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The map label for this gene is xdhB [H]

Identifier: 218884050

GI number: 218884050

Start: 708175

End: 709077

Strand: Reverse

Name: xdhB [H]

Synonym: DKAM_0739

Alternate gene names: 218884050

Gene position: 709077-708175 (Counterclockwise)

Preceding gene: 218884051

Following gene: 218884049

Centisome position: 51.94

GC content: 48.06

Gene sequence:

>903_bases
TTGGTAGACTATGAGGTGGTGGCAGTGTTCTACCGGTTACCTGAGATAAGGTATTATAGGCCATCTACACTTGATGAAGC
ACTCAAACTACTCGGCGAACTGAGTGAGAAGGCTAGAATACTGGCCGGGGGCACGGATCTAGTGCTCGACCTGAAGATTA
AGAGGTATAATGTGAGCGATTTAATAGATATATCCAAGTTAAACGAGTTAAGATACATTATTGACGAGGGAGACAGAATC
AGAATCGGTGCCTTAACAAGTATACAGGAGATAGCGGATTCCAGTGTCATCGCTGAGAAAGCACCATCACTGAAAAAAGC
TGCCGACGAGTTCGCGTACTGGCAGATAAGGAATATGGCTACTATTGGTGGTAATCTCTGTAATGCCTCTCCAGCAGCTG
ATACAGCACCACCACTACTAGTCCACGAGGCCCTCGTGAAGACCGCCAGCATCGAGGGCGAGAGAATAATACCAATCACA
GAATTCTTCAAAGGGCCCAGGCAGACGGCTCTCAAACCCAGTGAGATACTTGTCGAGGTGGCGATCCCAAGTAAGCCTCA
ACCCCCTTGGAGGCATGCTTATTATAAACTAGGTAGGAGGAGGGGACATGAGATCTCGGTAACATCGATAGCTATCGCTG
CATCGATCGATGCCGGGGTCTTCCAGGATATTAGAATAGCCCTAGGATCAATGGCTCCAACACCTGTTAGGGCGAGAAGT
GTTGAAGTGTCCCTAAAGGGAAGAAAGGTCAGCGAGTCGGTTATTGAGGAAGCCGTTGAGAAACTGAGTAGTGATGTGAA
GCCAATAAGCGATGTAAGGGCGTCAGCCGAGTATAGGCTCCACGTGTCTAAGGCATTGCTGAAGGATATGCTTCTCAAGC
TTGTTAAAGGAGGTGGTGAATAG

Upstream 100 bases:

>100_bases
CTCATACCTATGCCGGCCTCAATAGCTAATGCTGTAAGTCATGCACTAGGGGTCAATGTAACTAGGACACCATTGACCCC
TGAGGAGGTGCTTAGATTGA

Downstream 100 bases:

>100_bases
TGCTCGTTAGGTTCAGGCTTAATGGTAGAGATATAGAGCTAGATGTGCCATCTAATGAAACCCTGATAGACACCTTGAGG
CTGAGGCTGAAGGTAAAAAG

Product: FAD-binding molybdopterin dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MVDYEVVAVFYRLPEIRYYRPSTLDEALKLLGELSEKARILAGGTDLVLDLKIKRYNVSDLIDISKLNELRYIIDEGDRI
RIGALTSIQEIADSSVIAEKAPSLKKAADEFAYWQIRNMATIGGNLCNASPAADTAPPLLVHEALVKTASIEGERIIPIT
EFFKGPRQTALKPSEILVEVAIPSKPQPPWRHAYYKLGRRRGHEISVTSIAIAASIDAGVFQDIRIALGSMAPTPVRARS
VEVSLKGRKVSESVIEEAVEKLSSDVKPISDVRASAEYRLHVSKALLKDMLLKLVKGGGE

Sequences:

>Translated_300_residues
MVDYEVVAVFYRLPEIRYYRPSTLDEALKLLGELSEKARILAGGTDLVLDLKIKRYNVSDLIDISKLNELRYIIDEGDRI
RIGALTSIQEIADSSVIAEKAPSLKKAADEFAYWQIRNMATIGGNLCNASPAADTAPPLLVHEALVKTASIEGERIIPIT
EFFKGPRQTALKPSEILVEVAIPSKPQPPWRHAYYKLGRRRGHEISVTSIAIAASIDAGVFQDIRIALGSMAPTPVRARS
VEVSLKGRKVSESVIEEAVEKLSSDVKPISDVRASAEYRLHVSKALLKDMLLKLVKGGGE
>Mature_300_residues
MVDYEVVAVFYRLPEIRYYRPSTLDEALKLLGELSEKARILAGGTDLVLDLKIKRYNVSDLIDISKLNELRYIIDEGDRI
RIGALTSIQEIADSSVIAEKAPSLKKAADEFAYWQIRNMATIGGNLCNASPAADTAPPLLVHEALVKTASIEGERIIPIT
EFFKGPRQTALKPSEILVEVAIPSKPQPPWRHAYYKLGRRRGHEISVTSIAIAASIDAGVFQDIRIALGSMAPTPVRARS
VEVSLKGRKVSESVIEEAVEKLSSDVKPISDVRASAEYRLHVSKALLKDMLLKLVKGGGE

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG1319

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI71773480, Length=263, Percent_Identity=26.615969581749, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI91823271, Length=234, Percent_Identity=24.7863247863248, Blast_Score=68, Evalue=8e-12,
Organism=Escherichia coli, GI1789231, Length=283, Percent_Identity=34.6289752650177, Blast_Score=181, Evalue=8e-47,
Organism=Escherichia coli, GI1789245, Length=285, Percent_Identity=24.2105263157895, Blast_Score=64, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17540638, Length=307, Percent_Identity=28.0130293159609, Blast_Score=111, Evalue=4e-25,
Organism=Drosophila melanogaster, GI17737937, Length=269, Percent_Identity=27.8810408921933, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005107
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR002346 [H]

Pfam domain/function: PF03450 CO_deh_flav_C; PF00941 FAD_binding_5 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 33001; Mature: 33001

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDYEVVAVFYRLPEIRYYRPSTLDEALKLLGELSEKARILAGGTDLVLDLKIKRYNVSD
CCCHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHCEEEECCCEEEEEEEEEEECHHH
LIDISKLNELRYIIDEGDRIRIGALTSIQEIADSSVIAEKAPSLKKAADEFAYWQIRNMA
HHHHHHHHHHHHEECCCCEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
TIGGNLCNASPAADTAPPLLVHEALVKTASIEGERIIPITEFFKGPRQTALKPSEILVEV
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEECCHHHHHCCCHHHCCCHHHEEEEE
AIPSKPQPPWRHAYYKLGRRRGHEISVTSIAIAASIDAGVFQDIRIALGSMAPTPVRARS
ECCCCCCCCHHHHHHHHHHCCCCEEEEEEEEEEECCCHHHHHHHHHHHHCCCCCCCCEEE
VEVSLKGRKVSESVIEEAVEKLSSDVKPISDVRASAEYRLHVSKALLKDMLLKLVKGGGE
EEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVDYEVVAVFYRLPEIRYYRPSTLDEALKLLGELSEKARILAGGTDLVLDLKIKRYNVSD
CCCHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHCEEEECCCEEEEEEEEEEECHHH
LIDISKLNELRYIIDEGDRIRIGALTSIQEIADSSVIAEKAPSLKKAADEFAYWQIRNMA
HHHHHHHHHHHHEECCCCEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
TIGGNLCNASPAADTAPPLLVHEALVKTASIEGERIIPITEFFKGPRQTALKPSEILVEV
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEECCHHHHHCCCHHHCCCHHHEEEEE
AIPSKPQPPWRHAYYKLGRRRGHEISVTSIAIAASIDAGVFQDIRIALGSMAPTPVRARS
ECCCCCCCCHHHHHHHHHHCCCCEEEEEEEEEEECCCHHHHHHHHHHHHCCCCCCCCEEE
VEVSLKGRKVSESVIEEAVEKLSSDVKPISDVRASAEYRLHVSKALLKDMLLKLVKGGGE
EEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]