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The map label for this gene is pucD [H]

Identifier: 218884051

GI number: 218884051

Start: 709064

End: 711406

Strand: Reverse

Name: pucD [H]

Synonym: DKAM_0740

Alternate gene names: 218884051

Gene position: 711406-709064 (Counterclockwise)

Preceding gene: 218884054

Following gene: 218884050

Centisome position: 52.11

GC content: 49.89

Gene sequence:

>2343_bases
ATGGTGGATTCAACCAGCCTCCTGGAGAAATGGCTCTCAGCAAGTGAATTCCTCGTTATAGGTAGGAAAGTGTCAAGAGT
CGACTCCCTGGAAAAGGCTCTTGGTAAAGCATTATTCACTGAGGATTACTACATAGACTACTTCCTCGGTAATGCATTAT
ACGTTAAGCAAGTGTTAAGCACTTATCCACATGCAAGACTGAAGAGTATAAGCCTACCGGAACACCTGAGGAGTAAGGGC
GTGAAGTTGTTCACAGCTAGGGATATACCCGGGGAAAACCAGGTGGGATACGCGTTGCCTGATCAACCATTACTTGCAGA
AGGAAAGGTGAGATATCACGGGGAAGTAGTGGCACTGGTTGCCTCCATAGATATGGATGAAGCTCTCAGGGCAGTTGAGG
AGGTAAGGGTAGAGTATGAGCCCTTACCATATATACTGGATCCGTTGGAGGCTATGAATAGGAATGATATCCTTATCCAC
GAGGAAGCGGGCTCGAATATAGCGTTTAAGACGAGGGTTAGGAGGGGTAATGTCGAGGAGGGGTTTTCAAGAGCCCATGT
CATAGTTGAGAATGAGTATAGGCTACACCACCAGGAGCATGCATACCTGGAGACTGAAGCGGCGTTGGCGATCCCGAGTA
TTGAGGGGGGCGTGACTATAATAGGTGGGCTCCAGTATCCTCACCTCGGGCAGAGAATAGTTGCAAGGGTCCTGGGTTTA
CCATTAAGTAAGGTAAAAATAGTTGCACCTTACATAGGTGGAGGCTTCGGCGGTAAGGATGACGAGGGCCCGTTGGCATG
TGCTAAGGCAGCTCTTGTAGCCTACTTGACTGGTAAGCCAGCCCTACTGATATATAGTAGGGAGGAATCAATCAAGGTGC
ATCCTAAGAGGGAGGCGGCAATCATAAGGTATAGGAGCGGGGCTGATGCCGATGGGAGGCTCACGGCTATAGATGTAACA
ATAATACATGACACTGGTGCATACGCTAACAGAGGGCCCTTCATACTTTGGCGTGCAACAATGCATGCCTCCGGGCCCTA
TGTAGTACCCAATGCAAGGATCGATGGCTACGCTGTGTACACTAATAAAGTATACCAGGGCTCGTTCAGGGGCTTCGGCA
ACTTATCAATACAGTTCGCTGTTGAGAGGCAGATGGATCAATTAGCTGAGAGACTCGGGTTAGACCCAGTTGAATTCAGG
TTGAAGAACATTGTAAGAGAGGGCTCTTTCACTATCACAGGGCAGCTACTAGACCACTCTGTTGGAGTAGCCGATGCCTT
GGTAAAGGTTGCTAATACATGCCGGTGGCGTGAGAGGAGGCGTGAGATAGAGGAGTTCAATAAGCATAGTGAAAGAATTA
AGAAGGGTATTGGTGTGGCCGTGGCATGGCATGGTATTAGCACATCCAGGGGTGTACCAGACTGGTCAAACGCATATGTG
AAGATAGAGCAGGATGGCTCGGTCACGCTGTACACTGGCATCGTGGAGATTGGACAGGGCTCGCCGAGCTCAGCTCATGT
ACAAATAGTATGCGAGCTACTCGGTATAACACCCGACAGGATCAGAGTAGTGTATGGCACAACGGACTCCCCCGATACCG
GTGCAACCCATGCATCAAGGGGTAGTAGCATAGGGGGGATAGGGGTCTACGTAGCGGCTTCGAAGCTAAGGGAGAGGCTG
AGCGAGCTGGCATCCAGGGTCCTAGGAGTGCCCGTGGAGGACCTAGTGTTCGCGGATAACAAGGTCTACTCGAAGAGTAA
CCCTGGTAAGCAGATATCGCTGAGAGACCTCGTTAAGGAGGCGATGGCCAGGGGTGTCGAGTTATCTGCAACAGGCTATT
TCTTCCTACCAAAAGGTAGATTCGATGATGCTGTGGGGCAGGGATTCGCGTACCCAGCCTACAGCTATATCGTGGTAGTC
TCTGAGGTTGAAGTAGATACATTAACAGGCGTTGTAAGGGTTACACGGGTATATCCAGGCCTAGCTGCTGGAAGGATAAT
CAATCCCCAGCAGGTTGAGGGACAGATAGAGGGCGCTGTAGCTCAGGGCGTGGGATATGCATTGATGGAGAAACTAGTGT
TCAGTGATAACGGAGAGGTATTGAACACTAACCTAACGGACTACGTTATCCCGACGATCAAGGATGTACCGGAGATAGCT
GAGCCGATTTACGTTGAAGACTTATTCAAGTACGGTCCCTTCGGCGCTAAAGGTGTCGGTGAAATGGCCCTCATACCTAT
GCCGGCCTCAATAGCTAATGCTGTAAGTCATGCACTAGGGGTCAATGTAACTAGGACACCATTGACCCCTGAGGAGGTGC
TTAGATTGATTGGTAGACTATGA

Upstream 100 bases:

>100_bases
TTCTAATGAGTAGGCTCATAGCTATCACATTATGGATCGATGATATATTGAATAAAAAATATTTATTTATTATAGCAATA
AATTGACTTGAGGTGCACTT

Downstream 100 bases:

>100_bases
GGTGGTGGCAGTGTTCTACCGGTTACCTGAGATAAGGTATTATAGGCCATCTACACTTGATGAAGCACTCAAACTACTCG
GCGAACTGAGTGAGAAGGCT

Product: aldehyde oxidase and xanthine dehydrogenase

Products: NA

Alternate protein names: XDHase subunit D [H]

Number of amino acids: Translated: 780; Mature: 780

Protein sequence:

>780_residues
MVDSTSLLEKWLSASEFLVIGRKVSRVDSLEKALGKALFTEDYYIDYFLGNALYVKQVLSTYPHARLKSISLPEHLRSKG
VKLFTARDIPGENQVGYALPDQPLLAEGKVRYHGEVVALVASIDMDEALRAVEEVRVEYEPLPYILDPLEAMNRNDILIH
EEAGSNIAFKTRVRRGNVEEGFSRAHVIVENEYRLHHQEHAYLETEAALAIPSIEGGVTIIGGLQYPHLGQRIVARVLGL
PLSKVKIVAPYIGGGFGGKDDEGPLACAKAALVAYLTGKPALLIYSREESIKVHPKREAAIIRYRSGADADGRLTAIDVT
IIHDTGAYANRGPFILWRATMHASGPYVVPNARIDGYAVYTNKVYQGSFRGFGNLSIQFAVERQMDQLAERLGLDPVEFR
LKNIVREGSFTITGQLLDHSVGVADALVKVANTCRWRERRREIEEFNKHSERIKKGIGVAVAWHGISTSRGVPDWSNAYV
KIEQDGSVTLYTGIVEIGQGSPSSAHVQIVCELLGITPDRIRVVYGTTDSPDTGATHASRGSSIGGIGVYVAASKLRERL
SELASRVLGVPVEDLVFADNKVYSKSNPGKQISLRDLVKEAMARGVELSATGYFFLPKGRFDDAVGQGFAYPAYSYIVVV
SEVEVDTLTGVVRVTRVYPGLAAGRIINPQQVEGQIEGAVAQGVGYALMEKLVFSDNGEVLNTNLTDYVIPTIKDVPEIA
EPIYVEDLFKYGPFGAKGVGEMALIPMPASIANAVSHALGVNVTRTPLTPEEVLRLIGRL

Sequences:

>Translated_780_residues
MVDSTSLLEKWLSASEFLVIGRKVSRVDSLEKALGKALFTEDYYIDYFLGNALYVKQVLSTYPHARLKSISLPEHLRSKG
VKLFTARDIPGENQVGYALPDQPLLAEGKVRYHGEVVALVASIDMDEALRAVEEVRVEYEPLPYILDPLEAMNRNDILIH
EEAGSNIAFKTRVRRGNVEEGFSRAHVIVENEYRLHHQEHAYLETEAALAIPSIEGGVTIIGGLQYPHLGQRIVARVLGL
PLSKVKIVAPYIGGGFGGKDDEGPLACAKAALVAYLTGKPALLIYSREESIKVHPKREAAIIRYRSGADADGRLTAIDVT
IIHDTGAYANRGPFILWRATMHASGPYVVPNARIDGYAVYTNKVYQGSFRGFGNLSIQFAVERQMDQLAERLGLDPVEFR
LKNIVREGSFTITGQLLDHSVGVADALVKVANTCRWRERRREIEEFNKHSERIKKGIGVAVAWHGISTSRGVPDWSNAYV
KIEQDGSVTLYTGIVEIGQGSPSSAHVQIVCELLGITPDRIRVVYGTTDSPDTGATHASRGSSIGGIGVYVAASKLRERL
SELASRVLGVPVEDLVFADNKVYSKSNPGKQISLRDLVKEAMARGVELSATGYFFLPKGRFDDAVGQGFAYPAYSYIVVV
SEVEVDTLTGVVRVTRVYPGLAAGRIINPQQVEGQIEGAVAQGVGYALMEKLVFSDNGEVLNTNLTDYVIPTIKDVPEIA
EPIYVEDLFKYGPFGAKGVGEMALIPMPASIANAVSHALGVNVTRTPLTPEEVLRLIGRL
>Mature_780_residues
MVDSTSLLEKWLSASEFLVIGRKVSRVDSLEKALGKALFTEDYYIDYFLGNALYVKQVLSTYPHARLKSISLPEHLRSKG
VKLFTARDIPGENQVGYALPDQPLLAEGKVRYHGEVVALVASIDMDEALRAVEEVRVEYEPLPYILDPLEAMNRNDILIH
EEAGSNIAFKTRVRRGNVEEGFSRAHVIVENEYRLHHQEHAYLETEAALAIPSIEGGVTIIGGLQYPHLGQRIVARVLGL
PLSKVKIVAPYIGGGFGGKDDEGPLACAKAALVAYLTGKPALLIYSREESIKVHPKREAAIIRYRSGADADGRLTAIDVT
IIHDTGAYANRGPFILWRATMHASGPYVVPNARIDGYAVYTNKVYQGSFRGFGNLSIQFAVERQMDQLAERLGLDPVEFR
LKNIVREGSFTITGQLLDHSVGVADALVKVANTCRWRERRREIEEFNKHSERIKKGIGVAVAWHGISTSRGVPDWSNAYV
KIEQDGSVTLYTGIVEIGQGSPSSAHVQIVCELLGITPDRIRVVYGTTDSPDTGATHASRGSSIGGIGVYVAASKLRERL
SELASRVLGVPVEDLVFADNKVYSKSNPGKQISLRDLVKEAMARGVELSATGYFFLPKGRFDDAVGQGFAYPAYSYIVVV
SEVEVDTLTGVVRVTRVYPGLAAGRIINPQQVEGQIEGAVAQGVGYALMEKLVFSDNGEVLNTNLTDYVIPTIKDVPEIA
EPIYVEDLFKYGPFGAKGVGEMALIPMPASIANAVSHALGVNVTRTPLTPEEVLRLIGRL

Specific function: Oxidizes hypoxanthine and xanthine to uric acid [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=776, Percent_Identity=29.2525773195876, Blast_Score=289, Evalue=6e-78,
Organism=Homo sapiens, GI71773480, Length=773, Percent_Identity=27.5549805950841, Blast_Score=238, Evalue=2e-62,
Organism=Escherichia coli, GI1789230, Length=772, Percent_Identity=30.699481865285, Blast_Score=310, Evalue=2e-85,
Organism=Escherichia coli, GI1789246, Length=824, Percent_Identity=27.6699029126214, Blast_Score=250, Evalue=3e-67,
Organism=Escherichia coli, GI1786478, Length=785, Percent_Identity=27.1337579617834, Blast_Score=169, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17540638, Length=739, Percent_Identity=28.1461434370771, Blast_Score=249, Evalue=5e-66,
Organism=Caenorhabditis elegans, GI17539860, Length=782, Percent_Identity=27.2378516624041, Blast_Score=208, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI32566215, Length=771, Percent_Identity=26.1997405966278, Blast_Score=205, Evalue=7e-53,
Organism=Drosophila melanogaster, GI17737937, Length=723, Percent_Identity=30.9820193637621, Blast_Score=294, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24647193, Length=788, Percent_Identity=27.0304568527919, Blast_Score=180, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24647199, Length=755, Percent_Identity=25.2980132450331, Blast_Score=165, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24647201, Length=766, Percent_Identity=24.1514360313316, Blast_Score=156, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24647195, Length=711, Percent_Identity=23.7693389592124, Blast_Score=147, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24647197, Length=750, Percent_Identity=24.1333333333333, Blast_Score=143, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR017609 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 85240; Mature: 85240

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDSTSLLEKWLSASEFLVIGRKVSRVDSLEKALGKALFTEDYYIDYFLGNALYVKQVLS
CCCCHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHH
TYPHARLKSISLPEHLRSKGVKLFTARDIPGENQVGYALPDQPLLAEGKVRYHGEVVALV
HCCCCHHCCCCCHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEECCEEEEEE
ASIDMDEALRAVEEVRVEYEPLPYILDPLEAMNRNDILIHEEAGSNIAFKTRVRRGNVEE
ECCCHHHHHHHHHHHHHCCCCCCHHHCHHHHCCCCCEEEEECCCCCEEEEEEECCCCHHH
GFSRAHVIVENEYRLHHQEHAYLETEAALAIPSIEGGVTIIGGLQYPHLGQRIVARVLGL
CCCEEEEEEECCHHCCCCHHHEEECCCEEECCCCCCCEEEEECCCCCCHHHHHHHHHHCC
PLSKVKIVAPYIGGGFGGKDDEGPLACAKAALVAYLTGKPALLIYSREESIKVHPKREAA
CCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHEECCCCEEEEEECCCCEEECCCCCEE
IIRYRSGADADGRLTAIDVTIIHDTGAYANRGPFILWRATMHASGPYVVPNARIDGYAVY
EEEEECCCCCCCEEEEEEEEEEECCCCCCCCCCEEEEEEEECCCCCEEECCCCCCCEEEE
TNKVYQGSFRGFGNLSIQFAVERQMDQLAERLGLDPVEFRLKNIVREGSFTITGQLLDHS
ECEEEECCCCCCCCEEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEEHHHCC
VGVADALVKVANTCRWRERRREIEEFNKHSERIKKGIGVAVAWHGISTSRGVPDWSNAYV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCEE
KIEQDGSVTLYTGIVEIGQGSPSSAHVQIVCELLGITPDRIRVVYGTTDSPDTGATHASR
EEECCCCEEEEEEEEEECCCCCCCCHHEEEHHHHCCCCCCEEEEECCCCCCCCCCCCCCC
GSSIGGIGVYVAASKLRERLSELASRVLGVPVEDLVFADNKVYSKSNPGKQISLRDLVKE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEECCCCEECCCCCCCEEEHHHHHHH
AMARGVELSATGYFFLPKGRFDDAVGQGFAYPAYSYIVVVSEVEVDTLTGVVRVTRVYPG
HHHCCEEEECCEEEEECCCCCCHHHCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHCCC
LAAGRIINPQQVEGQIEGAVAQGVGYALMEKLVFSDNGEVLNTNLTDYVIPTIKDVPEIA
CCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHCCCCHHCCHHHH
EPIYVEDLFKYGPFGAKGVGEMALIPMPASIANAVSHALGVNVTRTPLTPEEVLRLIGRL
CCHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCEEECCCCHHHHHHHHCCC
>Mature Secondary Structure
MVDSTSLLEKWLSASEFLVIGRKVSRVDSLEKALGKALFTEDYYIDYFLGNALYVKQVLS
CCCCHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHH
TYPHARLKSISLPEHLRSKGVKLFTARDIPGENQVGYALPDQPLLAEGKVRYHGEVVALV
HCCCCHHCCCCCHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEECCEEEEEE
ASIDMDEALRAVEEVRVEYEPLPYILDPLEAMNRNDILIHEEAGSNIAFKTRVRRGNVEE
ECCCHHHHHHHHHHHHHCCCCCCHHHCHHHHCCCCCEEEEECCCCCEEEEEEECCCCHHH
GFSRAHVIVENEYRLHHQEHAYLETEAALAIPSIEGGVTIIGGLQYPHLGQRIVARVLGL
CCCEEEEEEECCHHCCCCHHHEEECCCEEECCCCCCCEEEEECCCCCCHHHHHHHHHHCC
PLSKVKIVAPYIGGGFGGKDDEGPLACAKAALVAYLTGKPALLIYSREESIKVHPKREAA
CCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHEECCCCEEEEEECCCCEEECCCCCEE
IIRYRSGADADGRLTAIDVTIIHDTGAYANRGPFILWRATMHASGPYVVPNARIDGYAVY
EEEEECCCCCCCEEEEEEEEEEECCCCCCCCCCEEEEEEEECCCCCEEECCCCCCCEEEE
TNKVYQGSFRGFGNLSIQFAVERQMDQLAERLGLDPVEFRLKNIVREGSFTITGQLLDHS
ECEEEECCCCCCCCEEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEEHHHCC
VGVADALVKVANTCRWRERRREIEEFNKHSERIKKGIGVAVAWHGISTSRGVPDWSNAYV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCEE
KIEQDGSVTLYTGIVEIGQGSPSSAHVQIVCELLGITPDRIRVVYGTTDSPDTGATHASR
EEECCCCEEEEEEEEEECCCCCCCCHHEEEHHHHCCCCCCEEEEECCCCCCCCCCCCCCC
GSSIGGIGVYVAASKLRERLSELASRVLGVPVEDLVFADNKVYSKSNPGKQISLRDLVKE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEECCCCEECCCCCCCEEEHHHHHHH
AMARGVELSATGYFFLPKGRFDDAVGQGFAYPAYSYIVVVSEVEVDTLTGVVRVTRVYPG
HHHCCEEEECCEEEEECCCCCCHHHCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHCCC
LAAGRIINPQQVEGQIEGAVAQGVGYALMEKLVFSDNGEVLNTNLTDYVIPTIKDVPEIA
CCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHCCCCHHCCHHHH
EPIYVEDLFKYGPFGAKGVGEMALIPMPASIANAVSHALGVNVTRTPLTPEEVLRLIGRL
CCHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCEEECCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 11344136 [H]