGGGCTTGTTGCCCCGGTGTCC
GGCGATATCAGCCTGATGCCGGGGACCGGTTCAAAACCGGCTTTCCGCAACATTGATGTGGACGTGGAGACCGGCAAGGT
AACAGGACTCTTCTAG

Upstream 100 bases:

>100_bases
CGGCATAGGCGACTGTCCCAAAGCGAAACTGCTCTTACGGGCGGGCAGCCATACCCGCCGGAACGTGCCATAGAACATGC
AACAACGATATGGAGCTGCC

Downstream 100 bases:

>100_bases
GGTATTTGAGTAGGATATTCCCTTCGGAGCAACAGTATAGACAAACTGCATTGCACCCCGTAAATGTCTGTTCACGAGGA
CACCAGGCAACTCAAAACAG

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 591; Mature: 590

Protein sequence:

>591_residues
MTLDPTKHPDWKIALDAESRMKTVETLAAELGLEKAELLPYGHYMGKVEQQAVMQRLKDRPNGKYIDVTAITPTPLGEGK
STTTIGLVQGLARRGRRSSAAIRQPSGGPTMGMKGSAAGGGLSQCIPLTPYSLNFTGDLHAVGAAHNLGMTALTSRMQHE
RNYDDATLEKLSGMARLNIDPTRINTGWVMDFCVQALRNIIIGIEGDGRRNDGFMMRSHFDITVASEVMCILSIARDLRD
LRERMGRMVLAHDRNGKPVTTSDLGVAGAMTAWLVEAAKPNLIQTIEGQPVFVHTGPFANIALGQSSVIADRVALKLSDY
HVTESGFAAEMGYEKFWNLKCHYSGLVPDAAVVVATVRALKNHGGAPQPKPGQALPEPYTREDVGLVEAGCANLLHHLGI
VRRSGVPAVVCINKFHTDTKAEVDAIRRICEQAGARVALSEHWEKGGEGALELADAVTDACNEKNEFRPLYNWNSPLTER
ITTIAQEVYGADGVEFEPLAAQRLKDLQERPDADELGVCMVKTQYSLSDKPALKGVPKGWRLHVRDVLFFGGAGLVAPVS
GDISLMPGTGSKPAFRNIDVDVETGKVTGLF

Sequences:

>Translated_591_residues
MTLDPTKHPDWKIALDAESRMKTVETLAAELGLEKAELLPYGHYMGKVEQQAVMQRLKDRPNGKYIDVTAITPTPLGEGK
STTTIGLVQGLARRGRRSSAAIRQPSGGPTMGMKGSAAGGGLSQCIPLTPYSLNFTGDLHAVGAAHNLGMTALTSRMQHE
RNYDDATLEKLSGMARLNIDPTRINTGWVMDFCVQALRNIIIGIEGDGRRNDGFMMRSHFDITVASEVMCILSIARDLRD
LRERMGRMVLAHDRNGKPVTTSDLGVAGAMTAWLVEAAKPNLIQTIEGQPVFVHTGPFANIALGQSSVIADRVALKLSDY
HVTESGFAAEMGYEKFWNLKCHYSGLVPDAAVVVATVRALKNHGGAPQPKPGQALPEPYTREDVGLVEAGCANLLHHLGI
VRRSGVPAVVCINKFHTDTKAEVDAIRRICEQAGARVALSEHWEKGGEGALELADAVTDACNEKNEFRPLYNWNSPLTER
ITTIAQEVYGADGVEFEPLAAQRLKDLQERPDADELGVCMVKTQYSLSDKPALKGVPKGWRLHVRDVLFFGGAGLVAPVS
GDISLMPGTGSKPAFRNIDVDVETGKVTGLF
>Mature_590_residues
TLDPTKHPDWKIALDAESRMKTVETLAAELGLEKAELLPYGHYMGKVEQQAVMQRLKDRPNGKYIDVTAITPTPLGEGKS
TTTIGLVQGLARRGRRSSAAIRQPSGGPTMGMKGSAAGGGLSQCIPLTPYSLNFTGDLHAVGAAHNLGMTALTSRMQHER
NYDDATLEKLSGMARLNIDPTRINTGWVMDFCVQALRNIIIGIEGDGRRNDGFMMRSHFDITVASEVMCILSIARDLRDL
RERMGRMVLAHDRNGKPVTTSDLGVAGAMTAWLVEAAKPNLIQTIEGQPVFVHTGPFANIALGQSSVIADRVALKLSDYH
VTESGFAAEMGYEKFWNLKCHYSGLVPDAAVVVATVRALKNHGGAPQPKPGQALPEPYTREDVGLVEAGCANLLHHLGIV
RRSGVPAVVCINKFHTDTKAEVDAIRRICEQAGARVALSEHWEKGGEGALELADAVTDACNEKNEFRPLYNWNSPLTERI
TTIAQEVYGADGVEFEPLAAQRLKDLQERPDADELGVCMVKTQYSLSDKPALKGVPKGWRLHVRDVLFFGGAGLVAPVSG
DISLMPGTGSKPAFRNIDVDVETGKVTGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI36796743, Length=612, Percent_Identity=45.4248366013072, Blast_Score=481, Evalue=1e-136,
Organism=Homo sapiens, GI222136639, Length=621, Percent_Identity=45.0885668276973, Blast_Score=479, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI17568737, Length=625, Percent_Identity=44.32, Blast_Score=469, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17568739, Length=625, Percent_Identity=44.32, Blast_Score=469, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6321643, Length=623, Percent_Identity=47.0304975922953, Blast_Score=506, Evalue=1e-144,
Organism=Saccharomyces cerevisiae, GI6319558, Length=625, Percent_Identity=44.48, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI62472483, Length=633, Percent_Identity=40.7582938388626, Blast_Score=443, Evalue=1e-124,
Organism=Drosophila melanogaster, GI45551871, Length=633, Percent_Identity=40.7582938388626, Blast_Score=443, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24645718, Length=633, Percent_Identity=40.7582938388626, Blast_Score=443, Evalue=1e-124,
Organism=Drosophila melanogaster, GI17137370, Length=633, Percent_Identity=40.7582938388626, Blast_Score=443, Evalue=1e-124,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_DESDA (B8J0C2)

Other databases:

- EMBL:   CP001358
- RefSeq:   YP_002479877.1
- GeneID:   7284988
- GenomeReviews:   CP001358_GR
- KEGG:   dds:Ddes_1296
- HOGENOM:   HBG677721
- ProtClustDB:   PRK13507
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 63965; Mature: 63834

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLDPTKHPDWKIALDAESRMKTVETLAAELGLEKAELLPYGHYMGKVEQQAVMQRLKDR
CCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHCC
PNGKYIDVTAITPTPLGEGKSTTTIGLVQGLARRGRRSSAAIRQPSGGPTMGMKGSAAGG
CCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
GLSQCIPLTPYSLNFTGDLHAVGAAHNLGMTALTSRMQHERNYDDATLEKLSGMARLNID
CHHHCCCCCCEEEECCCCCCEECCHHHCCHHHHHHHHHHHCCCCHHHHHHHCCCEEECCC
PTRINTGWVMDFCVQALRNIIIGIEGDGRRNDGFMMRSHFDITVASEVMCILSIARDLRD
CCCCCCCHHHHHHHHHHHHHEEEECCCCCCCCCEEEEEECCEEHHHHHHHHHHHHHHHHH
LRERMGRMVLAHDRNGKPVTTSDLGVAGAMTAWLVEAAKPNLIQTIEGQPVFVHTGPFAN
HHHHHCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCEEEEECCCCCE
IALGQSSVIADRVALKLSDYHVTESGFAAEMGYEKFWNLKCHYSGLVPDAAVVVATVRAL
EECCCHHHHHHHHEEEEECEEECCCCCHHHCCHHHHCCCEEEECCCCCHHHHHHHHHHHH
KNHGGAPQPKPGQALPEPYTREDVGLVEAGCANLLHHLGIVRRSGVPAVVCINKFHTDTK
HHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCH
AEVDAIRRICEQAGARVALSEHWEKGGEGALELADAVTDACNEKNEFRPLYNWNSPLTER
HHHHHHHHHHHHCCCEEEEHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
ITTIAQEVYGADGVEFEPLAAQRLKDLQERPDADELGVCMVKTQYSLSDKPALKGVPKGW
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHCCEEEEEEECCCCCCCCCCCCCCCC
RLHVRDVLFFGGAGLVAPVSGDISLMPGTGSKPAFRNIDVDVETGKVTGLF
EEEEEEEEEECCCCEEEECCCCEEEECCCCCCCCCCCCEEEEECCCEECCC
>Mature Secondary Structure 
TLDPTKHPDWKIALDAESRMKTVETLAAELGLEKAELLPYGHYMGKVEQQAVMQRLKDR
CCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHCC
PNGKYIDVTAITPTPLGEGKSTTTIGLVQGLARRGRRSSAAIRQPSGGPTMGMKGSAAGG
CCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
GLSQCIPLTPYSLNFTGDLHAVGAAHNLGMTALTSRMQHERNYDDATLEKLSGMARLNID
CHHHCCCCCCEEEECCCCCCEECCHHHCCHHHHHHHHHHHCCCCHHHHHHHCCCEEECCC
PTRINTGWVMDFCVQALRNIIIGIEGDGRRNDGFMMRSHFDITVASEVMCILSIARDLRD
CCCCCCCHHHHHHHHHHHHHEEEECCCCCCCCCEEEEEECCEEHHHHHHHHHHHHHHHHH
LRERMGRMVLAHDRNGKPVTTSDLGVAGAMTAWLVEAAKPNLIQTIEGQPVFVHTGPFAN
HHHHHCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCEEEEECCCCCE
IALGQSSVIADRVALKLSDYHVTESGFAAEMGYEKFWNLKCHYSGLVPDAAVVVATVRAL
EECCCHHHHHHHHEEEEECEEECCCCCHHHCCHHHHCCCEEEECCCCCHHHHHHHHHHHH
KNHGGAPQPKPGQALPEPYTREDVGLVEAGCANLLHHLGIVRRSGVPAVVCINKFHTDTK
HHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCH
AEVDAIRRICEQAGARVALSEHWEKGGEGALELADAVTDACNEKNEFRPLYNWNSPLTER
HHHHHHHHHHHHCCCEEEEHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
ITTIAQEVYGADGVEFEPLAAQRLKDLQERPDADELGVCMVKTQYSLSDKPALKGVPKGW
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHCCEEEEEEECCCCCCCCCCCCCCCC
RLHVRDVLFFGGAGLVAPVSGDISLMPGTGSKPAFRNIDVDVETGKVTGLF
EEEEEEEEEECCCCEEEECCCCEEEECCCCCCCCCCCCEEEEECCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA