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The map label for this gene is pbpC [H]

Identifier: 220904562

GI number: 220904562

Start: 1523887

End: 1526205

Strand: Reverse

Name: pbpC [H]

Synonym: Ddes_1293

Alternate gene names: 220904562

Gene position: 1526205-1523887 (Counterclockwise)

Preceding gene: 220904563

Following gene: 220904553

Centisome position: 53.11

GC content: 57.74

Gene sequence:

>2319_bases
ATGAGTCGGGGCGGGCACAGTTTGTGGCGGCTATTCCGTCCGGCACGCTGGTATTTTGCCTCGCTGATTGCCGTTCTGGG
GGCGGCTTTGCTCTGGCTGCACCATGCCCCGTGCAAATACCCCCTGGATGGCATCGGCTTTTCGCGCGTGGTCTATGATG
GTAAAGGTGGCCTCATGCGCCTGAGTCTTTCCAAAGATCAAAAATATCGTATACGTACGCGCTTGTCAGATATTCCGCCC
GCTGCCGTGGATTCGGTTTTGCGTTATGAAGACCGTTATTACTGGCAGCATCCGGGGGTCAATGTCCTGGCTCTTGCCCG
CGCCGGATTTGGTCTGTTGGCAGGCCGACGCATTATGGGCGGATCCACCATCACCATGCAGGTAGCGCGGCTGACACATG
GGCTGGAAACGGGAAAAATTGGCGCAAAGCTGTGGCAGATCGCTCTGGCCTTGCAACTGGAATGGCATTTCAGCAAGGAA
GAGATACTTGAAGCCTACTTCAATCTTGCGCCTTACGGGGGTAATGTTGAAGGTCTTGGGGCTGCGGCAATGGTGTATTT
TCACAAGATTCCGGAGCAGCTGACCCCCGGAGAAAGCACTGCCCTTATGCTGGTGCCGCAGAATCCTGTGCGGCGGCGGC
CTGCCGGGGATAATACACATTTCATGGACGCGTTCAGCCGCCTTGAGGCTGTCTGGCATGGCCGTCAAGAACATGCGCCC
TTGCGCGTATACGGACCCGAAAATTTGCCCTTTACAGCCCCCCATTTGAGCACCGAGCTTTTGCAGCAGGATGGCAGTGA
CACTCTGCACACCACGCTGGACCCGGCAAGTCAGCGCCGTCTTGAGCGCCAGCTACGTTTGTTTACCGCAAGACGGCATG
ATTACGGCCTTGTTAACGGGGCGGCGATGCTGCTTCATTGGCCCAGTATGGAAGTGCGGGCCCTTGCCGGTTCTGCAGAT
TTTTTCAATGCTGCCATTATGGGGCAGGTAGACGGAACCAGGGCGCGGCGTTCGCCCGGCTCTACACTCAAGCCTTTTAT
CTATGCCTTGGCTCTGGATCAGGGGCTTATCCACCCCTTGACCTTGTTGGCCGATACGCCACGCAGTTTTTCTGGTTATG
ATCCTGAAAATTACGACGGCAGTTTTCGAGGGCCTGTCAGCGCGAGTGAAGCGTTGAGGGCCAGCCGCAATGTGCCTGCC
ATTGCCCTGGCTGCCCGCTTGAGACAGCCTGGTTTTTATGAGTTTTTGAGCAGGGCCGGTGTGAATTTCGCATCCGGCGA
AGAGCATTATGGCTTGAGTCTGGTGCTTGGCGGGGCAGAGGTAAGCATGCGTGAGCTTGCCGGACTTTACGCCATGCTTG
CCAATAAGGGGGTTTGGCGTCCATTGCGCATGCTGCAGGGCGACAGGCGCACGGCGATTGCTCTGCCCCTGCTGTCGCCG
GAAGCGTCGTATGTTGCCCTCGCCATGCTGGAGGACGGGAATCCGGATCGCCTTGTCCGTTCGCAGGGGGGGACAGTGTT
GCCCTTGCGCCTTAAAACTGGCACCTCGAACGGTTTTCGGGATGCGTGGGCCGCAGGTATTGTCGGGCCGTATGTTCTTG
TGGTTTGGCTCGGCAATTTTGATAACAAGCCCAATCCGCTGCTTGTGGGCGGCATCAGCGCCGTGCCGTTGTTTACGCAG
ATAGCCCGTGACATCGCAATGGCCGAACCGTTGCAGGACTATCAGGCGGAGCCTGCGCACGGGCTTAATCTGGAGCGTGT
GGAGGTTTGCGCGGCAACCGGAGACCTGGACACATCTCTGTGCGAAGATACGGTTAAAACGTGGTTTATACCGGGAGTAT
CGCCGCTGGCTTCTTCCGGTGTATTCCGTCCCATACTCATAGACAGGCAAACGGGGCTGCGGGCCTGCATGCCACAGGCA
GACCGTACGGAGGTGCGTATATGGGAATTCTGGCCCACGGATATGGCGCAGATGTTTGCAAGAGCCGGAATGCCCAAGCC
CGAACCGCCGCCTTTTGCCCTCGAATGCGGGCGTGAAAACATGATTACGGGCGAAGCGCCACGTATAGTGCTGCCCAAGG
ATGGTCTGACCTACAAACTGAGCCTGAGCAGTCCGGGCCATGAAAACATGGTTTTTATGGCTCACGCCGATGCCGGTGTG
AAAACCCTGCACTGGTTTGTCAACGGCCGTTATCTGGGCAAGGGAGTGCCGGGCGAGGTCTTTTTATGGCGAGCCGTACC
CGGTGACATTGAGCTTCGTGTAGTGGATGACGCGGGTCGCGCCGGGAAAAAGCGCGTGCGTGTCCACGCTGTCCCCTAG

Upstream 100 bases:

>100_bases
CATGCAGAAAAAAGAAATTAAAAGCAGAGCCGCAATGGTTTCAACTTCCTTCGGGGACCAGAGAACATCCGCCAGGCCAA
CAGGTTCGGGAGCATCCGGC

Downstream 100 bases:

>100_bases
CGGCTGCTGCGAGATTTTTTATTTTGTGACAGCTCCAGAAGCGTTTTCAAAGCGCCTTTTCCGCCGGGTATCGAGATTCG
CCTCAAGGAACTGGCGCTCT

Product: penicillin-binding protein 1C

Products: NA

Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]

Number of amino acids: Translated: 772; Mature: 771

Protein sequence:

>772_residues
MSRGGHSLWRLFRPARWYFASLIAVLGAALLWLHHAPCKYPLDGIGFSRVVYDGKGGLMRLSLSKDQKYRIRTRLSDIPP
AAVDSVLRYEDRYYWQHPGVNVLALARAGFGLLAGRRIMGGSTITMQVARLTHGLETGKIGAKLWQIALALQLEWHFSKE
EILEAYFNLAPYGGNVEGLGAAAMVYFHKIPEQLTPGESTALMLVPQNPVRRRPAGDNTHFMDAFSRLEAVWHGRQEHAP
LRVYGPENLPFTAPHLSTELLQQDGSDTLHTTLDPASQRRLERQLRLFTARRHDYGLVNGAAMLLHWPSMEVRALAGSAD
FFNAAIMGQVDGTRARRSPGSTLKPFIYALALDQGLIHPLTLLADTPRSFSGYDPENYDGSFRGPVSASEALRASRNVPA
IALAARLRQPGFYEFLSRAGVNFASGEEHYGLSLVLGGAEVSMRELAGLYAMLANKGVWRPLRMLQGDRRTAIALPLLSP
EASYVALAMLEDGNPDRLVRSQGGTVLPLRLKTGTSNGFRDAWAAGIVGPYVLVVWLGNFDNKPNPLLVGGISAVPLFTQ
IARDIAMAEPLQDYQAEPAHGLNLERVEVCAATGDLDTSLCEDTVKTWFIPGVSPLASSGVFRPILIDRQTGLRACMPQA
DRTEVRIWEFWPTDMAQMFARAGMPKPEPPPFALECGRENMITGEAPRIVLPKDGLTYKLSLSSPGHENMVFMAHADAGV
KTLHWFVNGRYLGKGVPGEVFLWRAVPGDIELRVVDDAGRAGKKRVRVHAVP

Sequences:

>Translated_772_residues
MSRGGHSLWRLFRPARWYFASLIAVLGAALLWLHHAPCKYPLDGIGFSRVVYDGKGGLMRLSLSKDQKYRIRTRLSDIPP
AAVDSVLRYEDRYYWQHPGVNVLALARAGFGLLAGRRIMGGSTITMQVARLTHGLETGKIGAKLWQIALALQLEWHFSKE
EILEAYFNLAPYGGNVEGLGAAAMVYFHKIPEQLTPGESTALMLVPQNPVRRRPAGDNTHFMDAFSRLEAVWHGRQEHAP
LRVYGPENLPFTAPHLSTELLQQDGSDTLHTTLDPASQRRLERQLRLFTARRHDYGLVNGAAMLLHWPSMEVRALAGSAD
FFNAAIMGQVDGTRARRSPGSTLKPFIYALALDQGLIHPLTLLADTPRSFSGYDPENYDGSFRGPVSASEALRASRNVPA
IALAARLRQPGFYEFLSRAGVNFASGEEHYGLSLVLGGAEVSMRELAGLYAMLANKGVWRPLRMLQGDRRTAIALPLLSP
EASYVALAMLEDGNPDRLVRSQGGTVLPLRLKTGTSNGFRDAWAAGIVGPYVLVVWLGNFDNKPNPLLVGGISAVPLFTQ
IARDIAMAEPLQDYQAEPAHGLNLERVEVCAATGDLDTSLCEDTVKTWFIPGVSPLASSGVFRPILIDRQTGLRACMPQA
DRTEVRIWEFWPTDMAQMFARAGMPKPEPPPFALECGRENMITGEAPRIVLPKDGLTYKLSLSSPGHENMVFMAHADAGV
KTLHWFVNGRYLGKGVPGEVFLWRAVPGDIELRVVDDAGRAGKKRVRVHAVP
>Mature_771_residues
SRGGHSLWRLFRPARWYFASLIAVLGAALLWLHHAPCKYPLDGIGFSRVVYDGKGGLMRLSLSKDQKYRIRTRLSDIPPA
AVDSVLRYEDRYYWQHPGVNVLALARAGFGLLAGRRIMGGSTITMQVARLTHGLETGKIGAKLWQIALALQLEWHFSKEE
ILEAYFNLAPYGGNVEGLGAAAMVYFHKIPEQLTPGESTALMLVPQNPVRRRPAGDNTHFMDAFSRLEAVWHGRQEHAPL
RVYGPENLPFTAPHLSTELLQQDGSDTLHTTLDPASQRRLERQLRLFTARRHDYGLVNGAAMLLHWPSMEVRALAGSADF
FNAAIMGQVDGTRARRSPGSTLKPFIYALALDQGLIHPLTLLADTPRSFSGYDPENYDGSFRGPVSASEALRASRNVPAI
ALAARLRQPGFYEFLSRAGVNFASGEEHYGLSLVLGGAEVSMRELAGLYAMLANKGVWRPLRMLQGDRRTAIALPLLSPE
ASYVALAMLEDGNPDRLVRSQGGTVLPLRLKTGTSNGFRDAWAAGIVGPYVLVVWLGNFDNKPNPLLVGGISAVPLFTQI
ARDIAMAEPLQDYQAEPAHGLNLERVEVCAATGDLDTSLCEDTVKTWFIPGVSPLASSGVFRPILIDRQTGLRACMPQAD
RTEVRIWEFWPTDMAQMFARAGMPKPEPPPFALECGRENMITGEAPRIVLPKDGLTYKLSLSSPGHENMVFMAHADAGVK
TLHWFVNGRYLGKGVPGEVFLWRAVPGDIELRVVDDAGRAGKKRVRVHAVP

Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]

COG id: COG4953

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1788867, Length=779, Percent_Identity=32.9910141206675, Blast_Score=319, Evalue=3e-88,
Organism=Escherichia coli, GI1786343, Length=542, Percent_Identity=26.9372693726937, Blast_Score=111, Evalue=2e-25,
Organism=Escherichia coli, GI87082258, Length=211, Percent_Identity=31.2796208530806, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1789601, Length=148, Percent_Identity=33.1081081081081, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011815
- InterPro:   IPR009647
- InterPro:   IPR001460 [H]

Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.- [C]

Molecular weight: Translated: 84970; Mature: 84839

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRGGHSLWRLFRPARWYFASLIAVLGAALLWLHHAPCKYPLDGIGFSRVVYDGKGGLMR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCEEE
LSLSKDQKYRIRTRLSDIPPAAVDSVLRYEDRYYWQHPGVNVLALARAGFGLLAGRRIMG
EEECCCCCEEHHHHHCCCCHHHHHHHHHHCCCEEEECCCCCEEEEECCCCHHHHCCEEEC
GSTITMQVARLTHGLETGKIGAKLWQIALALQLEWHFSKEEILEAYFNLAPYGGNVEGLG
CCCCEEEHHHHHCCCCCCCHHHHHHHEEEEEEEEECCCHHHHHHHHHCCCCCCCCCCCCH
AAAMVYFHKIPEQLTPGESTALMLVPQNPVRRRPAGDNTHFMDAFSRLEAVWHGRQEHAP
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
LRVYGPENLPFTAPHLSTELLQQDGSDTLHTTLDPASQRRLERQLRLFTARRHDYGLVNG
EEEECCCCCCCCCCHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCEECC
AAMLLHWPSMEVRALAGSADFFNAAIMGQVDGTRARRSPGSTLKPFIYALALDQGLIHPL
EEEEEECCCCEEEEEECCCCHHCEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHH
TLLADTPRSFSGYDPENYDGSFRGPVSASEALRASRNVPAIALAARLRQPGFYEFLSRAG
HHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHCC
VNFASGEEHYGLSLVLGGAEVSMRELAGLYAMLANKGVWRPLRMLQGDRRTAIALPLLSP
CCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEEEEECC
EASYVALAMLEDGNPDRLVRSQGGTVLPLRLKTGTSNGFRDAWAAGIVGPYVLVVWLGNF
CCCEEEEEEEECCCCCHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHCEEEEEEECCC
DNKPNPLLVGGISAVPLFTQIARDIAMAEPLQDYQAEPAHGLNLERVEVCAATGDLDTSL
CCCCCCEEEECCHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCHHHEEEEEECCCCCHHH
CEDTVKTWFIPGVSPLASSGVFRPILIDRQTGLRACMPQADRTEVRIWEFWPTDMAQMFA
HHHHHHHEECCCCCHHHCCCCEEEEEEECCCCHHHHCCCCCCCEEEEEEECCHHHHHHHH
RAGMPKPEPPPFALECGRENMITGEAPRIVLPKDGLTYKLSLSSPGHENMVFMAHADAGV
HCCCCCCCCCCCEEECCCCCCCCCCCCEEEECCCCCEEEEEECCCCCCCEEEEEECCCCC
KTLHWFVNGRYLGKGVPGEVFLWRAVPGDIELRVVDDAGRAGKKRVRVHAVP
EEEEEEEECEEECCCCCCCEEEEEECCCCEEEEEECCCCCCCCCEEEEEECC
>Mature Secondary Structure 
SRGGHSLWRLFRPARWYFASLIAVLGAALLWLHHAPCKYPLDGIGFSRVVYDGKGGLMR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCEEE
LSLSKDQKYRIRTRLSDIPPAAVDSVLRYEDRYYWQHPGVNVLALARAGFGLLAGRRIMG
EEECCCCCEEHHHHHCCCCHHHHHHHHHHCCCEEEECCCCCEEEEECCCCHHHHCCEEEC
GSTITMQVARLTHGLETGKIGAKLWQIALALQLEWHFSKEEILEAYFNLAPYGGNVEGLG
CCCCEEEHHHHHCCCCCCCHHHHHHHEEEEEEEEECCCHHHHHHHHHCCCCCCCCCCCCH
AAAMVYFHKIPEQLTPGESTALMLVPQNPVRRRPAGDNTHFMDAFSRLEAVWHGRQEHAP
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
LRVYGPENLPFTAPHLSTELLQQDGSDTLHTTLDPASQRRLERQLRLFTARRHDYGLVNG
EEEECCCCCCCCCCHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCEECC
AAMLLHWPSMEVRALAGSADFFNAAIMGQVDGTRARRSPGSTLKPFIYALALDQGLIHPL
EEEEEECCCCEEEEEECCCCHHCEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHH
TLLADTPRSFSGYDPENYDGSFRGPVSASEALRASRNVPAIALAARLRQPGFYEFLSRAG
HHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHCC
VNFASGEEHYGLSLVLGGAEVSMRELAGLYAMLANKGVWRPLRMLQGDRRTAIALPLLSP
CCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEEEEECC
EASYVALAMLEDGNPDRLVRSQGGTVLPLRLKTGTSNGFRDAWAAGIVGPYVLVVWLGNF
CCCEEEEEEEECCCCCHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHCEEEEEEECCC
DNKPNPLLVGGISAVPLFTQIARDIAMAEPLQDYQAEPAHGLNLERVEVCAATGDLDTSL
CCCCCCEEEECCHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCHHHEEEEEECCCCCHHH
CEDTVKTWFIPGVSPLASSGVFRPILIDRQTGLRACMPQADRTEVRIWEFWPTDMAQMFA
HHHHHHHEECCCCCHHHCCCCEEEEEEECCCCHHHHCCCCCCCEEEEEEECCHHHHHHHH
RAGMPKPEPPPFALECGRENMITGEAPRIVLPKDGLTYKLSLSSPGHENMVFMAHADAGV
HCCCCCCCCCCCEEECCCCCCCCCCCCEEEECCCCCEEEEEECCCCCCCEEEEEECCCCC
KTLHWFVNGRYLGKGVPGEVFLWRAVPGDIELRVVDDAGRAGKKRVRVHAVP
EEEEEEEECEEECCCCCCCEEEEEECCCCEEEEEECCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10542235; 9205837; 9278503; 9841666 [H]