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The map label for this gene is purL [H]

Identifier: 218883833

GI number: 218883833

Start: 487586

End: 489781

Strand: Direct

Name: purL [H]

Synonym: DKAM_0522

Alternate gene names: 218883833

Gene position: 487586-489781 (Clockwise)

Preceding gene: 218883832

Following gene: 218883834

Centisome position: 35.71

GC content: 46.31

Gene sequence:

>2196_bases
TTGGTGAAAATGCCGCTGAGTGTTGAAGAGATAGATGAGATCAGGGATATACTTAAGAGAGAGCCAACCCGTGAAGAACT
AGTCATGTTCGAGGCTCATTGGAGCGAGCACTGTTCCTATAAGAGCAGTAGAAGACTACTTAGACTACTACCTAACAAGG
GTAATCATGTAGTGCTTGGGCCAGGCAGGGATGCACCGGCTGTTGAGGTTTTTCCGGGTATCTTAGCAGTATTCAAGATA
GAGAGTCATAACCATCCATCTGCTGTAGACCCGTATAATGGGGCGGCAACTGGTATAGGAGGTATTATAAGGGATATACT
CACGCTGGGTGCTAAGCCTATTGCACTACTGGATCTACTCTACATGGGCAACCCATTTAATCCACATGCAAAATGGTTGA
TTAGGAATATTGTTAAAGGAATAAGTGACTACGGTAACAGGGTTGGAGTACCCGTTGTAGCTGGTGACACATGGTTTGAT
GAATCATTCAATAAACAACCATTAGTCAATGTAGCATGTTTAGGCATAGTGGAGAAAAATAAGGCCGTTCTCTCCAAACC
TAGGCCCGGTGATCTAGTGGTTATAATCGGTAATTCAACCGGTAGGGATGGATTGCTCGGAAGTAGCTTCGCGTCAGCAC
CGTTGAAGGATAACATGGTTGAGGACATAGGTGCTGTGCAGATAGGTGATGCATTAATGGAGAAAATGCTCATAGATGTT
GTTAATGAGGTAGTGGAGAAAAAGCTAGTGGACTACATAAAAGACCTCGGCGGCGGCGGGCTTACAACAGCTATATCGGA
GGCTGCCGGGGACTATGATCTAGGTGTTGAAATATATTTAGACAGGCTGCATCTACGCATGGATCTAGAGCCATACGAGA
TCCTTGCCTCGGAAAGTCAGGAGAGGATGCTACTGGCTGTTCCACGCGAAAACTTCAATGAATTAATCGGGATCCTCGAG
AAATATGAGGTACCATATAGTGTTATAGGGATCTTCAATGATAGTGGTTTCATAAGAGTGTATTATAAGGGTAGAATAAT
TGCGGAAGTCCCCAGTAAGGCTATGGCTAGGCCACGTGCACTGGTAAGGAAATCCAAGCCGCCTGAAGACGTGTTGAAGG
GGCTAACTCCTCTCCAAGGCATCCCTGAGCCAGACCTGGAGGATGCCATTATAAGGATCTTCTCCTCACCTAATATTGTG
TCTAGGAGATGGATATATGAGCAGTACGATCACGAGGTAGGCGGTAGAACGGTTGTGAAACCAGGTATAGGTGATGCAGC
CGTCTTAAAGATTAATGATGATAAGGGTATAGCCGTGAAAGGCGATGGTAATCCAAGATACACGTGGCTCAATCCATTTA
ATGGAGCTGCAAACGTGGTGTCTGAGTGTTATAGAAACCTGGTCTCAGTGGGATCGACGCCGCTAGCTATAGTGGATGAA
TTAAATGCTGGTAACCCTGAGAAGCCTGAACACTACTGGTTCTTCGAGAATATGTTGAAGGGGCTGGCATGGATCTCGGA
TGAACTAGGCCTACCGGTTGTAGGGGGTAAGGTCAGCTTCTATAACGAGGATTCAAGCGGTAATCAAGTGAAACCAACCC
TAGCCATTGTAGGTATAGGTAGGGTTGAAAATGTAAGGAAAGCTAAGACAATGGAGTTTAAGGAGCCAGGGTCATATATA
GTTGTGATCGGGGAAACTCTTCCGGAAATAGGGGGTAGTGAATACCTGTACAGGGTACACGGCTTAGAGGTAGGTGAGAT
ACCTGTTCCGAGACCCCGTTTGGAATACATGCACGGGAGTACTGTAAGGATGCTCATCAACGAGGATGCAGTGTCCTCCG
TGCACGATGTTTCAATAGGAGGGCTTGTAACGAGTATGCTTGAGATGGCTGTGGCAAGCGGGCTTGGTGCTGAAGTAGAG
CTATCCCTTGTACCGTCGAGGGGTATTGATAGACTGGATTACCTATTATTCTCCGAGACCCAAGCGAGATACATTGTAGA
AGTACCGTTAAACAAGGTTGAGAAGGCTAGGAGGATACTCGATGAAATGAATGTAGTATACGGAGTAGTGGGAAGGGTGT
CGAGTAGAAGCCAGGTCGATCTTCTAGTGAATGGGAAGAGGATACTCGAGTTAGATATCGGTGTGCTCAGGGAGATCTAT
GCTGACTCCCTGGAGAAATACCTTGAGAGAGGCTAG

Upstream 100 bases:

>100_bases
CACATCCCGAGAGAGCCGTTGAACCTGAATTGACTCCAAGGGGCTTTAACCCCGGTGGCAAGCTTGTTTTTGAGAGTATA
TATTTCGCGCTCAGGAATGG

Downstream 100 bases:

>100_bases
TAATATATGTGTGGGATAGCCGCTTACATGGGAAGAGGGGATCACTTCAGGATCCTGGTTGAGCTATTATTGGAGTTGCA
GCATAGGGGACAGGAGGCTG

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II [H]

Number of amino acids: Translated: 731; Mature: 731

Protein sequence:

>731_residues
MVKMPLSVEEIDEIRDILKREPTREELVMFEAHWSEHCSYKSSRRLLRLLPNKGNHVVLGPGRDAPAVEVFPGILAVFKI
ESHNHPSAVDPYNGAATGIGGIIRDILTLGAKPIALLDLLYMGNPFNPHAKWLIRNIVKGISDYGNRVGVPVVAGDTWFD
ESFNKQPLVNVACLGIVEKNKAVLSKPRPGDLVVIIGNSTGRDGLLGSSFASAPLKDNMVEDIGAVQIGDALMEKMLIDV
VNEVVEKKLVDYIKDLGGGGLTTAISEAAGDYDLGVEIYLDRLHLRMDLEPYEILASESQERMLLAVPRENFNELIGILE
KYEVPYSVIGIFNDSGFIRVYYKGRIIAEVPSKAMARPRALVRKSKPPEDVLKGLTPLQGIPEPDLEDAIIRIFSSPNIV
SRRWIYEQYDHEVGGRTVVKPGIGDAAVLKINDDKGIAVKGDGNPRYTWLNPFNGAANVVSECYRNLVSVGSTPLAIVDE
LNAGNPEKPEHYWFFENMLKGLAWISDELGLPVVGGKVSFYNEDSSGNQVKPTLAIVGIGRVENVRKAKTMEFKEPGSYI
VVIGETLPEIGGSEYLYRVHGLEVGEIPVPRPRLEYMHGSTVRMLINEDAVSSVHDVSIGGLVTSMLEMAVASGLGAEVE
LSLVPSRGIDRLDYLLFSETQARYIVEVPLNKVEKARRILDEMNVVYGVVGRVSSRSQVDLLVNGKRILELDIGVLREIY
ADSLEKYLERG

Sequences:

>Translated_731_residues
MVKMPLSVEEIDEIRDILKREPTREELVMFEAHWSEHCSYKSSRRLLRLLPNKGNHVVLGPGRDAPAVEVFPGILAVFKI
ESHNHPSAVDPYNGAATGIGGIIRDILTLGAKPIALLDLLYMGNPFNPHAKWLIRNIVKGISDYGNRVGVPVVAGDTWFD
ESFNKQPLVNVACLGIVEKNKAVLSKPRPGDLVVIIGNSTGRDGLLGSSFASAPLKDNMVEDIGAVQIGDALMEKMLIDV
VNEVVEKKLVDYIKDLGGGGLTTAISEAAGDYDLGVEIYLDRLHLRMDLEPYEILASESQERMLLAVPRENFNELIGILE
KYEVPYSVIGIFNDSGFIRVYYKGRIIAEVPSKAMARPRALVRKSKPPEDVLKGLTPLQGIPEPDLEDAIIRIFSSPNIV
SRRWIYEQYDHEVGGRTVVKPGIGDAAVLKINDDKGIAVKGDGNPRYTWLNPFNGAANVVSECYRNLVSVGSTPLAIVDE
LNAGNPEKPEHYWFFENMLKGLAWISDELGLPVVGGKVSFYNEDSSGNQVKPTLAIVGIGRVENVRKAKTMEFKEPGSYI
VVIGETLPEIGGSEYLYRVHGLEVGEIPVPRPRLEYMHGSTVRMLINEDAVSSVHDVSIGGLVTSMLEMAVASGLGAEVE
LSLVPSRGIDRLDYLLFSETQARYIVEVPLNKVEKARRILDEMNVVYGVVGRVSSRSQVDLLVNGKRILELDIGVLREIY
ADSLEKYLERG
>Mature_731_residues
MVKMPLSVEEIDEIRDILKREPTREELVMFEAHWSEHCSYKSSRRLLRLLPNKGNHVVLGPGRDAPAVEVFPGILAVFKI
ESHNHPSAVDPYNGAATGIGGIIRDILTLGAKPIALLDLLYMGNPFNPHAKWLIRNIVKGISDYGNRVGVPVVAGDTWFD
ESFNKQPLVNVACLGIVEKNKAVLSKPRPGDLVVIIGNSTGRDGLLGSSFASAPLKDNMVEDIGAVQIGDALMEKMLIDV
VNEVVEKKLVDYIKDLGGGGLTTAISEAAGDYDLGVEIYLDRLHLRMDLEPYEILASESQERMLLAVPRENFNELIGILE
KYEVPYSVIGIFNDSGFIRVYYKGRIIAEVPSKAMARPRALVRKSKPPEDVLKGLTPLQGIPEPDLEDAIIRIFSSPNIV
SRRWIYEQYDHEVGGRTVVKPGIGDAAVLKINDDKGIAVKGDGNPRYTWLNPFNGAANVVSECYRNLVSVGSTPLAIVDE
LNAGNPEKPEHYWFFENMLKGLAWISDELGLPVVGGKVSFYNEDSSGNQVKPTLAIVGIGRVENVRKAKTMEFKEPGSYI
VVIGETLPEIGGSEYLYRVHGLEVGEIPVPRPRLEYMHGSTVRMLINEDAVSSVHDVSIGGLVTSMLEMAVASGLGAEVE
LSLVPSRGIDRLDYLLFSETQARYIVEVPLNKVEKARRILDEMNVVYGVVGRVSSRSQVDLLVNGKRILELDIGVLREIY
ADSLEKYLERG

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family [H]

Homologues:

Organism=Homo sapiens, GI31657129, Length=737, Percent_Identity=25.6445047489824, Blast_Score=132, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17553022, Length=795, Percent_Identity=25.0314465408805, Blast_Score=123, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6321498, Length=486, Percent_Identity=26.1316872427983, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24582111, Length=727, Percent_Identity=25.7221458046768, Blast_Score=123, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24582109, Length=727, Percent_Identity=25.7221458046768, Blast_Score=123, Evalue=6e-28,
Organism=Drosophila melanogaster, GI17137292, Length=727, Percent_Identity=25.7221458046768, Blast_Score=123, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 80527; Mature: 80527

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKMPLSVEEIDEIRDILKREPTREELVMFEAHWSEHCSYKSSRRLLRLLPNKGNHVVLG
CCCCCCCHHHHHHHHHHHHCCCCHHHEEEEEEHHHHHCCCHHHHHHHHHCCCCCCEEEEC
PGRDAPAVEVFPGILAVFKIESHNHPSAVDPYNGAATGIGGIIRDILTLGAKPIALLDLL
CCCCCCHHHHHHCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHH
YMGNPFNPHAKWLIRNIVKGISDYGNRVGVPVVAGDTWFDESFNKQPLVNVACLGIVEKN
HHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCEEEEEEEEECC
KAVLSKPRPGDLVVIIGNSTGRDGLLGSSFASAPLKDNMVEDIGAVQIGDALMEKMLIDV
CHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHCHHHHHHHHHHHHHHHH
VNEVVEKKLVDYIKDLGGGGLTTAISEAAGDYDLGVEIYLDRLHLRMDLEPYEILASESQ
HHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCEEEEEEEHEEECCCHHHHHHCCCC
ERMLLAVPRENFNELIGILEKYEVPYSVIGIFNDSGFIRVYYKGRIIAEVPSKAMARPRA
CCEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCEEEEECCHHHHHCCHH
LVRKSKPPEDVLKGLTPLQGIPEPDLEDAIIRIFSSPNIVSRRWIYEQYDHEVGGRTVVK
HHHCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEC
PGIGDAAVLKINDDKGIAVKGDGNPRYTWLNPFNGAANVVSECYRNLVSVGSTPLAIVDE
CCCCCEEEEEEECCCCEEEECCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEC
LNAGNPEKPEHYWFFENMLKGLAWISDELGLPVVGGKVSFYNEDSSGNQVKPTLAIVGIG
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCEEEEECCCCCCCEECCEEEEEECC
RVENVRKAKTMEFKEPGSYIVVIGETLPEIGGSEYLYRVHGLEVGEIPVPRPRLEYMHGS
CHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCEEEEEECEEECCCCCCCCHHHHCCCC
TVRMLINEDAVSSVHDVSIGGLVTSMLEMAVASGLGAEVELSLVPSRGIDRLDYLLFSET
EEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHCCCC
QARYIVEVPLNKVEKARRILDEMNVVYGVVGRVSSRSQVDLLVNGKRILELDIGVLREIY
CCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEEEHHHHHHHHH
ADSLEKYLERG
HHHHHHHHHCC
>Mature Secondary Structure
MVKMPLSVEEIDEIRDILKREPTREELVMFEAHWSEHCSYKSSRRLLRLLPNKGNHVVLG
CCCCCCCHHHHHHHHHHHHCCCCHHHEEEEEEHHHHHCCCHHHHHHHHHCCCCCCEEEEC
PGRDAPAVEVFPGILAVFKIESHNHPSAVDPYNGAATGIGGIIRDILTLGAKPIALLDLL
CCCCCCHHHHHHCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHH
YMGNPFNPHAKWLIRNIVKGISDYGNRVGVPVVAGDTWFDESFNKQPLVNVACLGIVEKN
HHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCEEEEEEEEECC
KAVLSKPRPGDLVVIIGNSTGRDGLLGSSFASAPLKDNMVEDIGAVQIGDALMEKMLIDV
CHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHCHHHHHHHHHHHHHHHH
VNEVVEKKLVDYIKDLGGGGLTTAISEAAGDYDLGVEIYLDRLHLRMDLEPYEILASESQ
HHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCEEEEEEEHEEECCCHHHHHHCCCC
ERMLLAVPRENFNELIGILEKYEVPYSVIGIFNDSGFIRVYYKGRIIAEVPSKAMARPRA
CCEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCEEEEECCHHHHHCCHH
LVRKSKPPEDVLKGLTPLQGIPEPDLEDAIIRIFSSPNIVSRRWIYEQYDHEVGGRTVVK
HHHCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEC
PGIGDAAVLKINDDKGIAVKGDGNPRYTWLNPFNGAANVVSECYRNLVSVGSTPLAIVDE
CCCCCEEEEEEECCCCEEEECCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEC
LNAGNPEKPEHYWFFENMLKGLAWISDELGLPVVGGKVSFYNEDSSGNQVKPTLAIVGIG
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCEEEEECCCCCCCEECCEEEEEECC
RVENVRKAKTMEFKEPGSYIVVIGETLPEIGGSEYLYRVHGLEVGEIPVPRPRLEYMHGS
CHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCEEEEEECEEECCCCCCCCHHHHCCCC
TVRMLINEDAVSSVHDVSIGGLVTSMLEMAVASGLGAEVELSLVPSRGIDRLDYLLFSET
EEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHCCCC
QARYIVEVPLNKVEKARRILDEMNVVYGVVGRVSSRSQVDLLVNGKRILELDIGVLREIY
CCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEEEHHHHHHHHH
ADSLEKYLERG
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA