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The map label for this gene is folE

Identifier: 218902722

GI number: 218902722

Start: 1515390

End: 1515959

Strand: Direct

Name: folE

Synonym: BCAH820_1605

Alternate gene names: 218902722

Gene position: 1515390-1515959 (Clockwise)

Preceding gene: 218902721

Following gene: 218902723

Centisome position: 28.58

GC content: 40.0

Gene sequence:

>570_bases
ATGGCAAAAGTTAATTTAGAACAAATTGAACATGCAGTACGCCTTATTTTAGAGGCAATTGGAGATGACCCTAATCGAGA
GGGAGTACTTGATACACCAAAGCGTGTTGCAAAAATGTACGCAGAAGTGTTCTCAGGTATGCATGAAGATCCGAAAGAAC
ATTTACACAAAGTGTTCGGAGAAGATCATGAGGAGCTTGTACTAGTAAAAGATATACCGTTTTATTCGATGTGTGAGCAT
CATTTAGTTCCATTCTATGGAGTTGCTCACGTTGCATATATTCCGCAAGGCGGAAAAGTGACAGGGTTAAGTAAATTAGC
TCGTACTGTAGATACAATTGCACGTCGTCCACAACTGCAAGAACGTATTACATCAACAGTAGCGAACTCTATTATGGAAG
TACTAGAGCCGCATGGTGTAATGGTAGTAGTAGAAGCAGAACATATGTGTATGACGATGCGCGGTGTGAAAAAGCCAGGT
GCAAAAACAGTAACAACAGCAGTACGTGGTGTGCTAGAAAATGATGCTGCAGCACGTAGTGAAATTTTATCTTTTATTAA
AACGAAGTAA

Upstream 100 bases:

>100_bases
AGAAGAGTTTCCTTTTTGGAAACTCTTCTTTTTGCTTTTAAAAACATAAATATGCTAGAATGTGTTCGTATCACTTTTAG
GTTTTCGGGAGGGCTAGCGG

Downstream 100 bases:

>100_bases
AGAAAAGTGGGAAACTGCTTTTCTTTTTTTTTTTTGTAAATAAATGATATAGTTTTAGCGAGGCACAGTGAGAATAGAAA
GATTACTTAAAAGAATAGAA

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I

Number of amino acids: Translated: 189; Mature: 188

Protein sequence:

>189_residues
MAKVNLEQIEHAVRLILEAIGDDPNREGVLDTPKRVAKMYAEVFSGMHEDPKEHLHKVFGEDHEELVLVKDIPFYSMCEH
HLVPFYGVAHVAYIPQGGKVTGLSKLARTVDTIARRPQLQERITSTVANSIMEVLEPHGVMVVVEAEHMCMTMRGVKKPG
AKTVTTAVRGVLENDAAARSEILSFIKTK

Sequences:

>Translated_189_residues
MAKVNLEQIEHAVRLILEAIGDDPNREGVLDTPKRVAKMYAEVFSGMHEDPKEHLHKVFGEDHEELVLVKDIPFYSMCEH
HLVPFYGVAHVAYIPQGGKVTGLSKLARTVDTIARRPQLQERITSTVANSIMEVLEPHGVMVVVEAEHMCMTMRGVKKPG
AKTVTTAVRGVLENDAAARSEILSFIKTK
>Mature_188_residues
AKVNLEQIEHAVRLILEAIGDDPNREGVLDTPKRVAKMYAEVFSGMHEDPKEHLHKVFGEDHEELVLVKDIPFYSMCEHH
LVPFYGVAHVAYIPQGGKVTGLSKLARTVDTIARRPQLQERITSTVANSIMEVLEPHGVMVVVEAEHMCMTMRGVKKPGA
KTVTTAVRGVLENDAAARSEILSFIKTK

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family

Homologues:

Organism=Homo sapiens, GI66932968, Length=187, Percent_Identity=47.5935828877005, Blast_Score=174, Evalue=4e-44,
Organism=Homo sapiens, GI4503949, Length=187, Percent_Identity=47.5935828877005, Blast_Score=174, Evalue=4e-44,
Organism=Homo sapiens, GI66932970, Length=155, Percent_Identity=45.1612903225806, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI66932972, Length=145, Percent_Identity=47.5862068965517, Blast_Score=131, Evalue=3e-31,
Organism=Escherichia coli, GI1788476, Length=179, Percent_Identity=36.8715083798883, Blast_Score=103, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17560486, Length=185, Percent_Identity=46.4864864864865, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6321706, Length=167, Percent_Identity=49.1017964071856, Blast_Score=167, Evalue=8e-43,
Organism=Drosophila melanogaster, GI24656782, Length=185, Percent_Identity=45.4054054054054, Blast_Score=163, Evalue=7e-41,
Organism=Drosophila melanogaster, GI24656796, Length=185, Percent_Identity=45.4054054054054, Blast_Score=162, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24656791, Length=185, Percent_Identity=45.4054054054054, Blast_Score=162, Evalue=2e-40,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): GCH1_BACAA (C3P598)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002866014.1
- ProteinModelPortal:   C3P598
- SMR:   C3P598
- EnsemblBacteria:   EBBACT00000127735
- GeneID:   7848097
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_1601
- GeneTree:   EBGT00050000002882
- ProtClustDB:   PRK09347
- GO:   GO:0005737
- HAMAP:   MF_00223
- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234
- TIGRFAMs:   TIGR00063

Pfam domain/function: PF01227 GTP_cyclohydroI

EC number: =3.5.4.16

Molecular weight: Translated: 21021; Mature: 20890

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVNLEQIEHAVRLILEAIGDDPNREGVLDTPKRVAKMYAEVFSGMHEDPKEHLHKVFG
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHC
EDHEELVLVKDIPFYSMCEHHLVPFYGVAHVAYIPQGGKVTGLSKLARTVDTIARRPQLQ
CCCCCEEEEECCCHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCHHHH
ERITSTVANSIMEVLEPHGVMVVVEAEHMCMTMRGVKKPGAKTVTTAVRGVLENDAAARS
HHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHH
EILSFIKTK
HHHHHHHCC
>Mature Secondary Structure 
AKVNLEQIEHAVRLILEAIGDDPNREGVLDTPKRVAKMYAEVFSGMHEDPKEHLHKVFG
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHC
EDHEELVLVKDIPFYSMCEHHLVPFYGVAHVAYIPQGGKVTGLSKLARTVDTIARRPQLQ
CCCCCEEEEECCCHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCHHHH
ERITSTVANSIMEVLEPHGVMVVVEAEHMCMTMRGVKKPGAKTVTTAVRGVLENDAAARS
HHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHH
EILSFIKTK
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA