Click here to switch to the map view.

The map label for this gene is aqpZ [H]

Identifier: 218905731

GI number: 218905731

Start: 4374787

End: 4375452

Strand: Direct

Name: aqpZ [H]

Synonym: BCAH820_4619

Alternate gene names: 218905731

Gene position: 4374787-4375452 (Clockwise)

Preceding gene: 218905730

Following gene: 218905735

Centisome position: 82.5

GC content: 36.34

Gene sequence:

>666_bases
ATGTTAAAAAAAGCAATCGCTGAATTTATTGGTACATTTGTACTAGTATTATTCGGAACTGGAGTAGCTGTCATTGGCGG
CGGAATTGAAGGAATTGGGACATTAGGAATCGCTATGGCTTTCGGTCTATCTATTGTGGCTATGGCATATAGCATCGGAA
CAATTTCTGGATGTCACATTAACCCAGCAGTATCAGTAGCTATGTTCATCAATAAAAGAATGAACGCTATGGAACTTTGT
TATTATGTATTAGCTCAAATTTTAGGTGGTTTATTAGGAACTGCAACATTGGTAACAATTTTACAATCCGCTAAAACACC
TTTAGATAATTTAGGACAAAATGGTTTTGGAACTCTTGGTTTATCTGGAGCATTTCTAGTTGAATTTATTTTAACTTTCG
TATTCATTTTAGTAATCGTTGCTGTAACAGGTAAAAAAGGAAGTTCTTCTCTAGCAGGATTAGTAATTGGTTTCACATTA
GTTTTAGTCCACTTATTAGGTATTCCGTTAACTGGGACTTCTGTTAACCCAGCTCGTAGTATCGCACCAGCTTTATTCGT
TGGCGGAGAAGCACTTTCTCAACTATGGGTATTCATCGTTGCACCAATTCTTGGCGGTATCGTAGCAGCTATCGTAGGCA
AATTCATTTTAAATACTGAAAAATAA

Upstream 100 bases:

>100_bases
TTGTCCCCCTATTTTGCCTTATCAGAATAGTATTTCATTGGCTGTTTATACTAAAACCTATGTTATAATACGTTTCATGC
GCAATAATAGGAGGTAAATT

Downstream 100 bases:

>100_bases
AATTTTCAATATTTCTGAATAAAAAAAGGCGAGCCCTCATTATGAGGATGCTCGCTTTTTTACTCTTTCATTTTAGACTT
TAAATTTGTAACTAATTGAT

Product: aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MLKKAIAEFIGTFVLVLFGTGVAVIGGGIEGIGTLGIAMAFGLSIVAMAYSIGTISGCHINPAVSVAMFINKRMNAMELC
YYVLAQILGGLLGTATLVTILQSAKTPLDNLGQNGFGTLGLSGAFLVEFILTFVFILVIVAVTGKKGSSSLAGLVIGFTL
VLVHLLGIPLTGTSVNPARSIAPALFVGGEALSQLWVFIVAPILGGIVAAIVGKFILNTEK

Sequences:

>Translated_221_residues
MLKKAIAEFIGTFVLVLFGTGVAVIGGGIEGIGTLGIAMAFGLSIVAMAYSIGTISGCHINPAVSVAMFINKRMNAMELC
YYVLAQILGGLLGTATLVTILQSAKTPLDNLGQNGFGTLGLSGAFLVEFILTFVFILVIVAVTGKKGSSSLAGLVIGFTL
VLVHLLGIPLTGTSVNPARSIAPALFVGGEALSQLWVFIVAPILGGIVAAIVGKFILNTEK
>Mature_221_residues
MLKKAIAEFIGTFVLVLFGTGVAVIGGGIEGIGTLGIAMAFGLSIVAMAYSIGTISGCHINPAVSVAMFINKRMNAMELC
YYVLAQILGGLLGTATLVTILQSAKTPLDNLGQNGFGTLGLSGAFLVEFILTFVFILVIVAVTGKKGSSSLAGLVIGFTL
VLVHLLGIPLTGTSVNPARSIAPALFVGGEALSQLWVFIVAPILGGIVAAIVGKFILNTEK

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4502179, Length=222, Percent_Identity=37.8378378378378, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI6912506, Length=221, Percent_Identity=35.2941176470588, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI4502183, Length=223, Percent_Identity=36.7713004484305, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI4502181, Length=218, Percent_Identity=35.7798165137615, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI4755125, Length=217, Percent_Identity=35.9447004608295, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI37694062, Length=224, Percent_Identity=33.0357142857143, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI86792455, Length=219, Percent_Identity=33.7899543378995, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI157266307, Length=240, Percent_Identity=32.0833333333333, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4826645, Length=247, Percent_Identity=33.1983805668016, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI4502187, Length=244, Percent_Identity=30.7377049180328, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI45446752, Length=189, Percent_Identity=32.2751322751323, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI22538420, Length=235, Percent_Identity=29.7872340425532, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1787101, Length=209, Percent_Identity=44.0191387559809, Blast_Score=151, Evalue=4e-38,
Organism=Escherichia coli, GI1790362, Length=246, Percent_Identity=27.2357723577236, Blast_Score=70, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71993722, Length=230, Percent_Identity=30.4347826086957, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17531431, Length=239, Percent_Identity=30.9623430962343, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17531429, Length=239, Percent_Identity=30.9623430962343, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17558372, Length=235, Percent_Identity=28.936170212766, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI212646268, Length=273, Percent_Identity=24.9084249084249, Blast_Score=73, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI71994009, Length=239, Percent_Identity=27.6150627615063, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321054, Length=211, Percent_Identity=28.436018957346, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24652747, Length=222, Percent_Identity=33.3333333333333, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45551084, Length=222, Percent_Identity=33.3333333333333, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24652751, Length=223, Percent_Identity=34.0807174887892, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19922038, Length=223, Percent_Identity=34.0807174887892, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24762344, Length=233, Percent_Identity=28.3261802575107, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24762346, Length=233, Percent_Identity=28.3261802575107, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24762348, Length=233, Percent_Identity=28.3261802575107, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI20130305, Length=233, Percent_Identity=28.3261802575107, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI17136672, Length=186, Percent_Identity=29.5698924731183, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI45550503, Length=227, Percent_Identity=27.7533039647577, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24762342, Length=195, Percent_Identity=26.1538461538462, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI19922828, Length=223, Percent_Identity=27.3542600896861, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 22613; Mature: 22613

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKKAIAEFIGTFVLVLFGTGVAVIGGGIEGIGTLGIAMAFGLSIVAMAYSIGTISGCHI
CCHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
NPAVSVAMFINKRMNAMELCYYVLAQILGGLLGTATLVTILQSAKTPLDNLGQNGFGTLG
CHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCC
LSGAFLVEFILTFVFILVIVAVTGKKGSSSLAGLVIGFTLVLVHLLGIPLTGTSVNPARS
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
IAPALFVGGEALSQLWVFIVAPILGGIVAAIVGKFILNTEK
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLKKAIAEFIGTFVLVLFGTGVAVIGGGIEGIGTLGIAMAFGLSIVAMAYSIGTISGCHI
CCHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
NPAVSVAMFINKRMNAMELCYYVLAQILGGLLGTATLVTILQSAKTPLDNLGQNGFGTLG
CHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCC
LSGAFLVEFILTFVFILVIVAVTGKKGSSSLAGLVIGFTLVLVHLLGIPLTGTSVNPARS
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
IAPALFVGGEALSQLWVFIVAPILGGIVAAIVGKFILNTEK
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]