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The map label for this gene is lhr [C]

Identifier: 218884027

GI number: 218884027

Start: 688431

End: 690584

Strand: Direct

Name: lhr [C]

Synonym: DKAM_0716

Alternate gene names: 218884027

Gene position: 688431-690584 (Clockwise)

Preceding gene: 218884025

Following gene: 218884028

Centisome position: 50.43

GC content: 49.91

Gene sequence:

>2154_bases
GTGGATCAAGCCATGGATATAGATGCACTACTAGGGTACGGTTTCCCCCGAGGATACATAGAGCTGTTAAAGACTAGGGG
GATAAGAAGGCTGAACCCTGTTCAGAGCGAGGCAGTGGAGAAGGGGTTGTTCACCGGGGGAAATCTCGTTGTCTCAGCCC
CAACAGCCTCCGGTAAAACACTCATAGCCGAGCTAGCCCTGGTCTACAACTGGCTGAACCATGGGAAGGGAGTATACCTA
ACGCCGTTGAGAGCGCTTGCCAGCGAGAAGTATGGGGAGTTCAAGACACTGGAGGCTCTAGGAGTGAGGGTAGGGGTTTC
AACAGGCGACTACGATGAGCCAGTCGAGTACCTGAGCTGGTACGATATAATAGTGGCTACATACGAGAGATTCGACAGTA
TACTAAGGCAGAAGCCGAGCTGGCTCCGCGATGTTGGATTAGTAGTCATAGACGAGATCCATATGGCTAGCGACCCTGAA
CGAGGACCAATAGTAGAGGTTATAGCAGCCAGACTCCTTAGGCAAGGCACCAGGATCATAGGTCTCTCCGCCACAATAGG
GAATCCAGAGGCTCTCGCAGAATGGCTTAACGCTGCGCTGGTTAACACCGATTGGAGGCCTGTGAGGCTTGTGGAGGGAT
ACCTGGATAAGAAGAAGCCTGGATTAGTCTTCCCCGTGGATAATAGAGTGGAGAGCGTTGACTTGGAGAACAGGGATCCA
TTCTTAGACATACCACTACATAACGTGGTTGAACTAGGGTTACAGACACTGGTTTTCATACATAACAGGAGGAAGGTAGA
GGATTATGCCGTAGAAGCCGCAAGACACCTTCCAATGCTCCCCGAGGATGCTGTAAAGCCATTTATCAGTGAACTAGAGG
ATGCGCCAACTAGTATTGAGAGAGATGTGCTTTCGGACCTTATCAGGAGAGGTGTTGGCTTCCATCATGCAGGATTATCC
AGTATAGCTAGGAGCACTGTAGAGAAGGCTTTTAGGAGCAGGCTTCTCAAGATAGTCTACGCGACGCCGACCCTAGCTGC
TGGAGTAAACCTTCCAGCTAGAAGGGTCCTGGTCTCCTTGAAACGCTATGATGCATCAAGGGGTAGGAGGGTGAATATAA
GTATCTCGGAGTACAAGCAGATGGCTGGGAGGGCTGGAAGACCCGGCTATGATGAAATAGGTGAATCAGTGATCACTGAT
GCATCAAGCAATAGCGAGGCCTTGAAGTATATTAATGGATCCCCTGAGCCGGTTGCAGGCAAGCTTCTCAGTGAGAGAAG
CCTCAGGATACATGTCTTATCACTAGTGGCTTCAGGTGAGGCGTCAAGCATCGATGAGGTATCAGAGATCCTTTCATCCA
CGCTCTCAATGAAGCAGGCTAAGGTCTCACCATTCCAATCAGCGAAGATAATGGGGGCCGTTAAACTACTCGAGGAGTTG
GGCATGATTGAGTACTCCGGTAACAATTCCATGAAAGCTACCAGGCTGGGCAGGGTGACATCCCACACCTACCTGGATCC
CTTAAGCATAAGCATATACAGGGAGCTGAAACCAGTCGAGCCTTCGGACATCTACCTGCTCCAAGTGGCCTGCTTAACAC
CGGACTTCAAGAGAAGCTCGCCATATATACAGGATAAGATCGTGGAGAGATTAGAAGACGTTGCTCTCGAGATGGCTGAT
CAGGGGATGATACCACCGCCCTCGAAAACCAGCCTAGACTATGAGGAGTGGTTGGATGGATTCATGCATGCCATGATACT
CTACGACTGGATAAACGAGGTTTCAGAGGATGAAATAGTATCAAGATACATGATTGGCCCAGGAGACCTCTACAGCATGA
GGGATACAGCATCATGGATCATCCATGCATTAGCCCGTGTAGAAGCGGTGCTGGGGGATATAAGGTTCCACAAAGCCCTC
GACACGTTGTCGAGAAGGATCGAGGAAGGGGTAAAGGAGGATGCACTAGAGCTGATCACACTGAGGCTTATTGGAAGGGT
TAGGGCAAGGATACTTATACAACACGGGATCAAGAGCCTCAGGGATCTAGCTGAGACACCGTTATCAAAGATAGCTTCCT
TACCGAAGTTCGGTCCAAGGATAGCTGAGGAGATAGATAGACAGCTCAGGGACCTCGGCTATAGGATTAATTAA

Upstream 100 bases:

>100_bases
TGCTTCCCTTGTCGAGAGAAGCGTGTGGAAGATCTTCCTAGACAATTAAAACACCCCGGCTACATACATATCCATTACGG
GATTTAATTACCTGAGTCAA

Downstream 100 bases:

>100_bases
ACACAAGCCTTTAACCTCCTGAAAACATTAAATCTTAATGTGAGACACATGGGTAGACTCATAGTCATCGATAACCCGCT
AGCTAAATACTATCTAACAC

Product: DEAD/DEAH box helicase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 717; Mature: 717

Protein sequence:

>717_residues
MDQAMDIDALLGYGFPRGYIELLKTRGIRRLNPVQSEAVEKGLFTGGNLVVSAPTASGKTLIAELALVYNWLNHGKGVYL
TPLRALASEKYGEFKTLEALGVRVGVSTGDYDEPVEYLSWYDIIVATYERFDSILRQKPSWLRDVGLVVIDEIHMASDPE
RGPIVEVIAARLLRQGTRIIGLSATIGNPEALAEWLNAALVNTDWRPVRLVEGYLDKKKPGLVFPVDNRVESVDLENRDP
FLDIPLHNVVELGLQTLVFIHNRRKVEDYAVEAARHLPMLPEDAVKPFISELEDAPTSIERDVLSDLIRRGVGFHHAGLS
SIARSTVEKAFRSRLLKIVYATPTLAAGVNLPARRVLVSLKRYDASRGRRVNISISEYKQMAGRAGRPGYDEIGESVITD
ASSNSEALKYINGSPEPVAGKLLSERSLRIHVLSLVASGEASSIDEVSEILSSTLSMKQAKVSPFQSAKIMGAVKLLEEL
GMIEYSGNNSMKATRLGRVTSHTYLDPLSISIYRELKPVEPSDIYLLQVACLTPDFKRSSPYIQDKIVERLEDVALEMAD
QGMIPPPSKTSLDYEEWLDGFMHAMILYDWINEVSEDEIVSRYMIGPGDLYSMRDTASWIIHALARVEAVLGDIRFHKAL
DTLSRRIEEGVKEDALELITLRLIGRVRARILIQHGIKSLRDLAETPLSKIASLPKFGPRIAEEIDRQLRDLGYRIN

Sequences:

>Translated_717_residues
MDQAMDIDALLGYGFPRGYIELLKTRGIRRLNPVQSEAVEKGLFTGGNLVVSAPTASGKTLIAELALVYNWLNHGKGVYL
TPLRALASEKYGEFKTLEALGVRVGVSTGDYDEPVEYLSWYDIIVATYERFDSILRQKPSWLRDVGLVVIDEIHMASDPE
RGPIVEVIAARLLRQGTRIIGLSATIGNPEALAEWLNAALVNTDWRPVRLVEGYLDKKKPGLVFPVDNRVESVDLENRDP
FLDIPLHNVVELGLQTLVFIHNRRKVEDYAVEAARHLPMLPEDAVKPFISELEDAPTSIERDVLSDLIRRGVGFHHAGLS
SIARSTVEKAFRSRLLKIVYATPTLAAGVNLPARRVLVSLKRYDASRGRRVNISISEYKQMAGRAGRPGYDEIGESVITD
ASSNSEALKYINGSPEPVAGKLLSERSLRIHVLSLVASGEASSIDEVSEILSSTLSMKQAKVSPFQSAKIMGAVKLLEEL
GMIEYSGNNSMKATRLGRVTSHTYLDPLSISIYRELKPVEPSDIYLLQVACLTPDFKRSSPYIQDKIVERLEDVALEMAD
QGMIPPPSKTSLDYEEWLDGFMHAMILYDWINEVSEDEIVSRYMIGPGDLYSMRDTASWIIHALARVEAVLGDIRFHKAL
DTLSRRIEEGVKEDALELITLRLIGRVRARILIQHGIKSLRDLAETPLSKIASLPKFGPRIAEEIDRQLRDLGYRIN
>Mature_717_residues
MDQAMDIDALLGYGFPRGYIELLKTRGIRRLNPVQSEAVEKGLFTGGNLVVSAPTASGKTLIAELALVYNWLNHGKGVYL
TPLRALASEKYGEFKTLEALGVRVGVSTGDYDEPVEYLSWYDIIVATYERFDSILRQKPSWLRDVGLVVIDEIHMASDPE
RGPIVEVIAARLLRQGTRIIGLSATIGNPEALAEWLNAALVNTDWRPVRLVEGYLDKKKPGLVFPVDNRVESVDLENRDP
FLDIPLHNVVELGLQTLVFIHNRRKVEDYAVEAARHLPMLPEDAVKPFISELEDAPTSIERDVLSDLIRRGVGFHHAGLS
SIARSTVEKAFRSRLLKIVYATPTLAAGVNLPARRVLVSLKRYDASRGRRVNISISEYKQMAGRAGRPGYDEIGESVITD
ASSNSEALKYINGSPEPVAGKLLSERSLRIHVLSLVASGEASSIDEVSEILSSTLSMKQAKVSPFQSAKIMGAVKLLEEL
GMIEYSGNNSMKATRLGRVTSHTYLDPLSISIYRELKPVEPSDIYLLQVACLTPDFKRSSPYIQDKIVERLEDVALEMAD
QGMIPPPSKTSLDYEEWLDGFMHAMILYDWINEVSEDEIVSRYMIGPGDLYSMRDTASWIIHALARVEAVLGDIRFHKAL
DTLSRRIEEGVKEDALELITLRLIGRVRARILIQHGIKSLRDLAETPLSKIASLPKFGPRIAEEIDRQLRDLGYRIN

Specific function: Unknown

COG id: COG1204

COG function: function code R; Superfamily II helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI139394648, Length=771, Percent_Identity=27.7561608300908, Blast_Score=219, Evalue=8e-57,
Organism=Homo sapiens, GI76880486, Length=528, Percent_Identity=30.8712121212121, Blast_Score=196, Evalue=7e-50,
Organism=Homo sapiens, GI40217847, Length=569, Percent_Identity=28.6467486818981, Blast_Score=186, Evalue=1e-46,
Organism=Homo sapiens, GI169218225, Length=569, Percent_Identity=28.8224956063269, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI110556640, Length=513, Percent_Identity=29.8245614035088, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI130484567, Length=442, Percent_Identity=31.447963800905, Blast_Score=162, Evalue=1e-39,
Organism=Homo sapiens, GI193211480, Length=438, Percent_Identity=28.9954337899543, Blast_Score=135, Evalue=2e-31,
Organism=Homo sapiens, GI67782311, Length=96, Percent_Identity=43.75, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI222831595, Length=200, Percent_Identity=31, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17537127, Length=601, Percent_Identity=29.9500831946755, Blast_Score=211, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17537519, Length=565, Percent_Identity=28.4955752212389, Blast_Score=187, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71995032, Length=406, Percent_Identity=33.2512315270936, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17542826, Length=439, Percent_Identity=29.6127562642369, Blast_Score=149, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI133930973, Length=469, Percent_Identity=26.6524520255864, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI86563272, Length=511, Percent_Identity=28.3757338551859, Blast_Score=132, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI71995036, Length=95, Percent_Identity=46.3157894736842, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17552356, Length=104, Percent_Identity=37.5, Blast_Score=79, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6321020, Length=568, Percent_Identity=28.8732394366197, Blast_Score=180, Evalue=8e-46,
Organism=Saccharomyces cerevisiae, GI6321710, Length=461, Percent_Identity=30.3687635574837, Blast_Score=171, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI9755332, Length=422, Percent_Identity=29.6208530805687, Blast_Score=135, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6323430, Length=187, Percent_Identity=33.6898395721925, Blast_Score=91, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6322411, Length=205, Percent_Identity=32.1951219512195, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17933644, Length=751, Percent_Identity=28.6284953395473, Blast_Score=192, Evalue=6e-49,
Organism=Drosophila melanogaster, GI28574898, Length=580, Percent_Identity=28.448275862069, Blast_Score=190, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24647182, Length=589, Percent_Identity=29.0322580645161, Blast_Score=181, Evalue=2e-45,
Organism=Drosophila melanogaster, GI17864608, Length=417, Percent_Identity=31.1750599520384, Blast_Score=144, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24660651, Length=487, Percent_Identity=27.9260780287474, Blast_Score=142, Evalue=8e-34,
Organism=Drosophila melanogaster, GI17933658, Length=160, Percent_Identity=37.5, Blast_Score=96, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR022965
- InterPro:   IPR003583 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C [H]

EC number: 3.6.1.-

Molecular weight: Translated: 79948; Mature: 79948

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQAMDIDALLGYGFPRGYIELLKTRGIRRLNPVQSEAVEKGLFTGGNLVVSAPTASGKT
CCCCCCHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCEEEECCCCCCHH
LIAELALVYNWLNHGKGVYLTPLRALASEKYGEFKTLEALGVRVGVSTGDYDEPVEYLSW
HHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCHHHHHHHHEEEECCCCCCCCHHHHHHH
YDIIVATYERFDSILRQKPSWLRDVGLVVIDEIHMASDPERGPIVEVIAARLLRQGTRII
HHHHHHHHHHHHHHHHCCCHHHHHCCHHHEEHHHHCCCCCCCHHHHHHHHHHHHCCCEEE
GLSATIGNPEALAEWLNAALVNTDWRPVRLVEGYLDKKKPGLVFPVDNRVESVDLENRDP
EEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCC
FLDIPLHNVVELGLQTLVFIHNRRKVEDYAVEAARHLPMLPEDAVKPFISELEDAPTSIE
EEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHH
RDVLSDLIRRGVGFHHAGLSSIARSTVEKAFRSRLLKIVYATPTLAAGVNLPARRVLVSL
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHCCCCCHHHHHHHH
KRYDASRGRRVNISISEYKQMAGRAGRPGYDEIGESVITDASSNSEALKYINGSPEPVAG
HHHCCCCCCEEEEEHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHH
KLLSERSLRIHVLSLVASGEASSIDEVSEILSSTLSMKQAKVSPFQSAKIMGAVKLLEEL
HHHHCCCHHEEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
GMIEYSGNNSMKATRLGRVTSHTYLDPLSISIYRELKPVEPSDIYLLQVACLTPDFKRSS
CCEEECCCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCC
PYIQDKIVERLEDVALEMADQGMIPPPSKTSLDYEEWLDGFMHAMILYDWINEVSEDEIV
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHH
SRYMIGPGDLYSMRDTASWIIHALARVEAVLGDIRFHKALDTLSRRIEEGVKEDALELIT
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRLIGRVRARILIQHGIKSLRDLAETPLSKIASLPKFGPRIAEEIDRQLRDLGYRIN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MDQAMDIDALLGYGFPRGYIELLKTRGIRRLNPVQSEAVEKGLFTGGNLVVSAPTASGKT
CCCCCCHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCEEEECCCCCCHH
LIAELALVYNWLNHGKGVYLTPLRALASEKYGEFKTLEALGVRVGVSTGDYDEPVEYLSW
HHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCCCHHHHHHHHEEEECCCCCCCCHHHHHHH
YDIIVATYERFDSILRQKPSWLRDVGLVVIDEIHMASDPERGPIVEVIAARLLRQGTRII
HHHHHHHHHHHHHHHHCCCHHHHHCCHHHEEHHHHCCCCCCCHHHHHHHHHHHHCCCEEE
GLSATIGNPEALAEWLNAALVNTDWRPVRLVEGYLDKKKPGLVFPVDNRVESVDLENRDP
EEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCC
FLDIPLHNVVELGLQTLVFIHNRRKVEDYAVEAARHLPMLPEDAVKPFISELEDAPTSIE
EEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHH
RDVLSDLIRRGVGFHHAGLSSIARSTVEKAFRSRLLKIVYATPTLAAGVNLPARRVLVSL
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHCCCCCHHHHHHHH
KRYDASRGRRVNISISEYKQMAGRAGRPGYDEIGESVITDASSNSEALKYINGSPEPVAG
HHHCCCCCCEEEEEHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHH
KLLSERSLRIHVLSLVASGEASSIDEVSEILSSTLSMKQAKVSPFQSAKIMGAVKLLEEL
HHHHCCCHHEEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
GMIEYSGNNSMKATRLGRVTSHTYLDPLSISIYRELKPVEPSDIYLLQVACLTPDFKRSS
CCEEECCCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCC
PYIQDKIVERLEDVALEMADQGMIPPPSKTSLDYEEWLDGFMHAMILYDWINEVSEDEIV
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHH
SRYMIGPGDLYSMRDTASWIIHALARVEAVLGDIRFHKALDTLSRRIEEGVKEDALELIT
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRLIGRVRARILIQHGIKSLRDLAETPLSKIASLPKFGPRIAEEIDRQLRDLGYRIN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on acid anhydrides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA