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The map label for this gene is hemC [H]

Identifier: 220904556

GI number: 220904556

Start: 1516181

End: 1517113

Strand: Direct

Name: hemC [H]

Synonym: Ddes_1287

Alternate gene names: 220904556

Gene position: 1516181-1517113 (Clockwise)

Preceding gene: 220904555

Following gene: 220904557

Centisome position: 52.77

GC content: 59.27

Gene sequence:

>933_bases
ATGCGTAATACCCTTACCATTGCTACACGCGGCAGCCGTCTGGCCCTTTGGCAGGCCGAACACGTCAAAAGCTGCCTCCA
GGCCATCAGGCCCGGTCTCGAGATCCGCCTTAATGTCATAAAAACAAAGGGGGACATCATTCTTGATGTTCCACTGGCAA
AGGTCGGCGGCAAGGGACTCTTTGTTAAGGAAATTGAAGAAGCCCTGCTCAACGGCGAGGCGGACCTGGCCGTTCACAGC
ATGAAAGACGTACCCATGGAGCTGCCTGAAGGGCTGATTCTCGGCTGCGTACCTCCGCGTGAAGATCCTACAGACTGTCT
GCTTTCGCACAAATATGATTCTGTAGCGGCCCTGCCCCCCAACGCCTGCGTGGGGACGAGCAGCCTGCGCCGTCAGTCCC
AGTTGCTGGCCCAGCGGCCGGACCTTCGCATTGAAAGCCTGCGCGGCAATGTGGATACGCGCCTGCGCAAACTGCAGGAA
GGCATGTATGACGCCATCATCCTTGCCTCTGCGGGCCTGAAACGGCTGGGGCTTTCCGCGCCGCACATGCACGCTCTTGA
CCCACATACTTTTTTGCCCGCAGTGGGCCAGGGAGCGCTGGGCATTGAGTGCCGCGAAAACGATTATGAACTTTTCACCC
TGCTGGCCGAGATGGAAGACAGCGCTACCCGTGTATGCGTTGAGGCCGAACGCGGATTTCTGGCCGGGCTTGAAGGCGGC
TGCCAGGTTCCCATTGCCGGCCACGCCCGCCTACTGGACGATGACACCCTCCGCCTCGAAGGTCTGGTGGCCGAAGTTGA
CGGCAGCCGCATTTTGCGTTGCAGCAAGGACGGGCACACCTCTCAGGCGCGCCGGTGGGGCCTTGAACTTGCCGGGGAAA
TTCTTGAGCAGGGCGGCAAAGGCATTCTCGAAAAACTTTATCGACAGTCATAG

Upstream 100 bases:

>100_bases
CTCACCCTGGCGACTACGCGCCCACGTCCGGCGGCGGAGGCGGCTGCGCCGGGTGCTCCGGCGGCAACTGCGCGAGCTGC
GGTCATTAGGCGGTACCATC

Downstream 100 bases:

>100_bases
GTATACTACATAGATATGTCCAAAATCTCTCCCCTGCCCGAATCCAGACTGCATGCTGCCATGGACCCAGCCCGCATCCC
CTGGGATGACAGCCATGCCA

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MRNTLTIATRGSRLALWQAEHVKSCLQAIRPGLEIRLNVIKTKGDIILDVPLAKVGGKGLFVKEIEEALLNGEADLAVHS
MKDVPMELPEGLILGCVPPREDPTDCLLSHKYDSVAALPPNACVGTSSLRRQSQLLAQRPDLRIESLRGNVDTRLRKLQE
GMYDAIILASAGLKRLGLSAPHMHALDPHTFLPAVGQGALGIECRENDYELFTLLAEMEDSATRVCVEAERGFLAGLEGG
CQVPIAGHARLLDDDTLRLEGLVAEVDGSRILRCSKDGHTSQARRWGLELAGEILEQGGKGILEKLYRQS

Sequences:

>Translated_310_residues
MRNTLTIATRGSRLALWQAEHVKSCLQAIRPGLEIRLNVIKTKGDIILDVPLAKVGGKGLFVKEIEEALLNGEADLAVHS
MKDVPMELPEGLILGCVPPREDPTDCLLSHKYDSVAALPPNACVGTSSLRRQSQLLAQRPDLRIESLRGNVDTRLRKLQE
GMYDAIILASAGLKRLGLSAPHMHALDPHTFLPAVGQGALGIECRENDYELFTLLAEMEDSATRVCVEAERGFLAGLEGG
CQVPIAGHARLLDDDTLRLEGLVAEVDGSRILRCSKDGHTSQARRWGLELAGEILEQGGKGILEKLYRQS
>Mature_310_residues
MRNTLTIATRGSRLALWQAEHVKSCLQAIRPGLEIRLNVIKTKGDIILDVPLAKVGGKGLFVKEIEEALLNGEADLAVHS
MKDVPMELPEGLILGCVPPREDPTDCLLSHKYDSVAALPPNACVGTSSLRRQSQLLAQRPDLRIESLRGNVDTRLRKLQE
GMYDAIILASAGLKRLGLSAPHMHALDPHTFLPAVGQGALGIECRENDYELFTLLAEMEDSATRVCVEAERGFLAGLEGG
CQVPIAGHARLLDDDTLRLEGLVAEVDGSRILRCSKDGHTSQARRWGLELAGEILEQGGKGILEKLYRQS

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=269, Percent_Identity=44.9814126394052, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI66933009, Length=270, Percent_Identity=44.8148148148148, Blast_Score=209, Evalue=3e-54,
Organism=Escherichia coli, GI48994974, Length=305, Percent_Identity=56.3934426229508, Blast_Score=307, Evalue=5e-85,
Organism=Saccharomyces cerevisiae, GI6319996, Length=276, Percent_Identity=41.6666666666667, Blast_Score=194, Evalue=1e-50,
Organism=Drosophila melanogaster, GI20130425, Length=282, Percent_Identity=39.7163120567376, Blast_Score=187, Evalue=8e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33745; Mature: 33745

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNTLTIATRGSRLALWQAEHVKSCLQAIRPGLEIRLNVIKTKGDIILDVPLAKVGGKGL
CCCEEEEEECCCEEEEEEHHHHHHHHHHHCCCCEEEEEEEEECCCEEEEECHHHHCCCCE
FVKEIEEALLNGEADLAVHSMKDVPMELPEGLILGCVPPREDPTDCLLSHKYDSVAALPP
EHHHHHHHHHCCCCCEEEHHHHCCCCCCCCCEEEECCCCCCCCHHHHHHCCCCCEECCCC
NACVGTSSLRRQSQLLAQRPDLRIESLRGNVDTRLRKLQEGMYDAIILASAGLKRLGLSA
CCCCCCHHHHHHHHHHHCCCCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCC
PHMHALDPHTFLPAVGQGALGIECRENDYELFTLLAEMEDSATRVCVEAERGFLAGLEGG
CCCCCCCCCHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCHHEEEEECCCCEEECCCCC
CQVPIAGHARLLDDDTLRLEGLVAEVDGSRILRCSKDGHTSQARRWGLELAGEILEQGGK
CCCCCCCCCEECCCCCEEEEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCH
GILEKLYRQS
HHHHHHHHCC
>Mature Secondary Structure
MRNTLTIATRGSRLALWQAEHVKSCLQAIRPGLEIRLNVIKTKGDIILDVPLAKVGGKGL
CCCEEEEEECCCEEEEEEHHHHHHHHHHHCCCCEEEEEEEEECCCEEEEECHHHHCCCCE
FVKEIEEALLNGEADLAVHSMKDVPMELPEGLILGCVPPREDPTDCLLSHKYDSVAALPP
EHHHHHHHHHCCCCCEEEHHHHCCCCCCCCCEEEECCCCCCCCHHHHHHCCCCCEECCCC
NACVGTSSLRRQSQLLAQRPDLRIESLRGNVDTRLRKLQEGMYDAIILASAGLKRLGLSA
CCCCCCHHHHHHHHHHHCCCCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCC
PHMHALDPHTFLPAVGQGALGIECRENDYELFTLLAEMEDSATRVCVEAERGFLAGLEGG
CCCCCCCCCHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCHHEEEEECCCCEEECCCCC
CQVPIAGHARLLDDDTLRLEGLVAEVDGSRILRCSKDGHTSQARRWGLELAGEILEQGGK
CCCCCCCCCEECCCCCEEEEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCH
GILEKLYRQS
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA