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The map label for this gene is mtnA [H]

Identifier: 218884524

GI number: 218884524

Start: 1134712

End: 1135785

Strand: Direct

Name: mtnA [H]

Synonym: DKAM_1213

Alternate gene names: 218884524

Gene position: 1134712-1135785 (Clockwise)

Preceding gene: 218884518

Following gene: 218884525

Centisome position: 83.12

GC content: 47.77

Gene sequence:

>1074_bases
ATGAGTACTCCCTACCCACTTAAAATAAGGGCTGTATGGTACGATAAAGAATCCAACGCTGTATGCTGGGTGAACACCCT
TAAACTCCCATTTAAAGAAGAGGTCTACTGCAGCAACAGCCCTGAGAGAGTTGCCAAGGCGATCATCGAGATGGAGATAC
GGGGGGCACCGGCAATAGGTGTCGCCGCTGCCCTAGCGGTTGGAAGCTATGCTGTTGGAGTAAGCAGTCTACCTCTAGGA
GACTTCGCTATGAGTGTGGGGAAAGCCATTGATACATTGTGGAGAACCCGTCCAACAGCACATAATCTATTCTATGCATT
GAATAGGTTGAGGAAGATACTTGAAGAAAACGTTGAGAAGAATACTTCACCAAGCGAGATAGCCAAGAGGATCCTGGATG
AAGCCCTTAAAGTAATGTGGGAGGATATAGAGTCTAATATAAGGATCGGCGAGTACGGCGCCGAGCTAATACCGGATGGT
GCCACTATACTAACACACTGCAACGCAGGAGCACTAGCCACATCGGCCTTCGGGACAGCTGAAGCAGTTATGAGGGTTGC
ATGGTATAAGGGCAAGAAGATAAAGGTTATAGCTACTGAAACCCGCCCCATGCTACAGGGAGCTAGGTTAACGGTGTGGG
AGCTCTGGAAGGAGGGTATACCGGTTACATTAATAACCGATAACATGGCTGGCTACGTCATCAGGAGGGGGCTAGTAGAC
GCTGTAATAGTGGGGGCAGACAGAGTGACAAGGGAGGGGTATGTGGTTAATAAGATAGGCACGTATATGATAGCCCTAGC
CGCGAAAAGGAACAATATACCATTCTACGTTGCAGCGCCCACTAGTACAATAGACTTGTCGAGTAGCATTAACGATGTGG
TGATAGAGGAGAGGAATCCAAGGGAGGTGAAATATGTATTGGATAAGCTTATAACGGTTGAAGAAGTAAACGCGTTAAAC
TACGCGTTCGACATAACCGATCCGGACCTCGTGACAGCCATAATAACTGAGAAAGGAATTGTATATCCCCCCTTCGAGGA
GAACCTGGAGAAGATAATGAAGGATCGTGGCTGA

Upstream 100 bases:

>100_bases
CAACTTAAACACCTTGCTGTATCAAGCATTAGTATCGGGTTTCAAGGTTATAATTTAAGCTTAAGATTGTGTTACCTGAA
TCAGGTGATGTCGATTGACA

Downstream 100 bases:

>100_bases
AAGACACATGCTTAAGGTGGGAGAGGAAGTCGGAGAATACTAGTGATTGACTATGCAGTACGAGTTATCCAACTTAGTAG
AGGCTATTAAAATAATCTAT

Product: translation initiation factor, aIF-2B subunit alpha-related

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase [H]

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MSTPYPLKIRAVWYDKESNAVCWVNTLKLPFKEEVYCSNSPERVAKAIIEMEIRGAPAIGVAAALAVGSYAVGVSSLPLG
DFAMSVGKAIDTLWRTRPTAHNLFYALNRLRKILEENVEKNTSPSEIAKRILDEALKVMWEDIESNIRIGEYGAELIPDG
ATILTHCNAGALATSAFGTAEAVMRVAWYKGKKIKVIATETRPMLQGARLTVWELWKEGIPVTLITDNMAGYVIRRGLVD
AVIVGADRVTREGYVVNKIGTYMIALAAKRNNIPFYVAAPTSTIDLSSSINDVVIEERNPREVKYVLDKLITVEEVNALN
YAFDITDPDLVTAIITEKGIVYPPFEENLEKIMKDRG

Sequences:

>Translated_357_residues
MSTPYPLKIRAVWYDKESNAVCWVNTLKLPFKEEVYCSNSPERVAKAIIEMEIRGAPAIGVAAALAVGSYAVGVSSLPLG
DFAMSVGKAIDTLWRTRPTAHNLFYALNRLRKILEENVEKNTSPSEIAKRILDEALKVMWEDIESNIRIGEYGAELIPDG
ATILTHCNAGALATSAFGTAEAVMRVAWYKGKKIKVIATETRPMLQGARLTVWELWKEGIPVTLITDNMAGYVIRRGLVD
AVIVGADRVTREGYVVNKIGTYMIALAAKRNNIPFYVAAPTSTIDLSSSINDVVIEERNPREVKYVLDKLITVEEVNALN
YAFDITDPDLVTAIITEKGIVYPPFEENLEKIMKDRG
>Mature_356_residues
STPYPLKIRAVWYDKESNAVCWVNTLKLPFKEEVYCSNSPERVAKAIIEMEIRGAPAIGVAAALAVGSYAVGVSSLPLGD
FAMSVGKAIDTLWRTRPTAHNLFYALNRLRKILEENVEKNTSPSEIAKRILDEALKVMWEDIESNIRIGEYGAELIPDGA
TILTHCNAGALATSAFGTAEAVMRVAWYKGKKIKVIATETRPMLQGARLTVWELWKEGIPVTLITDNMAGYVIRRGLVDA
VIVGADRVTREGYVVNKIGTYMIALAAKRNNIPFYVAAPTSTIDLSSSINDVVIEERNPREVKYVLDKLITVEEVNALNY
AFDITDPDLVTAIITEKGIVYPPFEENLEKIMKDRG

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) [H]

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily [H]

Homologues:

Organism=Homo sapiens, GI72534748, Length=348, Percent_Identity=36.7816091954023, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI23943880, Length=340, Percent_Identity=31.7647058823529, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI4503503, Length=220, Percent_Identity=30.9090909090909, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI187607323, Length=175, Percent_Identity=27.4285714285714, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI78000158, Length=175, Percent_Identity=27.4285714285714, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI78000156, Length=175, Percent_Identity=27.4285714285714, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17557462, Length=311, Percent_Identity=37.2990353697749, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17557123, Length=160, Percent_Identity=36.25, Blast_Score=82, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6325375, Length=400, Percent_Identity=31, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6322878, Length=201, Percent_Identity=30.3482587064677, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357667, Length=371, Percent_Identity=36.6576819407008, Blast_Score=201, Evalue=5e-52,
Organism=Drosophila melanogaster, GI24651647, Length=371, Percent_Identity=36.6576819407008, Blast_Score=201, Evalue=5e-52,
Organism=Drosophila melanogaster, GI281364091, Length=269, Percent_Identity=27.5092936802974, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24659399, Length=269, Percent_Identity=27.5092936802974, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24659407, Length=269, Percent_Identity=27.5092936802974, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19922816, Length=269, Percent_Identity=27.5092936802974, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21358605, Length=196, Percent_Identity=31.1224489795918, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559 [H]

Pfam domain/function: PF01008 IF-2B [H]

EC number: =5.3.1.23 [H]

Molecular weight: Translated: 39513; Mature: 39382

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPYPLKIRAVWYDKESNAVCWVNTLKLPFKEEVYCSNSPERVAKAIIEMEIRGAPAIG
CCCCCCEEEEEEEEECCCCEEEEEEEECCCCCCCEECCCCHHHHHHHHHHHHCCCCCHHH
VAAALAVGSYAVGVSSLPLGDFAMSVGKAIDTLWRTRPTAHNLFYALNRLRKILEENVEK
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
NTSPSEIAKRILDEALKVMWEDIESNIRIGEYGAELIPDGATILTHCNAGALATSAFGTA
CCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHCCCCCEEEEECCCCCHHHHHCHHH
EAVMRVAWYKGKKIKVIATETRPMLQGARLTVWELWKEGIPVTLITDNMAGYVIRRGLVD
HHHHHHHHCCCCEEEEEEECCCHHHCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHH
AVIVGADRVTREGYVVNKIGTYMIALAAKRNNIPFYVAAPTSTIDLSSSINDVVIEERNP
HEEECCCHHCCCCEEEEHHHHEEEEEEEECCCCCEEEECCCCEEECCCCCCCEEEECCCC
REVKYVLDKLITVEEVNALNYAFDITDPDLVTAIITEKGIVYPPFEENLEKIMKDRG
HHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHEECCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
STPYPLKIRAVWYDKESNAVCWVNTLKLPFKEEVYCSNSPERVAKAIIEMEIRGAPAIG
CCCCCEEEEEEEEECCCCEEEEEEEECCCCCCCEECCCCHHHHHHHHHHHHCCCCCHHH
VAAALAVGSYAVGVSSLPLGDFAMSVGKAIDTLWRTRPTAHNLFYALNRLRKILEENVEK
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
NTSPSEIAKRILDEALKVMWEDIESNIRIGEYGAELIPDGATILTHCNAGALATSAFGTA
CCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHCCCCCEEEEECCCCCHHHHHCHHH
EAVMRVAWYKGKKIKVIATETRPMLQGARLTVWELWKEGIPVTLITDNMAGYVIRRGLVD
HHHHHHHHCCCCEEEEEEECCCHHHCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHH
AVIVGADRVTREGYVVNKIGTYMIALAAKRNNIPFYVAAPTSTIDLSSSINDVVIEERNP
HEEECCCHHCCCCEEEEHHHHEEEEEEEECCCCCEEEECCCCEEECCCCCCCEEEECCCC
REVKYVLDKLITVEEVNALNYAFDITDPDLVTAIITEKGIVYPPFEENLEKIMKDRG
HHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHEECCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]