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The map label for this gene is mtr [H]

Identifier: 220904405

GI number: 220904405

Start: 1334770

End: 1335999

Strand: Reverse

Name: mtr [H]

Synonym: Ddes_1135

Alternate gene names: 220904405

Gene position: 1335999-1334770 (Counterclockwise)

Preceding gene: 220904406

Following gene: 220904404

Centisome position: 46.49

GC content: 55.93

Gene sequence:

>1230_bases
ATGGACTTCCGCTTTTCTCCTGTGCTTGGCGGCACCACTCTTGTTGCCGGCACGGCCATAGGCGCCGGTATGCTGGCCTT
ACCGATGGCCTCGGCCGGAATGTGGTTTTCGTGGTCAATCGGGCTGATGCTGATTTCCTGGATCATCATGCTGCGTTCAA
GCCAGGCACTGCTGGAAGTGAGCATGCATTTTGAACCCGGGGACAGCTTCCATACAATGGTCCGCGAACTGCTGGGACCC
AAATGGAGTCTCGTGAATGGCTTCGCCGTTGCCTTTGTGCTCTACACCCTGGTGTATGCCTATGTAAGCGGGGGCGGATC
CATAATCGAGCAAAGCATTACCTCCATAACCGGCACCGCGCCCCCGAGGCTGCTCAACAGCCTTGTATTCGCCCTGCTGC
TCACAGTATTTATCTGGTGGAGTTCCGAAGCGGTCGACAAGTTTTCCATCCTGCTTGTGGGCGGCATGGTCATATCTTAC
TTTATTTCCGTCAGCGGCATGATAACCCACTTGCGGGTAGACACACTGCTGGACCGTGGTGGCAGCGGCGGAGAAATGAT
CTTTCTGTGGGGGGCCGTTTCCACCTATCTGACGTCCTTCTGTTTTCACGCTTCTGTTCCGAGCCTGGTCAAGTATATGG
GCAAAGAGCCGCGCACCATTGATGCGAGCCTGCGCTACGGCACAATCGTGGCTCTGGTCTGCTATATATCCTGGCTGACT
GCCGCAGACGGCAACATTTCGCGCGCGGACTTCAGAGGCGTTATTGAAGCGGGCGGCAACGTTGGCGACCTGATGGCCGC
AGCAGGCAACAACCTGAGCAGTTTTTTGATTCTGCGGATGCTTGAAGGATTTTCGCTTCTGGCCGTTTCAACTTCTTTTC
TGGGAGCAGGCCTGGGACTTTTTGACTATATGGCCGACCTGTGCAATTTTGACAACAGCCGCTCCGGAAGAACCAAGACC
CTGTTGGTCACCTTTGTTCCGCCTATCCTGGGGGGCCTTATCTGGCCTGACGGCTTTTTGCCCGCCATCGGCTGGGCTGG
TCTGGCATCGGCATTCTGGGCAGTCATCATACCGGCCCTTTTGCTCAGCAACAGCCGCAAGCGCTATGGCAAGGCCGTGT
ACACTACGCCGGGCGGCCGCCTGACAGTGCCGCTGCTTCTGGCATATGGCTGCTTTGTCGCTGTTTGCCATACGCTTTTT
GTTTTCAATCTTTTACCCATGTACCGCTGA

Upstream 100 bases:

>100_bases
CCGGCGCCCTCTACAGCGTATGGCAGAACATTTCCGGAGCGCTGCTTTCCAATTTTTTTCATACCCGCCCAATGGATATC
ACCCCAAACAAGGAACTGTA

Downstream 100 bases:

>100_bases
AAGGAGCAATCATGAATAAGGAAGTCATCAGCACAGACAAGGCTCCTGCCGCCGTTGGCCCGTACAGCCAGGCCATCAAA
ACAGGCAACCTCATATTTCT

Product: aromatic amino acid transporter

Products: Indole [Cytoplasm]; L-tryptophan [Cytoplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Tryptophan permease [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MDFRFSPVLGGTTLVAGTAIGAGMLALPMASAGMWFSWSIGLMLISWIIMLRSSQALLEVSMHFEPGDSFHTMVRELLGP
KWSLVNGFAVAFVLYTLVYAYVSGGGSIIEQSITSITGTAPPRLLNSLVFALLLTVFIWWSSEAVDKFSILLVGGMVISY
FISVSGMITHLRVDTLLDRGGSGGEMIFLWGAVSTYLTSFCFHASVPSLVKYMGKEPRTIDASLRYGTIVALVCYISWLT
AADGNISRADFRGVIEAGGNVGDLMAAAGNNLSSFLILRMLEGFSLLAVSTSFLGAGLGLFDYMADLCNFDNSRSGRTKT
LLVTFVPPILGGLIWPDGFLPAIGWAGLASAFWAVIIPALLLSNSRKRYGKAVYTTPGGRLTVPLLLAYGCFVAVCHTLF
VFNLLPMYR

Sequences:

>Translated_409_residues
MDFRFSPVLGGTTLVAGTAIGAGMLALPMASAGMWFSWSIGLMLISWIIMLRSSQALLEVSMHFEPGDSFHTMVRELLGP
KWSLVNGFAVAFVLYTLVYAYVSGGGSIIEQSITSITGTAPPRLLNSLVFALLLTVFIWWSSEAVDKFSILLVGGMVISY
FISVSGMITHLRVDTLLDRGGSGGEMIFLWGAVSTYLTSFCFHASVPSLVKYMGKEPRTIDASLRYGTIVALVCYISWLT
AADGNISRADFRGVIEAGGNVGDLMAAAGNNLSSFLILRMLEGFSLLAVSTSFLGAGLGLFDYMADLCNFDNSRSGRTKT
LLVTFVPPILGGLIWPDGFLPAIGWAGLASAFWAVIIPALLLSNSRKRYGKAVYTTPGGRLTVPLLLAYGCFVAVCHTLF
VFNLLPMYR
>Mature_409_residues
MDFRFSPVLGGTTLVAGTAIGAGMLALPMASAGMWFSWSIGLMLISWIIMLRSSQALLEVSMHFEPGDSFHTMVRELLGP
KWSLVNGFAVAFVLYTLVYAYVSGGGSIIEQSITSITGTAPPRLLNSLVFALLLTVFIWWSSEAVDKFSILLVGGMVISY
FISVSGMITHLRVDTLLDRGGSGGEMIFLWGAVSTYLTSFCFHASVPSLVKYMGKEPRTIDASLRYGTIVALVCYISWLT
AADGNISRADFRGVIEAGGNVGDLMAAAGNNLSSFLILRMLEGFSLLAVSTSFLGAGLGLFDYMADLCNFDNSRSGRTKT
LLVTFVPPILGGLIWPDGFLPAIGWAGLASAFWAVIIPALLLSNSRKRYGKAVYTTPGGRLTVPLLLAYGCFVAVCHTLF
VFNLLPMYR

Specific function: Involved in transporting tryptophan across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789552, Length=387, Percent_Identity=42.8940568475452, Blast_Score=315, Evalue=4e-87,
Organism=Escherichia coli, GI1790145, Length=402, Percent_Identity=39.8009950248756, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1788218, Length=400, Percent_Identity=35, Blast_Score=202, Evalue=4e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 44046; Mature: 44046

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS00594 AROMATIC_AA_PERMEASE_1 ; PS01275 EFP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFRFSPVLGGTTLVAGTAIGAGMLALPMASAGMWFSWSIGLMLISWIIMLRSSQALLEV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHEEE
SMHFEPGDSFHTMVRELLGPKWSLVNGFAVAFVLYTLVYAYVSGGGSIIEQSITSITGTA
EECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC
PPRLLNSLVFALLLTVFIWWSSEAVDKFSILLVGGMVISYFISVSGMITHLRVDTLLDRG
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GSGGEMIFLWGAVSTYLTSFCFHASVPSLVKYMGKEPRTIDASLRYGTIVALVCYISWLT
CCCCCEEEEHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHH
AADGNISRADFRGVIEAGGNVGDLMAAAGNNLSSFLILRMLEGFSLLAVSTSFLGAGLGL
HCCCCCCHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCHHH
FDYMADLCNFDNSRSGRTKTLLVTFVPPILGGLIWPDGFLPAIGWAGLASAFWAVIIPAL
HHHHHHHHCCCCCCCCCCEEEEEEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
LLSNSRKRYGKAVYTTPGGRLTVPLLLAYGCFVAVCHTLFVFNLLPMYR
HHCCCHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDFRFSPVLGGTTLVAGTAIGAGMLALPMASAGMWFSWSIGLMLISWIIMLRSSQALLEV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHEEE
SMHFEPGDSFHTMVRELLGPKWSLVNGFAVAFVLYTLVYAYVSGGGSIIEQSITSITGTA
EECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC
PPRLLNSLVFALLLTVFIWWSSEAVDKFSILLVGGMVISYFISVSGMITHLRVDTLLDRG
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GSGGEMIFLWGAVSTYLTSFCFHASVPSLVKYMGKEPRTIDASLRYGTIVALVCYISWLT
CCCCCEEEEHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHH
AADGNISRADFRGVIEAGGNVGDLMAAAGNNLSSFLILRMLEGFSLLAVSTSFLGAGLGL
HCCCCCCHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCHHH
FDYMADLCNFDNSRSGRTKTLLVTFVPPILGGLIWPDGFLPAIGWAGLASAFWAVIIPAL
HHHHHHHHCCCCCCCCCCEEEEEEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
LLSNSRKRYGKAVYTTPGGRLTVPLLLAYGCFVAVCHTLFVFNLLPMYR
HHCCCHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Indole [Periplasm]; L-tryptophan [Periplasm]; Proton [Periplasm] [C]

Specific reaction: Proton [Periplasm] + indole [Periplasm] = Proton [Cytoplasm] + indole [Cytoplasm] L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1987112; 2061290; 9278503; 1904443; 7814318 [H]