Click here to switch to the map view.

The map label for this gene is purM [H]

Identifier: 218883839

GI number: 218883839

Start: 495611

End: 496630

Strand: Direct

Name: purM [H]

Synonym: DKAM_0528

Alternate gene names: 218883839

Gene position: 495611-496630 (Clockwise)

Preceding gene: 218883838

Following gene: 218883840

Centisome position: 36.3

GC content: 47.55

Gene sequence:

>1020_bases
ATGGATAACATGGGTGGTTCATGGAGTTATTCTAAATCCGGTGTAGACCTCTCTGCCCACAGGGAAATGCATAGGTATGT
ATTAGAGAGGATGGGGAAGCTAGATGATAGAGGCATTGAACCATATGGCTCTTTCTCGCAATGGGTGACTGTGGATGGTA
AGGCTATAGCCTTGCACATCGACGGCGTAGGTACAAAGACCATTGTGTTGAAGAAGCTGGGAAAGCTGAGGGTTGCTGGC
TGGGACTGCGTGGCAGTGAATGTAAACGATGTCGCATGCGACAACGTTGAGCCGGTGGCACTCCTCGATTACATAGCTCT
CCCCTCTAGTGATACTGATTCTTTCAGAGAGATTATAGATGGAATCATGGATGCAGCTGGCGAGCTGGGTGTAAAGCTGA
TCGGTGGAGAGACAGCTATAATGCCAGATCTAGTTAACGGCATTGATGTTGTCTGTATGGTTATAGGGTATAAGAAAGGT
AGTGGTAGGTATAGAGCTAGGGTCGGCGATTTAGTCATTGGTGTAAATAGCTGGGGTCTCCACGCCAATGGATATACACT
AGCGAGGAAAATAGTGGAGTCCACGCTTGGAAGCTATGATGCAGTTATAGATGGAGTCAATATAGGGAAGGAATTATCCA
AACCCACCCCCATATACTCTAGGCTCGTGCTTGAAGCGCTTGGATCAGGGTATGCATCAGCTGCAGCCCATATAACCGGG
GGCTCGTTCTATAAGGCAAAAAGGATTCTTCCTGGGGAAGCAGACATGGTGATCAAGGCGCCTGAACCACCCCCGATATT
CAAGGTGCTCATGAAGCTCGGTAACGTATCACCCCCAGAGATGTATAGGGTCTTCAACATGGGTATAGGATTAGTTCTTA
CAACGAGTAGAGATAATCTGGACGGGTTAAGCCGGCTCATTGAGGAACACGGTTTTCACCCATATGTAATCGGGGAGATT
GTTGAGGGGAACGGATTGGTTCATGTGATAACTCCGTATGGTGATATAGTTGAGTACTAG

Upstream 100 bases:

>100_bases
ATCGTGCAGATGCCTAAGGGTGTTCCAGTTGCAACGGTGGGCATTGATAACGCGGAGAACGCTGCATACCTTGCTCTGAG
AATAATAAACCTGTGCAGGG

Downstream 100 bases:

>100_bases
GTTTAACCCTAGGGACCTAATTGCACATTATGAGCCGGGGAGAATAGCTATTGCAGCTGTTGCAAGCCATTCAGCACTGG
ATGTATTCGATGGAGCTAAA

Product: phosphoribosylformylglycinamidine cyclo-ligase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MDNMGGSWSYSKSGVDLSAHREMHRYVLERMGKLDDRGIEPYGSFSQWVTVDGKAIALHIDGVGTKTIVLKKLGKLRVAG
WDCVAVNVNDVACDNVEPVALLDYIALPSSDTDSFREIIDGIMDAAGELGVKLIGGETAIMPDLVNGIDVVCMVIGYKKG
SGRYRARVGDLVIGVNSWGLHANGYTLARKIVESTLGSYDAVIDGVNIGKELSKPTPIYSRLVLEALGSGYASAAAHITG
GSFYKAKRILPGEADMVIKAPEPPPIFKVLMKLGNVSPPEMYRVFNMGIGLVLTTSRDNLDGLSRLIEEHGFHPYVIGEI
VEGNGLVHVITPYGDIVEY

Sequences:

>Translated_339_residues
MDNMGGSWSYSKSGVDLSAHREMHRYVLERMGKLDDRGIEPYGSFSQWVTVDGKAIALHIDGVGTKTIVLKKLGKLRVAG
WDCVAVNVNDVACDNVEPVALLDYIALPSSDTDSFREIIDGIMDAAGELGVKLIGGETAIMPDLVNGIDVVCMVIGYKKG
SGRYRARVGDLVIGVNSWGLHANGYTLARKIVESTLGSYDAVIDGVNIGKELSKPTPIYSRLVLEALGSGYASAAAHITG
GSFYKAKRILPGEADMVIKAPEPPPIFKVLMKLGNVSPPEMYRVFNMGIGLVLTTSRDNLDGLSRLIEEHGFHPYVIGEI
VEGNGLVHVITPYGDIVEY
>Mature_339_residues
MDNMGGSWSYSKSGVDLSAHREMHRYVLERMGKLDDRGIEPYGSFSQWVTVDGKAIALHIDGVGTKTIVLKKLGKLRVAG
WDCVAVNVNDVACDNVEPVALLDYIALPSSDTDSFREIIDGIMDAAGELGVKLIGGETAIMPDLVNGIDVVCMVIGYKKG
SGRYRARVGDLVIGVNSWGLHANGYTLARKIVESTLGSYDAVIDGVNIGKELSKPTPIYSRLVLEALGSGYASAAAHITG
GSFYKAKRILPGEADMVIKAPEPPPIFKVLMKLGNVSPPEMYRVFNMGIGLVLTTSRDNLDGLSRLIEEHGFHPYVIGEI
VEGNGLVHVITPYGDIVEY

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=345, Percent_Identity=33.3333333333333, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI209869995, Length=345, Percent_Identity=33.3333333333333, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI209869993, Length=345, Percent_Identity=33.3333333333333, Blast_Score=154, Evalue=1e-37,
Organism=Escherichia coli, GI1788845, Length=269, Percent_Identity=35.6877323420074, Blast_Score=139, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17567511, Length=276, Percent_Identity=33.695652173913, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6321203, Length=275, Percent_Identity=31.2727272727273, Blast_Score=127, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24582400, Length=279, Percent_Identity=28.673835125448, Blast_Score=104, Evalue=8e-23,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36542; Mature: 36542

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNMGGSWSYSKSGVDLSAHREMHRYVLERMGKLDDRGIEPYGSFSQWVTVDGKAIALHI
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCEEEEEEE
DGVGTKTIVLKKLGKLRVAGWDCVAVNVNDVACDNVEPVALLDYIALPSSDTDSFREIID
CCCCCHHHHHHHHCCEEECCCEEEEEECCCEECCCCCHHHHHHHHCCCCCCHHHHHHHHH
GIMDAAGELGVKLIGGETAIMPDLVNGIDVVCMVIGYKKGSGRYRARVGDLVIGVNSWGL
HHHHHHHHCCEEEECCCCCHHHHHHHHHHEEEHEEEEECCCCCEEEEECEEEEEECCCCC
HANGYTLARKIVESTLGSYDAVIDGVNIGKELSKPTPIYSRLVLEALGSGYASAAAHITG
CCCCHHHHHHHHHHHHCCHHHHEECCCCCHHHCCCCHHHHHHHHHHHCCCHHHHEEEECC
GSFYKAKRILPGEADMVIKAPEPPPIFKVLMKLGNVSPPEMYRVFNMGIGLVLTTSRDNL
CCCEEHHCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHCCCEEEEEECCCCH
DGLSRLIEEHGFHPYVIGEIVEGNGLVHVITPYGDIVEY
HHHHHHHHHCCCCCEEEEEEECCCCEEEEECCCHHHHCC
>Mature Secondary Structure
MDNMGGSWSYSKSGVDLSAHREMHRYVLERMGKLDDRGIEPYGSFSQWVTVDGKAIALHI
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCEEEEEEE
DGVGTKTIVLKKLGKLRVAGWDCVAVNVNDVACDNVEPVALLDYIALPSSDTDSFREIID
CCCCCHHHHHHHHCCEEECCCEEEEEECCCEECCCCCHHHHHHHHCCCCCCHHHHHHHHH
GIMDAAGELGVKLIGGETAIMPDLVNGIDVVCMVIGYKKGSGRYRARVGDLVIGVNSWGL
HHHHHHHHCCEEEECCCCCHHHHHHHHHHEEEHEEEEECCCCCEEEEECEEEEEECCCCC
HANGYTLARKIVESTLGSYDAVIDGVNIGKELSKPTPIYSRLVLEALGSGYASAAAHITG
CCCCHHHHHHHHHHHHCCHHHHEECCCCCHHHCCCCHHHHHHHHHHHCCCHHHHEEEECC
GSFYKAKRILPGEADMVIKAPEPPPIFKVLMKLGNVSPPEMYRVFNMGIGLVLTTSRDNL
CCCEEHHCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHCCCEEEEEECCCCH
DGLSRLIEEHGFHPYVIGEIVEGNGLVHVITPYGDIVEY
HHHHHHHHHCCCCCEEEEEEECCCCEEEEECCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726 [H]