Click here to switch to the map view.

The map label for this gene is moeB [H]

Identifier: 218884698

GI number: 218884698

Start: 1290642

End: 1291409

Strand: Direct

Name: moeB [H]

Synonym: DKAM_1387

Alternate gene names: 218884698

Gene position: 1290642-1291409 (Clockwise)

Preceding gene: 218884697

Following gene: 218884702

Centisome position: 94.54

GC content: 47.92

Gene sequence:

>768_bases
ATGAGTCTAAGCAGTGTAGAGTATGAGAGGTATAGTAGGCAGTTGCCAATAATAGGCGTGGAAGGGCAGTTGAAGCTTAA
GAAGACGAGCATCCTGGTCGCTGGTGCCGGCGGCCTCGCATCCACGATACTCTATTATTTAACAGCAGCTGGGGTCGGGA
GGATAGTGTTTATCGATGACGGGCTGGTGGAGCTGAGTAATCTCCAGAGGCAGATACTATACAATACAGAGGACATAGGG
AGACCAAAGGTGCTGGCTTCATATGAGAAGCTGGGGAAGCTGAATCCAGGTGTGACGCTGGAACCTATACAGGCGACTAT
AAGTAGGGAACTCCTGGATAAACTAGTCCCCAGCGTGGATATAGTTGTCGATGCCCTAGATAACTGGGAGACACGATTCC
TGCTTGACGAGTCTGCCTGGAGGTATGGAAAACCACTTGTTCACGCTGGGATTGGAGAGTATTATGGACAATTAACAGTT
GTAATACCTGGTAAAACCCCCTGTCTTAGATACTTGTTCCGCAGTGTTGGAGGAGGCGAGAGGGGGAGGGTCATAGTCAT
GGCTCATATACCGGGCTTGCTTGGATTACTGGAGGTAAACGAAGTATTTAAGCTCATACTGGGCTACGGTTCTCCATTAG
CCGGTAAAATACTATTGTTCAATGCGAAAACCCCTTCGATAGACCTTGTTGAAGTGAAGTATGAGAATAGTGAAGAAATA
GAAAAATACTGTGGCGAACCCGGAGTCAACCACCCATCTCGGGAGTAA

Upstream 100 bases:

>100_bases
AGCATATAGTGCTAAGGGAGGGAATCCCTCTAACAGAGGACGACATCATCAGGGATGGAGACGAGGTAGTTGTATACCTG
GTTAAATCAGGTGGGTAGGG

Downstream 100 bases:

>100_bases
CCAGCGTTATCCTATCGCCGTCTTTCAAAGGAGTATCTGGGGATAGAACTGGCTTATCGTTTACGAGTGTTACAAATATG
TAGTGTCCATCAATATATCT

Product: MoeB/thiF molybdopterin or thiamine synthase protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MSLSSVEYERYSRQLPIIGVEGQLKLKKTSILVAGAGGLASTILYYLTAAGVGRIVFIDDGLVELSNLQRQILYNTEDIG
RPKVLASYEKLGKLNPGVTLEPIQATISRELLDKLVPSVDIVVDALDNWETRFLLDESAWRYGKPLVHAGIGEYYGQLTV
VIPGKTPCLRYLFRSVGGGERGRVIVMAHIPGLLGLLEVNEVFKLILGYGSPLAGKILLFNAKTPSIDLVEVKYENSEEI
EKYCGEPGVNHPSRE

Sequences:

>Translated_255_residues
MSLSSVEYERYSRQLPIIGVEGQLKLKKTSILVAGAGGLASTILYYLTAAGVGRIVFIDDGLVELSNLQRQILYNTEDIG
RPKVLASYEKLGKLNPGVTLEPIQATISRELLDKLVPSVDIVVDALDNWETRFLLDESAWRYGKPLVHAGIGEYYGQLTV
VIPGKTPCLRYLFRSVGGGERGRVIVMAHIPGLLGLLEVNEVFKLILGYGSPLAGKILLFNAKTPSIDLVEVKYENSEEI
EKYCGEPGVNHPSRE
>Mature_254_residues
SLSSVEYERYSRQLPIIGVEGQLKLKKTSILVAGAGGLASTILYYLTAAGVGRIVFIDDGLVELSNLQRQILYNTEDIGR
PKVLASYEKLGKLNPGVTLEPIQATISRELLDKLVPSVDIVVDALDNWETRFLLDESAWRYGKPLVHAGIGEYYGQLTVV
IPGKTPCLRYLFRSVGGGERGRVIVMAHIPGLLGLLEVNEVFKLILGYGSPLAGKILLFNAKTPSIDLVEVKYENSEEIE
KYCGEPGVNHPSRE

Specific function: Involved In The Biosynthesis Of A Demolybdo Cofactor (Molybdopterin), Necessary For Molybdoenzymes. Plays A Role In The Activation Of The Small Subunit Of The Molybdopterin Converting Factor (Moad). [C]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=227, Percent_Identity=37.0044052863436, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI38045948, Length=166, Percent_Identity=30.7228915662651, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI23510338, Length=163, Percent_Identity=29.4478527607362, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI23510340, Length=163, Percent_Identity=29.4478527607362, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI38045942, Length=159, Percent_Identity=30.8176100628931, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI38045944, Length=159, Percent_Identity=30.8176100628931, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1787048, Length=227, Percent_Identity=36.1233480176211, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI87082356, Length=227, Percent_Identity=37.8854625550661, Blast_Score=130, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17540406, Length=230, Percent_Identity=32.6086956521739, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI193203301, Length=157, Percent_Identity=29.2993630573248, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI25152899, Length=90, Percent_Identity=40, Blast_Score=70, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6321903, Length=256, Percent_Identity=33.203125, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6322639, Length=166, Percent_Identity=30.1204819277108, Blast_Score=79, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6320598, Length=166, Percent_Identity=29.5180722891566, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24582879, Length=266, Percent_Identity=32.7067669172932, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI28573937, Length=165, Percent_Identity=28.4848484848485, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24660640, Length=144, Percent_Identity=30.5555555555556, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 28017; Mature: 27886

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSSVEYERYSRQLPIIGVEGQLKLKKTSILVAGAGGLASTILYYLTAAGVGRIVFIDD
CCCCCCHHHHHHCCCCEEECCCCEEEEEEEEEEEECCHHHHHHHHHHHHCCCCEEEEEEC
GLVELSNLQRQILYNTEDIGRPKVLASYEKLGKLNPGVTLEPIQATISRELLDKLVPSVD
CHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHCCCCE
IVVDALDNWETRFLLDESAWRYGKPLVHAGIGEYYGQLTVVIPGKTPCLRYLFRSVGGGE
EEEECCCCCCEEEEECCCCHHHCCCHHCCCHHHHCCEEEEEECCCCHHHHHHHHHCCCCC
RGRVIVMAHIPGLLGLLEVNEVFKLILGYGSPLAGKILLFNAKTPSIDLVEVKYENSEEI
CCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEEEECCHHHH
EKYCGEPGVNHPSRE
HHHCCCCCCCCCCCC
>Mature Secondary Structure 
SLSSVEYERYSRQLPIIGVEGQLKLKKTSILVAGAGGLASTILYYLTAAGVGRIVFIDD
CCCCCHHHHHHCCCCEEECCCCEEEEEEEEEEEECCHHHHHHHHHHHHCCCCEEEEEEC
GLVELSNLQRQILYNTEDIGRPKVLASYEKLGKLNPGVTLEPIQATISRELLDKLVPSVD
CHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHCCCCE
IVVDALDNWETRFLLDESAWRYGKPLVHAGIGEYYGQLTVVIPGKTPCLRYLFRSVGGGE
EEEECCCCCCEEEEECCCCHHHCCCHHCCCHHHHCCEEEEEECCCCHHHHHHHHHCCCCC
RGRVIVMAHIPGLLGLLEVNEVFKLILGYGSPLAGKILLFNAKTPSIDLVEVKYENSEEI
CCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEEEECCHHHH
EKYCGEPGVNHPSRE
HHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA