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The map label for this gene is lspA

Identifier: 218905023

GI number: 218905023

Start: 3747003

End: 3747461

Strand: Reverse

Name: lspA

Synonym: BCAH820_3907

Alternate gene names: 218905023

Gene position: 3747461-3747003 (Counterclockwise)

Preceding gene: 218905024

Following gene: 218905022

Centisome position: 70.67

GC content: 31.15

Gene sequence:

>459_bases
ATGATATATTATGTAATAGCGTTATTTGTCATTGCCATCGATCAAATATCGAAATGGCTAATTGTAAAGAACATGGAATT
GGGTACGAGCATTCCGATTATCGATAATGTATTATACATAACATCACATCGAAATAGAGGAGCTGCCTGGGGCATTTTAG
AAAATAAAATGTGGTTCTTCTACATTATTACAGTCGTTTTTGTAGTATTTATCGTATTTTATATGAAAAAATATGCGAAA
ACAGACAAGCTTCTAGGAATTTCATTAGGTCTAATTTTAGGCGGAGCAATTGGCAATTTTATTGATCGTGTATTTAGACA
AGAAGTAGTGGATTTCATTCACGTGTATATTTTCTCGTACAACTATCCAGTATTCAATATAGCTGATTCAGCATTATGTA
TTGGTGTTGTATTAATTATTATTCAAACATTATTAGAAGGCAAGAAAACAAAGGAGTAA

Upstream 100 bases:

>100_bases
CTTTTTTTAATTTATTTTATTCTTCTATAAAGGTTCATTGTGAAAAGGTTGCAGCTATGCTAAAATTTTGAGGTACACTG
TCTTTGTGGGGGAAATGAAA

Downstream 100 bases:

>100_bases
TTGAATGAGTGAAGTAGTACAAGTAACAGTTGCAGAAGAACAAAAAAATGAGCGAATTGATAAATTCGTTGCAGGAATAA
ATAATGAATGGTCACGTACA

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 152; Mature: 152

Protein sequence:

>152_residues
MIYYVIALFVIAIDQISKWLIVKNMELGTSIPIIDNVLYITSHRNRGAAWGILENKMWFFYIITVVFVVFIVFYMKKYAK
TDKLLGISLGLILGGAIGNFIDRVFRQEVVDFIHVYIFSYNYPVFNIADSALCIGVVLIIIQTLLEGKKTKE

Sequences:

>Translated_152_residues
MIYYVIALFVIAIDQISKWLIVKNMELGTSIPIIDNVLYITSHRNRGAAWGILENKMWFFYIITVVFVVFIVFYMKKYAK
TDKLLGISLGLILGGAIGNFIDRVFRQEVVDFIHVYIFSYNYPVFNIADSALCIGVVLIIIQTLLEGKKTKE
>Mature_152_residues
MIYYVIALFVIAIDQISKWLIVKNMELGTSIPIIDNVLYITSHRNRGAAWGILENKMWFFYIITVVFVVFIVFYMKKYAK
TDKLLGISLGLILGGAIGNFIDRVFRQEVVDFIHVYIFSYNYPVFNIADSALCIGVVLIIIQTLLEGKKTKE

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=147, Percent_Identity=36.0544217687075, Blast_Score=97, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_BACAA (C3P663)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002868129.1
- EnsemblBacteria:   EBBACT00000126925
- GeneID:   7848921
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_4058
- GeneTree:   EBGT00050000001848
- ProtClustDB:   PRK00376
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 17454; Mature: 17454

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 102-102 ACT_SITE 129-129

Signals:

None

Transmembrane regions:

HASH(0x1efd3820)-; HASH(0x1f01b530)-; HASH(0x1efe25d8)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYYVIALFVIAIDQISKWLIVKNMELGTSIPIIDNVLYITSHRNRGAAWGILENKMWFF
CHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHEEEEECCCCCCCCCCHHHCCHHHH
YIITVVFVVFIVFYMKKYAKTDKLLGISLGLILGGAIGNFIDRVFRQEVVDFIHVYIFSY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NYPVFNIADSALCIGVVLIIIQTLLEGKKTKE
CCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCH
>Mature Secondary Structure
MIYYVIALFVIAIDQISKWLIVKNMELGTSIPIIDNVLYITSHRNRGAAWGILENKMWFF
CHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHEEEEECCCCCCCCCCHHHCCHHHH
YIITVVFVVFIVFYMKKYAKTDKLLGISLGLILGGAIGNFIDRVFRQEVVDFIHVYIFSY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NYPVFNIADSALCIGVVLIIIQTLLEGKKTKE
CCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA