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The map label for this gene is moeA [C]

Identifier: 218884026

GI number: 218884026

Start: 686402

End: 688375

Strand: Reverse

Name: moeA [C]

Synonym: DKAM_0715

Alternate gene names: 218884026

Gene position: 688375-686402 (Counterclockwise)

Preceding gene: 218884029

Following gene: 218884024

Centisome position: 50.42

GC content: 51.22

Gene sequence:

>1974_bases
TTGTCTAGGAAGATCTTCCACACGCTTCTCTCGACAAGGGAAGCAGTTGAGGAAGTTGTGAAACGGGTGAAGCCAGCCCC
GAAAGGAGTAGAGGAGGTTGGTTTAGAGGAAGCCCTCTGGAGGATACTAGCAGAAGACATATATGCACCAGTTGACCACC
CACCCTTCGATAGGAGTGAGGTGGATGGTTACGCTGTGAGAAGCATTGACATCGAGTGGAGTGATGAATTATCCCCGGTT
GAACTCAGGGTGGCTGGCTCAGTAAGAGTTGATGAGGAACCCGGTATCGCATGTAGGCCTGGTGAAGCAATTGAAGTTGC
TACTGGAGCCATGGTACCAATGGACTGTGACTCCATTGTAATGGAGGAGTACACTGAGAGAACTGGTGAAGTAATCAAGG
TTTACAGGAGTACGAGTCCCGGTGAAAACATCTCGACTGCTGGCAGTGATGTATCAGCTGGAGACCTAGTCCTCCTCAAG
GGTACTAGGCTCAGTCACGAACATATAGCTTTACTAGCTGGCCTGGGGGTTAGAAGGATCCCCGTGTATGTGAAGCCCAG
GGCTGCAGTATACTCGACCGGCGACGAGGTCGTGGAGCCAGGTGAACCGCTGAGTGCTGGCAAGGTATATGATGTAAACG
GCTACCTTGTAACAAGCTATCTCAAGGAGCTCGGGGTTGACGCTGTATTCAGGGGCCGTCTTCCCGATGACTATGAGATT
CTGAGGAACACTATAGAAAGCGATCTCGGAAGCTATGACATGGTTTTCACTAGTGGAGGTACAAGCGCTGGGATCAGGGA
TCTCGTATACAGGGTGTTCGAGGAGCTGGGCGAGGTAGTGGTGCATGGTTTGAAGACCAAGCCGGGTAAGCCAACGGTTA
TAGCTGTATCCGGTGGTAGACTTCTCGTAGGTCTCCCAGGCTTCCCCTTATCATGCTACATGATACTGAGGGGTGTTGTG
AAGCCCATTGTCTCGCTTATGACTGGCCTCAGAGAGGATGAGAGGATAGTGGAGGCTACTCTACCGGTCAGGGTGAGGAA
GCAGGTTGGTAAGACCTGGTTGATACCTGTATCACTGGTTGAGGGGGTCAACGGGTATTCAGCATACCCTGTATCATTTA
GTAGCGGCAGCATAGCTTCGCTTATCTATAGTGATGGATACATTGAGCTCCCAGAGGACCTGGATACCGCTGAAGCCGGG
AGCAGGGTGAGGGTCTACTTGTTCAGGGATCCACCATCACCTGGGAGACTCAACATCATCGGGAGCAACGACCCATTACT
CATGGAGTTGTTGAGGGCTACTGGGCTGGCTTACTCCAGCAGGGTGTTGAACACGGGTAGTCTTGCCGGCTGGCACGCCG
TGGCAAGGGGTGAGGCGGATATAGCTCCAACCCACCTACTAGACGAGGAGACGCTGGTCTACAATATACCGTTCCTCAAG
AAGTTCAACCTGGAGGGTAAAGCGGTATTGATCAGGGGCTTCGACAGGCTTATAGGGATAGTAACAGCTCCAGGTAACCC
TAAGAAGATAGAAGGTATAGAGGACTTCCTTAGAAGCGACGTCAGGATAGTTAACAGGGTAAGGGGCTCCGGTATTAGGA
CTTACCTAGACCACCACCTCAAGAAGATACTTGGTGAGAAGGGGGTGCCCTTCACAAGGGTGAGGGAGCTTGTTAAAGGC
TATACATACGAGGTGAAAACGCATACAGCTGTAGCACTAGCAGTAAGGCAGGGGAGGGCTGATGCAGGAATAGCAGTAGG
CTACGTGGCGGAACTATTCAACCTGGGCTTCAAACCGTTGACATGGGAGGAATACGACCTACTAGTACCCGTGGAGAAAA
TGGGGAAGCCAGGTGTAAGGAGACTCATAGATGCATTGGTAAACAAAGAAATAATCGAGCCGCTACTCCAAGGCAAATAC
GGTAGATACTACAGGATACCAGTGAACGCAGGAAAGCCGAAGCATAATAGATAG

Upstream 100 bases:

>100_bases
GAAACCGTACCCTAGTAGTGCATCTATATCCATGGCTTGATCCACTTGACTCAGGTAATTAAATCCCGTAATGGATATGT
ATGTAGCCGGGGTGTTTTAA

Downstream 100 bases:

>100_bases
CCTAGGAGAGCAATACACTAGTTAATAGTAATTCCCCTGATGGTTAATGTTTATAAGATAAAATAACAAAAAATAAAAGT
TATTATTGATTTCCTGTCTT

Product: putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 657; Mature: 656

Protein sequence:

>657_residues
MSRKIFHTLLSTREAVEEVVKRVKPAPKGVEEVGLEEALWRILAEDIYAPVDHPPFDRSEVDGYAVRSIDIEWSDELSPV
ELRVAGSVRVDEEPGIACRPGEAIEVATGAMVPMDCDSIVMEEYTERTGEVIKVYRSTSPGENISTAGSDVSAGDLVLLK
GTRLSHEHIALLAGLGVRRIPVYVKPRAAVYSTGDEVVEPGEPLSAGKVYDVNGYLVTSYLKELGVDAVFRGRLPDDYEI
LRNTIESDLGSYDMVFTSGGTSAGIRDLVYRVFEELGEVVVHGLKTKPGKPTVIAVSGGRLLVGLPGFPLSCYMILRGVV
KPIVSLMTGLREDERIVEATLPVRVRKQVGKTWLIPVSLVEGVNGYSAYPVSFSSGSIASLIYSDGYIELPEDLDTAEAG
SRVRVYLFRDPPSPGRLNIIGSNDPLLMELLRATGLAYSSRVLNTGSLAGWHAVARGEADIAPTHLLDEETLVYNIPFLK
KFNLEGKAVLIRGFDRLIGIVTAPGNPKKIEGIEDFLRSDVRIVNRVRGSGIRTYLDHHLKKILGEKGVPFTRVRELVKG
YTYEVKTHTAVALAVRQGRADAGIAVGYVAELFNLGFKPLTWEEYDLLVPVEKMGKPGVRRLIDALVNKEIIEPLLQGKY
GRYYRIPVNAGKPKHNR

Sequences:

>Translated_657_residues
MSRKIFHTLLSTREAVEEVVKRVKPAPKGVEEVGLEEALWRILAEDIYAPVDHPPFDRSEVDGYAVRSIDIEWSDELSPV
ELRVAGSVRVDEEPGIACRPGEAIEVATGAMVPMDCDSIVMEEYTERTGEVIKVYRSTSPGENISTAGSDVSAGDLVLLK
GTRLSHEHIALLAGLGVRRIPVYVKPRAAVYSTGDEVVEPGEPLSAGKVYDVNGYLVTSYLKELGVDAVFRGRLPDDYEI
LRNTIESDLGSYDMVFTSGGTSAGIRDLVYRVFEELGEVVVHGLKTKPGKPTVIAVSGGRLLVGLPGFPLSCYMILRGVV
KPIVSLMTGLREDERIVEATLPVRVRKQVGKTWLIPVSLVEGVNGYSAYPVSFSSGSIASLIYSDGYIELPEDLDTAEAG
SRVRVYLFRDPPSPGRLNIIGSNDPLLMELLRATGLAYSSRVLNTGSLAGWHAVARGEADIAPTHLLDEETLVYNIPFLK
KFNLEGKAVLIRGFDRLIGIVTAPGNPKKIEGIEDFLRSDVRIVNRVRGSGIRTYLDHHLKKILGEKGVPFTRVRELVKG
YTYEVKTHTAVALAVRQGRADAGIAVGYVAELFNLGFKPLTWEEYDLLVPVEKMGKPGVRRLIDALVNKEIIEPLLQGKY
GRYYRIPVNAGKPKHNR
>Mature_656_residues
SRKIFHTLLSTREAVEEVVKRVKPAPKGVEEVGLEEALWRILAEDIYAPVDHPPFDRSEVDGYAVRSIDIEWSDELSPVE
LRVAGSVRVDEEPGIACRPGEAIEVATGAMVPMDCDSIVMEEYTERTGEVIKVYRSTSPGENISTAGSDVSAGDLVLLKG
TRLSHEHIALLAGLGVRRIPVYVKPRAAVYSTGDEVVEPGEPLSAGKVYDVNGYLVTSYLKELGVDAVFRGRLPDDYEIL
RNTIESDLGSYDMVFTSGGTSAGIRDLVYRVFEELGEVVVHGLKTKPGKPTVIAVSGGRLLVGLPGFPLSCYMILRGVVK
PIVSLMTGLREDERIVEATLPVRVRKQVGKTWLIPVSLVEGVNGYSAYPVSFSSGSIASLIYSDGYIELPEDLDTAEAGS
RVRVYLFRDPPSPGRLNIIGSNDPLLMELLRATGLAYSSRVLNTGSLAGWHAVARGEADIAPTHLLDEETLVYNIPFLKK
FNLEGKAVLIRGFDRLIGIVTAPGNPKKIEGIEDFLRSDVRIVNRVRGSGIRTYLDHHLKKILGEKGVPFTRVRELVKGY
TYEVKTHTAVALAVRQGRADAGIAVGYVAELFNLGFKPLTWEEYDLLVPVEKMGKPGVRRLIDALVNKEIIEPLLQGKYG
RYYRIPVNAGKPKHNR

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=333, Percent_Identity=31.2312312312312, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI66932975, Length=333, Percent_Identity=31.2312312312312, Blast_Score=145, Evalue=9e-35,
Organism=Escherichia coli, GI1787049, Length=322, Percent_Identity=37.2670807453416, Blast_Score=199, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI25147659, Length=340, Percent_Identity=30, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17562606, Length=415, Percent_Identity=24.8192771084337, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17136978, Length=300, Percent_Identity=28.6666666666667, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24638841, Length=300, Percent_Identity=28.6666666666667, Blast_Score=113, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 72101; Mature: 71970

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKIFHTLLSTREAVEEVVKRVKPAPKGVEEVGLEEALWRILAEDIYAPVDHPPFDRSE
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCC
VDGYAVRSIDIEWSDELSPVELRVAGSVRVDEEPGIACRPGEAIEVATGAMVPMDCDSIV
CCCEEEEEEEECCCCCCCCEEEEEECCEEECCCCCCEECCCCCEEEECCCCCCCCCHHHH
MEEYTERTGEVIKVYRSTSPGENISTAGSDVSAGDLVLLKGTRLSHEHIALLAGLGVRRI
HHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCEEC
PVYVKPRAAVYSTGDEVVEPGEPLSAGKVYDVNGYLVTSYLKELGVDAVFRGRLPDDYEI
EEEECCCEEEECCCCHHCCCCCCCCCCEEEECCCCHHHHHHHHCCCCEEEECCCCCHHHH
LRNTIESDLGSYDMVFTSGGTSAGIRDLVYRVFEELGEVVVHGLKTKPGKPTVIAVSGGR
HHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCE
LLVGLPGFPLSCYMILRGVVKPIVSLMTGLREDERIVEATLPVRVRKQVGKTWLIPVSLV
EEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHCCCEEEEEHHHH
EGVNGYSAYPVSFSSGSIASLIYSDGYIELPEDLDTAEAGSRVRVYLFRDPPSPGRLNII
CCCCCCEECEEECCCCCEEEEEECCCCEECCCCCCCCCCCCEEEEEEEECCCCCCEEEEE
GSNDPLLMELLRATGLAYSSRVLNTGSLAGWHAVARGEADIAPTHLLDEETLVYNIPFLK
CCCCHHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHCCCCCCCCHHCCCCCCEEEECCCCE
KFNLEGKAVLIRGFDRLIGIVTAPGNPKKIEGIEDFLRSDVRIVNRVRGSGIRTYLDHHL
EECCCCCEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
KKILGEKGVPFTRVRELVKGYTYEVKTHTAVALAVRQGRADAGIAVGYVAELFNLGFKPL
HHHHCCCCCCHHHHHHHHCCCEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCC
TWEEYDLLVPVEKMGKPGVRRLIDALVNKEIIEPLLQGKYGRYYRIPVNAGKPKHNR
CCCCCEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCC
>Mature Secondary Structure 
SRKIFHTLLSTREAVEEVVKRVKPAPKGVEEVGLEEALWRILAEDIYAPVDHPPFDRSE
CHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCC
VDGYAVRSIDIEWSDELSPVELRVAGSVRVDEEPGIACRPGEAIEVATGAMVPMDCDSIV
CCCEEEEEEEECCCCCCCCEEEEEECCEEECCCCCCEECCCCCEEEECCCCCCCCCHHHH
MEEYTERTGEVIKVYRSTSPGENISTAGSDVSAGDLVLLKGTRLSHEHIALLAGLGVRRI
HHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCEEC
PVYVKPRAAVYSTGDEVVEPGEPLSAGKVYDVNGYLVTSYLKELGVDAVFRGRLPDDYEI
EEEECCCEEEECCCCHHCCCCCCCCCCEEEECCCCHHHHHHHHCCCCEEEECCCCCHHHH
LRNTIESDLGSYDMVFTSGGTSAGIRDLVYRVFEELGEVVVHGLKTKPGKPTVIAVSGGR
HHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCE
LLVGLPGFPLSCYMILRGVVKPIVSLMTGLREDERIVEATLPVRVRKQVGKTWLIPVSLV
EEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHCCCEEEEEHHHH
EGVNGYSAYPVSFSSGSIASLIYSDGYIELPEDLDTAEAGSRVRVYLFRDPPSPGRLNII
CCCCCCEECEEECCCCCEEEEEECCCCEECCCCCCCCCCCCEEEEEEEECCCCCCEEEEE
GSNDPLLMELLRATGLAYSSRVLNTGSLAGWHAVARGEADIAPTHLLDEETLVYNIPFLK
CCCCHHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHCCCCCCCCHHCCCCCCEEEECCCCE
KFNLEGKAVLIRGFDRLIGIVTAPGNPKKIEGIEDFLRSDVRIVNRVRGSGIRTYLDHHL
EECCCCCEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
KKILGEKGVPFTRVRELVKGYTYEVKTHTAVALAVRQGRADAGIAVGYVAELFNLGFKPL
HHHHCCCCCCHHHHHHHHCCCEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCC
TWEEYDLLVPVEKMGKPGVRRLIDALVNKEIIEPLLQGKYGRYYRIPVNAGKPKHNR
CCCCCEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]