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The map label for this gene is folK [H]

Identifier: 220904456

GI number: 220904456

Start: 1395643

End: 1396167

Strand: Direct

Name: folK [H]

Synonym: Ddes_1186

Alternate gene names: 220904456

Gene position: 1395643-1396167 (Clockwise)

Preceding gene: 220904448

Following gene: 220904457

Centisome position: 48.57

GC content: 57.33

Gene sequence:

>525_bases
ATGCCCGAAAATTCGCCGGGAAAAGAATTCCAGGCTTACGTATGCCTTGGATCCAACTGTGCAAATGCGGAAGAGATGCT
GGTACGCGCCCGGCAGAAGTTGGCCGCCTTGCCGCGCATGCGTACAGGAGCAGCGTCGCCTCTCTACTGCACCGAACCAC
AGGGCTACGCGGACCAGTCCTGGTTTTTCAACCAAGTGATAGAGCTTTTTCCCGGTGCCTCCTGGACGCCGTGTTCTCTT
GTGGATGCCCTGCTGGATATTGAGGCAGATCTTGGCCGGGTGCGCAGCGCTGATCCGGCGCTACGCTTCGGACCGAGAGC
CATTGATGTCGATCTGCTGCTGTTCGGGCAGATAGGCAGCGAAAACCCTCACTGCCTTGTGCCGCATCCCCGCCTGACCC
AAAGGGCTTTTGCCCTTGTACCACTGCTTGATGTTGCCCCGCATGCCGTTATTGATGGTTTGCCCGCAACGGAATGGCTC
GCGCGCCTACAGTACAAAAAGGAAGGGCAGAGAATTTTTCAGTGA

Upstream 100 bases:

>100_bases
ATATCGTTGCCGCAGAGTGGACGCAGCCAAATTTGTCCGCTGTACGCGATTCGTCCAAGCGTTTATGTCCTAACGAGCAT
CCATGGGAAGGGGAAGACAT

Downstream 100 bases:

>100_bases
CTGGAAGAGGGGCCTGTGATAATCTTGTCCACGGCTTTCATGAATATTGTCGGAAGCCGCACAAGAGCCGTACGTGCCCG
TGCCCTGCACGGACCTAAGG

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 174; Mature: 173

Protein sequence:

>174_residues
MPENSPGKEFQAYVCLGSNCANAEEMLVRARQKLAALPRMRTGAASPLYCTEPQGYADQSWFFNQVIELFPGASWTPCSL
VDALLDIEADLGRVRSADPALRFGPRAIDVDLLLFGQIGSENPHCLVPHPRLTQRAFALVPLLDVAPHAVIDGLPATEWL
ARLQYKKEGQRIFQ

Sequences:

>Translated_174_residues
MPENSPGKEFQAYVCLGSNCANAEEMLVRARQKLAALPRMRTGAASPLYCTEPQGYADQSWFFNQVIELFPGASWTPCSL
VDALLDIEADLGRVRSADPALRFGPRAIDVDLLLFGQIGSENPHCLVPHPRLTQRAFALVPLLDVAPHAVIDGLPATEWL
ARLQYKKEGQRIFQ
>Mature_173_residues
PENSPGKEFQAYVCLGSNCANAEEMLVRARQKLAALPRMRTGAASPLYCTEPQGYADQSWFFNQVIELFPGASWTPCSLV
DALLDIEADLGRVRSADPALRFGPRAIDVDLLLFGQIGSENPHCLVPHPRLTQRAFALVPLLDVAPHAVIDGLPATEWLA
RLQYKKEGQRIFQ

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=143, Percent_Identity=35.6643356643357, Blast_Score=80, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 19232; Mature: 19101

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPENSPGKEFQAYVCLGSNCANAEEMLVRARQKLAALPRMRTGAASPLYCTEPQGYADQS
CCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCHH
WFFNQVIELFPGASWTPCSLVDALLDIEADLGRVRSADPALRFGPRAIDVDLLLFGQIGS
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCEEEEEEEEEECCCC
ENPHCLVPHPRLTQRAFALVPLLDVAPHAVIDGLPATEWLARLQYKKEGQRIFQ
CCCEEECCCCCHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PENSPGKEFQAYVCLGSNCANAEEMLVRARQKLAALPRMRTGAASPLYCTEPQGYADQS
CCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCHH
WFFNQVIELFPGASWTPCSLVDALLDIEADLGRVRSADPALRFGPRAIDVDLLLFGQIGS
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCEEEEEEEEEECCCC
ENPHCLVPHPRLTQRAFALVPLLDVAPHAVIDGLPATEWLARLQYKKEGQRIFQ
CCCEEECCCCCHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9168622 [H]